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Research Article

Clinical and biological importance of cytogenetic abnormalities in childhood and adult acute lymphoblastic leukemia

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Pages 492-503 | Published online: 08 Jul 2009

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Charlotte G. Nyvold, Knud Bendix, Margrethe Brandsborg, Stanislaw Pulczynski, Trine Silkjær & Peter Hokland. (2007) Multiplex PCR for the detection of BCL-1/IGH and BCL-2/IGH gene rearrangements – clinical validation in a prospective study of blood and bone marrow in 258 patients with or suspected of non-Hodgkin's lymphoma.. Acta Oncologica 46:1, pages 21-30.
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Rebeqa Gunnarsson, Sebastian Dilorenzo, Kristina B Lundin-Ström, Linda Olsson, Andrea Biloglav, Henrik Lilljebjörn, Marianne Rissler, Per Wahlberg, Anders Lundmark, Anders Castor, Mikael Behrendtz, Thoas Fioretos, Kajsa Paulsson, Anders Isaksson & Bertil Johansson. (2018) Mutation, methylation, and gene expression profiles in dup(1q)-positive pediatric B-cell precursor acute lymphoblastic leukemia. Leukemia 32:10, pages 2117-2125.
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C.D. DiNardo, V. Gharibyan, H. Yang, Y. Wei, S. Pierce, H.M. Kantarjian, G. Garcia-Manero & M. Rytting. (2013) Impact of aberrant DNA methylation patterns including CYP1B1 methylation in adolescents and young adults with acute lymphocytic leukemia. American Journal of Hematology 88:9, pages 784-789.
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Eva Olah, Erzsebet Balogh, Laszlo Pajor & Zsuzsanna Jakab. (2010) Ten-year Experiences on Initial Genetic Examination in Childhood Acute Lymphoblastic Leukaemia in Hungary (1993–2002). Technical Approaches and Clinical Implementation. Pathology & Oncology Research 17:1, pages 81-90.
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Anthony V. Moorman & Christine J. Harrison. 2011. Adult Acute Lymphocytic Leukemia. Adult Acute Lymphocytic Leukemia 61 75 .
Anna Andersson, Patrik Edén, Tor Olofsson & Thoas Fioretos. (2010) Gene expression signatures in childhood acute leukemias are largely unique and distinct from those of normal tissues and other malignancies. BMC Medical Genomics 3:1.
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Akihiko Yokohama, Anjali Mishra, Takeki Mitsui, Brian Becknell, Jessica Johns, Douglas Curphey, Bradley W. Blaser, Jeffrey B. VanDeusen, Hsiaoyin Mao, Jianhua Yu & Michael A. Caligiuri. (2010) A novel mouse model for the aggressive variant of NK cell and T cell large granular lymphocyte leukemia. Leukemia Research 34:2, pages 203-209.
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Francesco Ceppi, Angela Brown, David R. Betts, Felix Niggli & Maja Beck Popovic. (2009) Cytogenetic characterization of childhood acute lymphoblastic leukemia in Nicaragua. Pediatric Blood & Cancer 53:7, pages 1238-1241.
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Josef Davidsson, Henrik Lilljebjörn, Anna Andersson, Srinivas Veerla, Jesper Heldrup, Mikael Behrendtz, Thoas Fioretos & Bertil Johansson. (2009) The DNA methylome of pediatric acute lymphoblastic leukemia. Human Molecular Genetics 18:21, pages 4054-4065.
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Krzysztof Mrózek, David P. Harper & Peter D. Aplan. (2009) Cytogenetics and Molecular Genetics of Acute Lymphoblastic Leukemia. Hematology/Oncology Clinics of North America 23:5, pages 991-1010.
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James W. VardimanJüergen ThieleDaniel A. ArberRichard D. BrunningMichael J. BorowitzAnna PorwitNancy Lee HarrisMichelle M. Le BeauEva Hellström-LindbergAyalew Tefferi & Clara D. Bloomfield. (2009) The 2008 revision of the World Health Organization (WHO) classification of myeloid neoplasms and acute leukemia: rationale and important changes. Blood 114:5, pages 937-951.
