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Drug Development and Industrial Pharmacy Volume 45, 2019 - Issue 5
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Research Article

Homogeneity of amorphous solid dispersions – an example with KinetiSol®

Scott V. Jermaina Division of Molecular Pharmaceutics and Drug Delivery, College of Pharmacy, The University of Texas at Austin, Austin, TX, USA; Correspondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-3602-7091View further author information
ORCID Icon,
Dave Millerb DisperSol Technologies, LLC, Georgetown, TX, USA; View further author information
,
Angela Spangenbergb DisperSol Technologies, LLC, Georgetown, TX, USA; View further author information
,
Xingyu Luc Merck Research Laboratories (MRLs), Merck & Co., Inc., Kenilworth, NJ, USAView further author information
,
Chaeho Moona Division of Molecular Pharmaceutics and Drug Delivery, College of Pharmacy, The University of Texas at Austin, Austin, TX, USA; View further author information
,
Yongchao Sua Division of Molecular Pharmaceutics and Drug Delivery, College of Pharmacy, The University of Texas at Austin, Austin, TX, USA; ;c Merck Research Laboratories (MRLs), Merck & Co., Inc., Kenilworth, NJ, USAORCID Iconhttps://orcid.org/0000-0001-5063-3218View further author information
ORCID Icon &
Robert O. Williamsa Division of Molecular Pharmaceutics and Drug Delivery, College of Pharmacy, The University of Texas at Austin, Austin, TX, USA; ORCID Iconhttps://orcid.org/0000-0003-4993-6427View further author information
, IIIORCID Icon show all
Pages 724-735 | Received 20 Sep 2018, Accepted 04 Jan 2019, Published online: 25 Jan 2019

Citations (14)

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Sumit Kumar Saha, Amita Joshi, Romi Singh & Kiran Dubey. (2023) Review of industrially recognized polymers and manufacturing processes for amorphous solid dispersion based formulations. Pharmaceutical Development and Technology 28:7, pages 678-696.
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Articles from other publishers (13)

Ashley Lay-Fortenbery, Yongchao Su & Eric J. Munson. 2023. Principles and Practices of Lyophilization in Product Development and Manufacturing. Principles and Practices of Lyophilization in Product Development and Manufacturing 291 306 .
Srinivas Ajjarapu, Srikanth Banda, Pratap Basim & Narendar Dudhipala. (2022) Melt Fusion Techniques for Solubility Enhancement: A Comparison of Hot Melt Extrusion and KinetiSol® Technologies. Scientia Pharmaceutica 90:3, pages 51.
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Daniel A. DavisJr.Jr., Rishi Thakkar, Mohammed Maniruzzaman, Dave A. Miller & Robert O. WilliamsIIIIII. 2022. Formulating Poorly Water Soluble Drugs. Formulating Poorly Water Soluble Drugs 599 650 .
Sawittree Sahakijpijarn, Chaeho Moon & Robert O. WilliamsIIIIII. 2022. Formulating Poorly Water Soluble Drugs. Formulating Poorly Water Soluble Drugs 453 528 .
Sathish Dharani, Khaldia Sediri, Phillip Cook, Rajendran Arunagiri, Mansoor A. Khan & Ziyaur Rahman. (2021) Preparation and Characterization of Stable Amorphous Glassy Solution of BCS II and IV Drugs. AAPS PharmSciTech 23:1.
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Samarth D. Thakore, Junia Akhtar, Ranjna Jain, Amrit Paudel & Arvind K. Bansal. (2021) Analytical and Computational Methods for the Determination of Drug-Polymer Solubility and Miscibility. Molecular Pharmaceutics 18:8, pages 2835-2866.
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Stephen A. Thompson & Robert O. WilliamsIIIIII. (2021) Specific mechanical energy – An essential parameter in the processing of amorphous solid dispersions. Advanced Drug Delivery Reviews 173, pages 374-393.
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Daniel A. DavisJr.Jr., Rishi Thakkar, Yongchao Su, Robert O. WilliamsIIIIII & Mohammed Maniruzzaman. (2021) Selective Laser Sintering 3-Dimensional Printing as a Single Step Process to Prepare Amorphous Solid Dispersion Dosage Forms for Improved Solubility and Dissolution Rate. Journal of Pharmaceutical Sciences 110:4, pages 1432-1443.
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Mingyue Li, Wei Xu & Yongchao Su. (2021) Solid-state NMR spectroscopy in pharmaceutical sciences. TrAC Trends in Analytical Chemistry 135, pages 116152.
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Deck Khong Tan, Daniel A. DavisJrJr, Dave A. Miller, Robert O. WilliamsIIIIII & Ali Nokhodchi. (2020) Innovations in Thermal Processing: Hot-Melt Extrusion and KinetiSol® Dispersing. AAPS PharmSciTech 21:8.
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Daniel A. DavisJrJr, Dave A. Miller, Yongchao Su & Robert O. WilliamsIIIIII. (2020) Thermally Conductive Excipient Expands KinetiSol® Processing Capabilities. AAPS PharmSciTech 21:8.
Crossref
Scott V. Jermain, Michael B. Lowinger, Daniel J. Ellenberger, Dave A. Miller, Yongchao Su & Robert O. WilliamsIIIIII. (2020) In Vitro and In Vivo Behaviors of KinetiSol and Spray-Dried Amorphous Solid Dispersions of a Weakly Basic Drug and Ionic Polymer . Molecular Pharmaceutics 17:8, pages 2789-2808.
Crossref
Chaeho Moon, Sawittree Sahakijpijarn, John J. Koleng & Robert O. WilliamsIIIIII. (2019) Processing design space is critical for voriconazole nanoaggregates for dry powder inhalation produced by thin film freezing. Journal of Drug Delivery Science and Technology 54, pages 101295.
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