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Annals of Medicine Volume 40, 2008 - Issue 6
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Original Article

HLA-mismatched/haploidentical hematopoietic stem cell transplantation without in vitro T cell depletion for chronic myeloid leukemia: Improved outcomes in patients in accelerated phase and blast crisis phase

Huang Xiao-jun Peking University Institute of Hematology, People's Hospital, Beijing, China
,
Xu Lan-ping Peking University Institute of Hematology, People's Hospital, Beijing, China
,
Liu Kai-yan Peking University Institute of Hematology, People's Hospital, Beijing, China
,
Liu Dai-hong Peking University Institute of Hematology, People's Hospital, Beijing, China
,
Chen Huan Peking University Institute of Hematology, People's Hospital, Beijing, China
,
Han Wei Peking University Institute of Hematology, People's Hospital, Beijing, China
,
Chen Yu-hong Peking University Institute of Hematology, People's Hospital, Beijing, China
,
Wang Jing-zhi Peking University Institute of Hematology, People's Hospital, Beijing, China
,
Chen Yao Peking University Institute of Hematology, People's Hospital, Beijing, China
,
Zhang Xiao-hui Peking University Institute of Hematology, People's Hospital, Beijing, China
,
Shi Hong-xia Peking University Institute of Hematology, People's Hospital, Beijing, China
&
Lu Dao-pei Peking University Institute of Hematology, People's Hospital, Beijing, China
 show all
Pages 444-455 | Received 22 Aug 2007, Published online: 08 Jul 2009

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Ying-Jun Chang, Yu Wang & Xiao-Jun Huang. (2014) Haploidentical stem cell transplantation for the treatment of leukemia: current status. Expert Review of Hematology 7:5, pages 635-647.
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Articles from other publishers (45)

Christian Niederwieser & Nicolaus Kröger. (2022) Transplantation in CML in the TKI era: who, when, and how?. Hematology 2022:1, pages 114-122.
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Xiaodi Ma, Yangyang Zuo, Zhengli Xu, Yuanyuan Zhang, Yifei Cheng, Tingting Han, Pan Suo, Yuqian Sun, Feifei Tang, Fengrong Wang, Chenhua Yan, Yuhong Chen, Yu Wang, Xiaohui Zhang, Kaiyan Liu, Xiaojun Huang & Lanping Xu. (2022) Comparable clinical outcomes of haploidentical hematopoietic stem cell transplantation in patients with hepatitis-associated aplastic anemia and non-hepatitis-associated aplastic anemia. Annals of Hematology 101:8, pages 1815-1823.
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Lan‐Ping Xu, Yu Yu, Yi‐Fei Cheng, Yuan‐Yuan Zhang, Xiao‐Dong Mo, Ting‐Ting Han, Feng‐Rong Wang, Chen‐Hua Yan, Yu‐Qian Sun, Yu‐Hong Chen, Jing‐Zhi Wang, Zheng‐Li Xu, Fei‐Fei Tang, Wei Han, Yu Wang, Xiao‐Hui Zhang & Xiao‐Jun Huang. (2021) Development and validation of a mortality predicting scoring system for severe aplastic anaemia patients receiving haploidentical allogeneic transplantation. British Journal of Haematology 196:3, pages 735-742.
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Yan-Ru Ma, Wen-Jing Wang, Yi-Fei Cheng, Yuan-Yuan Zhang, Xiao-Dong Mo, Ting-Ting Han, Feng-Rong Wang, Chen-Hua Yan, Yu-Qian Sun, Yu-Hong Chen, Jing-Zhi Wang, Fei-Fei Tang, Wei Han, Yu Wang, Xiao-Hui Zhang, Xiao-Jun Huang & Lan-Ping Xu. (2020) Impact of ABO incompatibility on outcomes after haploidentical hematopoietic stem cell transplantation for severe aplastic anemia. Bone Marrow Transplantation 55:6, pages 1068-1075.
