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Drug Development and Industrial Pharmacy Volume 34, 2008 - Issue 10
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Research Article

Efficient Drug Delivery to Alveolar Macrophages and Lung Epithelial Lining Fluid Following Pulmonary Administration of Liposomal Ciprofloxacin in Rats with Pneumonia and Estimation of its Antibacterial Effects

Sumio Chono Department of Pharmaceutics, Graduate School of Pharmaceutical Sciences, Hokkaido Pharmaceutical University, Katsuraoka-cho, Otaru, JapanCorrespondence[email protected]
,
Tomoharu Tanino Department of Pharmaceutics, Graduate School of Pharmaceutical Sciences, Hokkaido Pharmaceutical University, Katsuraoka-cho, Otaru, Japan
,
Toshinobu Seki Department of Pharmaceutics, Graduate School of Pharmaceutical Sciences, Hokkaido Pharmaceutical University, Katsuraoka-cho, Otaru, Japan
&
Kazuhiro Morimoto Department of Pharmaceutics, Graduate School of Pharmaceutical Sciences, Hokkaido Pharmaceutical University, Katsuraoka-cho, Otaru, Japan
Pages 1090-1096 | Published online: 05 Nov 2008

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Mahdieh Farhangi, Arash Mahboubi, Farzad Kobarfard, Alireza Vatanara & Seyed Alireza Mortazavi. (2019) Optimization of a dry powder inhaler of ciprofloxacin-loaded polymeric nanomicelles by spray drying process. Pharmaceutical Development and Technology 24:5, pages 584-592.
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Mareike Klinger-Strobel, Christian Lautenschläger, Dagmar Fischer, Jochen G Mainz, Tony Bruns, Lorena Tuchscherr, Mathias W Pletz & Oliwia Makarewicz. (2015) Aspects of pulmonary drug delivery strategies for infections in cystic fibrosis – where do we stand?. Expert Opinion on Drug Delivery 12:8, pages 1351-1374.
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Wing-Hin Lee, Ching-Yee Loo, Daniela Traini & Paul M Young. (2015) Nano- and micro-based inhaled drug delivery systems for targeting alveolar macrophages. Expert Opinion on Drug Delivery 12:6, pages 1009-1026.
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Moayad Alhariri, Ali Azghani & Abdelwahab Omri. (2013) Liposomal antibiotics for the treatment of infectious diseases. Expert Opinion on Drug Delivery 10:11, pages 1515-1532.
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Sabina Antonela Antoniu. (2012) Inhaled ciprofloxacin for chronic airways infections caused by Pseudomonas aeruginosa. Expert Review of Anti-infective Therapy 10:12, pages 1439-1446.
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Sumio Chono, Keita Kaneko, Eri Yamamoto, Kohei Togami & Kazuhiro Morimoto. (2010) Effect of surface-mannose modification on aerosolized liposomal delivery to alveolar macrophages. Drug Development and Industrial Pharmacy 36:1, pages 102-107.
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Articles from other publishers (33)

