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Research Article

Fabrication of rosuvastatin-loaded polymeric nanocapsules: a promising modality for treating hepatic cancer delineated by apoptotic and cell cycle arrest assessment

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Pages 55-62 | Received 25 May 2018, Accepted 19 Aug 2018, Published online: 16 Sep 2018

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Seham I Elsayed, Germeen N S Girgis & Marwa S El-Dahan. (2023) Formulation and Evaluation of Pravastatin Sodium-Loaded PLGA Nanoparticles: In vitro–in vivo Studies Assessment. International Journal of Nanomedicine 18, pages 721-742.
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Alaa Ibrahim, Sara A. Abdel Gaber, Mohamed Fawzi Kabil, Omar A.H. Ahmed-Farid, Anna K.H. Hirsch, Ibrahim M. El-Sherbiny & Maha Nasr. (2022) Baicalin lipid nanocapsules for treatment of glioma: characterization, mechanistic cytotoxicity, and pharmacokinetic evaluation. Expert Opinion on Drug Delivery 19:11, pages 1549-1560.
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Rania F. Ahmed, Maha Nasr, Marawan Abd Elbaset, Alyaa Farouk Hessin, Omar A. H. Ahmed-Farid, Nermeen M. Shaffie & Marwa E. Shabana. (2022) Combating hematopoietic and hepatocellular abnormalities resulting from administration of cisplatin: role of liver targeted glycyrrhetinic acid nanoliposomes loaded with amino acids. Pharmaceutical Development and Technology 27:9, pages 925-941.
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Ramy Said-Elbahr, Maha Nasr, Mohamed A. Alhnan, Ismail Taha & Omaima Sammour. (2022) Simultaneous pulmonary administration of celecoxib and naringin using a nebulization-friendly nanoemulsion: A device-targeted delivery for treatment of lung cancer. Expert Opinion on Drug Delivery 19:5, pages 611-622.
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Abdullah I El-Kholy, Doaa Abdel Fadeel, Maha Nasr, Ibrahim El-Sherbiny & Maha Fadel. (2021) (Rose Bengal)/(Eosin Yellow)-Gold-Polypyrrole Hybrids: A Design for Dual Photo-Active Nano-System with Ultra-High Loading Capacity. Drug Design, Development and Therapy 15, pages 5011-5023.
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Eman M.E. Dokla, Riham I. El-Gogary, Nada M. Abd-Elsaid, Mariam Gad, Reem K. Abd-Elhalim, Hana H. Habib, Wesam Eldeeb, Esraa R. Eldahshan, Salma H. Nassar, Aya N. Issa, Neveen Rabeh, Samar Abd-Elkhalik & Maha Nasr. (2023) Nanoemulgel formulation of a benzimidazole derivative for wound healing. Journal of Drug Delivery Science and Technology 90, pages 105121.
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Mohamed Fawzi Kabil, Sara A. Abdel Gaber, Mohamed A. Hamzawy, Ibrahim M. El-Sherbiny & Maha Nasr. (2023) Folic/lactobionic acid dual-targeted polymeric nanocapsules for potential treatment of hepatocellular carcinoma. Drug Delivery and Translational Research.
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Rania F. Ahmed, Marawan Abd Elbaset, Hadir Farouk, Marwa E. Shabana, Omar A.H. Ahmed-Farid & Maha Nasr. (2023) Nanoliposomal amino acids counteracting protein malnutrition induced hematopoietic and hepatic complications. Journal of Drug Delivery Science and Technology 89, pages 105051.
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Venu Sampath Kumar Golla, Prasanthi Boddu & Swathi Nageswara. (2023) Statistical Experimental Approach in Designing pH-Sensitive Oxaliplatin Lipid Nanoparticles for Application in Colorectal Cancer Therapy. BioNanoScience 13:3, pages 1100-1109.
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Maria Alice de Oliveira, Raquel Silva Araújo & Vanessa Carla Furtado Mosqueira. (2023) PEGylated and functionalized polylactide-based nanocapsules: An overview. International Journal of Pharmaceutics 636, pages 122760.
