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Research Article

Development of olmesartan medoxomil optimized nanosuspension using the Box–Behnken design to improve oral bioavailability

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Pages 1186-1196 | Received 18 Aug 2016, Accepted 02 Mar 2017, Published online: 27 Mar 2017

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Monica R. P. Rao, Rohit Vidyadhar Godbole, Sameer G. Borate, Sanskar Mahajan & Tejal Gangwal. (2021) Nanosuspension coated multiparticulates for controlled delivery of albendazole. Drug Development and Industrial Pharmacy 47:3, pages 367-376.
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Waleed M. Khattab, Esmat E. Zein El-Dein & Sanaa A. El-Gizawy. (2020) Formulation of lyophilized oily-core poly-Ɛ-caprolactone nanocapsules to improve oral bioavailability of Olmesartan Medoxomil. Drug Development and Industrial Pharmacy 46:5, pages 795-805.
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Guoyuan Li, Yuting Lu, Yongchun Fan, Qing Ning & Weiguang Li. (2020) Enhanced oral bioavailability of magnolol via mixed micelles and nanosuspensions based on Soluplus®-Poloxamer 188. Drug Delivery 27:1, pages 1010-1017.
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Amand Alekhya & Abbaraju Krishna Sailaja. (2023) Formulation and Evaluation of Letrozole Nanosuspension By Probe Sonication Method using Box-behnken Design. Current Nanomaterials 8:3, pages 266-279.
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Jiangxiu Niu, Ming Yuan, Jingjing Chen, Liye Wang, Yueheng Qi, Kaiyue Bai, Yanli Fan & Panpan Gao. (2023) L-Cysteine-Modified Transfersomes for Enhanced Epidermal Delivery of Podophyllotoxin. Molecules 28:15, pages 5712.
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Sapana P. Ahirrao, Deepak S. Bhambere, Eknath D. Ahire, Neelam L. Dashputre, Smita P. Kakad & Umesh D. Laddha. (2023) Formulation and evaluation of Olmesartan Medoxomil nanosuspension. Materials Today: Proceedings.
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Tahir Khuroo, Arshad Khuroo, Afzal Hussain, Mohd Aamir Mirza, Amulya K. Panda, Javid Wani & Zeenat Iqbal. (2022) Qbd based and Box-Behnken design assisted Oral delivery of stable lactone (active) form of Topotecan as PLGA nanoformulation: Cytotoxicity, pharmacokinetic, in vitro, and ex vivo gut permeation studies. Journal of Drug Delivery Science and Technology 77, pages 103850.
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Kumara Swamy Samanthula, Mahendra Kumar CB, Agaiah Goud Bairi & Shobha Rani Satla. (2022) DEVELOPMENT, IN-VITRO AND EX-VIVO EVALUATION OF MUCO-ADHESIVE BUCCAL TABLETS OF HYDRALAZINE HYDROCHLORIDE. Brazilian Journal of Pharmaceutical Sciences 58.
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Komal Parmar & Kirti Oza. (2021) Increase in Dissolution Rate of Zotepine via Nanomilling Process — Impact of Dried Nanocrystalline Suspensions on Bioavailability. AAPS PharmSciTech 23:1.
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Narendar Dudhipala, Swetha Ettireddy, Ahmed Adel Ali Youssef & Goverdhan Puchchakayala. (2021) Cyclodextrin Complexed Lipid Nanoparticles of Irbesartan for Oral Applications: Design, Development, and In Vitro Characterization. Molecules 26:24, pages 7538.
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Waleed M. Khattab, Esmat E. Zein El-Dein & Sanaa A. El-Gizawy. (2020) Full Factorial Design and Optimization of Olmesartan Medoxomil–Loaded Oily-Core Polymeric Nanocapsules with Improved In-Vitro Stability. Journal of Pharmaceutical Innovation 16:4, pages 673-687.
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Kumara Swamy SamanthulaAgaiah Goud BairiShobha Rani SatlaMahendra Kumar CB. (2021) Effect of various Polymers on Drug Release from Mucoadhesive Tablets of Cefixime Trihydrate. Research Journal of Pharmaceutical Dosage Forms and Technology, pages 167-173.
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Kumara S. Samanthula, Ramesh Alli & Thirupathi Gorre. (2021) Preliminary Studies on Optimization of Anti-Parkinson Drug Loaded Lipid Nanoparticles Enriched Hydrogel Formulations for Management of Parkinson’s Disease. Current Nanomedicine 11:2, pages 112-126.
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NR Dudhipala, SR Ettireddy & GR Puchakayala. (2021) Attenuation of lipid levels in triton induced hyperlipidemia rats through rosuvastatin calcium nanoparticles: Pharmacokinetic and pharmacodynamic studies. Chemistry and Physics of Lipids 237, pages 105081.
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Kumara Swamy SRamesh Alli. (2021) Preparation, Characterization and Optimization of Irbesartan Loaded Solid Lipid Nanoparticles for Oral Delivery. Asian Journal of Pharmacy and Technology, pages 97-104.
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Lakavath Sunil Kumar. (2021) A Review on Novel vesicular systems for enhanced Oral bioavailability of Lipophilic drugs. Research Journal of Pharmaceutical Dosage Forms and Technology, pages 139-146.
