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Cancer Investigation Volume 25, 2007 - Issue 1
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ORIGINAL ARTICLE

Prostate Cancer Cells Increase Androgen Sensitivity by Increase in Nuclear Androgen Receptor and Androgen Receptor Coactivators; A Possible Mechanism of Hormone-Resistance of Prostate Cancer Cells

Naohiro Fujimoto Department of Urology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan
, M.D., Ph.D.,
Hiroshi Miyamoto Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, New York, USA
, M.D., Ph.D.,
Atsushi Mizokami Department of Urology, School of Medicine, Kanazawa University, Kanazawa, Japan
, M.D., Ph.D.,
Shuji Harada Department of Urology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan
, M.D., Ph.D.,
Masayoshi Nomura Department of Urology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan
, M.D., Ph.D.,
Yoichi Ueta Department of Physiology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan
, M.D., Ph.D.,
Takakazu Sasaguri Department of Pathology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan
, M.D., Ph.D. &
Tetsuro Matsumoto Department of Urology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan
, M.D., Ph.D. show all
Pages 32-37 | Published online: 11 Jun 2009

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Armando Olivas & Ramona Salcedo Price. (2021) Obesity, Inflammation, and Advanced Prostate Cancer. Nutrition and Cancer 73:11-12, pages 2232-2248.
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Ashley T. Fancher, Yun Hua, David A. Close, Wei Xu, Lee A. McDermott, Christopher J. Strock, Ulises Santiago, Carlos J. Camacho & Paul A. Johnston. (2023) Characterization of allosteric modulators that disrupt androgen receptor co-activator protein-protein interactions to alter transactivation–Drug leads for metastatic castration resistant prostate cancer. SLAS Discovery 28:7, pages 325-343.
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Nishimoto Koshiro, Kenichi Nakajima, Masafumi Oyama, Go Kaneko, Satoru Takahashi, Hideyasu Matsuyama, Hiroaki Shiina, Tomohiko Ichikawa, Hiroyuki Horikoshi, Katsuyoshi Hashine, Yutaka Sugiyama, Takeshi Miyao, Manabu Kamiyama, Kenichi Harada, Akito Ito & Atsushi Mizokami. (2022) Predictive factors for the effectiveness of novel androgen receptor axis‐targeted agents in patients with metastatic prostate cancer. International Journal of Urology 29:12, pages 1477-1487.
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Debasish Basak, Lisney Gregori, Fatema Johora & Subrata Deb. (2022) Preclinical and Clinical Research Models of Prostate Cancer: A Brief Overview. Life 12:10, pages 1607.
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Andrea Palicelli, Stefania Croci, Alessandra Bisagni, Eleonora Zanetti, Dario De Biase, Beatrice Melli, Francesca Sanguedolce, Moira Ragazzi, Magda Zanelli, Alcides Chaux, Sofia Cañete-Portillo, Maria Paola Bonasoni, Alessandra Soriano, Stefano Ascani, Maurizio Zizzo, Carolina Castro Ruiz, Antonio De Leo, Guido Giordano, Matteo Landriscina, Giuseppe Carrieri, Luigi Cormio, Daniel M. Berney, Jatin Gandhi, Giacomo Santandrea & Martina Bonacini. (2021) What Do We Have to Know about PD-L1 Expression in Prostate Cancer? A Systematic Literature Review. Part 4: Experimental Treatments in Pre-Clinical Studies (Cell Lines and Mouse Models). International Journal of Molecular Sciences 22:22, pages 12297.
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Fabrizio Fontana & Patrizia Limonta. (2021) Dissecting the Hormonal Signaling Landscape in Castration-Resistant Prostate Cancer. Cells 10:5, pages 1133.
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Mani Arulkumar, Varatharajan Mathivanan, Ramalingam Revathi & Zhao-Yang Wang. 2021. Nanotechnology in Medicine. Nanotechnology in Medicine 105 121 .
Ashley T. FancherYun HuaChristopher J. StrockPaul A. Johnston. (2019) Assays to Interrogate the Ability of Compounds to Inhibit the AF-2 or AF-1 Transactivation Domains of the Androgen Receptor. ASSAY and Drug Development Technologies 17:8, pages 364-386.
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Zhonglin Cai, Weijie Chen, Jianzhong Zhang & Hongjun Li. (2018) Androgen receptor: what we know and what we expect in castration-resistant prostate cancer. International Urology and Nephrology 50:10, pages 1753-1764.
