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Original Article

Phosphorylated/Activated HER2 as a Marker of Clinical Resistance to Single Agent Taxane Chemotherapy for Metastatic Breast Cancer

, , , , , , , , , , & , M.D. show all
Pages 483-487 | Published online: 11 Jun 2009

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Patricia Vrignaud, Dorothée Semiond, Veronique Benning, Eric Beys, Hervé Bouchard & Sunil Gupta. (2014) Preclinical profile of cabazitaxel. Drug Design, Development and Therapy 8, pages 1851-1867.
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Fernanda Milanezi, Silvia Carvalho & Fernando C Schmitt. (2008) EGFR/HER2 in breast cancer: a biological approach for molecular diagnosis and therapy. Expert Review of Molecular Diagnostics 8:4, pages 417-434.
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Richard M. Gallo & David J. Riese II. (2007) The antibody sc-33040-R fails to specifically recognize phosphorylation of ErbB4 on tyrosine1056. Growth Factors 25:5, pages 329-333.
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Articles from other publishers (30)

Noura Al‐Zeheimi & Sirin A. Adham. (2020) Modeling Neoadjuvant chemotherapy resistance in vitro increased NRP‐1 and HER2 expression and converted MCF7 breast cancer subtype. British Journal of Pharmacology 177:9, pages 2024-2041.
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Sungbin Park, Heejoo Kim, Hwee Won Ji, Hyeon Woo Kim, Sung Hwan Yun, Eun Ha Choi & Sun Jung Kim. (2019) Cold Atmospheric Plasma Restores Paclitaxel Sensitivity to Paclitaxel-Resistant Breast Cancer Cells by Reversing Expression of Resistance-Related Genes. Cancers 11:12, pages 2011.
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Jizhuang Wang, Chuanzhen Hu, Jun Wang, Yuhui Shen, Qiyuan Bao, Fangzhou He, Hongyi Wang, Liangzhi Gong, Zhuochao Liu, Fangqiong Hu, Jing Liang, Qi Zhou, Li Wei, Junxiang Wen & Weibin Zhang. (2019) Checkpoint Blockade in Combination With Doxorubicin Augments Tumor Cell Apoptosis in Osteosarcoma. Journal of Immunotherapy 42:9, pages 321-330.
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Siao-Syun Guan, Cheng-Tien Wu, Chen-Yuan Chiu, Tsai-Yueh Luo, Jeng-Yih Wu, Tse-Zung Liao & Shing-Hwa Liu. (2018) Polyethylene glycol-conjugated HER2-targeted peptides as a nuclear imaging probe for HER2-overexpressed gastric cancer detection in vivo. Journal of Translational Medicine 16:1.
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YONGPING LIU, YANG LING, QIUFENG QI, MING ZHU, MEIZHEN WAN, YAPING ZHANG & CHANGSONG ZHANG. (2015) Trastuzumab increases the sensitivity of HER2-amplified human gastric cancer cells to oxaliplatin and cisplatin by affecting the expression of telomere-associated proteins. Oncology Letters 9:2, pages 999-1005.
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Yalai Bai, Huan Cheng, Jennifer Bordeaux, Veronique Neumeister, Sudha Kumar, David L. Rimm & David F. Stern. (2013) Comparison of HER2 and Phospho-HER2 Expression between Biopsy and Resected Breast Cancer Specimens Using a Quantitative Assessment Method. PLoS ONE 8:11, pages e79901.
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Patricia Vrignaud, Dorothée Sémiond, Pascale Lejeune, Hervé Bouchard, Loreley Calvet, Cecile Combeau, Jean-François Riou, Alain Commerçon, François Lavelle & Marie-Christine Bissery. (2013) Preclinical Antitumor Activity of Cabazitaxel, a Semisynthetic Taxane Active in Taxane-Resistant Tumors. Clinical Cancer Research 19:11, pages 2973-2983.
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Laura Cortesi, Elisabetta De Matteis, Claudia Cirilli, Luigi Marcheselli, Manuela Proietto & Massimo Federico. (2018) Outcome Evaluation in Pre-Trastuzumab Era between Different Breast Cancer Phenotypes: A Population-Based Study on Italian Women. Tumori Journal 98:6, pages 743-750.
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S. Murray, E. Briasoulis, H. Linardou, D. Bafaloukos & C. Papadimitriou. (2012) Taxane resistance in breast cancer: Mechanisms, predictive biomarkers and circumvention strategies. Cancer Treatment Reviews 38:7, pages 890-903.
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Joep P.J. de Hoon, Jürgen Veeck, Birgit E.P.J. Vriens, Tim G.A. Calon, Manon van Engeland & Vivianne C.G. Tjan-Heijnen. (2012) Taxane resistance in breast cancer: A closed HER2 circuit?. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 1825:2, pages 197-206.
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Yalai Bai, Juliana Tolles, Huan Cheng, Summar Siddiqui, Arun Gopinath, Eirini Pectasides, Robert L Camp, David L Rimm & Annette M Molinaro. (2011) Quantitative assessment shows loss of antigenic epitopes as a function of pre-analytic variables. Laboratory Investigation 91:8, pages 1253-1261.
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Naoki Hayashi, Takayuki IwamotoAna M. Gonzalez‐AnguloJaime Ferrer‐Lozano, Ana Lluch, Naoki Niikura, Chandra Bartholomeusz, Seigo NakamuraGabriel N. Hortobagyi & Naoto T. Ueno. (2011) Prognostic Impact of Phosphorylated HER‐2 in HER‐2 + Primary Breast Cancer . The Oncologist 16:7, pages 956-965.