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Kristina Karrman, Eigil Kjeldsen, Carin Lassen, Margareth Isaksson, Josef Davidsson, Anna Andersson, Henrik Hasle, Thoas Fioretos & Bertil Johansson. (2009) The t(X;7)(q22;q34) in paediatric T-cell acute lymphoblastic leukaemia results in overexpression of the insulin receptor substrate 4 gene through illegitimate recombination with the T-cell receptor beta locus. British Journal of Haematology 144:4, pages 546-551.
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Catarina Lundin, Jesper Heldrup, Tomas Ahlgren, Tor Olofsson & Bertil Johansson. (2009) B-cell precursor t(8;14)(q11;q32)-positive acute lymphoblastic leukemia in children is strongly associated with Down syndrome or with a concomitant Philadelphia chromosome. European Journal of Haematology 82:1, pages 46-53.
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Anna ScutoMark KirschbaumClaudia KowolikLeo Kretzner, Agnes Juhasz, Peter Atadja, Vinod PullarkatRavi BhatiaStephen FormanYun Yen & Richard Jove. (2008) The novel histone deacetylase inhibitor, LBH589, induces expression of DNA damage response genes and apoptosis in Ph− acute lymphoblastic leukemia cells. Blood 111:10, pages 5093-5100.
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Kajsa Paulsson, Jean-Baptiste Cazier, Finlay MacDougallJane StevensIrina StasevichNikoletta VrceljTracy ChaplinDebra M. LillingtonT. Andrew ListerBryan D. Young. (2008) Microdeletions are a general feature of adult and adolescent acute lymphoblastic leukemia: Unexpected similarities with pediatric disease. Proceedings of the National Academy of Sciences 105:18, pages 6708-6713.
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Erik Forestier, Fredrika Gauffin, Mette K. Andersen, Kirsi Autio, Georg Borgström, Irina Golovleva, Britt Gustafsson, Sverre Heim, Kristina Heinonen, Mats Heyman, Randi Hovland, Johann H. Johannsson, Gitte Kerndrup, Richard Rosenquist, Jacqueline Schoumans, Birgitta Swolin, Bertil Johansson & Ann Nordgren. (2007) Clinical and cytogenetic features of pediatric dic(9;20)(p13.2;q11.2)‐positive B‐cell precursor acute lymphoblastic leukemias: A nordic series of 24 cases and review of the literature. Genes, Chromosomes and Cancer 47:2, pages 149-158.
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Kajsa Paulsson, Andrea Horvat, Bodil Strömbeck, Fredrik Nilsson, Jesper Heldrup, Mikael Behrendtz, Erik Forestier, Anna Andersson, Thoas Fioretos & Bertil Johansson. (2008) Mutations ofFLT3,NRAS,KRAS, andPTPN11 are frequent and possibly mutually exclusive in high hyperdiploid childhood acute lymphoblastic leukemia. Genes, Chromosomes and Cancer 47:1, pages 26-33.
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Kajsa Paulsson, Tord Jonson, Ingrid Øra, Tor Olofsson, Ioannis Panagopoulos & Bertil Johansson. (2007) Characterisation of genomic translocation breakpoints and identification of an alternative TCF3 / PBX1 fusion transcript in t(1;19)(q23;p13)‐positive acute lymphoblastic leukaemias . British Journal of Haematology 138:2, pages 196-201.
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A Andersson, C Ritz, D Lindgren, P Edén, C Lassen, J Heldrup, T Olofsson, J Råde, M Fontes, A Porwit-MacDonald, M Behrendtz, M Höglund, B Johansson & T Fioretos. (2007) Microarray-based classification of a consecutive series of 121 childhood acute leukemias: prediction of leukemic and genetic subtype as well as of minimal residual disease status. Leukemia 21:6, pages 1198-1203.
