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TRENDS IN MOLECULAR MEDICINE

Hemophagocytic lymphohistiocytosis: Diagnosis, pathophysiology, treatment, and future perspectives

James W. Verbsky Division of Rheumatology, Department of Pediatrics, Medical College of Wisconsin, MilwaukeeUSA
&
William J. Grossman Division of Hematology/Oncology/Blood & Marrow Transplantation, Department of Pediatrics, Medical College of Wisconsin, MilwaukeeUSA
Pages 20-31 | Published online: 08 Jul 2009

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Yi-Zhen Liu, Lan-Qing Bi, Gui-Lin Chang, Ye Guo & Si Sun. (2019) Clinical characteristics of extranodal NK/T-cell lymphoma-associated hemophagocytic lymphohistiocytosis. Cancer Management and Research 11, pages 997-1002.
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Jingshi Wang, Wei Han, Zhuo Gao, Yini Wang, Lin Wu, Jia Zhang, Wenyuan Lai & Zhao Wang. (2017) Elevation of CD16+CD56+ NK-cells and down-regulation of serum interleukin-21 (IL-21) and IL-1α after splenectomy in relapsed hemophagocytic lymphohistiocytosis of unknown cause. Hematology 22:8, pages 477-483.
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Hiroyuki Nakamura, Toshio Odani, Yuka Shimizu, Tsuyoshi Takeda & Hideaki Kikuchi. (2016) Usefulness of tacrolimus for refractory adult-onset still's disease: Report of six cases. Modern Rheumatology 26:6, pages 963-967.
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Melissa R George. (2014) Hemophagocytic lymphohistiocytosis: review of etiologies and management. Journal of Blood Medicine 5, pages 69-86.
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Phillip Ruppert, Emily C. Edmonds, Michael Brook, Suzanne Musil & S. Duke Han. (2012) Neuropsychological Assessment in a Case of Adult-Onset Hemophagocytic Lymphohistiocytosis (HLH). The Clinical Neuropsychologist 26:6, pages 1038-1052.
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Hideyuki Watanabe, Nobuhisa Hirase, Hideaki Goda, Hiroshi Nishikawa & Shoichiro Ikuyama. (2012) Oral low-dose tacrolimus therapy for refractory hemophagocytic syndrome associated with systemic lupus erythematosus. Modern Rheumatology 22:2, pages 284-289.
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Sumit Gupta & Sheila Weitzman. (2010) Primary and secondary hemophagocytic lymphohistiocytosis: clinical features, pathogenesis and therapy. Expert Review of Clinical Immunology 6:1, pages 137-154.
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Aaron D. Viny, Alan Lichtin, Brad Pohlman, Thomas Loughran & Jaroslaw Maciejewski. (2008) Chronic B-cell dyscrasias are an important clinical feature of T-LGL leukemia. Leukemia & Lymphoma 49:5, pages 932-938.
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Maria Irma Seixas Duarte & Amaro Nunes Duarte Neto. 2018. Practical Hepatic Pathology: a Diagnostic Approach. Practical Hepatic Pathology: a Diagnostic Approach 247 264 .
Esraa M. Eloseily & Randy Q. Cron. 2018. The Microbiome in Rheumatic Diseases and Infection. The Microbiome in Rheumatic Diseases and Infection 151 182 .
Sanam Loghavi & Robert P. Hasserjian. 2018. Diagnosis of Blood and Bone Marrow Disorders. Diagnosis of Blood and Bone Marrow Disorders 17 79 .
Nouf Althonaian, Abdulrahman Alsultan, Eva Morava & Majid Alfadhel. 2018. JIMD Reports, Volume 42. JIMD Reports, Volume 42 105 111 .
Ysabella M. Esteban, Jill L. O. de Jong & Melissa S. Tesher. (2017) An Overview of Hemophagocytic Lymphohistiocytosis. Pediatric Annals 46:8.
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Natalia Suvorava, Steven Richmond, Neil Patel, Brian Bell & Hector Mesa. (2016) Between a rock and a hard place. American Journal of Hematology 91:3, pages 351-353.
Crossref
Tsutomu Koike, Kanako Motoyoshi, Kazuyuki Ryu, Hidenori Yamazaki, Kota Kakeshita, Shinobu Shida, Minami Mizutani, Hayato Fujioka, Yukie Yasumoto, Shiori Shiraishi, Ayako Takashima, Fumihiro Tomoda & Koichiro Kinugawa. (2016) Hemophagocytic syndrome occurred after severe sepsis in a hemodialysis patient: An autopsy case report. Nihon Toseki Igakkai Zasshi 49:12, pages 841-846.
