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A Mini‐Review

Melatonin Synthesis in the Human Pineal Gland: Advantages, Implications, and Difficulties

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Pages 369-379 | Published online: 07 Jul 2009

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (3)

Saurav Saha, Kshetrimayum Manisana Singh & Braj Bansh Prasad Gupta. (2020) Season-dependent differential effect of temperature on diurnal rhythm of expression of core clock genes in the pineal organ of an air-breathing catfish, Clarias gariepinus. Biological Rhythm Research 51:1, pages 120-138.
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Cheng Ni, Gang Tan, Ailun Luo, Min Qian, Yi Tang, Yang Zhou, Jun Wang, Min Li, Yan Zhang, Donglin Jia, Changyi Wu & Xiangyang Guo. (2013) Melatonin Premedication Attenuates Isoflurane Anesthesia-Induced β-Amyloid Generation and Cholinergic Dysfunction in the Hippocampus of Aged Rats. International Journal of Neuroscience 123:4, pages 213-220.
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Said Lyoumi, Caroline Martin‐Schmitt, Yvan Touitou, Hervé Puy & Yasmina Djeridane. (2008) Melatonin and Environmental Lighting Regulate ALA‐S Gene Expression and So Porphyrin Biosynthesis in the Rat Harderian Gland. Chronobiology International 25:6, pages 851-867.
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Xian Chen, Yancun Zhao, Pedro Laborda, Yong Yang & Fengquan Liu. (2023) Molecular Cloning and Characterization of a Serotonin N-Acetyltransferase Gene, xoSNAT3, from Xanthomonas oryzae pv. oryzae. International Journal of Environmental Research and Public Health 20:3, pages 1865.
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Mohammed Albreiki. 2022. Melatonin - Recent Updates. Melatonin - Recent Updates.
Xiao-Wen Hou, Ying Wang, Qian Wu, Chaofu Ke & Chen-Wei Pan. (2022) A review of study designs and data analyses in metabolomics studies in myopia. Analytical Biochemistry 655, pages 114850.
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Alekhya Peruri, Alexandra Morgan, Alida D’Souza, Bridget Mellon, Carey W. Hung, Gabriella Kayal, Haejung Shin, Kim Nguyen, Malek Zahed, Mason Yount, Reilly Ellis, Taylor Wynne, Virginia Fritz, Zachary Simmons & Kelly C. S. Roballo. (2022) Pineal Gland from the Cell Culture to Animal Models: A Review. Life 12:7, pages 1057.
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Ioanna Mpoulimari & Elias Zintzaras. (2022) Synthesis of genetic association studies on autism spectrum disorders using a genetic model-free approach. Psychiatric Genetics 32:3, pages 91-104.
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Seiya Ohki, Miyu Kunimatsu, Shingo Ogawa, Hiroki Takano, Tomomi Furihata, Hiromi Shibasaki & Akitomo Yokokawa. (2022) Development and Validation of an LC–MS/MS-Based Method for Quantifying Urinary Endogenous 6-Hydroxymelatonin. Chemical and Pharmaceutical Bulletin 70:5, pages 375-382.
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Zeynab Kohandel, Tahereh Farkhondeh, Michael Aschner & Saeed Samarghandian. (2021) Molecular targets for the management of gastrointestinal cancer using melatonin, a natural endogenous body hormone. Biomedicine & Pharmacotherapy 140, pages 111782.
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Althea Robinson Shelton & Beth Malow. (2021) Neurodevelopmental Disorders Commonly Presenting with Sleep Disturbances. Neurotherapeutics 18:1, pages 156-169.
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Mindaugas Kvietkauskas, Viktorija Zitkute, Bettina Leber, Kestutis Strupas, Philipp Stiegler & Peter Schemmer. (2020) The role of melatonin in colorectal cancer treatment: a comprehensive review. Therapeutic Advances in Medical Oncology 12, pages 175883592093171.