Venkata Deepthi Vemuri, Rekharani Kushwaha, Gollu Gowri, Nalini Mathala, Swathi Nalla, Sasikala Allam & Gurijala Lekhya. (2023) An Overview on Macrophage Targeting: A Promising Approach. Critical Reviews™ in Therapeutic Drug Carrier Systems 40:5, pages 47-92.
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Sooyoung Shin, Soonbum Kwon & Yoon Yeo. (2022) Meta-Analysis of Drug Delivery Approaches for Treating Intracellular Infections. Pharmaceutical Research 39:6, pages 1085-1114.
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Merve Karpuz & Mine Silindir‐Gunay. 2022. Nanoengineering of Biomaterials. Nanoengineering of Biomaterials 469 503 .
Jing Huang, Jiquan Guo, Xiaoling Zou, Jiaxin Zhu, Shaozhu Wu & Tiantuo Zhang. (2021) Bioinspired Heteromultivalent Chitosan- α -Fe 2 O 3 /Gadofullerene Hybrid Composite for Enhanced Antibiotic-Resistant Bacterial Pneumonia . Journal of Biomedical Nanotechnology 17:6, pages 1217-1228.
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V.N. Azger Dustachkeer, Christy Rosaline Nirmal, Sam Ebenezer Rajadas, Shainaba A. Saadhali, Silambuchelvi Kannayan & Vishnu Priya Padmanaban. 2021. A Mechanistic Approach to Medicines for Tuberculosis Nanotherapy. A Mechanistic Approach to Medicines for Tuberculosis Nanotherapy 149 173 .
Chad W. Stratilo, Scott Jager, Melissa Crichton & James D. Blanchard. (2020) Evaluation of liposomal ciprofloxacin formulations in a murine model of anthrax. PLOS ONE 15:1, pages e0228162.
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Danielle S.W. Benoit, Clyde T. Overby, Kenneth R. Sims Jr.Marian A. Ackun-Farmmer. 2020. Biomaterials Science. Biomaterials Science 1237 1266 .
Sergey Zaichik, Christian Steinbring, Claudia Menzel, Ludwig Knabl, Dorothea Orth-Höller, Helmut Ellemunter, Katharina Niedermayr & Andreas Bernkop-Schnürch. (2018) Development of self-emulsifying drug delivery systems (SEDDS) for ciprofloxacin with improved mucus permeating properties. International Journal of Pharmaceutics 547:1-2, pages 282-290.
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Ruba S. Darweesh & Masahiro Sakagami. (2018) In vitro lung epithelial cell transport and anti-interleukin-8 releasing activity of liposomal ciprofloxacin. European Journal of Pharmaceutical Sciences 115, pages 68-76.
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Diego Maselli, Holly Keyt & Marcos Restrepo. (2017) Inhaled Antibiotic Therapy in Chronic Respiratory Diseases. International Journal of Molecular Sciences 18:5, pages 1062.
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Karleigh A. Hamblin, Stuart J. Armstrong, Kay B. Barnes, Carwyn Davies, Thomas Laws, James D. Blanchard, Sarah V. Harding & Helen S. Atkins. (2017) Inhaled Liposomal Ciprofloxacin Protects against a Lethal Infection in a Murine Model of Pneumonic Plague. Frontiers in Microbiology 8.
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Shuyu Xie, Fei Yang, Yanfei Tao, Dongmei Chen, Wei Qu, Lingli Huang, Zhenli Liu, Yuanhu Pan & Zonghui Yuan. (2017) Enhanced intracellular delivery and antibacterial efficacy of enrofloxacin-loaded docosanoic acid solid lipid nanoparticles against intracellular Salmonella. Scientific Reports 7:1.
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Abel M. Maharramov, Mahammadali A. Ramazanov & Ulviyya A. Hasanova. 2017. Antimicrobial Nanoarchitectonics. Antimicrobial Nanoarchitectonics 445 473 .
Adriano Brandelli, Cristian Mauricio Barreto Pinilla & Nathalie Almeida Lopes. 2017. Nanotechnology Applied To Pharmaceutical Technology. Nanotechnology Applied To Pharmaceutical Technology 55 90 .
Yihua Pei & Yoon Yeo. (2016) Drug delivery to macrophages: Challenges and opportunities. Journal of Controlled Release 240, pages 202-211.
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Yukimune Kanehira, Kohei Togami, Hitoshi Tada & Sumio Chono. (2016) Tumor distribution and anti-tumor effect of doxorubicin following intrapulmonary administration to mice with metastatic lung tumor. Journal of Drug Delivery Science and Technology 33, pages 143-148.
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Catherine Ladavière & Ruxandra Gref. (2015) Toward an optimized treatment of intracellular bacterial infections: input of nanoparticulate drug delivery systems. Nanomedicine 10:19, pages 3033-3055.
