245
Views
34
CrossRef citations to date
0
Altmetric
Research Article

The Use of Lipid-Based Formulations to Increase the Oral Bioavailability of Panax Notoginseng Saponins Following a Single Oral Gavage to Rats

, , , &
Pages 65-72 | Published online: 25 Sep 2008

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (6)

Yuhui Wang, Jinyang Shen, Xiaolin Yang, Ye Jin, Zhonglin Yang, Rufeng Wang, Fuming Zhang & Robert J. Linhardt. (2019) Mechanism of enhanced oral absorption of akebia saponin D by a self-nanoemulsifying drug delivery system loaded with phospholipid complex. Drug Development and Industrial Pharmacy 45:1, pages 124-129.
Read now
Jinyang Shen, Jianping Bi, Hongli Tian, Ye Jin, Yuan Wang, Xiaolin Yang, Zhonglin Yang, Junping Kou & Fei Li. (2016) Preparation and evaluation of a self-nanoemulsifying drug delivery system loaded with Akebia saponin D–phospholipid complex. International Journal of Nanomedicine 11, pages 4919-4929.
Read now
Ghulam Abbas, Khalid Rauf & Wajahat Mahmood. (2015) Saponins: the phytochemical with an emerging potential for curing clinical depression. Natural Product Research 29:4, pages 302-307.
Read now
Chun Shi, Ning Na, Xiaoming Zhu & Jie Xu. (2013) Estrogenic effect of Ginsenoside Rg1 on APP processing in post-menopausal platelets. Platelets 24:1, pages 51-62.
Read now
Kareem AbuBakr Soliman, Howida Kamal Ibrahim & Mahmoud Mohamed Ghorab. (2012) Formulation of Risperidone as Self-Nanoemulsifying Drug Delivery System in Form of Effervescent Tablets. Journal of Dispersion Science and Technology 33:8, pages 1127-1133.
Read now
Zhongbin Wu, Dan Guo, Li Deng, Yue Zhang, Qiuxia Yang & Jianming Chen. (2011) Preparation and evaluation of a self-emulsifying drug delivery system of etoposide–phospholipid complex. Drug Development and Industrial Pharmacy 37:1, pages 103-112.
Read now

Articles from other publishers (28)