Crossref
Ju-Hee SeoJun Ah LeeDong Ho KimJoongbum ChoJung Sub Lim. (2016) Tuberculosis-associated hemophagocytic lymphohistiocytosis in adolescent diagnosed by polymerase chain reaction. Korean Journal of Pediatrics 59:1, pages 43.
Crossref
Kota AZUMA, Masao TAMURA, Masafumi KURAJOH, Yuji HOSONO, Ran NAKAJIMA, Kazuyuki TSUBOI, Takeo ABE, Chie OGITA, Yuichi YOKOYAMA, Tetsuya FURUKAWA, Takahiro YOSHIKAWA, Atsushi SAITO, Aki NISHIOKA, Masahiro SEKIGUCHI, Naoto AZUMA, Masayasu KITANO, Shinichiro TSUNODA, Koichiro OMURA, Hidenori KOYAMA, Kiyoshi MATSUI, Tsuneyo MIMORI & Hajime SANO. (2016) A case of anti-aminoacyl tRNA synthetase antibody syndrome complicated by hemophagocytic syndrome. Japanese Journal of Clinical Immunology 39:6, pages 538-544.
Crossref
Alexei A. Grom. 2016. Textbook of Pediatric Rheumatology. Textbook of Pediatric Rheumatology 642 649.e3 .
Gemma L. Green, Arash Aframian, Parthiban Vinayakam & Mark S. Cornell. (2015) Macrophage activation syndrome or septic arthritis. Journal of Pediatric Orthopaedics B 24:4, pages 330-335.
Crossref
Edward M. Behrens & Randy Q. Cron. (2015) Kill or Be Killed. The Journal of Immunology 194:11, pages 5041-5043.
Crossref
Ellen Brisse, Carine H. Wouters & Patrick Matthys. (2015) Hemophagocytic lymphohistiocytosis (HLH): A heterogeneous spectrum of cytokine-driven immune disorders. Cytokine & Growth Factor Reviews 26:3, pages 263-280.
Crossref
Wang Jing-Shi, Wang Yi-Ni, Wu Lin & Wang Zhao. (2014) Splenectomy as a treatment for adults with relapsed hemophagocytic lymphohistiocytosis of unknown cause. Annals of Hematology 94:5, pages 753-760.
Crossref
Su Bin Kim, Makeardhwaj Sarvadaman Shrivastava & Marianna Strakhan. (2015) A Rare Cause of Acquired Immune Deficiency Syndrome Related Pancytopenia. Hematology Reports 7:1, pages 5475.
Crossref
Rasa Medovic, Biljana Vuletic, Zorica Raskovic, Aleksandra Simovic, Jelena Nestorovic–Tanaskovic & Zoran Igrutinovic. (2015) Secondary Haemophagocytic Lymphohistiocytosis – The Differential Diagnosis Dilemma In Paediatrics. Serbian Journal of Experimental and Clinical Research 16:1, pages 55-63.
Crossref
Kyueng-Whan Min, Ho Young Jung, Hye Seung Han, Tae Sook Hwang, Sung-Yong Kim, Wan Seop Kim, So Dug Lim & Wook Youn Kim. (2015) Ileal mass-like lesion induced by Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis in a patient with aplastic anemia. APMIS 123:1, pages 81-86.
Crossref
Ling Zhang, Jun Zhou & Lubomir Sokol. (2014) Hereditary and Acquired Hemophagocytic Lymphohistiocytosis. Cancer Control 21:4, pages 301-312.
Crossref
Kirubakaran Navamani, Manivachagan Muthappa Natarajan, Arul Premanand Lionel & Sathish Kumar. (2014) Hepatitis A Virus Infection-Associated Hemophagocytic Lymphohistiocytosis in Two Children. Indian Journal of Hematology and Blood Transfusion 30:S1, pages 239-242.
Crossref
Mingce Zhang, Edward M. Behrens, T. Prescott Atkinson, Bita Shakoory, Alexei A. Grom & Randy Q. Cron. (2014) Genetic Defects in Cytolysis in Macrophage Activation Syndrome. Current Rheumatology Reports 16:9.
Crossref
J.L. Mostaza-Fernández, J. Guerra Laso, D. Carriedo Ule & J.M.G. Ruiz de Morales. (2014) Hemophagocytic lymphohistiocytosis associated with viral infections: Diagnostic challenge and therapeutic dilemma. Revista Clínica Española (English Edition) 214:6, pages 320-327.