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Jung Goo Lee, Young Sup Woo, Sung Woo Park, Dae-Hyun Seog, Mi Kyoung Seo & Won-Myong Bahk. (2019) The Neuroprotective Effects of Melatonin: Possible Role in the Pathophysiology of Neuropsychiatric Disease. Brain Sciences 9:10, pages 285.
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Yaswanth Kuthati, Sheng-Hsiung Lin, Ing-Jung Chen & Chih-Shung Wong. (2019) Melatonin and their analogs as a potential use in the management of Neuropathic pain. Journal of the Formosan Medical Association 118:8, pages 1177-1186.
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Wiebe Braam, Friederike Ehrhart, Anneke P.H.M. Maas, Marcel G. Smits & Leopold Curfs. (2018) Low maternal melatonin level increases autism spectrum disorder risk in children. Research in Developmental Disabilities 82, pages 79-89.
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Xiaoying Xu, Xiaoyan Liu, Shuran Ma, Ya Xu, Ying Xu, Xiazhen Guo & Dekui Li. (2018) Association of Melatonin Production with Seasonal Changes, Low Temperature, and Immuno-Responses in Hamsters. Molecules 23:3, pages 703.
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Wamidh Talib. (2018) Melatonin and Cancer Hallmarks. Molecules 23:3, pages 518.
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Marion Benabou, Thomas Rolland, Claire S. Leblond, Gaël A. Millot, Guillaume Huguet, Richard Delorme, Marion Leboyer, Cécile Pagan, Jacques Callebert, Erik Maronde & Thomas Bourgeron. (2017) Heritability of the melatonin synthesis variability in autism spectrum disorders. Scientific Reports 7:1.
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Stephanie Kearney, Lisa O'Donoghue, L. Kirsty Pourshahidi, Diego Cobice & Kathryn J. Saunders. (2017) Myopes have significantly higher serum melatonin concentrations than non‐myopes. Ophthalmic and Physiological Optics 37:5, pages 557-567.
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Kshetrimayum Manisana Singh, Saurav Saha & Braj Bansh Prasad Gupta. (2017) Season-dependent effects of photoperiod and temperature on circadian rhythm of arylalkylamine N -acetyltransferase2 gene expression in pineal organ of an air-breathing catfish, Clarias gariepinus. Journal of Photochemistry and Photobiology B: Biology 173, pages 140-149.
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Jinyoung Won, Yunho Jin, Jeonghyun Choi, Sookyoung Park, Tae Lee, Sang-Rae Lee, Kyu-Tae Chang & Yonggeun Hong. (2017) Melatonin as a Novel Interventional Candidate for Fragile X Syndrome with Autism Spectrum Disorder in Humans. International Journal of Molecular Sciences 18:6, pages 1314.
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S. E. Goldman, M. L. Alder, H. J. Burgess, B. A. Corbett, R. Hundley, D. Wofford, D. B. Fawkes, L. Wang, M. L. Laudenslager & B. A. Malow. (2017) Characterizing Sleep in Adolescents and Adults with Autism Spectrum Disorders. Journal of Autism and Developmental Disorders 47:6, pages 1682-1695.
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Althea Robinson-Shelton & Beth A. Malow. (2015) Sleep Disturbances in Neurodevelopmental Disorders. Current Psychiatry Reports 18:1.
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Olivia J. Veatch, Angela C. Maxwell-Horn & Beth A. Malow. (2015) Sleep in Autism Spectrum Disorders. Current Sleep Medicine Reports 1:2, pages 131-140.
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Olivia J. Veatch, Julie S. Pendergast, Melissa J. Allen, Roberta M. Leu, Carl Hirschie Johnson, Sarah H. Elsea & Beth A. Malow. (2014) Genetic Variation in Melatonin Pathway Enzymes in Children with Autism Spectrum Disorder and Comorbid Sleep Onset Delay. Journal of Autism and Developmental Disorders 45:1, pages 100-110.
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. 2014. Melatonin. Melatonin 458 467 .
Morten Møller, Pansiri Phansuwan-Pujito & Corin Badiu. (2014) Neuropeptide Y in the Adult and Fetal Human Pineal Gland. BioMed Research International 2014, pages 1-7.