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Inchoel Shin, Hyun Joo Kim, Won Heum Nah, Hyun Jun Park, Myung Chan Gye & Hae Young Park. (2011) Expression of activated HER2 in human testes. Fertility and Sterility 95:8, pages 2725-2728.
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Lisa DeFazio-Eli, Kristi Strommen, Trang Dao-Pick, Gordon Parry, Laurie Goodman & John Winslow. (2011) Quantitative assays for the measurement of HER1-HER2 heterodimerization and phosphorylation in cell lines and breast tumors: applications for diagnostics and targeted drug mechanism of action. Breast Cancer Research 13:2.
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Bhavatarini Vangamudi, Dun-Fa Peng, Qiuyin Cai, Wael El-Rifai, Wei Zheng & Abbes Belkhiri. (2010) t-DARPP regulates phosphatidylinositol-3-kinase-dependent cell growth in breast cancer. Molecular Cancer 9:1.
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Sharon A Glynn, Robyn L Prueitt, Lisa A Ridnour, Brenda J Boersma, Tiffany M Dorsey, David A Wink, Julie E Goodman, Harris G Yfantis, Dong H Lee & Stefan Ambs. (2010) COX-2 activation is associated with Akt phosphorylation and poor survival in ER-negative, HER2-positive breast cancer. BMC Cancer 10:1.
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Isabel F Pinhel, Fiona A MacNeill, Margaret J Hills, Janine Salter, Simone Detre, Roger A'Hern, Ashutosh Nerurkar, Peter Osin, Ian E Smith & Mitch Dowsett. (2010) Extreme loss of immunoreactive p-Akt and p-Erk1/2 during routine fixation of primary breast cancer. Breast Cancer Research 12:5.
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Pei Yu, Ling Zhou, Weifeng Ke & Ke Li. (2010) Clinical significance of pAKT and CD44v6 overexpression with breast cancer. Journal of Cancer Research and Clinical Oncology 136:8, pages 1283-1292.
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Jeffrey S. Ross, Elzbieta A. Slodkowska, W. Fraser Symmans, Lajos Pusztai, Peter M. Ravdin & Gabriel N. Hortobagyi. (2009) The HER-2 Receptor and Breast Cancer: Ten Years of Targeted Anti–HER-2 Therapy and Personalized Medicine. The Oncologist 14:4, pages 320-368.
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Franklin L. Chen, Wenle Xia & Neil L. Spector. (2008) Acquired Resistance to Small Molecule ErbB2 Tyrosine Kinase Inhibitors. Clinical Cancer Research 14:21, pages 6730-6734.
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Kiyomi Taniyama, Katsunari Ishida, Tamaki Toda, Junichi Motoshita, Kazuya Kuraoka, Akihisa Saito, Yoichi Tani, Toshinori Uike, Seiichi Teramoto & Masato Koseki. (2008) Tyrosine1248-phosphorylated HER2 expression and HER2 gene amplification in female invasive ductal carcinomas. Breast Cancer 15:3, pages 231-240.
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Barbara T. McGrogan, Breege Gilmartin, Desmond N. Carney & Amanda McCann. (2008) Taxanes, microtubules and chemoresistant breast cancer. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 1785:2, pages 96-132.
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Shou-Ching Tang. (2008) Predictive Markers of Tubulin-Targeting Agents in Breast Cancer. Clinical Breast Cancer 8, pages S79-S84.
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Yanyuan Wu, Hezla Mohamed, Ram Chillar, Ishrat Ali, Sheila Clayton, Dennis Slamon & Jaydutt V Vadgama. (2008) Clinical significance of Akt and HER2/neu overexpression in African-American and Latina women with breast cancer. Breast Cancer Research 10:1.
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E. Azambuja, V. Durbecq, D.D. Rosa, M. Colozza, D. Larsimont, M. Piccart-Gebhart & F. Cardoso. (2008) HER-2 overexpression/amplification and its interaction with taxane-based therapy in breast cancer. Annals of Oncology 19:2, pages 223-232.
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T.A. Grushko, V.L. Filiaci, A.J. Mundt, K. Ridderstr?le, O.I. Olopade & G.F. Fleming. (2008) An exploratory analysis of HER-2 amplification and overexpression in advanced endometrial carcinoma: A gynecologic oncology group study. Gynecologic Oncology 108:1, pages 3-9.
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Vassiliki Karantza-Wadsworth, Shyam Patel, Olga Kravchuk, Guanghua Chen, Robin Mathew, Shengkan Jin & Eileen White. (2007) Autophagy mitigates metabolic stress and genome damage in mammary tumorigenesis. Genes & Development 21:13, pages 1621-1635.
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Anil Potti, Holly K Dressman, Andrea Bild, Richard F Riedel, Gina Chan, Robyn Sayer, Janiel Cragun, Hope Cottrill, Michael J Kelley, Rebecca Petersen, David Harpole, Jeffrey Marks, Andrew Berchuck, Geoffrey S Ginsburg, Phillip Febbo, Johnathan Lancaster & Joseph R Nevins. (2006) Genomic signatures to guide the use of chemotherapeutics. Nature Medicine 12:11, pages 1294-1300.
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Sabeeha Muneer, Susan Peck & Joyce A. O'Shaughnessy. (2006) Highlights from: the 42nd Annual Meeting of the American Society of Clinical Oncology; Atlanta, GA, June 2006. Clinical Breast Cancer 7:4, pages 306-314.
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Carol Lovegrove. (2006) Activated HER2 expression and resistance to taxane chemotherapy. Nature Clinical Practice Oncology 3:1, pages 9-10.
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