Crossref
J.L. Mostaza-Fernández, J. Guerra Laso, D. Carriedo Ule & J.M.G. Ruiz de Morales. (2014) Linfohistiocitosis hemofagocítica asociada a infecciones virales: reto diagnóstico y dilema terapéutico. Revista Clínica Española 214:6, pages 320-327.
Crossref
Gritta E. Janka & Kai Lehmberg. (2014) Hemophagocytic syndromes — An update. Blood Reviews 28:4, pages 135-142.
Crossref
Gilles Hejblum, Olivier Lambotte, Lionel Galicier, Paul Coppo, Christophe Marzac, C?dric Aumont & Laurence Fardet. (2014) A Web-Based Delphi Study for Eliciting Helpful Criteria in the Positive Diagnosis of Hemophagocytic Syndrome in Adult Patients. PLoS ONE 9:4, pages e94024.
Crossref
Kyung Ah Yoh, Ho Sup Lee, Lee Chun Park, Eun Mi Lee, Seong Hoon Shin, Dae Jin Park, Byeong Jin Ye & Yang Soo Kim. (2014) The Prognostic Significance of Elevated Levels of Serum Ferritin Before Chemotherapy in Patients With Non-Hodgkin Lymphoma. Clinical Lymphoma Myeloma and Leukemia 14:1, pages 43-49.
Crossref
Rosaria Casciaro, Federico Cresta, Federica Favilli, Aldo Naselli, Alessandra De Alessandri & Laura Minicucci. (2014) Macrophage activation syndrome induced by A/H1N1 influenza in cystic fibrosis. Pediatric Pulmonology 49:2, pages E10-E12.
Crossref
Yun-Ho Lin, Yu-Hui Lin & Zhi-Yuan Shi. (2014) A Case Report of Scrub Typhus-Associated Hemophagocytic Syndrome and a Review of Literature. Japanese Journal of Infectious Diseases 67:2, pages 115-117.
Crossref
Sung Min JungYun Hwa JungHyun Jin NohIn Sook WooChi Wha Han. (2014) A case of Wegener's granulomatosis mimicking recurrent hemophagocytic lymphohistiocytosis. The Korean Journal of Internal Medicine 29:3, pages 393.
Crossref
Bushra Alblewi, Iqbal A. Bukhari, Manal Hasan, Abdulaziz Alzahani, Raed Bukhari, Layla Bashawri & Muhammad Al Shawarby. (2014) Hemophagocytic syndrome and acute pancreatitis in acute systemic lupus erythematosus. Journal of Dermatology & Dermatologic Surgery 18:1-2, pages 35-37.
Crossref
James W. Verbsky & Talal A. Chatila. 2014. Stiehm's Immune Deficiencies. Stiehm's Immune Deficiencies 497 516 .
Gritta E. Janka & Kai Lehmberg. (2013) Hemophagocytic lymphohistiocytosis: pathogenesis and treatment. Hematology 2013:1, pages 605-611.
Crossref
Valentina Ansuini, Donato Rigante & Susanna Esposito. (2013) Debate around infection-dependent hemophagocytic syndrome in paediatrics. BMC Infectious Diseases 13:1.
Crossref
James W. Verbsky & Talal A. Chatila. (2013) Immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) and IPEX-related disorders. Current Opinion in Pediatrics 25:6, pages 708-714.
Crossref
Rohtesh S. Mehta & Roy E. Smith. (2013) Hemophagocytic lymphohistiocytosis (HLH): a review of literature. Medical Oncology 30:4.
Crossref
Yini Wang, Zhao Wang, Lin Wu, Jia Zhang, Jingshi Wang & Lijuan Yan. (2013) Recombinant human thrombopoietin is an effective treatment for thrombocytopenia in hemophagocytic lymphohistiocytosis. Annals of Hematology 92:12, pages 1695-1699.
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Beatriz Rodríguez-Medina, Marino Blanes, Carmen Vinaixa, Victoria Aguilera, Ángel Rubín, Martín Prieto & Marina Berenguer. (2013) Haemophagocytic syndrome in a liver transplant patient during treatment with Telaprevir. Annals of Hepatology 12:6, pages 974-978.
Crossref
Sanjata Roy Chaudhary, Manish Kumar & Kumar Arpit. (2013) Fulminant hepatic failure in kala-azar: Is it hemophagocytic lymphohistiocytosis?. Pediatric Infectious Disease 5:3, pages 127-129.
