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Mini Review

Phytoestrogens: End of a tale?

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Pages 423-438 | Published online: 08 Jul 2009

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (12)

Alice W. Lee, Valerie Poynor & Archana J. McEligot. (2022) Urinary Phytoestrogen Levels Are Associated with Female Hormonal Cancers: An Analysis of NHANES Data From 1999 to 2010. Nutrition and Cancer 74:8, pages 2748-2756.
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Cesare R. Sirtori, Chiara Pavanello, Laura Calabresi & Massimiliano Ruscica. (2017) Nutraceutical approaches to metabolic syndrome. Annals of Medicine 49:8, pages 678-697.
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Qixing Nie, Mengmeng Xing, Jielun Hu, Xiaojuan Hu, Shaoping Nie & Mingyong Xie. (2017) Metabolism and health effects of phyto-estrogens. Critical Reviews in Food Science and Nutrition 57:11, pages 2432-2454.
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Susana Alejandra Palma-Duran, Graciela Caire-Juvera, María del Refugio Robles-Burgeño, María Isabel Ortega-Vélez, María de Lourdes Gutiérrez-Coronado, María del Carmen Bermúdez Almada, Karina Chávez-Suárez, Melissa Campa-Siqueiros, Patricia Grajeda-Cota, María del Socorro Saucedo-Tamayo & Ana Isabel Valenzuela-Quintanar. (2015) Serum levels of phytoestrogens as biomarkers of intake in Mexican women. International Journal of Food Sciences and Nutrition 66:7, pages 819-825.
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Kyung-A Hwang & Kyung-Chul Choi. (2015) Anticarcinogenic Effects of Dietary Phytoestrogens and Their Chemopreventive Mechanisms. Nutrition and Cancer 67:5, pages 796-803.
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Anna Arnoldi, Chiara Zanoni, Carmen Lammi & Giovanna Boschin. (2015) The Role of Grain Legumes in the Prevention of Hypercholesterolemia and Hypertension. Critical Reviews in Plant Sciences 34:1-3, pages 144-168.
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Torsten Bohn, Michelle Blackwood, David Francis, Qingguo Tian, StevenJ. Schwartz & StevenK. Clinton. (2013) Bioavailability of Phytochemical Constituents From a Novel Soy Fortified Lycopene Rich Tomato Juice Developed for Targeted Cancer Prevention Trials. Nutrition and Cancer 65:6, pages 919-929.
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R.T. Pivik, RoscoeA. Dykman, Hongkui Jing, JanetM. Gilchrist & ThomasM. Badger. (2009) Early Infant Diet and the Omega 3 Fatty Acid DHA: Effects on Resting Cardiovascular Activity and Behavioral Development During the First Half-Year of Life. Developmental Neuropsychology 34:2, pages 139-158.
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Cesare R Sirtori, James Anderson & Anna Arnoldi. (2007) Nutritional And Nutraceutical Considerations For Dyslipidemia. Future Lipidology 2:3, pages 313-339.
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Mark Messina & Branin Lane. (2007) Soy protein, soybean isoflavones and coronary heart disease risk: Where do we stand?. Future Lipidology 2:1, pages 55-74.
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Articles from other publishers (108)

Mahtab Omidvari, Gavin R. Flematti, Ming Pei You, Payman Abbaszadeh‐Dahaji & Martin J. Barbetti. (2023) Plant growth stage and Phoma medicaginis inoculum concentration together determine severity of Phoma black stem and leaf spot and consequent phytoestrogen production in annual Medicago spp. . Plant Pathology 72:8, pages 1463-1475.
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Alessio Cimmino, Giovanni Francesco Fasciglione, Magda Gioia, Stefano Marini & Chiara Ciaccio. (2023) Multi-Anticancer Activities of Phytoestrogens in Human Osteosarcoma. International Journal of Molecular Sciences 24:17, pages 13344.
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Lynnette Leidy Sievert, Taniya Sharmeen, Khurshida Begum, Shanthi Muttukrishna, Osul Chowdhury & Gillian R. Bentley. (2023) Frequency of Phytoestrogen Consumption and Symptoms at Midlife among Bangladeshis in Bangladesh and London. Nutrients 15:17, pages 3676.