Mohamed Ben-Eltriki, Gehana Shankar, Emma S. Tomlinson Guns & Subrata Deb. (2023) Pharmacokinetics and pharmacodynamics of Rh2 and aPPD ginsenosides in prostate cancer: a drug interaction perspective. Cancer Chemotherapy and Pharmacology 92:6, pages 419-437.
Crossref
Qi-rui Hu, Huan Hong, Zhi-hong Zhang, Hua Feng, Ting Luo, Jing Li, Ze-yuan Deng & Fang Chen. (2023) Methods on improvements of the poor oral bioavailability of ginsenosides: Pre-processing, structural modification, drug combination, and micro- or nano- delivery system. Journal of Ginseng Research 47:6, pages 694-705.
Crossref
Xinzhen Fu, Kun Chen, Zhi Li, Huaying Fan, Bo Xu, Ming Liu, Lin Guo, Zeping Xie, Ke Liu, Shumin Zhang & Lijuan Kou. (2022) Pharmacokinetics and Oral Bioavailability of Panax Notoginseng Saponins Administered to Rats Using a Validated UPLC–MS/MS Method . Journal of Agricultural and Food Chemistry 71:1, pages 469-479.
Crossref
Juan Huang, Ming Jiong Gong, Jun Qi Bai, He Su, Lu Gong, Zhi Hai Huang, Xiao Hui Qiu, Wen Xu & Jing Zhang. (2022) Differential metabolic profiles of ginsenosides in artificial gastric juice using ultra‐high‐pressure liquid chromatography coupled with linear ion trap‐Orbitrap mass spectrometry. Biomedical Chromatography 36:12.
Crossref
Hui Chen, Ying Zhao, Ran Li, Bin Chen, Zhiman Luo, Yaling Shi, Kaiqiu Wang, Wei Zhang & Shiyuan Lin. (2022) Preparation and In Vitro and In Vivo Evaluation Of Panax Notoginseng Saponins-loaded Nanoparticles Coated with Trimethyl Chitosan Derivatives. Journal of Pharmaceutical Sciences 111:6, pages 1659-1666.
Crossref
Hong Wang, Yu Zheng, Qiang Sun, Zhen Zhang, Mengnan Zhao, Cheng Peng & Sanjun Shi. (2021) Ginsenosides emerging as both bifunctional drugs and nanocarriers for enhanced antitumor therapies. Journal of Nanobiotechnology 19:1.
Crossref
Bikram Khadka, Jae-Young Lee, Dong Ho Park, Ki-Taek Kim & Jong-Sup Bae. (2020) The Role of Natural Compounds and their Nanocarriers in the Treatment of CNS Inflammation. Biomolecules 10:10, pages 1401.
Crossref
Bang-Yue Luo, Jia-Li Jiang, Yi-Fan Fang, Fang Yang, Meng-Die Yin, Bing-Chen Zhang, Rui-Rui Zhao & Jing-Wei Shao. (2020) The effects of ginsenosides on platelet aggregation and vascular intima in the treatment of cardiovascular diseases: From molecular mechanisms to clinical applications. Pharmacological Research 159, pages 105031.
Crossref
Guangyao Shi, Dinghui Liu, Bin Zhou, Yong Liu, Baoshun Hao, Shujie Yu, Lin Wu, Min Wang, Zhiming Song, Chaodong Wu, Jieming Zhu & Xiaoxian Qian. (2020) Ginsenoside Rb1 Alleviates Oxidative Low-Density Lipoprotein–Induced Vascular Endothelium Senescence via the SIRT1/Beclin-1/Autophagy Axis. Journal of Cardiovascular Pharmacology 75:2, pages 155-167.
Crossref
Akhtar Hussain Sh, Mohamed Shahen, Liujingjing .Shenfengxia .Yonghua Wang. (2019) Herbal Traditional Medicines Ginseng (Panax quinquennium L.) Effects on Anti-nose Cancer and Anti-toxin in Systematic Pharmacology Treatment Mechanism for Nose Cancer: A Review. International Journal of Pharmacology 15:1, pages 10-18.
Crossref
Md. Jakaria, Md. Ezazul Haque, Joonsoo Kim, Duk-Yeon Cho, In-Su Kim & Dong-Kug Choi. (2018) Active ginseng components in cognitive impairment: Therapeutic potential and prospects for delivery and clinical study. Oncotarget 9:71, pages 33601-33620.
Crossref
Zülal Özdemir, Uladzimir Bildziukevich, Martina Wimmerová, Anna Macůrková, Petra Lovecká & Zdeněk Wimmer. (2018) Plant Adaptogens: Natural Medicaments for 21 st Century? . ChemistrySelect 3:7, pages 2196-2214.
Crossref
Yang Ye, Tian Mengyuan, Guo Lan-Ping, Liu Dahui, Qu Yu & Cui Xiu-Ming. (2018) Effect of different cleaning processes on saponins' loss rate and total ash clearance rate of Notoginseng and heavy metal health risk assessment. Journal of Food Processing and Preservation 42:1, pages e13409.
Crossref
Joaquín Navarro del Hierro, Teresa Herrera, Tiziana Fornari, Guillermo Reglero & Diana Martin. (2018) The gastrointestinal behavior of saponins and its significance for their bioavailability and bioactivities. Journal of Functional Foods 40, pages 484-497.
