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Drug Development and Industrial Pharmacy Volume 34, 2008 - Issue 10
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Research Article

Synthesis of Piperazinylalkyl Ester Prodrugs of Ketorolac and their In Vitro Evaluation for Transdermal Delivery

Amjad Qandil Department of Medicinal Chemistry and Pharmacognosy, Faculty of Pharmacy, Jordan University of Science and Technology, Irbid, JordanCorrespondence[email protected]
,
Soraya Al-Nabulsi Department of Medicinal Chemistry and Pharmacognosy, Faculty of Pharmacy, Jordan University of Science and Technology, Irbid, Jordan
,
Bashar Al-Taani Department of Pharmaceutical Technology, Faculty of Pharmacy, Jordan University of Science and Technology, Irbid, Jordan
&
Bassam Tashtoush Department of Pharmaceutical Technology, Faculty of Pharmacy, Jordan University of Science and Technology, Irbid, Jordan
Pages 1054-1063 | Published online: 20 Oct 2008

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Amjad M. Qandil, Noor M. Jamhawi, Bassam M. Tashtoush, Ahmad M. Al-Ajlouni, Nasir M Idkaidek & Aiman A. Obaidat. (2013) The hydrolysis kinetics of monobasic and dibasic aminoalkyl esters of ketorolac. Drug Development and Industrial Pharmacy 39:9, pages 1346-1356.
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Junzhu Pan, Lifang Ma, Bo Li, Yanhua Li & Li Guo. (2012) Novel Dendritic Naproxen Prodrugs with Poly(aspartic Acid) Oligopeptide: Synthesis and Hydroxyapatite Binding in Vitro. Synthetic Communications 42:23, pages 3441-3454.
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Bridg’ette Israel, Solomon T. Garner, Mohan Thakare, Deborah Elder, Trinia Abney, Parastoo Azadi, J. Warren Beach, James C. Price, Hisham Ahmed & Anthony C. Capomacchia. (2012) Transdermal permeation of novel n-acetyl-glucosamine/NSAIDs mutual prodrugs. Pharmaceutical Development and Technology 17:1, pages 48-54.
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Mariia Nesterkina, Serhii Smola, Nataliya Rusakova & Iryna Kravchenko. (2021) Terpenoid Hydrazones as Biomembrane Penetration Enhancers: FT-IR Spectroscopy and Fluorescence Probe Studies. Molecules 27:1, pages 206.
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Yawen Yu, Liangxiao Wang, Junping Han, Aiping Wang, Liuxiang Chu, Xinran Xi, Ronglin Kan, Chunjie Sha & Kaoxiang Sun. (2021) Synthesis and Characterization of a Series of Temozolomide Esters and Its Anti-glioma Study. Journal of Pharmaceutical Sciences 110:10, pages 3431-3438.
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Kamal Shah, Jeetendra K. Gupta, Nagendra S. Chauhan, Neeraj Upmanyu, Sushant K. Shrivastava & Pradeep Mishra. (2017) Prodrugs of NSAIDs: A Review. The Open Medicinal Chemistry Journal 11:1, pages 146-195.
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Kenji Sugibayashi. 2017. Skin Permeation and Disposition of Therapeutic and Cosmeceutical Compounds. Skin Permeation and Disposition of Therapeutic and Cosmeceutical Compounds 205 224 .
Jaya Preethi Peesa, Prasanna Raju Yalavarthi, Arun Rasheed & Venkata Basaveswara Rao Mandava. (2016) A perspective review on role of novel NSAID prodrugs in the management of acute inflammation. Journal of Acute Disease 5:5, pages 364-381.
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Vijay Pawar, Rushabh Thosani, Ashish Kanhed, Rajani Giridhar & Mange Ram Yadav. (2014) Potential of Piperazinylalkylester Prodrugs of 6-Methoxy-2-Naphthylacetic Acid (6-MNA) for Percutaneous Drug Delivery. AAPS PharmSciTech 16:3, pages 518-527.
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Jelena Predic Atkinson, Howard I. Maibach & Nina Dragicevic. 2015. Percutaneous Penetration Enhancers Chemical Methods in Penetration Enhancement. Percutaneous Penetration Enhancers Chemical Methods in Penetration Enhancement 93 108 .
David N'Da. (2014) Prodrug Strategies for Enhancing the Percutaneous Absorption of Drugs. Molecules 19:12, pages 20780-20807.
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Kuo-Sheng Liu, Pei-Wen Hsieh, Ibrahim A. Aljuffali, Yin-Ku Lin, Shu-Hao Chang, Jhi-Joung Wang & Jia-You Fang. (2014) Impact of Ester Promoieties on Transdermal Delivery of Ketorolac. Journal of Pharmaceutical Sciences 103:3, pages 974-986.
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Amjad Qandil. (2012) Prodrugs of Nonsteroidal Anti-Inflammatory Drugs (NSAIDs), More Than Meets the Eye: A Critical Review. International Journal of Molecular Sciences 13:12, pages 17244-17274.
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Monika Dąbrowska, Małgorzata Starek & Jerzy Skuciński. (2011) Lipophilicity study of some non-steroidal anti-inflammatory agents and cephalosporin antibiotics: A review. Talanta 86, pages 35-51.
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Amjad M. Qandil, Farah H. El Mohtadi & Bassam M. Tashtoush. (2011) Chemical and in vitro enzymatic stability of newly synthesized celecoxib lipophilic and hydrophilic amides. International Journal of Pharmaceutics 416:1, pages 85-96.
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Kalpana S Paudel, Mikolaj Milewski, Courtney L Swadley, Nicole K Brogden, Priyanka Ghosh & Audra L Stinchcomb. (2010) Challenges and opportunities in dermal/transdermal delivery. Therapeutic Delivery 1:1, pages 109-131.
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Annalisa Curcio, Oscar Sasso, Daniela Melisi, Maria Nieddu, Giovanna La Rana, Roberto Russo, Elisabetta Gavini, Gianpiero Boatto, Enrico Abignente, Antonio Calignano & Maria Grazia Rimoli. (2009) Galactosyl Prodrug of Ketorolac: Synthesis, Stability, and Pharmacological and Pharmacokinetic Evaluations. Journal of Medicinal Chemistry 52:12, pages 3794-3800.
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