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Research Article

A Novel Superdisintegrating Agent Made from Physically Modified Chitosan with Silicon Dioxide

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Pages 373-383 | Published online: 25 Sep 2008

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Read on this site (12)

Shereen H. Noshi, Mervat Shafik Ibrahim, Abeer Salama, Iman A. Fathy & Nihal Mohamed Elmahdy Elsayyad. (2023) Chondroitin Sulphate-Chitosan polyelectrolyte complexes for etorocoxib transdermal delivery: in silico, in vitro and in vivo studies. Pharmaceutical Development and Technology 28:8, pages 785-798.
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Faisal Al-Akayleh, Nisrein Jaber, Mayyas Al-Remawi, Ghazi Al Odwan & Nidal Qinna. (2022) Chitosan-biotin topical film: preparation and evaluation of burn wound healing activity. Pharmaceutical Development and Technology 27:4, pages 479-489.
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Prashantkumar K. Parmar, Srilaxmi G. Rao & Arvind K. Bansal. (2021) Co-processing of small molecule excipients with polymers to improve functionality. Expert Opinion on Drug Delivery 18:7, pages 907-928.
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Yu Xia, Chun-Yang Shi, Jian-Guo Fang & Wen-Qing Wang. (2018) Approaches to developing fast release pellets via wet extrusion-spheronization. Pharmaceutical Development and Technology 23:5, pages 432-441.
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Kamran Zaheer & Peter Langguth. (2018) Formulation strategy towards minimizing viscosity mediated negative food effect on disintegration and dissolution of immediate release tablets. Drug Development and Industrial Pharmacy 44:3, pages 444-451.
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Payal Sharma, Sameer R. Modi & Arvind K. Bansal. (2015) Co-processing as a tool to improve aqueous dispersibility of cellulose ethers. Drug Development and Industrial Pharmacy 41:11, pages 1745-1758.
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Alvaro Goyanes & Ramón Martínez-Pacheco. (2015) New co-processed MCC-based excipient for fast release of low solubility drugs from pellets prepared by extrusion-spheronization. Drug Development and Industrial Pharmacy 41:3, pages 362-368.
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Min Zhu, Yufang Zhu, Lingxia Zhang & Jianlin Shi. (2013) Preparation of chitosan/mesoporous silica nanoparticle composite hydrogels for sustained co-delivery of biomacromolecules and small chemical drugs. Science and Technology of Advanced Materials 14:4.
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Alvaro Goyanes, Consuelo Souto & Ramón Martínez-Pacheco. (2013) Chitosan–kaolin coprecipitate as disintegrant in microcrystalline cellulose-based pellets elaborated by extrusion–spheronization. Pharmaceutical Development and Technology 18:1, pages 137-145.
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John Rojas, Ira Buckner & Vijay Kumar. (2012) Co-proccessed excipients with enhanced direct compression functionality for improved tableting performance. Drug Development and Industrial Pharmacy 38:10, pages 1159-1170.
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Alvaro Goyanes, Consuelo Souto & Ramón Martínez-Pacheco. (2011) A comparison of chitosan-silica and sodium starch glycolate as disintegrants for spheronized extruded microcrystalline cellulose pellets. Drug Development and Industrial Pharmacy 37:7, pages 825-831.
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Meirong Song, Yanyan Li, Cailing Fai, Shumin Cui & Baoan Cui. (2011) The controlled release of tilmicosin from silica nanoparticles. Drug Development and Industrial Pharmacy 37:6, pages 714-718.
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Articles from other publishers (39)

