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Research Article

Review of Genetics in Age Related Macular Degeneration

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Pages 229-240 | Published online: 02 Jul 2009

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Pierre Bitoun, Eva Pipiras & Florence Rigaudiere. (2012) Congenital Macular Dystrophy, Corpus Callosum Agenesis, Hippocampi Hypoplasia – A Novel Neuro-Ophthalmic Syndrome: Case Report. Ophthalmic Genetics 33:1, pages 39-43.
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. (2013) Age-related macular degeneration. Revista da Associa??o M?dica Brasileira (English Edition) 59:2, pages 106-111.
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Isabelle Audo, Kinga M Bujakowska, Thierry Léveillard, Saddek Mohand-Saïd, Marie-Elise Lancelot, Aurore Germain, Aline Antonio, Christelle Michiels, Jean-Paul Saraiva, Mélanie Letexier, José-Alain Sahel, Shomi S Bhattacharya & Christina Zeitz. (2012) Development and application of a next-generation-sequencing (NGS) approach to detect known and novel gene defects underlying retinal diseases. Orphanet Journal of Rare Diseases 7:1, pages 8.
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Julien Bruban, Agathe Maoui, Na?ma Chalour, Na An, Laurent Jonet, Charles Feumi, Jacques Tr?ton, Florian Sennlaub, Francine Behar-Cohen, Fr?d?ric Mascarelli & Virginie Dinet. (2011) CCR2/CCL2-mediated inflammation protects photoreceptor cells from amyloid-?-induced apoptosis. Neurobiology of Disease 42:1, pages 55-72.
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Crossref
Juan A. Ayala‐Haedo, Paul J. Gallins, Patrice L. Whitehead, Stephen G. Schwartz, Jaclyn L. Kovach, Eric A. Postel, Anita Agarwal, Gaofeng Wang, Jonathan L. Haines, Margaret A. Pericak‐Vance & William K. Scott. (2010) Analysis of Single Nucleotide Polymorphisms in the NOS2A Gene and Interaction with Smoking in Age‐Related Macular Degeneration . Annals of Human Genetics 74:3, pages 195-201.
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Crossref
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Crossref
Don H. Anderson, Monte J. Radeke, Natasha B. Gallo, Ethan A. Chapin, Patrick T. Johnson, Christy R. Curletti, Lisa S. Hancox, Jane Hu, Jessica N. Ebright, Goldis Malek, Michael A. Hauser, Catherine Bowes Rickman, Dean Bok, Gregory S. Hageman & Lincoln V. Johnson. (2010) The pivotal role of the complement system in aging and age-related macular degeneration: Hypothesis re-visited. Progress in Retinal and Eye Research 29:2, pages 95-112.
Crossref
David E Lederer, Scott W Cousins & Karl G Csaky. 2010. Ocular Disease. Ocular Disease 536 543 .
L.V. Johnson. 2010. Encyclopedia of the Eye. Encyclopedia of the Eye 193 198 .
Jaya P. Gnana-Prakasam, Pamela M. Martin, Sylvia B. Smith & Vadivel Ganapathy. (2010) Expression and function of iron-regulatory proteins in retina. IUBMB Life, pages NA-NA.
Crossref
Jaya P. Gnana-PrakasamMuthusamy ThangarajuKebin LiuYonju HaPamela M. MartinSylvia B. SmithVadivel Ganapathy. (2009) Absence of iron-regulatory protein Hfe results in hyperproliferation of retinal pigment epithelium: role of cystine/glutamate exchanger. Biochemical Journal 424:2, pages 243-252.
Crossref
Katarzyna Janik-Papis, Malgorzata Zaras, Anna Krzyzanowska, Katarzyna Wozniak, Janusz Blasiak, Jerzy Szaflik & Jacek P. Szaflik. (2009) Association between vascular endothelial growth factor gene polymorphisms and age-related macular degeneration in a Polish population. Experimental and Molecular Pathology 87:3, pages 234-238.