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Lan-Ping Xu, Shun-Qing Wang, Yan-Ru Ma, Su-Jun Gao, Yi-Fei Cheng, Yuan-Yuan Zhang, Wen-Jian Mo, Xiao-Dong Mo, Yu-Ping Zhang, Chen-Hua Yan, Yu-Hong Chen, Ming Zhou, Yu Wang, Xiao-Hui Zhang, Kai-Yan Liu & Xiao-Jun Huang. (2019) Who is the best haploidentical donor for acquired severe aplastic anemia? Experience from a multicenter study. Journal of Hematology & Oncology 12:1.
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Meng Lv, Yingjun Chang & Xiaojun Huang. (2018) Everyone has a donor: contribution of the Chinese experience to global practice of haploidentical hematopoietic stem cell transplantation. Frontiers of Medicine 13:1, pages 45-56.
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. Experimental and Clinical Transplantation.
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Yonghua Li, Fengqi Duan, Haowen Xiao, Xiaoxiong Wu, Shunqing Wang, Duorong Xu, Qifa Liu, Zhiping Fan, Danian Nie, Yongrong Lai, Bingyi Wu, Dongjun Lin, Xin Du, Jianyu Weng, Zujun Jiang, Yan Pang, Ling Ouyang, Zenghui Liu, Leqin Zhang, Na Han, Lixuan Chen & Yang Xiao. (2018) Therapeutic Outcomes of Haploidentical Allogeneic Hematopoietic Stem Cell Transplantation in Patients With Severe Aplastic Anemia: A Multicenter Study. Transplantation 102:10, pages 1724-1731.
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Le-Qing Cao, Lan-Ping Xu, Xiao-Hui Zhang, Yu Wang, Yan-Rong Liu, Kai-Yan Liu, Xiao-Jun Huang & Ying-Jun Chang. (2018) Relationship of Cell Compositions in Allografts with Outcomes after Haploidentical Transplantation for Acquired Severe Aplastic Anemia. Chinese Medical Journal 131:18, pages 2185-2192.
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L-P Xu, Z-L Xu, F-R Wang, X-D Mo, T-T Han, W Han, Y-H Chen, Y-Y Zhang, J-Z Wang, Y Wang, C-H Yan, Y-Q Sun, F-F Tang, X-H Zhang & X-J Huang. (2018) Unmanipulated haploidentical transplantation conditioning with busulfan, cyclophosphamide and anti-thymoglobulin for adult severe aplastic anaemia. Bone Marrow Transplantation 53:2, pages 188-192.
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Monzr M. Al Malki, Stefan O. Ciurea & Richard E. Champlin. 2018. Haploidentical Transplantation. Haploidentical Transplantation 261 269 .
Dong-mei Han, Xiao-li Zheng, Li Ding, Hong-min Yan, Zhi-dong Wang, Mei Xue, Ling Zhu, Jing Liu & Heng-xiang Wang. (2017) Risk factors in patients undergoing haploidentical hematopoietic stem cell transplantation for high-risk childhood acute leukemia. International Journal of Hematology 106:6, pages 820-831.
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Ying-Jun Chang, Leo Luznik, Ephraim J. Fuchs & Xiao-Jun Huang. (2016) How do we choose the best donor for T-cell-replete, HLA-haploidentical transplantation?. Journal of Hematology & Oncology 9:1.
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Lan-Ping Xu, Shun-Qing Wang, De-Pei Wu, Jian-Min Wang, Su-Jun Gao, Ming Jiang, Cun-Bang Wang, Xi Zhang, Qi-Fa Liu, Ling-Hui Xia, Xin Wang & Xiao-Jun Huang. (2016) Haplo-identical transplantation for acquired severe aplastic anaemia in a multicentre prospective study. British Journal of Haematology 175:2, pages 265-274.