Crossref
Peihe ZhengYinbin ChenYangyang FuHecheng WangJia WangSiwen ZhengShengyuan XiaoYingping Wang. (2017) Influence of B-Complex Vitamins on the Pharmacokinetics of Ginsenosides Rg 1 , Rb 1 , and Ro After Oral Administration . Journal of Medicinal Food 20:11, pages 1127-1132.
Crossref
Yin Bin Chen, Yu Fang Wang, Wei Hou, Ying Ping Wang, Sheng Yuan Xiao, Yang Yang Fu, Jia Wang, Si Wen Zheng & Pei He Zheng. (2017) Effect of B-complex vitamins on the antifatigue activity and bioavailability of ginsenoside Re after oral administration. Journal of Ginseng Research 41:2, pages 209-214.
Crossref
Kareem AbuBakr Soliman, Howida Kamal Ibrahim & Mahmoud Mohammed Ghorab. (2016) Formulation of avanafil in a solid self-nanoemulsifying drug delivery system for enhanced oral delivery. European Journal of Pharmaceutical Sciences 93, pages 447-455.
Crossref
Hiroyuki Inagaki, Ryouichi Ito, Yuko Setoguchi, Yukihiro Oritani & Tatsuhiko Ito. (2016) Administration of Piceatannol Complexed with α-Cyclodextrin Improves Its Absorption in Rats. Journal of Agricultural and Food Chemistry 64:18, pages 3557-3563.
Crossref
Natasya Trivena Rokot, Timothy Sean Kairupan, Kai-Chun Cheng, Joshua Runtuwene, Nova Hellen Kapantow, Marie Amitani, Akinori Morinaga, Haruka Amitani, Akihiro Asakawa & Akio Inui. (2016) A Role of Ginseng and Its Constituents in the Treatment of Central Nervous System Disorders. Evidence-Based Complementary and Alternative Medicine 2016, pages 1-7.
Crossref
Jinyang Shen, Ye Jin, Hongli Tian, Yuan Wang, Xiaolin Yang, Zhonglin Yang, Changrun Guo & Fei Li. (2016) Enhancement of oral bioavailability of akebia saponin D by destroying self-micelles and inhibiting multidrug resistance-associated protein mediated efflux. RSC Advances 6:76, pages 72439-72446.
Crossref
Mohammed M. Mehanna, Jana K. Alwattar & Hoda A. Elmaradny. (2015) Optimization, physicochemical characterization and in vivo assessment of spray dried emulsion: A step toward bioavailability augmentation and gastric toxicity minimization. International Journal of Pharmaceutics 496:2, pages 766-779.
Crossref
Shun-Xing Li, Yang Mu & Feng-Ying Zheng. (2013) Influence of Gastrointestinal Digestion and Edible Plant Combination on Oral Bioavailability of Triterpene Saponins, Using a Biomimetic Digestion and Absorption System and Determination by HPLC. Journal of Agricultural and Food Chemistry 61:44, pages 10599-10603.
Crossref
Mingfei Zeng, Linmei Pan, Shunmei Qi, Yuntai Cao, Huaxu Zhu, Liwei Guo & Jing Zhou. (2013) Systematic review of recent advances in pharmacokinetics of four classical Chinese medicines used for the treatment of cerebrovascular disease. Fitoterapia 88, pages 50-75.
Crossref
Kar Wah Leung. 2013. Natural Products. Natural Products 3497 3514 .
Paulo José Salústio, Patrícia Pontes, Claúdia Conduto, Inês Sanches, Catarina Carvalho, João Arrais & Helena M. Cabral Marques. (2011) Advanced Technologies for Oral Controlled Release: Cyclodextrins for Oral Controlled Release. AAPS PharmSciTech 12:4, pages 1276-1292.
Crossref
Stefano Perni, Isabella Calzuola, Gian Luigi Gianfranceschi, Flavio Giavarini, Paolo Lucci, Deborah Pacetti, Natale Giuseppe Frega & Valeria Marsili. (2011) Biochemical and mass spectrometry recognition of phospholipid–peptide complexes in wheat sprouts extract. Journal of Peptide Science 17:11, pages 744-750.
Crossref
Jianjun Zhang, Yuan Gao, Shuai Qian, Xin Liu & Hui Zu. (2011) Physicochemical and pharmacokinetic characterization of a spray-dried malotilate emulsion. International Journal of Pharmaceutics 414:1-2, pages 186-192.
Crossref
Jing Xiong, Jianxin Guo, Luosheng Huang, Boyu Meng & Qineng Ping. (2008) Self-micelle formation and the incorporation of lipid in the formulation affect the intestinal absorption of Panax notoginseng. International Journal of Pharmaceutics 360:1-2, pages 191-196.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.