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Sukhbir Singh, Ishrat Zahoor, Neelam Sharma, Tapan Behl, Neha Kanojia, Aayush Sehgal, Syam Mohan, Yosif Almoshari, Ahmad Salawi, Lotfi Aleya & Simona Bungau. (2022) Insights into the pivotal role of statins and its nanoformulations in hyperlipidemia. Environmental Science and Pollution Research 29:51, pages 76514-76531.
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Sara Barakat, Maha Nasr, Rania F. Ahmed, Sabry Badawy & Nahed Mortada. (2022) Recent Formulation Advances of Mangiferin. Revista Brasileira de Farmacognosia 32:6, pages 871-882.
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Eman A. Bseiso, Sarah A. Abd El-Aal, Maha Nasr, Omaima A. Sammour & Nabaweya A. Abd El Gawad. (2022) Intranasally administered melatonin core-shell polymeric nanocapsules: A promising treatment modality for cerebral ischemia. Life Sciences 306, pages 120797.
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Moustafa S. Ali, Mona Elhabak, Rihab Osman & Maha Nasr. (2022) Towards more efficient inhalable chemotherapy: Fabrication of nanodiamonds-releasing microspheres. International Journal of Pharmaceutics 626, pages 122169.
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Alaa Ibrahim, Islam A. Khalil & Ibrahim M. El-Sherbiny. (2022) Development and Evaluation of Core-Shell Nanocarrier System for Enhancing the Cytotoxicity of Doxorubicin/Metformin Combination Against Breast Cancer Cell Line. Journal of Pharmaceutical Sciences 111:9, pages 2581-2591.
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Dalia O. Saleh, Maha Nasr, Azza Hassan, Sally A. El‐Awdan & Gehad A. Abdel Jaleel. (2022) Curcumin nanoemulsion ameliorates brain injury in diabetic rats. Journal of Food Biochemistry 46:7.
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Sandra N. Milik, Amal Kamal Abdel-Aziz, Morad M. El-Hendawy, Riham I. El-Gogary, Mona Kamal Saadeldin, Saverio Minucci, Christian D. Klein & Khaled A.M. Abouzid. (2022) Insights into the design of inhibitors of the EGFR family with anticancer activity overcoming resistance: A case of optimizing thieno[2,3-d]pyrimidine-based EGFR inhibitors. Journal of Molecular Structure 1259, pages 132724.
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Riham I. El-Gogary, Maha Nasr, Laila A. Rahsed & Mohamed A. Hamzawy. (2022) Ferulic acid nanocapsules as a promising treatment modality for colorectal cancer: Preparation and in vitro/in vivo appraisal. Life Sciences 298, pages 120500.
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Omar Abu-Azzam, Saed Aldalaen & Maha Nasr. (2022) Potentiation of the Cytotoxic Activity of Nutraceutical Phloretin against Cervical Cancer by Formulation into Microemulsion. Pharmaceutical Chemistry Journal 55:11, pages 1215-1218.
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Mohamed Fawzi Kabil, Maha Nasr & Ibrahim M. El-Sherbiny. (2021) Conventional and hybrid nanoparticulate systems for the treatment of hepatocellular carcinoma: An updated review. European Journal of Pharmaceutics and Biopharmaceutics 167, pages 9-37.
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Amir R. Afshari, Hamid Mollazadeh, Neil C. Henney, Tannaz Jamialahmad & Amirhossein Sahebkar. (2021) Effects of statins on brain tumors: a review. Seminars in Cancer Biology 73, pages 116-133.
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Razan Altaweel, Aws Lafi, Weaam Ebrahim, Sherif S. Ebada & Maha Nasr. (2021) Honey-Based Extracts and Their Microemulsions in the Treatment of Liver and Breast Cancers. Pharmaceutical Chemistry Journal 55:5, pages 476-482.
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Nirmala Tilija Pun & Chul-Ho Jeong. (2021) Statin as a Potential Chemotherapeutic Agent: Current Updates as a Monotherapy, Combination Therapy, and Treatment for Anti-Cancer Drug Resistance. Pharmaceuticals 14:5, pages 470.