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Yan-Ru Ma, Xiao-Jun Huang, Zheng-Li Xu, Kai-Yan Liu, Huan Chen, Xiao-Hui Zhang, Wei Han, Yu-Hong Chen, Feng-Rong Wang, Jing-Zhi Wang, Yu Wang, Yao Chen, Chen-Hua Yan & Lan-Ping Xu. (2016) Transplantation from haploidentical donor is not inferior to that from identical sibling donor for patients with chronic myeloid leukemia in blast crisis or chronic phase from blast crisis. Clinical Transplantation 30:9, pages 994-1001.
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Lan-Ping Xu, Zheng-Li Xu, Xiao-Hui Zhang, Huan Chen, Yu-Hong Chen, Wei Han, Yao Chen, Feng-Rong Wang, Jing-Zhi Wang, Yu Wang, Chen-Hua Yan, Xiao-Dong Mo, Kai-Yan Liu & Xiao-Jun Huang. (2016) Allogeneic Stem Cell Transplantation for Patients with T315I BCR-ABL Mutated Chronic Myeloid Leukemia. Biology of Blood and Marrow Transplantation 22:6, pages 1080-1086.
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Uday Deotare, Dennis Dong Hwan Kim & Jeffrey H. Lipton. (2016) Management of Elderly Patients with Newly Diagnosed Chronic Myeloid Leukemia in the Accelerated or Blastic Phase. Drugs & Aging 33:5, pages 335-345.
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Lanping Xu, Huanling Zhu, Jianda Hu, Depei Wu, Hao Jiang, Qian Jiang & Xiaojun Huang. (2015) Superiority of allogeneic hematopoietic stem cell transplantation to nilotinib and dasatinib for adult patients with chronic myelogenous leukemia in the accelerated phase. Frontiers of Medicine 9:3, pages 304-311.
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Zachariah DeFilipp & Hanna Jean Khoury. (2015) Management of Advanced-Phase Chronic Myeloid Leukemia. Current Hematologic Malignancy Reports 10:2, pages 173-181.
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Munira Shabbir-Moosajee, Lindsey Lombardi & Stefan O. Ciurea. (2015) An overview of conditioning regimens for haploidentical stem cell transplantation with post-transplantation cyclophosphamide. American Journal of Hematology 90:6, pages 541-548.
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K Adekola, U Popat & S O Ciurea. (2014) An update on allogeneic hematopoietic progenitor cell transplantation for myeloproliferative neoplasms in the era of tyrosine kinase inhibitors. Bone Marrow Transplantation 49:11, pages 1352-1359.
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H Jiang, L-P Xu, D-H Liu, K-Y Liu, S-S Chen, B Jiang, Q Jiang, H Chen, Y-H Chen, W Han, X-H Zhang, Y Wang, J-Z Wang, F-R Wang, Y-Z Qin, Y-Y Lai & X-J Huang. (2014) Allogeneic hematopoietic SCT in combination with tyrosine kinase inhibitor treatment compared with TKI treatment alone in CML blast crisis. Bone Marrow Transplantation 49:9, pages 1146-1154.
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X-Y Zhao, Y-J Chang, L-P Xu, X-H Zhang, K-Y Liu, D Li & X-J Huang. (2014) HLA and KIR genotyping correlates with relapse after T-cell-replete haploidentical transplantation in chronic myeloid leukaemia patients. British Journal of Cancer 111:6, pages 1080-1088.
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H-t Wang, Y-j Chang, L-p Xu, D-h Liu, Y Wang, K-y Liu & X-j Huang. (2014) EBMT risk score can predict the outcome of leukaemia after unmanipulated haploidentical blood and marrow transplantation. Bone Marrow Transplantation 49:7, pages 927-933.
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Y-y Zhang, D-h Liu, K-y Liu, L-p Xu, H Chen, W Han, Y Wang & X-j Huang. (2014) HLA-haploidentical hematopoietic SCT from collateral related donors without in vitro T-cell depletion for hematological malignancies. Bone Marrow Transplantation 49:4, pages 496-501.