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Haoyuan Wu, Jing Yuan, Haixu Yin, Bo Jing, Chang Sun, Ivan Stève Nguepi Tsopmejio, Zhouyu Jin & Hui Song. (2023) Flammulina velutipes stem regulates oxidative damage and synthesis of yolk precursors in aging laying hens by regulating the liver–blood–ovary axis. Poultry Science 102:1, pages 102261.
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Azadeh Izadyari Aghmiuni, Arezoo Ghadi & Elmira Azmoun. 2023. Engineered Biomaterials. Engineered Biomaterials 153 197 .
Jessica Wyse, Sajid Latif, Saliya Gurusinghe, Jeffrey McCormick, Leslie A. Weston & Cyril P. Stephen. (2022) Phytoestrogens: A Review of Their Impacts on Reproductive Physiology and Other Effects upon Grazing Livestock. Animals 12:19, pages 2709.
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Rumaisa Rashid, Anamika Kumari, Naibedya Chattopadhyay, Rajesh Jha & Singh Rajender. (2022) Genistein lowers fertility with pronounced effect in males: Meta‐analyses on pre‐clinical studies. Andrologia 54:9.
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Adrian Szczepański, Dobrochna Adamek-Urbańska, Robert Kasprzak, Hubert Szudrowicz, Jerzy Śliwiński & Maciej Kamaszewski. (2022) Lupin: A promising alternative protein source for aquaculture feeds?. Aquaculture Reports 26, pages 101281.
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Mahtab Omidvari, Gavin R. Flematti, Ming Pei You, Payman Abbaszadeh-Dahaji & Martin J. Barbetti. (2022) Temperature and Soil Moisture Drive Coumestrol Concentration in Annual Medicago spp. in the Presence but Not Absence of Phoma Black Stem and Leaf Spot (Phoma medicaginis). Agronomy 12:8, pages 1863.
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S. Mary Princess Sulekha. (2022) Traditional Siddha Approach to Treatment of Cognitive Impairment in Menopause. Current Pharmacology Reports 8:4, pages 312-320.
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Pallath Muhammed Nuzaiba, Tincy Varghese, Subodh Gupta, Narottam Prasad Sahu & Prem Prakash Srivastava. (2022) Estrogenic and vitellogenic responses in genistein fed adult male Cyprinus carpio. Aquaculture 548, pages 737559.
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Faiz-ul Hassan, Asif Nadeem, Zhipeng Li, Maryam Javed, Qingyou Liu, Jahanzaib Azhar, Muhammad Saif-ur Rehman, Kuiqing Cui & Saif ur Rehman. (2021) Role of Peroxisome Proliferator-Activated Receptors (PPARs) in Energy Homeostasis of Dairy Animals: Exploiting Their Modulation through Nutrigenomic Interventions. International Journal of Molecular Sciences 22:22, pages 12463.
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Blassan P. George, Rahul Chandran & Heidi Abrahamse. (2021) Role of Phytochemicals in Cancer Chemoprevention: Insights. Antioxidants 10:9, pages 1455.
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Jessica M. Wyse, Sajid Latif, Saliya Gurusinghe, Erica D. Berntsen, Leslie A. Weston & Cyril P. Stephen. (2021) Characterization of Phytoestrogens in Medicago sativa L. and Grazing Beef Cattle. Metabolites 11:8, pages 550.