Crossref
Christine A. Curcio, Mark Johnson, Jiahn-Dar Huang & Martin Rudolf. (2009) Aging, age-related macular degeneration, and the response-to-retention of apolipoprotein B-containing lipoproteins. Progress in Retinal and Eye Research 28:6, pages 393-422.
Crossref
Dimitra I. Marioli, Nikolaos Pharmakakis, Angeliki Deli, Ioannis Havvas & Ioannis K. Zarkadis. (2009) Complement factor H and LOC387715 gene polymorphisms in a Greek population with age-related macular degeneration. Graefe's Archive for Clinical and Experimental Ophthalmology 247:11, pages 1547-1553.
Crossref
Matthew CampbellAnh T. H. NguyenAnna-Sophia KiangLawrence C. S. TamOliviero L. Gobbo, Christian Kerskens, Sorcha Ni DhubhghaillMarian M. HumphriesG.-Jane FarrarPaul F. KennaPeter Humphries. (2009) An experimental platform for systemic drug delivery to the retina. Proceedings of the National Academy of Sciences 106:42, pages 17817-17822.
Crossref
Olli Arjamaa, Mikko Nikinmaa, Antero Salminen & Kai Kaarniranta. (2009) Regulatory role of HIF-1α in the pathogenesis of age-related macular degeneration (AMD). Ageing Research Reviews 8:4, pages 349-358.
Crossref
Na-Ping Tang, Bo Zhou, Bin Wang & Rong-Bin Yu. (2009) HTRA1 Promoter Polymorphism and Risk of Age-Related Macular Degeneration: A Meta-Analysis. Annals of Epidemiology 19:10, pages 740-745.
Crossref
N.K. Wills, N. Kalariya, V.M. Sadagopa Ramanujam, J.R. Lewis, S. Haji Abdollahi, A. Husain & F.J.G.M. van Kuijk. (2009) Human retinal cadmium accumulation as a factor in the etiology of age-related macular degeneration. Experimental Eye Research 89:1, pages 79-87.
Crossref
Kyung Hwa Kang, Greg Lemke & Jin Woo Kim. (2009) The PI3K–PTEN tug-of-war, oxidative stress and retinal degeneration. Trends in Molecular Medicine 15:5, pages 191-198.
Crossref
Lisa A. Brennan & Marc Kantorow. (2009) Mitochondrial function and redox control in the aging eye: Role of MsrA and other repair systems in cataract and macular degenerations. Experimental Eye Research 88:2, pages 195-203.
Crossref
Ribhi Hazin, P. David Freeman & Malik Y. Kahook. (2009) Age-Related Macular Degeneration: A Guide for the Primary Care Physician. Journal of the National Medical Association 101:2, pages 134-138.
Crossref
Heping Xu & John V. Forrester. 2009. Uveitis and Immunological Disorders. Uveitis and Immunological Disorders 61 71 .
Christine A. Curcio, Martin Rudolf & Lan Wang. 2010. Lipidomics. Lipidomics 267 281 .
Michael K. Pangburn, Viviana P. Ferreira & Claudio Cortes. (2008) Discrimination between host and pathogens by the complement system. Vaccine 26, pages I15-I21.
Crossref
Christine Skerka & Peter F. Zipfel. (2008) Complement factor H related proteins in immune diseases. Vaccine 26, pages I9-I14.
Crossref
Martin Rudolf, Goldis Malek, Jeffrey D. Messinger, Mark E. Clark, Lan Wang & Christine A. Curcio. (2008) Sub-retinal drusenoid deposits in human retina: Organization and composition. Experimental Eye Research 87:5, pages 402-408.
Crossref
P K Buch, J W Bainbridge & R R Ali. (2008) AAV-mediated gene therapy for retinal disorders: from mouse to man. Gene Therapy 15:11, pages 849-857.
Crossref
Sayoko E. Moroi & John R. Heckenlively. (2008) Progress Toward Personalized Medicine for Age-related Macular Degeneration. Ophthalmology 115:6, pages 925-926.
Crossref

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