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Florian Wunderer, Sina Kühne, Antje Jilg, Katrin Ackermann, Tamas Sebesteny, Erik Maronde & Jörg H. Stehle. (2013) Clock Gene Expression in the Human Pituitary Gland. Endocrinology 154:6, pages 2046-2057.
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Hanan Awad Alkozi. (2013) Melatonin and derivatives as promising tools for glaucoma treatment. World Journal of Ophthalmology 3:4, pages 32.
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Fatmah A.M. Al-Omary. 2013. Profiles of Drug Substances, Excipients, and Related Methodology. Profiles of Drug Substances, Excipients, and Related Methodology 159 226 .
Indrajit Chowdhury & Saumen Maitra. 2011. Melatonin in the Promotion of Health, Second Edition. Melatonin in the Promotion of Health, Second Edition 1 60 .
Erik Maronde, Anastasia Saade, Katrin Ackermann, Hany Goubran-Botros, Cecile Pagan, Roman Bux, Thomas Bourgeron, Faramarz Dehghani & Jörg H. Stehle. (2011) Dynamics in enzymatic protein complexes offer a novel principle for the regulation of melatonin synthesis in the human pineal gland. Journal of Pineal Research 51:1, pages 145-155.
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Jörg H. Stehle, Anastasia Saade, Oliver Rawashdeh, Katrin Ackermann, Antje Jilg, Tamás Sebestény & Erik Maronde. (2011) A survey of molecular details in the human pineal gland in the light of phylogeny, structure, function and chronobiological diseases. Journal of Pineal Research 51:1, pages 17-43.
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Venkatramanujam Srinivasan, D. Warren Spence, Seithikurippu R. Pandi-Perumal, Gregory M. Brown & Daniel P. Cardinali. (2011) Melatonin in Mitochondrial Dysfunction and Related Disorders. International Journal of Alzheimer's Disease 2011, pages 1-16.
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María Eugenia Letelier, José Jara-Sandoval, Alfredo Molina-Berríos, Mario Faúndez, Paula Aracena-Parks & Felipe Aguilera. (2010) Melatonin protects the cytochrome P450 system through a novel antioxidant mechanism. Chemico-Biological Interactions 185:3, pages 208-214.
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G Gómez-Moreno, J Guardia, MJ Ferrera, A Cutando & RJ Reiter. (2010) Melatonin in diseases of the oral cavity. Oral Diseases 16:3, pages 242-247.
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Venkataramanujam Srinivasan, Seithikurippu R. Pandi-Perumal, D.Warren Spence, Adam Moscovitch, Ilya Trakht, Gregory M. Brown & Daniel P. Cardinali. (2010) Potential use of melatonergic drugs in analgesia: Mechanisms of action. Brain Research Bulletin 81:4-5, pages 362-371.
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Venkataramanujan Srinivasan, D. Warren Spence, Adam Moscovitch, Seithikurippu R. Pandi-Perumal, Ilya Trakht, Gregory M. Brown & Daniel P. Cardinali. (2010) Malaria: therapeutic implications of melatonin. Journal of Pineal Research 48:1, pages 1-8.
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Venkataramanujan Srinivasan, D Warren Spence, Seithikurippu R. Pandi-Perumal, Ilya Trakht & Daniel P. Cardinali. (2008) Therapeutic Actions of Melatonin in Cancer: Possible Mechanisms. Integrative Cancer Therapies 7:3, pages 189-203.
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Katrin Ackermann, Faramarz Dehghani, Roman Bux, Gerold Kauert & Jörg H. Stehle. (2007) Day?night expression patterns of clock genes in the human pineal gland. Journal of Pineal Research 43:2, pages 185-194.
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Mario F.P. Peres, Marcelo Rodrigues Masruha & Alan M. Rapoport. (2007) Melatonin therapy for headache disorders. Drug Development Research 68:6, pages 329-334.
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Erik Maronde & Jörg H. Stehle. (2007) The mammalian pineal gland: known facts, unknown facets. Trends in Endocrinology & Metabolism 18:4, pages 142-149.
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