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Massimiliano Ruscica, Peter E. Penson, Nicola Ferri, Cesare R. Sirtori, Matteo Pirro, G.B. John Mancini, Naveed Sattar, Peter P. Toth, Amirhossein Sahebkar, Carl J. Lavie, Nathan D. Wong, Maciej Banach, Julio Acosta, Mutaz Al-Khnifsawi, Fahad Alnouri, Fahma Amar, Atanas G. Atanasov, Gani Bajraktari, Maciej Banach, Sonu Bhaskar, Bojko Bjelakovic, Eric Bruckert, Richard Ceska, Arrigo F.G. Cicero, Xavier Collet, Olivier Descamps, Dragan Djuric, Ronen Durst, Marat V. Ezhov, Zlatko Fras, Dan Gaita, Adrian V. Hernandez, Steven R. Jones, Jacek Jozwiak, Nona Kakauridze, Amani Kallel, Niki Katsiki, Amit Khera, Karam Kostner, Raimondas Kubilius, Gustavs Latkovskis, G.B. John Mancini, A. David Marais, Seth S. Martin, Julio Acosta Martinez, Mohsen Mazidi, Dimitri P. Mikhailidis, Erkin Mirrakhimov, Andre R. Miserez, Olena Mitchenko, Natalya P. Mitkovskaya, Patrick M. Moriarty, Seyed Mohammad Nabavi, Devaki Nair, Demosthenes B. Panagiotakos, György Paragh, Daniel Pella, Peter E. Penson, Zaneta Petrulioniene, Matteo Pirro, Arman Postadzhiyan, Raman Puri, Ashraf Reda, Željko Reiner, Dina Radenkovic, Michał Rakowski, Jemaa Riadh, Dimitri Richter, Manfredi Rizzo, Massimiliano Ruscica, Amirhossein Sahebkar, Naveed Sattar, Maria-Corina Serban, Abdulla M.A. Shehab, Aleksandr B. Shek, Cesare R. Sirtori, Claudia Stefanutti, Tomasz Tomasik, Peter P. Toth, Margus Viigimaa, Pedro Valdivielso, Dragos Vinereanu, Branislav Vohnout, Stephan von Haehling, Michal Vrablik, Nathan D. Wong, Hung-I Yeh, Jiang Zhisheng & Andreas Zirlik. (2021) Impact of nutraceuticals on markers of systemic inflammation: Potential relevance to cardiovascular diseases – A position paper from the International Lipid Expert Panel (ILEP). Progress in Cardiovascular Diseases 67, pages 40-52.
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Justyna Gorzkiewicz, Grzegorz Bartosz & Izabela Sadowska-Bartosz. (2021) The Potential Effects of Phytoestrogens: The Role in Neuroprotection. Molecules 26:10, pages 2954.
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Sonu Singhal, Mala Singh, Rakesh K. Singh, Vinod K. Tiwari & Surabhi Bajpai. 2021. Discovery and Development of Anti-Breast Cancer Agents from Natural Products. Discovery and Development of Anti-Breast Cancer Agents from Natural Products 295 351 .
Jéssica C. P. Petrine & Bruno Del Bianco‐Borges. (2020) The influence of phytoestrogens on different physiological and pathological processes: An overview. Phytotherapy Research 35:1, pages 180-197.
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I Gusti Agung Ayu Kartika, In Jae Bang, Catur Riani, Muhamad Insanu, Jong Hwan Kwak, Kyu Hyuck Chung & I Ketut Adnyana. (2020) Isolation and Characterization of Phenylpropanoid and Lignan Compounds from Peperomia pellucida [L.] Kunth with Estrogenic Activities. Molecules 25:21, pages 4914.
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Sergei V. Jargin. (2020) Scientific Papers and Patents on Substances with Unproven Effects. Part 2. Recent Patents on Drug Delivery & Formulation 13:3, pages 160-173.
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Bo Shuai, Rui Zhu, Yan-ping Yang, Lin Shen, Xiao-juan Xu, Chen Ma & Lin Lu. (2016) Positive Effects of Qing’e Pill (青娥丸) on Trabecular Microarchitecture and its Mechanical Properties in Osteopenic Ovariectomised Mice. Chinese Journal of Integrative Medicine 25:4, pages 270-277.
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Desmawati Desmawati & Delmi Sulastri. (2019) Phytoestrogens and Their Health Effect. Open Access Macedonian Journal of Medical Sciences 7:3, pages 495-499.
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Zainab TahaSakina E. Eltom. (2018) The Role of Diet and Lifestyle in Women with Breast Cancer: An Update Review of Related Research in the Middle East. BioResearch Open Access 7:1, pages 73-80.
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Christopher J. Borgert, John C. Matthews & Stephen P. Baker. (2018) Human-relevant potency threshold (HRPT) for ERα agonism. Archives of Toxicology 92:5, pages 1685-1702.