Crossref
Flavia G. N. Rosado & Annette S. Kim. (2013) Hemophagocytic Lymphohistiocytosis. American Journal of Clinical Pathology 139:6, pages 713-727.
Crossref
Jan K. Davidson-Moncada, Emily McDuffee & Mark Roschewski. (2013) CD5 + Diffuse Large B-Cell Lymphoma With Hemophagocytosis . Journal of Clinical Oncology 31:6, pages e76-e79.
Crossref
Kavitha Subramaniam, James D'Rozario & Paul Pavli. (2013) Lymphoma and other lymphoproliferative disorders in inflammatory bowel disease: A review. Journal of Gastroenterology and Hepatology 28:1, pages 24-30.
Crossref
Marco Pizzi, Elena Sabattini, Gaia Goteri, Paolo Pierani, Francesco Bacci, Carlo Sagramoso, Simona Righi & Stefano A Pileri. (2012) Familial haemophagocytic lymphohistiocytosis-related plasma cell neoplasm: a case report. Journal of Clinical Pathology 65:11, pages 1050-1052.
Crossref
C. D?sid?ri-Vaillant, S. Exbrayat, J. Sapin-Lory, D. Lambrechts, M. Rouxel & X. Nicolas. (2012) Syndrome d?activation macrophagique ? Herpes simplex virus apr?s hyst?roscopie. Journal de Gyn?cologie Obst?trique et Biologie de la Reproduction 41:7, pages 672-675.
Crossref
Dong Kyun Han, Hee Jo Baek, Myung-Geun Shin, Jin Woong Kim, Hoon Kook & Tai Ju Hwang. (2012) Scrub Typhus-associated Severe Hemophagocytic Lymphohistiocytosis With Encephalomyelitis Leading to Permanent Sequelae. Journal of Pediatric Hematology/Oncology 34:7, pages 531-533.
Crossref
Xi Yang, Toshio Miyawaki & Hirokazu Kanegane. (2012) SAP and XIAP deficiency in hemophagocytic lymphohistiocytosis. Pediatrics International 54:4, pages 447-454.
Crossref
Narayanan Venkatasubramani, James Verbsky, Colin Rudolph & Manu Sood. (2012) Hemophagocytic Lymphohistiocytosis With Multiorgan Involvement in Children With Chronic Intestinal Pseudo-obstruction Receiving Parenteral Nutrition Support. Journal of Pediatric Gastroenterology & Nutrition 55:2, pages 218-220.
Crossref
V. Arena, F. De-Giorgio, I. Pennacchia, R. Manna, G. Vetrugno, E. Stigliano, N. Milic, G. Gasbarrini & L. Abenavoli. (2012) Haemophagocytic Syndrome Associated with Mucormycosis Infection. International Journal of Immunopathology and Pharmacology 25:3, pages 751-755.
Crossref
Abdelali Tali, Amal Addebbous, Laila Zougaghi & Laila Chabaa. (2012) Pathogénie, intérêts diagnostique et pronostique de l’hypertriglycéridémie dans les lymphohistiocytoses hémophagocytaires. Revue Francophone des Laboratoires 2012:444, pages 75-78.
Crossref
A Ravelli, A A Grom, E M Behrens & R Q Cron. (2012) Macrophage activation syndrome as part of systemic juvenile idiopathic arthritis: diagnosis, genetics, pathophysiology and treatment. Genes & Immunity 13:4, pages 289-298.
Crossref
Ryoji Kobayashi, Kuniko Takanashi, Daisuke Suzuki, Takashi Nasu, Kimiaki Uetake & Yoshinori Matsumoto. (2012) Retinitis from cytomegalovirus during maintenance treatment for acute lymphoblastic leukemia. Pediatrics International 54:2, pages 288-290.
Crossref
J Loebbermann, H Thornton, L Durant, T Sparwasser, K E Webster, J Sprent, F J Culley, C Johansson & P J Openshaw. (2012) Regulatory T cells expressing granzyme B play a critical role in controlling lung inflammation during acute viral infection. Mucosal Immunology 5:2, pages 161-172.
Crossref
Masao Hagihara, Morihiro Inoue, Jian Hua & Yasunobu Iwaki. (2012) Lymphocyte-depleted Hodgkin Lymphoma Complicating Hemophagocytic Lymphohistiocytosis as an Initial Manifestation: A Case Report and Review of the Literature. Internal Medicine 51:21, pages 3067-3072.
