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Research Article

Valsartan/Hydrochlorothiazide is Effective in Hypertensive Patients Inadequately Controlled by Valsartan Monotherapy

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Pages 36-43 | Published online: 08 Jul 2009

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Moo-Yong Rhee, Sang Hong Baek, Weon Kim, Chang Gyu Park, Seung Woo Park, Byung-Hee Oh, Sang-Hyun Kim, Jae-Joong Kim, Joon-Han Shin, Byung-Su Yoo, Se-Joong Rim, Jong-Won Ha, Joon Hyung Doh, Youngkeun Ahn, Jei Keon Chae, Jeong Bae Park, Soon-Kil Kim & Cheol Ho Kim. (2015) Efficacy of fimasartan/hydrochlorothiazide combination in hypertensive patients inadequately controlled by fimasartan monotherapy. Drug Design, Development and Therapy 9, pages 2847-2854.
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Chia-Wei Liou, Tung-Chen Yeh, I-Chung Chen, Chi-Hung Huang, Yi-Jen Hung, Kwan-Lih Hsu, Jian-Der Lee, Meng-Huan Lei, Kuan-Cheng Chang, Pei-Yung Liao, Zhih-Cherng Chen, Jackson Wang & Charles Jia-Yin Hou. (2011) Efficacy and safety of valsartan in hypertensive Taiwanese patients: Post-marketing surveillance study. Blood Pressure 20:sup2, pages 13-21.
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Ramón C. Hermida, Diana E. Ayala, Artemio Mojón, María J. Fontao & José R. Fernández. (2011) Chronotherapy With Valsartan/Hydrochlorothiazide Combination in Essential Hypertension: Improved Sleep-Time Blood Pressure Control With Bedtime Dosing. Chronobiology International 28:7, pages 601-610.
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Jujhar Bains & William B Smith. (2011) Valsartan plus hydrochlorothiazide: a review of its use since its introduction. Expert Opinion on Pharmacotherapy 12:12, pages 1975-1984.
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David T Nash & Michael S McNamara. (2009) Valsartan combination therapy in the management of hypertension – patient perspectives and clinical utility. Integrated Blood Pressure Control 2, pages 39-54.
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Ning-L. Sun, Jun-R. Zhu, Yanxing Zhao & Ying-M. Tu. (2008) Combination antihypertensive therapy with valsartan and hydrochlorothiazide in Chinese patients with mild-to-moderate hypertension. Current Medical Research and Opinion 24:10, pages 2863-2871.
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Jaakko Tuomilehto, Andrzej Tykarski, Peter Baumgart, Bernard Reimund, Stephanie Le Breton & Philippe Ferber. (2008) Combination therapy with valsartan/hydrochlorothiazide at doses up to 320/25 mg improves blood pressure levels in patients with hypertension inadequately controlled by valsartan 320 mg monotherapy. Blood Pressure 17:sup1, pages 15-23.
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Nisha B Mistry, Arne S Westheim & Sverre E Kjeldsen. (2006) The angiotensin receptor antagonist valsartan: a review of the literature with a focus on clinical trials. Expert Opinion on Pharmacotherapy 7:5, pages 575-581.
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Articles from other publishers (33)

Mengxin Xie, Tianjiao Tang & Hongsheng Liang. (2023) Efficacy of single‐pill combination in uncontrolled essential hypertension: A systematic review and network meta‐analysis. Clinical Cardiology.
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Linlin Ma, Keyang Zheng, Jiafu Yan & Wenli Cheng. (2021) Efficacy of ARB/HCTZ Combination Therapy in Uncontrolled Hypertensive Patients Compared with ARB Monotherapy: A Meta-Analysis. International Journal of Hypertension 2021, pages 1-7.
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Lars C. Rump, Bettina Ammentorp, Petra Laeis & Jürgen Scholze. (2015) Adding Hydrochlorothiazide to Olmesartan/Amlodipine Increases Efficacy in Patients With Inadequate Blood Pressure Control on Dual‐Combination Therapy. The Journal of Clinical Hypertension 18:1, pages 60-69.