Ahmed Saud Abdulhameed, Ruihong Wu, Salis Auwal Musa, Hasan M. Agha, Zeid A. ALOthman, Ali H. Jawad & Sameer Algburi. (2024) Bisphenol-A-diglycidyl ether modified chitosan/nano-SiO2 via hydrothermal process: A statistical modeling and adsorption mechanism for reactive orange 16 dye removal. International Journal of Biological Macromolecules 256, pages 128267.
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Ruihong Wu, Ahmed Saud Abdulhameed, Ali H. Jawad, Soon Kong Yong, He Li, Zeid A. ALOthman, Lee D. Wilson & Sameer Algburi. (2023) Development of a chitosan/nanosilica biocomposite with arene functionalization via hydrothermal synthesis for acid red 88 dye removal. International Journal of Biological Macromolecules 252, pages 126342.
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Chonticha Amornrojvaravut & Jomjai Peerapattana. (2023) Application of co-precipitated glutinous rice starch as a multifunctional excipient in direct compression tablets. Heliyon 9:9, pages e19904.
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Ruihong Wu, Ahmed Saud Abdulhameed, Soon Kong Yong, He Li, Zeid A. ALOthman, Lee D. Wilson & Ali H. Jawad. (2023) Functionalization of chitosan biopolymer with SiO2 nanoparticles and benzaldehyde via hydrothermal process for acid red 88 dye adsorption: Box-Behnken design optimization. International Journal of Biological Macromolecules 247, pages 125806.
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Rachana D Pockle, Rajashree S Masareddy, Archana S Patil & Pragati D Patil. (2023) A comprehensive review on pharmaceutical excipients. Therapeutic Delivery 14:7, pages 443-458.
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Pratap Kalita, Abdul Baquee Ahmed, Saikat Sen & Raja Chakraborty. (2023) Citric acid esterified Glutinous Assam bora rice starch enhances disintegration and dissolution efficiency of model drug. International Journal of Biological Macromolecules 227, pages 424-436.
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Faisal Al-Akayleh, Nisrein Jaber & Mayyas Al-Remawi. (2020) Designing, Preparation, and Evaluation of Orodispersible Chitosan Anionic Salt Tablets. Journal of Pharmaceutical Innovation 17:1, pages 129-141.
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Chonwipa Yarangsee, Phanphen Wattanaarsakit, Jakkapan Sirithunyalug & Phuriwat Leesawat. (2021) Particle Engineering of Chitosan and Kaolin Composite as a Novel Tablet Excipient by Nanoparticles Formation and Co-Processing. Pharmaceutics 13:11, pages 1844.
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Jan Tomas, Jakub Dvořák, Ondřej Dammer & František Štěpánek. (2021) Frequency analysis of stress relaxation patterns reveals the effect of formulation and process history on tablet disintegration. Powder Technology 379, pages 438-446.
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Alperen Abaci, Christina Gedeon, Anna Kuna & Murat Guvendiren. (2021) Additive Manufacturing of Oral Tablets: Technologies, Materials and Printed Tablets. Pharmaceutics 13:2, pages 156.
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R. Benabbas, N.M. Sanchez-Ballester, B. Bataille, T. Sharkawi & I. Soulairol. (2021) Development and pharmaceutical performance of a novel co-processed excipient of alginic acid and microcrystalline cellulose. Powder Technology 378, pages 576-584.
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Daisuke Sugiura, Yoshinori Onuki, Yoshiaki Fujita, Akihiro Nakamura & Tsutomu Harada. (2020) Effect of Disintegrants on Prolongation of Tablet Disintegration Induced by Immersion in Xanthan Gum-Containing Thickening Solution: Contribution of Disintegrant Interactions with Disintegration Fluids. Chemical and Pharmaceutical Bulletin 68:11, pages 1055-1060.
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Karnkamol Trisopon, Nisit Kittipongpatana & Ornanong Suwannapakul Kittipongpatana. (2020) A Spray-Dried, Co-Processed Rice Starch as a Multifunctional Excipient for Direct Compression. Pharmaceutics 12:6, pages 518.
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Maykel González Torres. (2020) 3D-composite scaffolds from radiation-induced chitosan grafted poly(3-hydroxybutyrate) polyurethane. Materials Today Communications 23, pages 100902.
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Adrian Szewczyk & Magdalena Prokopowicz. (2020) Mesoporous silica pellets – A promising oral drug delivery system?. Journal of Drug Delivery Science and Technology 56, pages 101491.
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Phuong H.L. Tran & Thao T.D. Tran. (2020) Recent Strategic Developments in the Use of Superdisintegrants for Drug Delivery. Current Pharmaceutical Design 26:6, pages 701-709.
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Deeb Abu Fara, Linda Al-Hmoud, Iyad Rashid, Babur Z. Chowdhry & Adnan Badwan. (2020) Understanding the Performance of a Novel Direct Compression Excipient Comprising Roller Compacted Chitin. Marine Drugs 18:2, pages 115.
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Kamran Zaheer & Peter Langguth. (2019) Designing robust immediate release tablet formulations avoiding food effects for BCS class 3 drugs. European Journal of Pharmaceutics and Biopharmaceutics 139, pages 177-185.
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Katarzyna Walczak, Jessica Thiele, Daniel Geisler, Klaus Boening & Mieszko Wieckiewicz. (2018) Effect of Chemical Disinfection on Chitosan Coated PMMA and PETG Surfaces—An In Vitro Study. Polymers 10:5, pages 536.