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J. X. Yang, M. T. Chaudhry, J. Y. Yao, S. N. Wang, B. Zhou, M. Wang, C. Y. Han, Y. You & Y. Li. (2018) Effects of phyto-oestrogen quercetin on productive performance, hormones, reproductive organs and apoptotic genes in laying hens. Journal of Animal Physiology and Animal Nutrition 102:2, pages 505-513.
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Sharmilee P. Mane, Stuart K. Johnson, Marcello Duranti, Vishnu K. Pareek & Ranjeet P. Utikar. (2018) Lupin seed γ-conglutin: Extraction and purification methods - A review. Trends in Food Science & Technology 73, pages 1-11.
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Majorie B. M. van Duursen. (2017) Modulation of estrogen synthesis and metabolism by phytoestrogens in vitro and the implications for women's health . Toxicology Research 6:6, pages 772-794.
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Lei Tao, Libing Wei, Yishi Liu, Yang Ding, Xiuting Liu, Xin Zhang, Xiaoping Wang, Yuyuan Yao, Jinrong Lu, Qing Wang & Rong Hu. (2017) Gen-27, a newly synthesized flavonoid, inhibits glycolysis and induces cell apoptosis via suppression of hexokinase II in human breast cancer cells. Biochemical Pharmacology 125, pages 12-25.
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Nadja Engel, Anna Adamus, Nicolas Schauer, Juliane Kühn, Barbara Nebe, Guido Seitz & Karin Kraft. (2017) Synergistic Action of Genistein and Calcitriol in Immature Osteosarcoma MG-63 Cells by SGPL1 Up-Regulation. PLOS ONE 12:1, pages e0169742.
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Stuart K. Johnson, Jonathan Clements, Casiana Blanca J. Villarino & Ranil Coorey. 2017. Gluten-Free Ancient Grains. Gluten-Free Ancient Grains 179 221 .
Shreelekha Dutta & Aparna Khanna. (2016) Aglycone rich extracts of phytoestrogens cause ROS-mediated DNA damage in breast carcinoma cells. Biomedicine & Pharmacotherapy 84, pages 1513-1523.
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Luka Kristanc & Samo Kreft. (2016) European medicinal and edible plants associated with subacute and chronic toxicity part I: Plants with carcinogenic, teratogenic and endocrine-disrupting effects. Food and Chemical Toxicology 92, pages 150-164.
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Juan Pablo Rigalli, Guillermo Nicolás Tocchetti, Maite Rocío Arana, Silvina Stella Maris Villanueva, Viviana Alicia Catania, Dirk Theile, María Laura Ruiz & Johanna Weiss. (2016) The phytoestrogen genistein enhances multidrug resistance in breast cancer cell lines by translational regulation of ABC transporters. Cancer Letters 376:1, pages 165-172.
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Jia-Qi Sun, Gan-Lin Zhang, Yi Zhang, Nan Nan, Xu Sun, Ming-Wei Yu, Hong Wang, Jin-Ping Li & Xiao-Min Wang. (2016) Spatholobus suberectus Column Extract Inhibits Estrogen Receptor Positive Breast Cancer via Suppressing ER MAPK PI3K/AKT Pathway . Evidence-Based Complementary and Alternative Medicine 2016, pages 1-13.
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C.B.J. Villarino, V. Jayasena, R. Coorey, S. Chakrabarti-Bell, R. Foley, K. Fanning & S.K. Johnson. (2015) The effects of lupin (Lupinus angustifolius) addition to wheat bread on its nutritional, phytochemical and bioactive composition and protein quality. Food Research International 76, pages 58-65.
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Carmen Lammi, Chiara Zanoni & Anna Arnoldi. (2015) IAVPGEVA, IAVPTGVA, and LPYP, three peptides from soy glycinin, modulate cholesterol metabolism in HepG2 cells through the activation of the LDLR-SREBP2 pathway. Journal of Functional Foods 14, pages 469-478.