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Joseph L. Izzo Jr, Howard S. Weintraub, Daniel A. Duprez, Das Purkayastha, Dion Zappe, Rita Samuel & William C. Cushman. (2011) Treating Systolic Hypertension in the Very Elderly With Valsartan-Hydrochlorothiazide vs Either Monotherapy: ValVET Primary Results. The Journal of Clinical Hypertension 13:10, pages 722-730.
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Gianfranco Parati, Roland Asmar, Grzegorz Bilo, Albert Kandra, Robert Di Giovanni & Thomas Mengden. (2010) Effectiveness and safety of high-dose valsartan monotherapy in hypertension treatment: the ValTop study. Hypertension Research 33:10, pages 986-994.
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James L. Pool, Robert Glazer, Nora Crikelair & Drew Levy. (2009) The Role of Baseline Blood Pressure in Guiding Treatment Choice. Clinical Drug Investigation 29:12, pages 791-802.
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Henry R. Black, Jacqueline Bailey, Dion Zappe & Rita Samuel. (2009) Valsartan. Drugs 69:17, pages 2393-2414.
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Yves Lacourcière, Jackson T. Wright, Rita Samuel, Dion Zappe, Das Purkayastha & Henry R. Black. (2009) Effects of force-titrated valsartan/hydrochlorothiazide versus amlodipine/hydrochlorothiazide on ambulatory blood pressure in patients with stage 2 hypertension: the EVALUATE study. Blood Pressure Monitoring 14:3, pages 112-120.
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Vasilios Papademetriou. (2009) Inhibition of the renin-angiotensin-aldosterone system to prevent ischemic and atherothrombotic events. American Heart Journal 157:6, pages S24-S30.
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R. M. Nixon, E. Müller, A. Lowy & H. Falvey. (2009) Valsartan vs. other angiotensin II receptor blockers in the treatment of hypertension: a meta-analytical approach. International Journal of Clinical Practice 63:5, pages 766-775.
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Jan Basile. (2009) Blood pressure responder rates versus goal rates: which metric matters?. Therapeutic Advances in Cardiovascular Disease 3:2, pages 157-174.
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B Dahlöf. (2008) Management of cardiovascular risk with RAS inhibitor/CCB combination therapy. Journal of Human Hypertension 23:2, pages 77-85.
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S Zhang, B Yu, L Li, Z Du & Z Guan. (2008) Randomized, Double-blinded Trial Evaluation of Valsartan/Hydrochlorothiazide Combination Therapy in Mild to Moderate Essential Hypertension in North-east China. Journal of International Medical Research 36:4, pages 630-637.
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William B. White, David A. Calhoun, Rita Samuel, Addison A. Taylor, Dion H. Zappe & Das Purkayastha. (2008) Improving Blood Pressure Control: Increase the Dose of Diuretic or Switch to a Fixed-Dose Angiotensin Receptor Blocker/Diuretic? The Valsartan Hydrochlorothiazide Diuretic for Initial Control and Titration to Achieve Optimal Therapeutic Effect (Val-DICTAT. The Journal of Clinical Hypertension 10:6, pages 450-458.
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Brendan M. Everett, Robert J. Glynn, Eleanor Danielson & Paul M Ridker. (2008) Combination therapy versus monotherapy as initial treatment for stage 2 hypertension: A prespecified subgroup analysis of a community-based, randomized, open-label trial. Clinical Therapeutics 30:4, pages 661-672.
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Biff F Palmer. (2008) Improving BP Control with Combined Renin-Angiotensin System Blockade and Thiazide Diuretics in Hypertensive Patients with Diabetes Mellitus or Kidney Disease. American Journal of Cardiovascular Drugs 8:1, pages 9-14.
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David H G Smith. (2008) Comparison of Angiotensin II Type 1 Receptor Antagonists in the Treatment of Essential Hypertension. Drugs 68:9, pages 1207-1225.
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Joel M. Neutel & Lawrence I. Gilderman. (2008) Hypertension Control in the Elderly. The Journal of Clinical Hypertension 10:s1, pages 33-39.