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Yonni E. Apeji, Avosuahi R. Oyi, Adamu B. Isah, Teryila S. Allagh, Sameer R. Modi & Arvind K. Bansal. (2017) Development and Optimization of a Starch-Based Co-processed Excipient for Direct Compression Using Mixture Design. AAPS PharmSciTech 19:2, pages 866-880.
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Yoshinori Onuki, Atsushi Kosugi, Masashi Hamaguchi, Yuki Marumo, Shungo Kumada, Daijiro Hirai, Junko Ikeda & Yoshihiro Hayashi. (2018) A comparative study of disintegration actions of various disintegrants using Kohonen's self-organizing maps. Journal of Drug Delivery Science and Technology 43, pages 141-148.
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. (2017) Comparative analysis of co-processed starches prepared by three different methods. British Journal of Pharmacy 2:1.
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Mieszko Więckiewicz, Eric Wolf, Katarzyna Walczak, Heike Meissner & Klaus Boening. (2017) Chitosan Coating on Silica-Modified Polymethyl Methacrylate for Dental Applications. Coatings 7:10, pages 168.
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Wang-Zhan Jiang, Yang Cai & Hao-Ying Li. (2017) Chitosan-based spray-dried mucoadhesive microspheres for sustained oromucosal drug delivery. Powder Technology 312, pages 124-132.
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Faisal Alakayleh, Iyad Rashid, Mahmoud M.H. Al-Omari, Khaldoun Al-Sou'od, Babur Z. Chowdhry & Adnan A. Badwan. (2016) Compression profiles of different molecular weight chitosans. Powder Technology 299, pages 107-118.
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Parind Mahendrakumar Desai, Celine Valeria Liew & Paul Wan Sia Heng. (2016) Review of Disintegrants and the Disintegration Phenomena. Journal of Pharmaceutical Sciences 105:9, pages 2545-2555.
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Mayyas Al-Remawi. (2015) Application of N-hexoyl chitosan derivatives with high degree of substitution in the preparation of super-disintegrating pharmaceutical matrices. Journal of Drug Delivery Science and Technology 29, pages 31-41.
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Adnan Badwan, Iyad Rashid, Mahmoud Omari & Fouad Darras. (2015) Chitin and Chitosan as Direct Compression Excipients in Pharmaceutical Applications. Marine Drugs 13:3, pages 1519-1547.
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John Rojas. 2015. Excipient Applications in Formulation Design and Drug Delivery. Excipient Applications in Formulation Design and Drug Delivery 589 612 .
Iyad Rashid, Mahmoud M. H. Al Omari & Adnan A. Badwan. (2013) From native to multifunctional starch‐based excipients designed for direct compression formulation. Starch - Stärke 65:7-8, pages 552-571.
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Parind Mahendrakumar Desai, Celine Valeria Liew & Paul Wan Sia Heng. (2012) Understanding Disintegrant Action by Visualization. Journal of Pharmaceutical Sciences 101:6, pages 2155-2164.
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Ornanong Suwannapakul Kittipongpatana & Nisit Kittipongpatana. (2012) Preparation and physicomechanical properties of co-precipitated rice starch-colloidal silicon dioxide. Powder Technology 217, pages 377-382.
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Bhatu Badgujar & Atish Mundada. (2011) The technologies used for developing orally disintegrating tablets: A review. Acta Pharmaceutica 61:2, pages 117-139.
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Nidal Daraghmeh, Iyad Rashid, Mahmoud M. H. Al Omari, Stephen A. Leharne, Babur Z. Chowdhry & Adnan Badwan. (2010) Preparation and Characterization of a Novel Co-processed Excipient of Chitin and Crystalline Mannitol. AAPS PharmSciTech 11:4, pages 1558-1571.
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Iyad Rashid, Nidal Daraghmeh, Mayyas Al-Remawi, Stephen A. Leharne, Babur Z. Chowdhry & Adnan Badwan. (2010) Characterization of the impact of magnesium stearate lubrication on the tableting properties of chitin-Mg silicate as a superdisintegrating binder when compared to Avicel® 200. Powder Technology 203:3, pages 609-619.
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Sarah Gordon, Elena Teichmann, Katherine Young, Kim Finnie, Thomas Rades & Sarah Hook. (2010) In vitro and in vivo investigation of thermosensitive chitosan hydrogels containing silica nanoparticles for vaccine delivery. European Journal of Pharmaceutical Sciences 41:2, pages 360-368.
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Mangesh R. Bhalekar, Swapnil S. Desale & Ashwini R. Madgulkar. (2010) Synthesis of MCC–PEG Conjugate and Its Evaluation as a Superdisintegrant. AAPS PharmSciTech 11:3, pages 1171-1178.
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Rana Al-Shaikh Hamid, Faisal Al-Akayleh, Mohammad Shubair, Iyad Rashid, Mayyas Al Remawi & Adnan Badwan. (2010) Evaluation of Three Chitin Metal Silicate Co-Precipitates as a Potential Multifunctional Single Excipient in Tablet Formulations. Marine Drugs 8:5, pages 1699-1715.
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Iyad Rashid, Nidal Daraghmeh, Mayyas Al-Remawi, Stephen A. Leharne, Babur Z. Chowdhry & Adnan Badwan. (2009) Characterization of chitin–metal silicates as binding superdisintegrants. Journal of Pharmaceutical Sciences 98:12, pages 4887-4901.
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