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Athanasios Chatzimoschou, Maria Simitsopoulou, Charalampos Antachopoulos, Thomas J. Walsh & Emmanuel Roilides. (2015) Antipseudomonal Agents Exhibit Differential Pharmacodynamic Interactions with Human Polymorphonuclear Leukocytes against Established Biofilms of Pseudomonas aeruginosa. Antimicrobial Agents and Chemotherapy 59:4, pages 2198-2205.
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Padma V. Devarajan, Shilpa M. Dawre & Rinku Dutta. 2015. Targeted Drug Delivery : Concepts and Design. Targeted Drug Delivery : Concepts and Design 113 148 .
Shuyu Xie, Yanfei Tao, Yuanhu Pan, Wei Qu, Guyue Cheng, Lingli Huang, Dongmei Chen, Xu Wang, Zhenli Liu & Zonghui Yuan. (2014) Biodegradable nanoparticles for intracellular delivery of antimicrobial agents. Journal of Controlled Release 187, pages 101-117.
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David Cipolla, Boris Shekunov, Jim Blanchard & Anthony Hickey. (2014) Lipid-based carriers for pulmonary products: Preclinical development and case studies in humans. Advanced Drug Delivery Reviews 75, pages 53-80.
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Misagh Alipour & Zacharias E Suntres. (2014) Liposomal antibiotic formulations for targeting the lungs in the treatment of Pseudomonas aeruginosa . Therapeutic Delivery 5:4, pages 409-427.
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Frank BoehmMisagh Alipour, Abdelwahab Omri & Zacharias Suntres. 2013. Nanomedical Device and Systems Design. Nanomedical Device and Systems Design 455 490 .
Julie Ann Justo, Larry H. Danziger & Mark H. Gotfried. (2013) Efficacy of inhaled ciprofloxacin in the management of non-cystic fibrosis bronchiectasis. Therapeutic Advances in Respiratory Disease 7:5, pages 272-287.
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Hui Xin Ong, Daniela Traini, Mary Bebawy & Paul M. Young. (2013) Ciprofloxacin Is Actively Transported across Bronchial Lung Epithelial Cells Using a Calu-3 Air Interface Cell Model. Antimicrobial Agents and Chemotherapy 57:6, pages 2535-2540.
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Pritam Sahota, James Popp, Jerry Hardisty & Chirukandath GopinathDavid Lewis & Tom McKevitt. 2013. Toxicologic Pathology. Toxicologic Pathology 367 420 .
Susana Andrea Breda, Maria Laura Guzmán, Alejandra Confalonieri, Claudia González, Monica Sparo, Ruben Hilario Manzo, Sergio Sánchez Bruni & Maria Eugenia Olivera. (2013) Systemic Exposure, Tissue Distribution, and Disease Evolution of a High Solubility Ciprofloxacin–Aluminum Complex in a Murine Model of Septicemia Induced by Salmonella enterica Serotype Enteritidis . Molecular Pharmaceutics 10:2, pages 598-605.
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Kazuhiro Morimoto. (2013) Designs of Optimized Microbial Therapy Systems of Respiratory Infections呼吸器感染症の抗菌薬を用いた最適治療法の構築. YAKUGAKU ZASSHI 133:1, pages 81-92.
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Tiago dos Santos, Juan Varela, Iseult Lynch, Anna Salvati & Kenneth A. Dawson. (2011) Quantitative Assessment of the Comparative Nanoparticle-Uptake Efficiency of a Range of Cell Lines. Small 7:23, pages 3341-3349.
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Keith A. Rodvold, Jomy M. George & Liz Yoo. (2011) Penetration of Anti-Infective Agents into Pulmonary Epithelial Lining Fluid. Clinical Pharmacokinetics 50:10, pages 637-664.
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Ben Forbes, Bahman Asgharian, Lea Ann Dailey, Douglas Ferguson, Per Gerde, Mark Gumbleton, Lena Gustavsson, Colin Hardy, David Hassall, Rhys Jones, Ruth Lock, Janet Maas, Tim McGovern, Gary R. Pitcairn, Graham Somers & Ron K. Wolff. (2011) Challenges in inhaled product development and opportunities for open innovation. Advanced Drug Delivery Reviews 63:1-2, pages 69-87.
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K.D. Bruce, G.B. Rogers & N. Patel. (2011) Microbiological insights into respiratory infections and the opportunities for inhaled therapy. Journal of Drug Delivery Science and Technology 21:4, pages 301-309.
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Janani Swaminathan & Carsten Ehrhardt. 2011. Controlled Pulmonary Drug Delivery. Controlled Pulmonary Drug Delivery 313 334 .

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