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. 2006. Wiley Handbook of Current and Emerging Drug Therapies. Wiley Handbook of Current and Emerging Drug Therapies.
David T. Nash. (2007) Rationale for Combination Therapy in Hypertension Management: Focus on Angiotensin Receptor Blockers and Thiazide Diuretics. Southern Medical Journal 100:4, pages 386-392.
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Alberto Villamil, Steven G Chrysant, David Calhoun, Bonnie Schober, Huang Hsu, Linda Matrisciano-Dimichino & Jack Zhang. (2007) Renin inhibition with aliskiren provides additive antihypertensive efficacy when used in combination with hydrochlorothiazide. Journal of Hypertension 25:1, pages 217-226.
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James L. Pool, Robert Glazer, Myron Weinberger, Roxanne Alvarado, Jie Huang & Alan Graff. (2007) Comparison of valsartan/hydrochlorothiazide combination therapy at doses up to 320/25 mg versus monotherapy: A double-blind, placebo-controlled study followed by long-term combination therapy in hypertensive adults. Clinical Therapeutics 29:1, pages 61-73.
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R. Fogari, A. Zoppi, A. Mugellini, P. Preti, M. Destro, A. Rinaldi & G. Derosa. (2006) Hydrochlorothiazide added to valsartan is more effective than when added to olmesartan in reducing blood pressure in moderately hypertensive patients inadequately controlled by monotherapy. Advances in Therapy 23:5, pages 680-695.
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R. Düsing. (2006) Angiotensin II-receptor blocker dosages: How high should we go?. International Journal of Clinical Practice 60:2, pages 179-183.
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Sverre E Kjeldsen, Hans R Brunner, Gordon T McInnes & Pelle Stolt. (2005) Valsartan in the treatment of hypertension. Aging Health 1:1, pages 27-36.
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Yves Lacourcière,Luc Poirier,Daniel Hebert,Linda Assouline,Pelle Stolt,Bonita Rehel,Yasser Khder,. (2005) Antihypertensive Efficacy and Tolerability of Two Fixed-Dose Combinations of Valsartan and Hydrochlorothiazide Compared with Valsartan Monotherapy in Patients with Stage 2 or 3 Systolic Hypertension: An 8-Week, Randomized, Double-Blind, Parallel-Group Trial. Clinical Therapeutics 27:7, pages 1013-1021.
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Luis M. Ruilope, Ettore Malacco, Yasser Khder, Albert Kandra, Gerd Bönner & Daniela Heintz. (2005) Efficacy and tolerability of combination therapy with valsartan plus hydrochlorothiazide compared with amlodipine monotherapy in hypertensive patients with other cardiovascular risk factors: The VAST study. Clinical Therapeutics 27:5, pages 578-588.
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R. Fuenfstueck, R. -D. Hempel, A. Ansari, G. Weidinger & S. Klebs. (2005) Efficacy and safety of combination therapy using high- or low-dose hydrochlorothiazide with valsartan or other angiotensin-receptor blockers. Advances in Therapy 22:3, pages 263-277.
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Paolo Palatini. (2007) Combination Therapy in the Management of Hypertension: Focus on Angiotensin Receptor Blockers Combined With Diuretics. The Journal of Clinical Hypertension 7:2, pages 96-101.
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L. Michael Prisant & Laura Lyngby Mulloy. 2005. Hypertension in the Elderly. Hypertension in the Elderly 399 425 .
Lawrence Baruch. (2007) Hypertension and the Elderly: More Than Just Blood Pressure Control. The Journal of Clinical Hypertension 6:5, pages 249-255.
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Massimo Volpe. (2004) Hypertension therapy: Mixing, matching, and meeting targets. Advances in Therapy 21:2, pages 107-122.
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Ettore Malacco, Natale Vari, Vincenzo Capuano, Vitaliano Spagnuolo, Carlo Borgnino, Paolo Palatini & Val-Syst Investigators. (2003) A randomized, double-blind, active-controlled, parallel-group comparison of valsartan and amlodipine in the treatment of isolated systolic hypertension in elderly patients: The Val-Syst study. Clinical Therapeutics 25:11, pages 2765-2780.
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