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Ashley T. FancherYun HuaDaniel P. CamarcoDavid A. CloseChristopher J. StrockPaul A. Johnston. (2018) High-Content Screening Campaign to Identify Compounds That Inhibit or Disrupt Androgen Receptor-Transcriptional Intermediary Factor 2 Protein-Protein Interactions for the Treatment of Prostate Cancer. ASSAY and Drug Development Technologies 16:6, pages 297-319.
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Reyna Cristina Colli-Dula, Xiefan Fang, David Moraga-Amador, Nacira Albornoz-Abud, Roberto Zamora-Bustillos, Ana Conesa, Omar Zapata-Perez, Diego Moreno & Emanuel Hernandez-Nuñez. (2018) Transcriptome analysis reveals novel insights into the response of low-dose benzo(a)pyrene exposure in male tilapia. Aquatic Toxicology 201, pages 162-173.
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B Cioni, W Zwart & A M Bergman. (2018) Androgen receptor moonlighting in the prostate cancer microenvironment. Endocrine-Related Cancer 25:6, pages R331-R349.
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Yun Hua, Daniel P. Camarco, Christopher J. Strock & Paul A. Johnston. 2018. High Content Screening. High Content Screening 211 227 .
Muhammed H Rahaman, Malika Kumarasiri, Laychiluh B Mekonnen, Mingfeng Yu, Sarah Diab, Hugo Albrecht, Robert W Milne & Shudong Wang. (2016) Targeting CDK9: a promising therapeutic opportunity in prostate cancer. Endocrine-Related Cancer 23:12, pages T211-T226.
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Keisuke Takeda, Noboru Hara, Tsutomu Nishiyama, Masayuki Tasaki, Fumio Ishizaki & Yoshihiko Tomita. (2016) Corepressive function of nuclear receptor coactivator 2 in androgen receptor of prostate cancer cells treated with antiandrogen. BMC Cancer 16:1.
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Ashley T. FancherYun HuaDaniel P. CamarcoDavid A. CloseChristopher J. StrockPaul A. Johnston. (2016) Reconfiguring the AR-TIF2 Protein–Protein Interaction HCS Assay in Prostate Cancer Cells and Characterizing the Hits from a LOPAC Screen. ASSAY and Drug Development Technologies 14:8, pages 453-477.
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Naohiro FUJIMOTO. (2016) Role of the Androgen-Androgen Receptor Axis in the Treatment Resistance of Advanced Prostate Cancer: From Androgen-Dependent to Castration Resistant and Further. Journal of UOEH 38:2, pages 129-138.
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Huy Q. Ta, Melissa L. Ivey, Henry F. FriersonJrJr, Mark R. Conaway, Jaroslaw Dziegielewski, James M. Larner & Daniel Gioeli. (2015) Checkpoint Kinase 2 Negatively Regulates Androgen Sensitivity and Prostate Cancer Cell Growth. Cancer Research 75:23, pages 5093-5105.
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Jennifer L Bishop, Alastair Davies, Kirsi Ketola & Amina Zoubeidi. (2015) Regulation of tumor cell plasticity by the androgen receptor in prostate cancer. Endocrine-Related Cancer 22:3, pages R165-R182.
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Atsushi Mizokami & Mikio Namiki. (2015) Reconsideration of progression to CRPC during androgen deprivation therapy. The Journal of Steroid Biochemistry and Molecular Biology 145, pages 164-171.
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Mannan Nouri, Ellca Ratther, Nataly Stylianou, Colleen C. Nelson, Brett G. Hollier & Elizabeth D. Williams. (2014) Androgen-Targeted Therapy-Induced Epithelial Mesenchymal Plasticity and Neuroendocrine Transdifferentiation in Prostate Cancer: An Opportunity for Intervention. Frontiers in Oncology 4.
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Yun HuaTong Ying ShunChristopher J. StrockPaul A. Johnston. (2014) High-Content Positional Biosensor Screening Assay for Compounds to Prevent or Disrupt Androgen Receptor and Transcriptional Intermediary Factor 2 Protein–Protein Interactions. ASSAY and Drug Development Technologies 12:7, pages 395-418.
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Damien A. Leach, Eleanor F. Need, Andrew P. Trotta, Melanie J. Grubisha, Donald B. DeFranco & Grant Buchanan. (2014) Hic-5 influences genomic and non-genomic actions of the androgen receptor in prostate myofibroblasts. Molecular and Cellular Endocrinology 384:1-2, pages 185-199.
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Konstantinos Kamposioras & Evangelos Briasoulis. 2014. Bone Metastases. Bone Metastases 247 273 .