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Kumara Swamy Samanthula, Ramesh Alli & Thirupathi Gorre. (2021) Preparation, In Vitro characterization and stability studies of ropinirole lipid nanoparticles enriched hydrogel for treatment of neurodegeneration diseases. Journal of Drug Delivery and Therapeutics 11:2-S, pages 66-75.
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D Raju. (2021) Case studies of enhanced pharmacodynamic activity of poorly oral bioavailable drugs via solid lipid nanoparticles. Journal of Drug Delivery and Therapeutics 11:2, pages 204-208.
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Vasu Deva Reddy Matta. (2021) A concise review on preparation methods used for the development of solid lipid nanoparticles. Journal of Drug Delivery and Therapeutics 11:1-s, pages 162-169.
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Kumara Swamy Samanthula, Agaiah Goud Bairi & CB Mahendra Kumar. (2021) Muco-adhesive buccal tablets of candesartan cilexetil for oral delivery: preparation, in-vitro and ex-vivo evaluation. Journal of Drug Delivery and Therapeutics 11:1-s, pages 35-42.
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Vasu Deva Reddy Matta. (2021) Excipients, drug release mechanism and physicochemical characterization methods of Solid lipid nanoparticles. Journal of Drug Delivery and Therapeutics 11:1-s, pages 139-146.
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Sunil Kumar Lakavath. (2020) Novel Delivery System Used for Oral Bioavailability Enhancement of Poorly Water Soluble Drugs. Journal of Drug Delivery and Therapeutics 10:6-s, pages 139-144.
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Gorre Thirupathi, Samanthula Kumara Swamy & Alli Ramesh. (2020) Solid lipid nanocarriers as alternative drug delivery system for improved oral delivery of drugs. Journal of Drug Delivery and Therapeutics 10:6-s, pages 168-172.
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B. Nagaraj, C. Tirumalesh, S. Dinesh & D. Narendar. (2020) Zotepine loaded lipid nanoparticles for oral delivery: development, characterization, and in vivo pharmacokinetic studies. Future Journal of Pharmaceutical Sciences 6:1.
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Narendar Dudhipala, Ahmed Adel Ali Youssef & Nagaraj Banala. (2020) Colloidal lipid nanodispersion enriched hydrogel of antifungal agent for management of fungal infections: Comparative in-vitro, ex-vivo and in-vivo evaluation for oral and topical application. Chemistry and Physics of Lipids 233, pages 104981.
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Narendar Dudhipala & Ahmed Adel AY. (2020) Amelioration of ketoconazole in lipid nanoparticles for enhanced antifungal activity and bioavailability through oral administration for management of fungal infections. Chemistry and Physics of Lipids 232, pages 104953.
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Vamshi M. Krishna, Vijaya B. Kumar & Narendar Dudhipala. (2020) In-situ Intestinal Absorption and Pharmacokinetic Investigations of Carvedilol Loaded Supersaturated Self-emulsifying Drug System. Pharmaceutical Nanotechnology 8:3, pages 207-224.
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Alptug Karakucuk & Nevin Celebi. (2020) Investigation of Formulation and Process Parameters of Wet Media Milling to Develop Etodolac Nanosuspensions. Pharmaceutical Research 37:6.
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Narendar Dudhipala & Thirupathi Gorre. (2020) Neuroprotective Effect of Ropinirole Lipid Nanoparticles Enriched Hydrogel for Parkinson’s Disease: In Vitro, Ex Vivo, Pharmacokinetic and Pharmacodynamic Evaluation. Pharmaceutics 12:5, pages 448.
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Cernam Tirumalesh, Dinesh Suram, Narendar Dudhipala & Nagaraj Banala. (2020) Enhanced Pharmacokinetic Activity of Zotepine via Nanostructured Lipid Carrier System in Wistar Rats for Oral Application. Pharmaceutical Nanotechnology 8:2, pages 148-160.
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Nagarjun Rangaraj, Sravanthi Reddy Pailla, Paramesh Chowta & Sunitha Sampathi. (2019) Fabrication of Ibrutinib Nanosuspension by Quality by Design  Approach: Intended for Enhanced Oral Bioavailability and Diminished Fast Fed Variability. AAPS PharmSciTech 20:8.
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Sarwar Beg, Hani Choudhry, Mazin A Zamzami, Khalid S Alharbi, Mahfoozur Rahman & Bhupinder Singh. (2018) Nanocolloidal lipidic carriers of olmesartan medoxomil surface-tailored with Concavalin-A for lectin receptor targeting. Nanomedicine 13:24, pages 3107-3128.
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Jihad Mahmoud Alsofany, Manal Yassin Hamza & Aly Ahmed Abdelbary. (2018) Fabrication of Nanosuspension Directly Loaded Fast-Dissolving Films for Enhanced Oral Bioavailability of Olmesartan Medoxomil: In Vitro Characterization and Pharmacokinetic Evaluation in Healthy Human Volunteers. AAPS PharmSciTech 19:5, pages 2118-2132.
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