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Cancer Investigation Volume 26, 2008 - Issue 10
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ORIGINAL ARTICLESCellular and Molecular Biology

MG-132 Inhibits Telomerase Activity, Induces Apoptosis and G1 Arrest Associated with Upregulated p27kip1 Expression and Downregulated Survivin Expression in Gastric Carcinoma Cells

Weiguo Zhang Department of Gastroenterology, Taihe Hospital, Yunyang Medical College, Shiyan, Hubei, China
,
Qiang Tong Department of Gastroenterology, Taihe Hospital, Yunyang Medical College, Shiyan, Hubei, China
,
Shengbao Li Department of Gastroenterology, Taihe Hospital, Yunyang Medical College, Shiyan, Hubei, China
,
Xiaohu Wang Department of Gastroenterology, Taihe Hospital, Yunyang Medical College, Shiyan, Hubei, China
&
Qiang Wang Department of Gastroenterology, Taihe Hospital, Yunyang Medical College, Shiyan, Hubei, China
Pages 1032-1036 | Published online: 11 Jun 2009

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Chun-Feng Meng, Xin-Jiang Zhu, Guo Peng & Dong-Qiu Dai. (2010) Role of Histone Modifications and DNA Methylation in the Regulation of O6-Methylguanine-DNA Methyltransferase Gene Expression in Human Stomach Cancer Cells. Cancer Investigation 28:4, pages 331-339.
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Weiguo Zhang, Qiang Tong, Qingming Wu, Shengbao Li, Xiaohu Wang & Qiang Wang. (2009) Upregulated p27kip1 can Downregulate Survivin Expression and Inhibit Telomerase Activity in Gastric Carcinoma Cells. Cancer Investigation 27:9, pages 898-900.
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Articles from other publishers (13)

Jing Chen, Haotian Guo, Haitao Jiang, Mwichie Namusamba, Changli Wang, Tian Lan, Tianyi Wang & Bing Wang. (2019) A BAP31 intrabody induces gastric cancer cell death by inhibiting p27 kip1 proteasome degradation . International Journal of Cancer 144:8, pages 2051-2062.
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Yan Wang & Mengchun Wang. (2016) Prognostic significance of expression of cysteine-rich 61 and cyclooxygenase-2 in gastric cancer. BMC Gastroenterology 16:1.
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Yinnan Chen & Yanmin Zhang. (2016) Functional and mechanistic analysis of telomerase: An antitumor drug target. Pharmacology & Therapeutics 163, pages 24-47.
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Li Lu, Hui-Fang Song, Jiao-Long Wei, Xue-Qin Liu, Wen-Hui Song, Ba-Yi Yan, Gui-Jiao Yang, Ang Li & Wu-Lin Yang. (2014) Ameliorating replicative senescence of human bone marrow stromal cells by PSMB5 overexpression. Biochemical and Biophysical Research Communications 443:4, pages 1182-1188.
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Lin Xia, ChangXin Shen, YouRong Fu, Li Tian & Ming Chen. (2013) MGC29506 induces cell cycle arrest and is downregulated in gastric cancer. Cellular Immunology 281:1, pages 31-36.
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Adil Anwar, David A. Norris & Mayumi Fujita. (2011) Ubiquitin proteasomal pathway mediated degradation of p53 in melanoma. Archives of Biochemistry and Biophysics 508:2, pages 198-203.
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Yong Hwan Han & Woo Hyun Park. (2010) MG132 as a proteasome inhibitor induces cell growth inhibition and cell death in A549 lung cancer cells via influencing reactive oxygen species and GSH level. Human & Experimental Toxicology 29:7, pages 607-614.
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William Ka Kei Wu, Chi Hin Cho, Chung Wa Lee, Kaichun Wu, Daiming Fan, Jun Yu & Joseph Jao Yiu Sung. (2010) Proteasome inhibition: A new therapeutic strategy to cancer treatment. Cancer Letters 293:1, pages 15-22.
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Yong Hwan Han & Woo Hyun Park. (2010) MG132, a proteasome inhibitor decreased the growth of Calu-6 lung cancer cells via apoptosis and GSH depletion. Toxicology in Vitro 24:4, pages 1237-1242.
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Satoru Kase, Shikun He, Shozo Sonoda, Mizuki Kitamura, Christine Spee, Eric Wawrousek, Stephen J. Ryan, Ram Kannan & David R. Hinton. (2010) αB-crystallin regulation of angiogenesis by modulation of VEGF. Blood 115:16, pages 3398-3406.
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Xiaozhong Yu, Joshua F. Robinson, Jaspreet S. Sidhu, Sungwoo Hong & Elaine M. Faustman. (2010) A System-Based Comparison of Gene Expression Reveals Alterations in Oxidative Stress, Disruption of Ubiquitin-Proteasome System and Altered Cell Cycle Regulation after Exposure to Cadmium and Methylmercury in Mouse Embryonic Fibroblast. Toxicological Sciences 114:2, pages 356-377.
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William Ka Kei Wu, Viviana Volta, Chi Hin Cho, Ya Chun Wu, Hai Tao Li, Le Yu, Zhi Jie Li & Joseph Jao Yiu Sung. (2009) Repression of protein translation and mTOR signaling by proteasome inhibitor in colon cancer cells. Biochemical and Biophysical Research Communications 386:4, pages 598-601.
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Liang Qiao & Benjamin C.Y. Wong. (2009) Targeting apoptosis as an approach for gastrointestinal cancer therapy. Drug Resistance Updates 12:3, pages 55-64.
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