N Fujimoto, T Kubo, H Inatomi, H T T Bui, M Shiota, T Sho & T Matsumoto. (2013) Polymorphisms of the androgen transporting gene SLCO2B1 may influence the castration resistance of prostate cancer and the racial differences in response to androgen deprivation. Prostate Cancer and Prostatic Diseases 16:4, pages 336-340.
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Takeshi Yamada, Masashi Nakayama, Tomohito Shimizu, Shinpei Nonen, Yasutomo Nakai, Kazuo Nishimura, Yasushi Fujio, Akihiko Okuyama, Junichi Azuma & Norio Nonomura. (2012) Genetic polymorphisms of CYP17A1 in steroidogenesis pathway are associated with risk of progression to castration-resistant prostate cancer in Japanese men receiving androgen deprivation therapy. International Journal of Clinical Oncology 18:4, pages 711-717.
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Takashi Shima, Atsushi Mizokami, Toru Miyagi, Keiichi Kawai, Kouji Izumi, Misako Kumaki, Mitsuo Ofude, Jian Zhang, Evan T. Keller & Mikio Namiki. (2012) Down‐regulation of calcium/calmodulin‐dependent protein kinase kinase 2 by androgen deprivation induces castration‐resistant prostate cancer. The Prostate 72:16, pages 1789-1801.
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Brian W. C. Tse, Kieran F. Scott & Pamela J. Russell. (2012) Paradoxical Roles of Tumour Necrosis Factor-Alpha in Prostate Cancer Biology. Prostate Cancer 2012, pages 1-8.
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Kelly G. Bryant, Jeanette Camacho, Jean-François Jasmin, Chenguang Wang, Sankar Addya, Mathew C. Casimiro, Paolo Fortina, Sucharitha Balasubramaniam, Karen E. Knudsen, Roland Schwarting, Michael P. Lisanti & Isabelle Mercier. (2011) Caveolin-1 overexpression enhances androgen-dependent growth and proliferation in the mouse prostate. The International Journal of Biochemistry & Cell Biology 43:9, pages 1318-1329.
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X Li, M Martinez-Ferrer, V Botta, C Uwamariya, J Banerjee & N A Bhowmick. (2010) Epithelial Hic-5/ARA55 expression contributes to prostate tumorigenesis and castrate responsiveness. Oncogene 30:2, pages 167-177.
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Marie‐Hélène Lévesque, Mohamed El‐Alfy, Leonello Cusan & Fernand Labrie. (2009) Androgen receptor as a potential sign of prostate cancer metastasis. The Prostate 69:15, pages 1704-1711.
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Pernilla Wikström, Josip Marusic, Pär Stattin & Anders Bergh. (2009) Low stroma androgen receptor level in normal and tumor prostate tissue is related to poor outcome in prostate cancer patients. The Prostate 69:8, pages 799-809.
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Siting Feng, Qizhu Tang, Meng Sun, Jae Yeon Chun, Christopher P. Evans & Allen C. Gao. (2009) Interleukin-6 increases prostate cancer cells resistance to bicalutamide via TIF2. Molecular Cancer Therapeutics 8:3, pages 665-671.
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Trevor M. Penning & Michael C. Byrns. (2009) Steroid Hormone Transforming Aldo-Keto Reductases and Cancer. Annals of the New York Academy of Sciences 1155:1, pages 33-42.
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Elaine Y.C. Hsia, June X. Zou & Hong‐Wu Chen. 2009. 261 298 .
Konstantinos Kamposioras & Evangelos Briasoulis. 2009. Bone Metastases. Bone Metastases 299 320 .
Shuyuan Yeh, Yuanjie Niu, Hiroshi Miyamoto, Tamin Chang & Chawnshang Chang. 2009. Androgen Action in Prostate Cancer. Androgen Action in Prostate Cancer 73 89 .
Latif A. Wafa, Robert Snoek & Paul S. Rennie. 2009. Androgen Action in Prostate Cancer. Androgen Action in Prostate Cancer 341 374 .
Helen E. MacLean, W. S. Maria Chiu, Cathy Ma, Julie F. McManus, Rachel A. Davey, Rhoda Cameron, Amanda J. Notini & Jeffrey D. Zajac. (2008) A floxed allele of the androgen receptor gene causes hyperandrogenization in male mice . Physiological Genomics 33:1, pages 133-137.
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Adam Schayowitz, Gauri Sabnis, Vincent C.O. Njar & Angela M.H. Brodie. (2008) Synergistic effect of a novel antiandrogen, VN/124-1, and signal transduction inhibitors in prostate cancer progression to hormone independence in vitro . Molecular Cancer Therapeutics 7:1, pages 121-132.
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