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K.M. Njåstad, S.A. Adler, J. Hansen-Møller, E. Thuen, A.-M. Gustavsson & H. Steinshamn. (2014) Gastrointestinal metabolism of phytoestrogens in lactating dairy cows fed silages with different botanical composition. Journal of Dairy Science 97:12, pages 7735-7750.
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EUN JEONG CHOI, JAE YEON JUNG & GUN-HEE KIM. (2014) Genistein inhibits the proliferation and differentiation of MCF-7 and 3T3-L1 cells via the regulation of ERα expression and induction of apoptosis. Experimental and Therapeutic Medicine 8:2, pages 454-458.
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Bhupendra Singh, Rivka Shoulson, Anwesha Chatterjee, Amruta Ronghe, Nimee K. Bhat, Daniel C. Dim & Hari K. Bhat. (2014) Resveratrol inhibits estrogen-induced breast carcinogenesis through induction of NRF2-mediated protective pathways. Carcinogenesis 35:8, pages 1872-1880.
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Yufeng Qin, Guizhen Du, Minjian Chen, Weiyue Hu, Chuncheng Lu, Wei Wu, Bo Hang, Zuomin Zhou, Xinru Wang & Yankai Xia. (2014) Combined effects of urinary phytoestrogens metabolites and polymorphisms in metabolic enzyme gene on idiopathic male infertility. Archives of Toxicology 88:8, pages 1527-1536.
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Anita Fechner, Michael Kiehntopf & Gerhard Jahreis. (2014) The Formation of Short-Chain Fatty Acids Is Positively Associated with the Blood Lipid–Lowering Effect of Lupin Kernel Fiber in Moderately Hypercholesterolemic Adults. The Journal of Nutrition 144:5, pages 599-607.
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Chia-Jung Hsieh, Po-Lin Kuo, Ying-Chan Hsu, Ya-Fang Huang, Eing-Mei Tsai & Ya-Ling Hsu. (2014) Arctigenin, a dietary phytoestrogen, induces apoptosis of estrogen receptor-negative breast cancer cells through the ROS/p38 MAPK pathway and epigenetic regulation. Free Radical Biology and Medicine 67, pages 159-170.
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EUN JEONG CHOI & GUN-HEE KIM. (2013) Antiproliferative activity of daidzein and genistein may be related to ERα/c-erbB-2 expression in human breast cancer cells. Molecular Medicine Reports 7:3, pages 781-784.
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KYUNG-A HWANG, NAM-HEE KANG, BO-RIM YI, HYE-RIM LEE, MIN-AH PARK & KYUNG-CHUL CHOI. (2013) Genistein, a soy phytoestrogen, prevents the growth of BG-1 ovarian cancer cells induced by 17β-estradiol or bisphenol A via the inhibition of cell cycle progression. International Journal of Oncology 42:2, pages 733-740.
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Areej Siddiqui, Prasad Dandawate, Rukhsana Rub, Subhash Padhye, Shama Aphale, Alpana Moghe, Amrit Jagyasi, K. Venkateswara Swamy, Bhupendra Singh, Anwesha Chatterjee, Amruta Ronghe & Hari K. Bhat. (2013) Novel Aza-resveratrol analogs: Synthesis, characterization and anticancer activity against breast cancer cell lines. Bioorganic & Medicinal Chemistry Letters 23:3, pages 635-640.
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Hye-Sook Seo, Han-Seok Choi, Soon-Re Kim, Youn Kyung Choi, Sang-Mi Woo, Incheol Shin, Jong-Kyu Woo, Sang-Yoon Park, Yong Cheol Shin & Seong-Kyu Ko. (2012) Apigenin induces apoptosis via extrinsic pathway, inducing p53 and inhibiting STAT3 and NFκB signaling in HER2-overexpressing breast cancer cells. Molecular and Cellular Biochemistry 366:1-2, pages 319-334.
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Manuela I. Bader, Christine Reitmayer, Claudia Arndt, Jannette Wober, Georg Kretzschmar, Oliver Zierau & Günter Vollmer. (2012) Age dependency of estrogen responsiveness in the uterus and adipose tissue of aromatase-knockout (ArKO) mice. The Journal of Steroid Biochemistry and Molecular Biology 128:1-2, pages 29-37.
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