Crossref
Yuzo Oda, Yoshinori Urushidani, Shinji Ooi, Akira Endoh, Rika Nakamura, Koji Adachi & Hiroko Fukushima. (2012) Hemophagocytic Lymphohistiocytosis in a Rheumatoid Arthritis Patient Treated with Infliximab. Internal Medicine 51:6, pages 655-657.
Crossref
Hideo Koh, Takahiko Nakane, Erina Sakamoto, Takako Katayama, Hirohisa Nakamae, Masahiko Ohsawa & Masayuki Hino. (2012) Serum Cytokine Profiles in Hemophagocytic Syndrome following Allogeneic Hematopoietic Stem Cell Transplantation. Acta Haematologica 127:3, pages 182-185.
Crossref
Alena Dabrazhynetskaya, Jinxia Ma, Andre Ortlieb Guerreiro-Cacais, Zita Arany, Eva Rudd, Jan-Inge Henter, Klas Karre, Jelena Levitskaya & Victor Levitsky. (2012) Syntaxin 11 marks a distinct intracellular compartment recruited to the immunological synapse of NK cells to colocalize with cytotoxic granules. Journal of Cellular and Molecular Medicine 16:1, pages 129-141.
Crossref
Jan Thoden, Siegbert Rieg, Nils Venhoff, Vanessa Wennekes, Annette Schmitt-Graeff, Dirk Wagner & Winfried V. Kern. (2012) Fatal hemophagocytic syndrome in a patient with a previously well-controlled asymptomatic HIV infection after EBV reactivation. Journal of Infection 64:1, pages 110-112.
Crossref
N Kevin Ives, Giorgina Mieli-Vergani, Nedim Hadžić, Simon Newell, Ian Sugarman, Mark D Stringer & Alistair G Smyth. 2012. Rennie & Roberton's Textbook of Neonatology. Rennie & Roberton's Textbook of Neonatology 671 754 .
Suzan M. Salti, Erin M. Hammelev, Jenny L. Grewal, Sreelatha T. Reddy, Sarah J. Zemple, William J. Grossman, Mitchell H. Grayson & James W. Verbsky. (2011) Granzyme B Regulates Antiviral CD8+ T Cell Responses. The Journal of Immunology 187:12, pages 6301-6309.
Crossref
Catherine K. Argyraki, Stella Gabeta, Kalliopi Zachou, Maria Boulbou, Asterios Polyzos & George N. Dalekos. (2011) Favourable outcome of life-threatening infectious-related haemophagocytic syndrome after combination treatment with corticosteroids and intravenous immunoglobulin infusions. European Journal of Internal Medicine 22:6, pages e155-e157.
Crossref
T. M. Cotroneo, L. A. Colby & I. L. Bergin. (2011) Hemophagocytic Syndrome in a Pancytopenic Simian Retrovirus–Infected Male Rhesus Macaque ( Macaca mulatta ) . Veterinary Pathology 48:6, pages 1138-1143.
Crossref
Vincent F. Biank, Mehul K. Sheth, Julie Talano, David Margolis, Pippa Simpson, Subra Kugathasan & Michael Stephens. (2011) Association of Crohn?s Disease, Thiopurines, and Primary Epstein-Barr Virus Infection with Hemophagocytic Lymphohistiocytosis. The Journal of Pediatrics 159:5, pages 808-812.
Crossref
Anshu Malhotra & Anil Shanker. (2011) NK cells: immune cross-talk and therapeutic implications. Immunotherapy 3:10, pages 1143-1166.
Crossref
Ikram Ul Haq Chaudhary, Shoukat Ahmad Bojal, Adel Attia, Battal Al-Dossary, Afra Qasem Al Dayel & Samir Sami Amr. (2011) Mediastinal endodermal sinus tumor associated with fatal hemophagocytic syndrome. Hematology/Oncology and Stem Cell Therapy 4:3, pages 138-141.
Crossref
Tamara Y. Chang, Julie Jaffray, Bruce Woda, Peter E. Newburger & G. Naheed Usmani. (2010) Hemophagocytic lymphohistiocytosis with MUNC13‐4 gene mutation or reduced natural killer cell function prior to onset of childhood leukemia . Pediatric Blood & Cancer 56:5, pages 856-858.
Crossref
Antonio Cascio, Salvatore Giordano, Piera Dones, Silvia Venezia, Chiara Iaria & Ottavio Ziino. (2011) Haemophagocytic syndrome and rickettsial diseases. Journal of Medical Microbiology 60:4, pages 537-542.
Crossref
Ronald Jaffe. 2011. Diagnostic Pediatric Hematopathology. Diagnostic Pediatric Hematopathology 504 539 .
