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Annals of Medicine Volume 37, 2005 - Issue 6
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Original Article

Inhibition of breast cancer cell extracellular matrix degradative activity by chemically modified tetracyclines

Ying Gu Department of Biochemistry
,
Hsi‐Ming Lee Department of Oral Biology and Pathology, School of Dental Medicine, State University of New York at Stony Brook, Stony Brook, NY 11794‐8702, U S A
,
Lorne M. Golub Department of Oral Biology and Pathology, School of Dental Medicine, State University of New York at Stony Brook, Stony Brook, NY 11794‐8702, U S A
,
Timo Sorsa Department of Oral and Maxillofacial Diseases and Institute of Dentistry, Helsinki University Central Hospital (HUCH) and University of Helsinki
,
Yrjö T. Konttinen Department of Medicine/invärtes medicin, Helsinki University Central Hospital (HUCH) and ORTON Orthopaedic Hospital of the Invalid Foundation, Helsinki Finland and COXA Hospital for Joint Replacement, Tampere, Finland
&
Sanford R. Simon Department of Biochemistry; Department of Pathology, State University of New York at Stony Brook, Stony Brook, New York 11794, U S A
Pages 450-460 | Received 07 Feb 2005, Accepted 10 Aug 2005, Published online: 08 Jul 2009

Citations (15)

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Jie Deng, Lorne M Golub, Hsi-Ming Lee, Michael C Lin, Heta Dinesh Bhatt, Hou-Lin Hong, Francis Johnson, Joseph Scaduto, Thomas Zimmerman & Ying Gu. (2020) Chemically-Modified Curcumin 2.24: A Novel Systemic Therapy for Natural Periodontitis in Dogs. Journal of Experimental Pharmacology 12, pages 47-60.
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B.L. Marcial, S.F. Sousa, H.F. Dos Santos & M.J. Ramos. (2014) Structural and dynamics analysis of matrix metalloproteinases MMP-2 complexed with chemically modified tetracyclines (CMTs). Journal of Biomolecular Structure and Dynamics 32:12, pages 1907-1918.
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Takuya Nakajima, Keiichi Hishikari, Masahito Ogawa, Ryo Watanabe, Jun-ichi Suzuki, Ayako Nagashima, Mayumi Masumura, Kiyoshi Takayama, Yasunobu Hirata, Ryozo Nagai & Mitsuaki Isobe. (2010) Clarithromycin attenuates myocardial ischemia–reperfusion injury. Expert Opinion on Therapeutic Targets 14:9, pages 881-893.
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Articles from other publishers (12)

Muhammad Tufail. (2023) Unlocking the potential of the tumor microenvironment for cancer therapy. Pathology - Research and Practice 251, pages 154846.
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Yuewen Gao, Zhengwu Pan, Hongqi Li & Fei Wang. (2023) Antitumor Therapy Targeting the Tumor Microenvironment. Journal of Oncology 2023, pages 1-16.
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Shilpi Goenka & Sanford R. Simon. (2021) Comparative study of doxycycline, sancycline, and 4-dedimethylamino sancycline (CMT-3) on epidermal melanogenesis. Archives of Dermatological Research 315:2, pages 249-257.
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Sanjib Das, Sk Abdul Amin & Tarun Jha. (2021) Inhibitors of gelatinases (MMP-2 and MMP-9) for the management of hematological malignancies. European Journal of Medicinal Chemistry 223, pages 113623.
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Susana Proença, Bernardo Antunes, Rita C. Guedes, Filipa Ramilo-Gomes, M. Fátima Cabral, Judite Costa, Ana S. Fernandes, Matilde Castro, Nuno G. Oliveira & Joana P. Miranda. (2019) Pyridine-Containing Macrocycles Display MMP-2/9 Inhibitory Activity and Distinct Effects on Migration and Invasion of 2D and 3D Breast Cancer Models. International Journal of Molecular Sciences 20:20, pages 5109.
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Catarina Roma-Rodrigues, Rita Mendes, Pedro Baptista & Alexandra Fernandes. (2019) Targeting Tumor Microenvironment for Cancer Therapy. International Journal of Molecular Sciences 20:4, pages 840.
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Lin Zhao, Jiaying Xu, Yang Jiao, Haichao Wang & Saijun Fan. (2014) Novel mechanisms involving chemically modified tetracycline 3 cytotoxicity. Anti-Cancer Drugs 25:10, pages 1165-1174.
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Satish Kumar, Glenn T. Clark & Raymond A. Dionne. 2012. Orofacial Pain. Orofacial Pain 145 150 .
Ying Gu, Hsi-Ming Lee, Sanford R. Simon & Lorne M. Golub. (2011) Chemically modified tetracycline-3 (CMT-3): A novel inhibitor of the serine proteinase, elastase. Pharmacological Research 64:6, pages 595-601.
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Ying Gu, Hsi-Ming Lee, Timo Sorsa, Sanford R. Simon & Lorne M. Golub. (2010) Doxycyline inhibits mononuclear cell-mediated connective tissue breakdown. FEMS Immunology & Medical Microbiology 58:2, pages 218-225.
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Jinger Xie, Ayyappan Nair & Terry W. Hermiston. (2008) A comparative study examining the cytotoxicity of inducible gene expression system ligands in different cell types. Toxicology in Vitro 22:1, pages 261-266.
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Jed F. Fisher & Shahriar Mobashery. (2006) Recent advances in MMP inhibitor design. Cancer and Metastasis Reviews 25:1, pages 115-136.
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