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Cancer Investigation Volume 27, 2009 - Issue 2
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ORIGINAL ARTICLES Cellular and Molecular Biology

Inhibition of Cell Proliferation, Vascular Endothelial Growth Factor and Tumor Growth by Albendazole

Mohammad Hossein Pourgholami Cancer Research laboratories, University of New South Wales, Department of Surgery, St George Hospital (SESIAHS), Sydney, Australia
,
Zhao Yan Cai Cancer Research laboratories, University of New South Wales, Department of Surgery, St George Hospital (SESIAHS), Sydney, Australia
,
Lisa Wang Cancer Research laboratories, University of New South Wales, Department of Surgery, St George Hospital (SESIAHS), Sydney, Australia
,
Samina Badar Cancer Research laboratories, University of New South Wales, Department of Surgery, St George Hospital (SESIAHS), Sydney, Australia
,
Matthew Links Cancer Care Center, University of New South Wales, Department of Surgery, St George Hospital (SESIAHS), Sydney, Australia
&
David Lawson Morris Cancer Research laboratories, University of New South Wales, Department of Surgery, St George Hospital (SESIAHS), Sydney, Australia
Pages 171-177 | Published online: 11 Jun 2009

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Zhe Wang, Xiangping Deng, Shujuan Xiong, Runde Xiong, Juan Liu, Liu Zou, Xiaoyong Lei, Xuan Cao, Zhizhong Xie, Yanming Chen, Yunmei Liu, Xing Zheng & Guotao Tang. (2018) Design, synthesis and biological evaluation of chrysin benzimidazole derivatives as potential anticancer agents. Natural Product Research 32:24, pages 2900-2909.
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Articles from other publishers (20)