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Xiaodong Mo & Xiaojun Huang. (2013) Advancement of human leukocyte antigen-partially matched related hematopoietic stem cell transplantation. Frontiers of Medicine 7:3, pages 306-315.
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Giuseppe Saglio & Carmen FavaDeena Iskander, Jane F Apperley & Jir? Pavlu. 2013. The Treatment of Chronic Myeloid Leukemia. The Treatment of Chronic Myeloid Leukemia 62 76 .
Jiří Pavlů & Jane F. Apperley. (2012) Allogeneic Stem Cell Transplantation for Chronic Myeloid Leukemia. Current Hematologic Malignancy Reports 8:1, pages 43-51.
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Yu Wang, Dai-Hong Liu, Kai-Yan Liu, Lan-Ping Xu, Xiao-Hui Zhang, Wei Han, Huan Chen, Yu-Hong Chen, Feng-Rong Wang, Jing-Zhi Wang, Yu-Qian Sun & Xiao-Jun Huang. (2013) Long-term follow-up of haploidentical hematopoietic stem cell transplantation without in vitro T cell depletion for the treatment of leukemia. Cancer 119:5, pages 978-985.
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Meng Lv & Xiao-Jun Huang. (2012) Allogeneic hematopoietic stem cell transplantation in China: where we are and where to go. Journal of Hematology & Oncology 5:1.
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Min Xie, Hai-Xia Fu, Ying-Jun Chang, Lan-Ping Xu, Dai-Hong Liu, Xiao-Hui Zhang, Wei Han, Kai-Yan Liu & Xiao-Jun Huang. (2012) Characteristics and influencing factors of CD19+ B cell reconstitution in patients following haploidentical/mismatched hematopoietic stem cell transplantation. International Journal of Hematology 96:1, pages 109-121.
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Yu Wang, Dai-Hong Liu, Lan-Ping Xu, Kai-Yan Liu, Huan Chen, Yu-Hong Chen, Wei Han, Xiao-hui Zhang & Xiao-Jun Huang. (2012) Haploidentical/Mismatched Hematopoietic Stem Cell Transplantation without In?Vitro T Cell Depletion for T Cell Acute Lymphoblastic Leukemia. Biology of Blood and Marrow Transplantation 18:5, pages 716-721.
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Ying-Jun Chang, Xiang-Yu Zhao, Ming-Rui Huo, Lan-Ping Xu, Dai-Hong Liu, Kai-Yan Liu & Xiao-Jun Huang. (2011) Immune Reconstitution Following Unmanipulated HLA-Mismatched/Haploidentical Transplantation Compared with HLA-Identical Sibling Transplantation. Journal of Clinical Immunology 32:2, pages 268-280.
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Ming‐Rui Huo, Lan‐Ping Xu, Li D, Dai‐Hong Liu, Kai‐Yan Liu, Huan Chen, Wei Han, Yu‐Hong Chen, Wang Y, Jing‐Zhi Wang, Xiao‐Hui Zhang, Xiang‐Yu Zhao & Xiao‐Jun Huang. (2011) The effect of HLA disparity on clinical outcome after HLA‐haploidentical blood and marrow transplantation. Clinical Transplantation 26:2, pages 284-291.
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Xiao-Jun Huang. (2011) Immunomodulatory strategies for relapse after haploidentical hematopoietic stem cell transplantation in hematologic malignancy patients. Best Practice & Research Clinical Haematology 24:3, pages 351-358.
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Yong-Xian Hu, Qu Cui, Bin Liang & He Huang. (2011) Relapsing Hematologic Malignancies after Haploidentical Hematopoietic Stem Cell Transplantation. Biology of Blood and Marrow Transplantation 17:8, pages 1099-1111.