Jeffry Blackwell, Christian T. Cable, Daniel Smith, Carl Boethel, Jules B. Puschett & Jules B. Puschett. (2011) A 41-Year-Old Man With Massive Splenomegaly, Fevers and Night Sweats. The American Journal of the Medical Sciences 341:2, pages 141-145.
Crossref
Eizo Watanabe. (2011) Diagnosis and treatment of hemophagocytic syndrome. Nihon Shuchu Chiryo Igakukai zasshi 18:1, pages 13-16.
Crossref
Alexei A. Grom. 2011. Textbook of Pediatric Rheumatology. Textbook of Pediatric Rheumatology 674 681 .
Maria Irma Seixas Duarte. 2011. Practical Hepatic Pathology: A Diagnostic Approach. Practical Hepatic Pathology: A Diagnostic Approach 273 288 .
Richard D. Brunning & Daniel A. Arber. 2011. Rosai and Ackerman's Surgical Pathology. Rosai and Ackerman's Surgical Pathology 1927 2012 .
Eli M Eisenstein & Dana G Wolf. (2010) Cytomegalovirus infection in pediatric rheumatic diseases: a review. Pediatric Rheumatology 8:1.
Crossref
Bibi Shahin Shamsian, Atoosa Gharib, Nima Rezaei, Shadi Abdar Esfahani, Samin Alavi, Kourosh Goudarzipour & Mohammad Taghi Arzanian. (2010) Development of secondary T‐cell acute lymphoblastic leukemia in a child with hemophagocytic lymphohistiocytosis. Pediatric Blood & Cancer 55:4, pages 725-726.
Crossref
Alexei A Grom & Elizabeth D Mellins. (2010) Macrophage activation syndrome: advances towards understanding pathogenesis. Current Opinion in Rheumatology 22:5, pages 561-566.
Crossref
Maciej Przybylski, Tomasz Dzieciątkowski, Dorota Zduńczyk, Wiesław Wiktor Jędrzejczak & Mirosław Łuczak. (2010) Microbiological Findings and Treatment of EBV-Associated Hemophagocytic Lymphohistiocytosis: A Case Report. Archivum Immunologiae et Therapiae Experimentalis 58:3, pages 247-252.
Crossref
G. Carvalheiras, D. Anjo, T. Mendon?a, C. Vasconcelos & F. Farinha. (2009) Hemophagocytic syndrome as one of the main primary manifestations in acute systemic lupus erythematosus - case report and literature review. Lupus 19:6, pages 756-761.
Crossref
Nadine Rouphael Maakaroun, Abeer Moanna, Jesse T Jacob & Helmut Albrecht. (2010) Viral infections associated with haemophagocytic syndrome. Reviews in Medical Virology 20:2, pages 93-105.
Crossref
Ramon Andrade Bezerra de Mello, Elsa Fonseca, Manuela Brochado & João Manuel Quinaz. (2010) Hemophagocytic Syndrome Associated with Hodgkin's Lymphoma First Presenting as Fever and Pancytopenia. Case Reports in Medicine 2010, pages 1-4.
Crossref
Tim Lahm, Helena N. Spartz, Dean A. Hawley, Diane S. Leland, Karen M. Wolf, Homer L. TwiggIIIIII & Michael D. Ober. (2010) Fatal adenovirus serotype 21 infection associated with hemophagocytic lymphohistiocytosis and multiorgan failure. Respiratory Medicine CME 3:4, pages 223-225.
Crossref
Robert P. Hasserjian. 2010. Diagnostic Pathology of Infectious Disease. Diagnostic Pathology of Infectious Disease 325 340 .
Christopher W. Woods, Wanda T. Bradshaw & Amanda G. Woods. (2009) Hemophagocytic Lymphohistiocytosis in the Premature Neonate. Advances in Neonatal Care 9:6, pages 265-273.
Crossref
Zhao Wang, Yini Wang, Jingshi Wang, Cuicui Feng, Liping Tian & Lin Wu. (2009) Early diagnostic value of low percentage of glycosylated ferritin in secondary hemophagocytic lymphohistiocytosis. International Journal of Hematology 90:4, pages 501-505.
Crossref
. (2009) Letters to the Editor. Journal of Paediatrics and Child Health 45:10, pages 621-622.
Crossref
Anna Lünemann, Jan D. Lünemann & Christian Münz. (2009) Regulatory NK-Cell Functions in Inflammation and Autoimmunity. Molecular Medicine 15:9-10, pages 352-358.