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Erik Forestier, Mette K. Andersen, Kirsi Autio, Elisabeth Blennow, Georg Borgström, Irina Golovleva, Sverre Heim, Kristina Heinonen, Randi Hovland, Johann H. Johannsson, Gitte Kerndrup, Ann Nordgren, Richard Rosenquist, Birgitta Swolin & Bertil Johansson. (2007) Cytogenetic patterns inETV6/RUNX1-positive pediatric B-cell precursor acute lymphoblastic leukemia: A Nordic series of 245 cases and review of the literature. Genes, Chromosomes and Cancer 46:5, pages 440-450.
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Felix Mitelman, Bertil Johansson & Fredrik Mertens. (2007) The impact of translocations and gene fusions on cancer causation. Nature Reviews Cancer 7:4, pages 233-245.
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Deepa Bhojwani, Naomi Moskowitz, Elizabeth A Raetz & William L Carroll. (2007) Potential of Gene Expression Profiling in the Management of Childhood Acute Lymphoblastic Leukemia. Pediatric Drugs 9:3, pages 149-156.
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Jacqueline Schoumans, Bertil Johansson, Martin Corcoran, Ekaterina Kuchinskaya, Irina Golovleva, Dan Grandér, Erik Forestier, Johan Staaf, Åke Borg, Britt Gustafsson, Elisabeth Blennow & Ann Nordgren. (2006) Characterisation of dic(9;20)(p11?13;q11) in childhood B-cell precursor acute lymphoblastic leukaemia by tiling resolution array-based comparative genomic hybridisation reveals clustered breakpoints at 9p13.2 and 20q11.2. British Journal of Haematology 135:4, pages 492-499.
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K Paulsson, M Heidenblad, H Mörse, Å Borg, T Fioretos & B Johansson. (2006) Identification of cryptic aberrations and characterization of translocation breakpoints using array CGH in high hyperdiploid childhood acute lymphoblastic leukemia. Leukemia 20:11, pages 2002-2007.
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Kristina Karrman, Anna Andersson, Helga Bjorgvinsdottir, Bodil Strombeck, Carin Lassen, Tor Olofsson, Florence Nguyen-Khac, Roland Berger, Olivier Bernard, Thoas Fioretos & Bertil Johansson. (2006) Deregulation of cyclin D2 by juxtaposition with T-cell receptor alpha/delta locus in t(12;14)(p13;q11)-positive childhood T-cell acute lymphoblastic leukemia. European Journal of Haematology 77:1, pages 27-34.
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Ioannis Panagopoulos, Bodil Strombeck, Margareth Isaksson, Jesper Heldrup, Tor Olofsson & Bertil Johansson. (2006) Fusion of ETV6 with an intronic sequence of the BAZ2A gene in a paediatric pre-B acute lymphoblastic leukaemia with a cryptic chromosome 12 rearrangement. British Journal of Haematology 133:3, pages 270-275.
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Josef Davidsson, Kajsa Paulsson & Bertil Johansson. (2006) Searching for cryptic chromosomal aberrations in high hyperdiploid childhood acute lymphoblastic leukaemias. European Journal of Haematology 76:5, pages 449-450.
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K Paulsson, A N Békássy, T Olofsson, F Mitelman, B Johansson & I Panagopoulos. (2005) A novel and cytogenetically cryptic t(7;21)(p22;q22) in acute myeloid leukemia results in fusion of RUNX1 with the ubiquitin-specific protease gene USP42. Leukemia 20:2, pages 224-229.
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Anna Andersson, Tor Olofsson, David Lindgren, Björn Nilsson, Cecilia Ritz, Patrik Edén, Carin Lassen, Johan Råde, Magnus Fontes, Helena Mörse, Jesper Heldrup, Mikael Behrendtz, Felix Mitelman, Mattias Höglund, Bertil Johansson & Thoas Fioretos. (2005) Molecular signatures in childhood acute leukemia and their correlations to expression patterns in normal hematopoietic subpopulations. Proceedings of the National Academy of Sciences 102:52, pages 19069-19074.
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Andrew P WengArthur Lau. (2005) Notch signaling in T-cell acute lymphoblastic leukemia. Future Oncology 1:4, pages 511-519.
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