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Qian Jiang, Lan-Ping Xu, Dai-Hong Liu, Kai-Yan Liu, Shan-Shan Chen, Bin Jiang, Hao Jiang, Huan Chen, Yu-Hong Chen, Wei Han, Xiao-Hui Zhang, Yu Wang, Ya-Zhen Qin, Yan-Rong Liu, Yue-Yun Lai & Xiao-Jun Huang. (2011) Imatinib mesylate versus allogeneic hematopoietic stem cell transplantation for patients with chronic myelogenous leukemia in the accelerated phase. Blood 117:11, pages 3032-3040.
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Xiao-Jun Huang & Ying-Jun Chang. (2011) Unmanipulated HLA-Mismatched/Haploidentical Blood and Marrow Hematopoietic Stem Cell Transplantation. Biology of Blood and Marrow Transplantation 17:2, pages 197-204.
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Meinolf Suttorp, Isaac Yaniv & Kirk R. Schultz. (2011) Controversies in the Treatment of CML in Children and Adolescents: TKIs versus BMT?. Biology of Blood and Marrow Transplantation 17:1, pages S115-S122.
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Y Chen, K Liu, L Xu, H Chen, D Liu, X Zhang, H Shi, W Han, Y Wang, T Zhao, J Wang, J Wang & X Huang. (2010) HLA-mismatched hematopoietic SCT without in vitro T-cell depletion for myelodysplastic syndrome. Bone Marrow Transplantation 45:8, pages 1333-1339.
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Siti Sarah Daud, Kamariah Ibrahim, Soo Sin Choong, Lelamekala Vengidasan, Lee Ai Chong & Hany Ariffin. (2010) Microfluidic chip-based assay for post-hematopoietic stem cell transplantation chimerism monitoring using polymorphic tandem repeat markers. Analytical Biochemistry 397:2, pages 181-185.
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Ying‐Jun Chang, Lan‐Ping Xu, Dai‐Hong Liu, Kai‐Yan Liu, Wei Han, Yu‐Hong Chen, Yu Wang, Huan Chen, Jing‐Zhi Wang, Xiao‐Hui Zhang, Xiang‐Yu Zhao & Xiao‐Jun Huang. (2009) The impact of CD34 + cell dose on platelet engraftment in pediatric patients following unmanipulated haploidentical blood and marrow transplantation . Pediatric Blood & Cancer 53:6, pages 1100-1106.
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Ying-Jun Chang, Xiang-Yu Zhao, Ming-Rui Huo, Lan-Ping Xu, Dai-Hong Liu, Kai-Yan Liu & Xiao-Jun Huang. (2009) Influence of Lymphocyte Recovery on Outcome of Haploidentical Transplantation for Hematologic Malignancies. Medicine 88:6, pages 322-330.
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Huang Xiao-Jun, Xu Lan-Ping, Liu Kai-Yan, Liu Dai-Hong, Wang Yu, Chen Huan, Chen Yu-Hong, Han Wei, Wang Jing-Zhi, Chen Yao, Zhang Xiao-Hui, Shi Hong-Xia, Wang Feng-Rong & Tang Fei-Fei. (2009) Partially Matched Related Donor Transplantation Can Achieve Outcomes Comparable with Unrelated Donor Transplantation for Patients with Hematologic Malignancies. Clinical Cancer Research 15:14, pages 4777-4783.
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Ying-Jun Chang, Lan-Ping Xu, Dai-Hong Liu, Kai-Yan Liu, Wei Han, Yu-Hong Chen, Yu-Wang, Huan Chen, Jing-Zhi Wang, Xiao-Hui Zhang, Xiang-Yu Zhao & Xiao-Jun Huang. (2009) Platelet Engraftment in Patients with Hematologic Malignancies following Unmanipulated Haploidentical Blood and Marrow Transplantation: Effects of CD34+ Cell Dose and Disease Status. Biology of Blood and Marrow Transplantation 15:5, pages 632-638.
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