Crossref
Nicola J. Topham & Eric W. Hewitt. (2009) Natural killer cell cytotoxicity: how do they pull the trigger?. Immunology 128:1, pages 7-15.
Crossref
C. Ponticelli & O. D. C. Alberighi. (2009) Haemophagocytic syndrome--a life-threatening complication of renal transplantation. Nephrology Dialysis Transplantation 24:9, pages 2623-2627.
Crossref
Hiroko Shinoda, Akihiko Yoshida & Julie Teruya-Feldstein. (2009) Malignant Histiocytoses/Disseminated Histiocytic Sarcoma With Hemophagocytic Syndrome in a Patient With Mediastinal Germ Cell Tumor. Applied Immunohistochemistry & Molecular Morphology 17:4, pages 338-344.
Crossref
Bülent Karapinar, Deniz Yilmaz, Can Balkan, Mehmet Akin, Yilmaz Ay & Kaan Kvakli. (2009) An unusual cause of multiple organ dysfunction syndrome in the pediatric intensive care unit: Hemophagocytic lymphohistiocytosis. Pediatric Critical Care Medicine 10:3, pages 285-290.
Crossref
Tomas Doyle, Sanjay Bhagani & Kate Cwynarski. (2009) Haemophagocytic syndrome and HIV. Current Opinion in Infectious Diseases 22:1, pages 1-6.
Crossref
Michael S. Kong, Samuel H. Engel, George H. Zalzal & Diego Preciado. (2009) Necrotizing epiglottitis and hemophagocytic lymphohistiocytosis. International Journal of Pediatric Otorhinolaryngology 73:1, pages 119-125.
Crossref
Lochie Teague & Robin P Corbett. 2009. Hematopoietic Stem Cell Transplantation in Clinical Practice. Hematopoietic Stem Cell Transplantation in Clinical Practice 113 122 .
Didier Bessis, Camille Francès, Bernard Guillot & Jean-Jacques GuilhouAgnès Sparsa, Jean Sibilia & Didier Bessis. 2008. Manifestations dermatologiques des maladies du système hématopoïétique et oncologie dermatologique. Manifestations dermatologiques des maladies du système hématopoïétique et oncologie dermatologique 83 112 .
Joseph S. Pagano. 2009. DNA Tumor Viruses. DNA Tumor Viruses 217 240 .
Akiyo Furutani, Toshihiko Imamura, Ikuyo Ueda, Mami Takanashi, Yoshifumi Hirashima, Takuya Nakatani, Tohru Inaba & Akira Morimoto. (2008) Hemophagocytic lymphohistiocytosis during maintenance treatment of precursor B-cell acute lymphoblastic leukemia. International Journal of Hematology 88:5, pages 610-612.
Crossref
J Stebbing, S Ngan, H Ibrahim, P Charles, M Nelson, P Kelleher, K N Naresh & M Bower. (2008) The successful treatment of haemophagocytic syndrome in patients with human immunodeficiency virus-associated multi-centric Castleman's disease. Clinical and Experimental Immunology 154:3, pages 399-405.
Crossref
Esther Romero Ramírez, Juan Bravo Soto & Magdalena Palomares Bayo. (2008) Síndrome hemofagocítico en hemodiálisis. Medicina Clínica 131:17, pages 678.
Crossref
Tim Lahm, Tyson Neumann, Karen M. Wolf, Homer L. TwiggIIIIII & Michael D. Ober. (2008) ADENOVIRUS-ASSOCIATED HEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS WITH ACUTE RESPIRATORY DISTRESS SYNDROME AND MULTIORGAN FAILURE. Chest 134:4, pages 22C.
Crossref
John K. C. ChanLaurence LamantElizabeth Algar, Georges DelsolWilliam Y. W. TsangKing C. LeeKarin Tiedemann & Chung W. Chow. (2008) ALK+ histiocytosis: a novel type of systemic histiocytic proliferative disorder of early infancy. Blood 112:7, pages 2965-2968.
Crossref
Rebecca L. Olin, Kim E. Nichols, Mojdeh Naghashpour, Mariusz Wasik, Brenda Shelly, Edward A. Stadtmauer & Dan T. Vogl. (2008) Successful use of the anti‐CD25 antibody daclizumab in an adult patient with hemophagocytic lymphohistiocytosis. American Journal of Hematology 83:9, pages 747-749.
