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Seminars in Ophthalmology Volume 19, 2004 - Issue 1-2
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Research Article

Evolution of retinal laser therapy: minimum intensity photocoagulation (MIP). Can the laser heal the retina without harming it?

Giorgio Dorin IRIDEX Corporation Mountain View California USACorrespondence[email protected]
Pages 62-68 | Published online: 02 Jul 2009

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Hilary S. Brader & Lucy H. Y. Young. (2016) Subthreshold Diode Micropulse Laser: A Review. Seminars in Ophthalmology 31:1-2, pages 30-39.
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Sobha Sivaprasad & Giorgio Dorin. (2012) Subthreshold diode laser micropulse photocoagulation for the treatment of diabetic macular edema. Expert Review of Medical Devices 9:2, pages 189-197.
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J. A. Cardillo, M. W. Rodrigues, R. C. Oliveira, A. M. V. Messias & R. Jorge. (2022) Pascal short-pulse plus subthreshold endpoint management laser therapy for diabetic macular edema: the “sandwich technique”. International Journal of Retina and Vitreous 8:1.
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Luisa Frizziero, Andrea Calciati, Giulia Midena, Tommaso Torresin, Raffaele Parrozzani, Elisabetta Pilotto & Edoardo Midena. (2021) Subthreshold Micropulse Laser Modulates Retinal Neuroinflammatory Biomarkers in Diabetic Macular Edema. Journal of Clinical Medicine 10:14, pages 3134.
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John P. M. Wood, Marzieh Tahmasebi, Robert J. Casson, Malcolm Plunkett & Glyn Chidlow. (2021) Physiological response of the retinal pigmented epithelium to 3‐ns pulse laser application, in vitro and in vivo. Clinical & Experimental Ophthalmology 49:5, pages 454-469.
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Maria Carla Donati, Vittoria Murro, Dario Pasquale Mucciolo, Dario Giorgio, Giacomo Cinotti, Gianni Virgili & Stanislao Rizzo. (2020) Subthreshold yellow micropulse laser for treatment of diabetic macular edema: Comparison between fixed and variable treatment regimen. European Journal of Ophthalmology 31:3, pages 1254-1260.
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Yulia I. Kukharskaya, Elena V. Ivanova & Pavel L. Volodin. (2021) Retinal vein occlusion: Modern approaches to treatment. Aspirantskiy Vestnik Povolzhiya 21:1-2, pages 128-138.
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Diego Alejandro Valera-Cornejo, Marlon García-Roa, Jaime Quiroz-Mendoza, Alejandro Arias-Gómez, Paulina Ramírez-Neria, Yolanda Villalpando-Gómez, Veronica Romero-Morales & Renata García-Franco. (2021) Micropulse laser in patients with refractory and treatment-naïve center–involved diabetic macular edema: short terms visual and anatomic outcomes. Therapeutic Advances in Ophthalmology 13, pages 251584142097911.
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Mahmoud Alaa Abouhussein & Amir Ramadan Gomaa. (2020) Aflibercept plus micropulse laser versus aflibercept monotherapy for diabetic macular edema: 1-year results of a randomized clinical trial. International Ophthalmology 40:5, pages 1147-1154.
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A Arsan, H S Kanar & A Sonmez. (2018) Visual outcomes and anatomic changes after sub-threshold micropulse yellow laser (577-nm) treatment for chronic central serous chorioretinopathy: long-term follow-up. Eye 32:4, pages 726-733.
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Paula Scholz, Lebriz Altay & Sascha Fauser. (2017) A Review of Subthreshold Micropulse Laser for Treatment of Macular Disorders. Advances in Therapy 34:7, pages 1528-1555.
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Sejal Shah & Seenu M. Hariprasad. (2016) Application of Micropulse Lasers in Treating Macular Diseases. Ophthalmic Surgery, Lasers and Imaging Retina 47:11, pages 985-990.
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Luke Chehade, Glyn Chidlow, John Wood & Robert J Casson. (2016) Short-pulse duration retinal lasers: a review. Clinical & Experimental Ophthalmology 44:8, pages 714-721.
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Daniel Palanker. (2016) Evolution of Concepts and Technologies in Ophthalmic Laser Therapy. Annual Review of Vision Science 2:1, pages 295-319.
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Glyn Chidlow, Malcolm Plunkett, Robert J. Casson & John P.M. Wood. (2016) Investigations into localized re-treatment of the retina with a 3-nanosecond laser. Lasers in Surgery and Medicine 48:6, pages 602-615.
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Sejal Shah & Jorge Fortun. (2016) Laser Therapy in the Management of Diabetic Retinopathy. Current Ophthalmology Reports 4:2, pages 90-96.