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Deezagi Abdolkhaleg, Jamalnia Armaghan & Jaefary Hanieh. (2021) Rosuvastatin inhibit the cell proliferation and the expression of angiogenic factors Vascular Endothelial Growth Factor and Matrix-Metalloproteinase-9 in DU-145 human prostate cancer cells. International Journal of Immunotherapy and Cancer Research, pages 008-014.
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Diana El-Hussien, Ghada M. El-Zaafarany, Maha Nasr & Omaima Sammour. (2021) Chrysin nanocapsules with dual anti-glycemic and anti-hyperlipidemic effects: Chemometric optimization, physicochemical characterization and pharmacodynamic assessment. International Journal of Pharmaceutics 592, pages 120044.
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Nabila M. Sweed, Ahmed M. Fayez, Soad Z. El-Emam & Marwa H. S. Dawoud. (2020) Response surface optimization of self nano-emulsifying drug delivery system of rosuvastatin calcium for hepatocellular carcinoma. Journal of Pharmaceutical Investigation 51:1, pages 85-101.
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Aseel Khaled Al Sarayrah, Rasha Zakaria Al Tarawneh, Maha Nasr & Sherif S. Ebada. (2020) Comparative Study of the Efficacy of Different Artemisia Cina Extracts and their Nanoparticulated Forms against A549 Lung Cancer Cell Line. Pharmaceutical Chemistry Journal 54:9, pages 938-942.
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Lucyna Matusewicz, Aleksander Czogalla & Aleksander F Sikorski. (2020) Attempts to use statins in cancer therapy: An update. Tumor Biology 42:7, pages 101042832094176.
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Maha Nasr & Rawan Al-Karaki. (2020) Nanotechnological Innovations Enhancing the Topical Therapeutic Efficacy of Quercetin: A Succinct Review. Current Drug Delivery 17:4, pages 270-278.
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Ayman Ismail, Maha Nasr & Omaima Sammour. (2020) Nanoemulsion as a feasible and biocompatible carrier for ocular delivery of travoprost: Improved pharmacokinetic/pharmacodynamic properties. International Journal of Pharmaceutics 583, pages 119402.
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Riham I. El-Gogary, Mohamed A. Khattab & Hend Abd-Allah. (2020) Intra-articular multifunctional celecoxib loaded hyaluronan nanocapsules for the suppression of inflammation in an osteoarthritic rat model. International Journal of Pharmaceutics 583, pages 119378.
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Rawan Al-Karaki, Areeg Awadallah, Hesham M. Tawfeek & Maha Nasr. (2020) Preparation, Characterization and Cytotoxic Activity of New Oleuropein Microemulsion Against HCT-116 Colon Cancer Cells. Pharmaceutical Chemistry Journal 53:12, pages 1118-1121.
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Sara M. Abdel Samie & Maha Nasr. 2020. Drug Delivery Aspects. Drug Delivery Aspects 227 245 .
MA Elkady, S Shalaby, F Fathi & S El-Mandouh. (2019) Effects of quercetin and rosuvastatin each alone or in combination on cyclophosphamide-induced premature ovarian failure in female albino mice. Human & Experimental Toxicology 38:11, pages 1283-1295.
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Riham I. El-Gogary, Sara A. Abdel Gaber & Maha Nasr. (2019) Polymeric nanocapsular baicalin: Chemometric optimization, physicochemical characterization and mechanistic anticancer approaches on breast cancer cell lines. Scientific Reports 9:1.
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Maha Nasr, Omar Makhlouf, Rasha Almajali, Areeg Awadallah, Faisal Madanat, Khaleel Sami, Leen Alsunna, Rawan Al-Karaki & Zakaria Ibrahim. (2019) Exploring the unique anticancer properties of curcumin nanoparticles. Clinical Oncology and Research, pages 1-5.
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Maha Nasr & Sara A. Wahdan. (2019) Neuroprotective effects of novel nanosystems simultaneously loaded with vinpocetine and piracetam after intranasal administration. Life Sciences 226, pages 117-129.
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