Crossref
Fanny Ménard, Caroline Besson, Patricia Rincé, Olivier Lambotte, Thierry Lazure, Danielle Canioni, Olivier Hermine, Pierre Brousset, Antoine Martin, Philippe Gaulard, Martine Raphaël & Claire Larroche. (2008) Hodgkin Lymphoma–Associated Hemophagocytic Syndrome: A Disorder Strongly Correlated with Epstein‐Barr Virus. Clinical Infectious Diseases 47:4, pages 531-534.
Crossref
Karen A Francolla, Arnold Altman & Francisco A Sylvester. (2008) Hemophagocytic Syndrome in an Adolescent With Crohn Disease Receiving Azathioprine and Infliximab. Journal of Pediatric Gastroenterology & Nutrition 47:2, pages 193-195.
Crossref
James W Verbsky & William J Grossman. (2008) RSV Infection?An Immune Balancing Act: Commentary on the article by Bem et al. on Page 650. Pediatric Research 63:6, pages 599-601.
Crossref
Gregory K. Friedman, Yuki Hammers, Vishnu Reddy & Joseph G. Pressey. (2008) Myelofibrosis in a patient with familial hemophagocytic lymphohistiocytosis. Pediatric Blood & Cancer 50:6, pages 1260-1262.
Crossref
Christopher C. Dvorak, Amanda Sandford, Abraham Fong, Morton J. Cowan, Tracy I. George & David B. Lewis. (2008) Maternal T-cell Engraftment Associated With Severe Hemophagocytosis of the Bone Marrow in Untreated X-linked Severe Combined Immunodeficiency. Journal of Pediatric Hematology/Oncology 30:5, pages 396-400.
Crossref
Felipe Francisco Tuon, Virginia Soares Gomes, Valdir Sabbaga Amato, Maria Esther Graf, Guilherme Henrique Hencklain Fonseca, Carolina Lazari & Antonio Carlos Nicodemo. (2008) Hemophagocytic syndrome associated with hepatitis A: case report and literature review. Revista do Instituto de Medicina Tropical de São Paulo 50:2, pages 123-127.
Crossref
Sandra S. Chaves, Penina Haber, Kimp Walton, Robert P. Wise, Hector S. Izurieta, D. Scott Schmid & Jane F. Seward. (2008) Safety of Varicella Vaccine after Licensure in the United States: Experience from Reports to the Vaccine Adverse Event Reporting System, 1995–2005. The Journal of Infectious Diseases 197:s2, pages S170-S177.
Crossref
Edward M. Behrens. (2008) Macrophage activation syndrome in rheumatic disease: What is the role of the antigen presenting cell?. Autoimmunity Reviews 7:4, pages 305-308.
Crossref
Kyung-Hwa ParkHo-Sung YuSook-In JungDong-Hyeon ShinJong-Hee Shin. (2008) Acute Human Immunodeficiency Virus Syndrome Presenting with Hemophagocytic Lymphohistiocytosis. Yonsei Medical Journal 49:2, pages 325.
Crossref
Ben Z. Katz. 2008. Principles and Practice of Pediatric Infectious Disease. Principles and Practice of Pediatric Infectious Disease 1036 1044 .
Nadine G Rouphael, Naasha J Talati, Camille Vaughan, Kelly Cunningham, Roger Moreira & Carolyn Gould. (2007) Infections associated with haemophagocytic syndrome. The Lancet Infectious Diseases 7:12, pages 814-822.
Crossref
Claire Larroche, Marianne Ziol, S?mia Zidi, Robin Dhote & Dominique Roulot. (2007) Atteinte h?patique au cours du syndrome d?activation macrophagique. Gastroent?rologie Clinique et Biologique 31:11, pages 959-966.
Crossref
Jindrich CinatlJrJr, Martin Michaelis & Hans W. Doerr. (2007) The threat of avian influenza a (H5N1): part II: Clues to pathogenicity and pathology. Medical Microbiology and Immunology 196:4, pages 191-201.
Crossref
. 2007. Medical Complications of Kidney Transplantation. Medical Complications of Kidney Transplantation 393 408 .
Young Ik Seo, Rojin Park, Tae Youn Choi, Jeung Won Shin, Jong Ho Won, Hee-Sook Park, Nam-Soo Lee & Duck Cho. (2007) A Case of Therapy-Related Acute Monocytic Leukemia following Low-dose of Etoposide Treatment for Hemophagocytic Lymphohistiocytosis. The Korean Journal of Laboratory Medicine 27:4, pages 244.
Crossref
James W. Verbsky & William J. Grossman. (2006) Cellular and Genetic Basis of Primary Immune Deficiencies. Pediatric Clinics of North America 53:4, pages 649-684.
Crossref

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