Sameh Saber, Mohamed Nasr, Ahmed S. Saad, Ahmed A.E. Mourad, Naglaa A. Gobba, Ahmed Shata, Abdel-Moneim Hafez, Ramy N. Elsergany, Heba I. Elagamy, Eman El-Ahwany, Noha A. Amin, Samuel Girgis, Yaser H.A. Elewa, Mohamed H. Mahmoud, Gaber El-Saber Batiha, Magdy Abou El-Rous, Islam Kamal, Mohamed M.Y. Kaddah & Ahmed E. Khodir. (2021) Albendazole-loaded cubosomes interrupt the ERK1/2-HIF-1α-p300/CREB axis in mice intoxicated with diethylnitrosamine: A new paradigm in drug repurposing for the inhibition of hepatocellular carcinoma progression. Biomedicine & Pharmacotherapy 142, pages 112029.
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Joyobrato Nath, Rajib Paul, Sankar Kumar Ghosh, Jaishree Paul, Baby Singha & Nitu Debnath. (2020) Drug repurposing and relabeling for cancer therapy: Emerging benzimidazole antihelminthics with potent anticancer effects. Life Sciences 258, pages 118189.
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Hassan Abidi, Mehrorang Ghaedi, Abdollah Rafiei, Ali Jelowdar, Anayatollah Salimi, Arash Asfaram & Abbas Ostovan. (2018) Magnetic solid lipid nanoparticles co-loaded with albendazole as an anti-parasitic drug: Sonochemical preparation, characterization, and in vitro drug release. Journal of Molecular Liquids 268, pages 11-18.
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Jianming Liang, Ruixiang Li, Yuwei He, Chengli Ling, Qi Wang, Yongzhuo Huang, Jing Qin, Weigen Lu & Jianxin Wang. (2018) A novel tumor-targeting treatment strategy uses energy restriction via co-delivery of albendazole and nanosilver. Nano Research 11:9, pages 4507-4523.
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Gregory Marslin, Karthik Siram, Xiang Liu, Vinoth Khandelwal, Xiaolei Shen, Xiang Wang & Gregory Franklin. (2017) Solid Lipid Nanoparticles of Albendazole for Enhancing Cellular Uptake and Cytotoxicity against U-87 MG Glioma Cell Lines. Molecules 22:11, pages 2040.
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Xuan Zhang, Jing Zhao, Xiangyang Gao, Dongsheng Pei & Chao Gao. (2016) Anthelmintic drug albendazole arrests human gastric cancer cells at the mitotic phase and induces apoptosis. Experimental and Therapeutic Medicine.
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Věra Králová, Veronika Hanušová, Emil Rudolf, Kristýna Čáňová & Lenka Skálová. (2016) Flubendazole induces mitotic catastrophe and senescence in colon cancer cells in vitro . Journal of Pharmacy and Pharmacology 68:2, pages 208-218.
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Lubna Noorani, Martina Stenzel, Roger Liang, Mohammad H Pourgholami & David L Morris. (2015) Albumin nanoparticles increase the anticancer efficacy of albendazole in ovarian cancer xenograft model. Journal of Nanobiotechnology 13:1.
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Zahra Dorosti, Morteza Yousefi, Seyedeh Maryam Sharafi & Hossein Yousofi Darani. (2014) Mutual action of anticancer and antiparasitic drugs: are there any shared targets?. Future Oncology 10:15, pages 2529-2539.
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Mohammad Hossein Pourgholami, Parvin Ataie-Kachoie, Samina Badar & David Lawson Morris. (2013) Minocycline inhibits malignant ascites of ovarian cancer through targeting multiple signaling pathways. Gynecologic Oncology 129:1, pages 113-119.
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Yoseop Kim, Elviana D. Liemmawal, Mohammad H. Pourgholami, David L. Morris & Martina H. Stenzel. (2012) Comparison of Shell-Cross-Linked Micelles with Soft and Glassy Cores as a Drug Delivery Vehicle for Albendazole: Is There a Difference in Performance?. Macromolecules 45:13, pages 5451-5462.
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Yoseop Kim, Mohammad H. Pourgholami, David L. Morris & Martina H. Stenzel. (2012) Effect of Cross-Linking on the Performance of Micelles As Drug Delivery Carriers: A Cell Uptake Study. Biomacromolecules 13:3, pages 814-825.
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Afshin Amini, Samar Masoumi Moghaddam, David L. Morris & Mohammad H. Pourgholami. (2012) Utility of Vascular Endothelial Growth Factor Inhibitors in the Treatment of Ovarian Cancer: From Concept to Application. Journal of Oncology 2012, pages 1-14.
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Yoseop Kim, Mohammad H. Pourgholami, David L. Morris & Martina H. Stenzel. (2011) An Optimized RGD-Decorated Micellar Drug Delivery System for Albendazole for the Treatment of Ovarian Cancer: From RAFT Polymer Synthesis to Cellular Uptake. Macromolecular Bioscience 11:2, pages 219-233.
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Mohammad H Pourgholami, Zhao Y Cai, Samina Badar, Kiran Wangoo, Marianne S Poruchynsky & David L Morris. (2010) Potent inhibition of tumoral hypoxia-inducible factor 1α by albendazole. BMC Cancer 10:1.
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Mohammad H. Pourgholami, Levon M. Khachigian, Roger G. Fahmy, Samina Badar, Lisa Wang, Stephanie Wai Ling Chu & David Lawson Morris. (2010) Albendazole inhibits endothelial cell migration, tube formation, vasopermeability, VEGF receptor-2 expression and suppresses retinal neovascularization in ROP model of angiogenesis. Biochemical and Biophysical Research Communications 397:4, pages 729-734.
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Mohammad H. Pourgholami, Michael Szwajcer, Melvin Chin, Winston Liauw, Jonathan Seef, Peter Galettis, David L. Morris & Matthew Links. (2009) Phase I clinical trial to determine maximum tolerated dose of oral albendazole in patients with advanced cancer. Cancer Chemotherapy and Pharmacology 65:3, pages 597-605.
Crossref
Yunjie Zhao, Mohammad H. Pourgholami, David L. Morris, J. Grant Collins & Anthony I. Day. (2010) Enhanced cytotoxicity of benzimidazole carbamate derivatives and solubilisation by encapsulation in cucurbit[n]uril. Organic & Biomolecular Chemistry 8:14, pages 3328.
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Vanessa Incani, Afsaneh Lavasanifar & Hasan Uludağ. (2010) Lipid and hydrophobic modification of cationic carriers on route to superior gene vectors. Soft Matter 6:10, pages 2124.
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Badar Shaikh, Nathan Rummel, Charles Gieseker, Christie-Sue Cheely & Renate Reimschuessel. (2009) Residue depletion of albendazole and its metabolites in the muscle tissue of large mouth and hybrid striped bass after oral administration. Journal of Chromatography A 1216:46, pages 8173-8176.
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