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Zhouyue Li, Yanping Song, Xiao Chen, Zhongshan Chen & Qin Ding. (2015) Biological Modulation of Mouse RPE Cells in Response to Subthreshold Diode Micropulse Laser Treatment. Cell Biochemistry and Biophysics 73:2, pages 545-552.
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W Pei-pei, H Shi-zhou, T Zhen, L Lin, L Ying, O Jiexiong, Z Wen-bo & J Chen-jin. (2015) Randomised clinical trial evaluating best-corrected visual acuity and central macular thickness after 532-nm subthreshold laser grid photocoagulation treatment in diabetic macular oedema. Eye 29:3, pages 313-322.
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B. ShapiroS. KulkarniA. NacevA. SarwarD. Preciado & D.A. Depireux. (2014) Shaping Magnetic Fields to Direct Therapy to Ears and Eyes. Annual Review of Biomedical Engineering 16:1, pages 455-481.
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Yoon Hyung KwonDong Kyu LeeOh Woong Kwon. (2014) The Short-term Efficacy of Subthreshold Micropulse Yellow (577-nm) Laser Photocoagulation for Diabetic Macular Edema. Korean Journal of Ophthalmology 28:5, pages 379.
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Xinyuan Zhang, Huan Zeng, Shian Bao, Ningli Wang & Mark C Gillies. (2014) Diabetic macular edema: new concepts in patho-physiology and treatment. Cell & Bioscience 4:1, pages 27.
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Stefan Koinzer, Mark Saeger, Carola Hesse, Lea Portz, Susanne Kleemann, Kerstin Schlott, Ralf Brinkmann & Johann Roider. (2013) Correlation with OCT and histology of photocoagulation lesions in patients and rabbits. Acta Ophthalmologica 91:8, pages e603-e611.
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Christopher K. Sramek, Loh-Shan B. Leung, Yannis M. Paulus & Daniel V. Palanker. (2012) Therapeutic Window of Retinal Photocoagulation With Green (532-nm) and Yellow (577-nm) Lasers. Ophthalmic Surgery, Lasers and Imaging Retina 43:4, pages 341-347.
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John P.M. Wood, Malcolm Plunkett, Victor Previn, Glyn Chidlow & Robert J. Casson. (2011) Nanosecond pulse lasers for retinal applications. Lasers in Surgery and Medicine 43:6, pages 499-510.
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P. Chen, C. P. Zhang, X. B. Fu, T. M. Zhang, C. Z. Wang, H. W. Qian & Q. San. (2011) Pilot study about dose-effect relationship of ocular injury in argon laser photocoagulation. Laser Physics 21:3, pages 554-558.
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Sobha Sivaprasad, Mohammed Elagouz, Dominic McHugh, Olajumoke Shona & Giorgio Dorin. (2010) Micropulsed Diode Laser Therapy: Evolution and Clinical Applications. Survey of Ophthalmology 55:6, pages 516-530.
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Katharina Kriechbaum, Matthias Bolz, Gabor G. Deak, Sonja Prager, Christoph Scholda & Ursula Schmidt-Erfurth. (2010) High-Resolution Imaging of the Human Retina In Vivo after Scatter Photocoagulation Treatment Using a Semiautomated Laser System. Ophthalmology 117:3, pages 545-551.
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Young-Gun ParkDong Hyun JeeJi-Wook Yang. (2010) Comparison of the Effects of Patterned and Conventional Laser Photocoagulation in Branch Retinal Vein Occlusion. Journal of the Korean Ophthalmological Society 51:10, pages 1368.
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Thomas R. Friberg, Peter M. Brennen, William R. Freeman, David C. Musch & The PTAMD Study Group. (2009) Prophylactic Treatment of Age-Related Macular Degeneration Report Number 2: 810-Nanometer Laser to Eyes With Drusen: Bilaterally Eligible Patients. Ophthalmic Surgery, Lasers and Imaging Retina 40:6, pages 530-538.
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Bum Joo ChoTae Wan KimSe Joon WooHum ChungJang Won Heo. (2009) Short-term Clinical Outcome of Patterned Scanning Laser Photocoagulation With Short Exposure Time in Diabetic Retinopathy. Journal of the Korean Ophthalmological Society 50:3, pages 376.
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DAVID M. SQUIRRELL, ALISTAIR W. STEWART, BRIAN C. JOONDEPH, HELEN V. DANESH–MEYER, CHARLES N. J. MCGHEE & MARK L. DONALDSON. (2008) Large-Spot Subthreshold Infrared Laser to Treat Diabetic Macular Edema. Retina 28:4, pages 615-621.
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John Bradley, Meihua Ju & Gregory S. Robinson. (2007) Combination therapy for the treatment of ocular neovascularization. Angiogenesis 10:2, pages 141-148.
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Federico Ricci, Sabina Pucci, Fabiola Sesti, Filippo Missiroli, Luciano Cerulli & Luigi Giusto Spagnoli. (2007) Modulation of Ku70/80, Clusterin/ApoJ Isoforms and Bax Expression in Indocyanine-Green-Mediated Photo-Oxidative Cell Damage. Ophthalmic Research 39:3, pages 164-173.
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