Advanced search
Publication Cover
Seminars in Ophthalmology Volume 23, 2008 - Issue 3
Submit an article Journal homepage
1,308
Views
73
CrossRef citations to date
0
Altmetric
Research Article

Ocular Toxicity of Hydroxychloroquine

Rodney Tehrani Loyola University Medical Center, Maywood, IL, USA
,
Rochella A. Ostrowski Loyola University Medical Center, Maywood, IL, USA
,
Richard Hariman Loyola University Medical Center, Maywood, IL, USA
&
Walter M. Jay Loyola University Medical Center, Maywood, IL, USA
Pages 201-209 | Published online: 02 Jul 2009

Citations (73)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (10)

Wilson Heriot, Vickie HY Wong, Zheng He, Anh Hoang, Jeremiah KH Lim, Tomoharu Nishimura, Da Zhao, Andrew B Metha & Bang V Bui. (2023) Effect of hydroxychloroquine or chloroquine and short wavelength light on in vivo retinal function and structure in mouse eyes. Clinical and Experimental Optometry 106:5, pages 523-531.
Read now
Manisha Malani, Manthan S. Hiremath, Surbhi Sharma, Manisha Jhunjhunwala, Shovanlal Gayen, Chittaranjan Hota & Jayabalan Nirmal. (2023) Interaction of systemic drugs causing ocular toxicity with organic cation transporter: an artificial intelligence prediction. Journal of Biomolecular Structure and Dynamics 0:0, pages 1-12.
Read now
Mehtap Çağlayan, Lütfi Akyol, Mehmet Ali Balcı, Hasan Öncül, Mehmet Fuat Alakuş & Umut Dağ. (2021) Evaluation of corneal safety in systemic lupus erythematosus patients undergoing long-term hydroxychloroquine treatment. Cutaneous and Ocular Toxicology 40:1, pages 21-25.
Read now
Mario R. Romano, Alessio Montericcio, Clara Montalbano, Raffaele Raimondi, Davide Allegrini, Gabriella Ricciardelli, Martina Angi, Luca Pagano & Vito Romano. (2020) Facing COVID-19 in Ophthalmology Department. Current Eye Research 45:6, pages 653-658.
Read now
Tevfik Oğurel, Murat Atabey Özer, Yaprak Akbulut, Nesrin Büyüktortop Gökçınar, Zafer Onaran & Kemal Üreten. (2019) Corneal thickness and endothelial changes in long-term hydroxychloroquine use. Cutaneous and Ocular Toxicology 38:3, pages 286-289.
Read now
Rosanna Dammacco, Pasquale Procaccio, Vito Racanelli, Angelo Vacca & Franco Dammacco. (2018) Ocular Involvement in Systemic Lupus Erythematosus: The Experience of Two Tertiary Referral Centers. Ocular Immunology and Inflammation 26:8, pages 1154-1165.
Read now
David J Browning & Chong Lee. (2014) Relative sensitivity and specificity of 10-2 visual fields, multifocal electroretinography, and spectral domain optical coherence tomography in detecting hydroxychloroquine and chloroquine retinopathy. Clinical Ophthalmology 8, pages 1389-1399.
Read now
Gilbert J Kersh. (2013) Antimicrobial therapies for Q fever. Expert Review of Anti-infective Therapy 11:11, pages 1207-1214.
Read now
Won June Lee, Myung-Kyoo Ko & Byung Ro Lee. (2012) Hydroxychloroquine retinopathy combined with retinal pigment epithelium detachment. Cutaneous and Ocular Toxicology 31:2, pages 144-147.
Read now
Eric Chen, David M Brown, Matthew S Benz, Richard H Fish, Tien P Wong, Rosa Y Kim & James C Major. (2010) Spectral domain optical coherence tomography as an effective screening test for hydroxychloroquine retinopathy (the “flying saucer” sign). Clinical Ophthalmology 4, pages 1151-1158.
Read now

Articles from other publishers (63)

Yusuf Ziya GÜVEN, Fahrettin AKAY, Berkay AKMAZ, Dilek SOLMAZ, Önay GERCİK & Servet AKAR. (2023) Evaluation of retinal microvascular network in patients with systemic sclerosis: An optical cohorence tomography angiography study. Photodiagnosis and Photodynamic Therapy 44, pages 103774.
Crossref
Liang Ee Low, Chee Kei Kong, Wei-Hsum Yap, Sangeetaprivya P. Siva, Siew Hua Gan, Wei Sheng Siew, Long Chiau Ming, Ashley Sean Lai-Foenander, Sui Kiat Chang, Wai-Leng Lee, Yongjiang Wu, Kooi-Yeong Khaw, Yong Sze Ong, Beng Ti Tey, Sachin Kumar Singh, Kamal Dua, Dinesh Kumar Chellappan & Bey-Hing Goh. (2023) Hydroxychloroquine: Key therapeutic advances and emerging nanotechnological landscape for cancer mitigation. Chemico-Biological Interactions 386, pages 110750.
Crossref
Marco Zeppieri. (2023) Ophthalmologic implications to consider when using hydroxychloroquine to treat COVID-19 and induced arthritis. World Journal of Experimental Medicine 13:4, pages 95-98.
Crossref
Aisvarya Vasu, Radha Anamalai, Gowtham Kim & Muthayya Muthukumar. (2023) Clinical profile of ocular morbidities associated with systemic lupus erythematosus. Indian Journal of Clinical and Experimental Ophthalmology 9:2, pages 135-139.
Crossref
Raul F Membreno, Tharindu De Silva, Elvira Agrón, Tiarnan DL Keenan & Catherine A Cukras. (2023) Quantitative analysis of optical coherence tomography imaging in patients with different severities of hydroxychloroquine toxicity. British Journal of Ophthalmology 107:6, pages 849-855.
Crossref
Barton L Blackorby, Himanshu Banda, Bradley T Smith & Gaurav K Shah. (2023) Macular Findings of Patients on Pentosan Polysulfate Sodium. Military Medicine 188:3-4, pages e579-e583.
Crossref
Akram Sadat Ahmadi, Nazanin Zahra Shafiei-Jandaghi, Kaveh Sadeghi, Mohammadreza Salehi, Talat Mokhtari-Azad & Jila Yavarian. (2022) Sudden onset of decreased vision following Delta variant of SARS-CoV-2 infection: a case report. Future Virology 17:11, pages 801-806.
Crossref
Adrià Molero-Valenzuela, Pere Fontova, Daniel Alonso-Carrillo, Israel Carreira-Barral, Ana Aurora Torres, María García-Valverde, Cristina Benítez-García, Ricardo Pérez-Tomás, Roberto Quesada & Vanessa Soto-Cerrato. (2022) A Novel Late-Stage Autophagy Inhibitor That Efficiently Targets Lysosomes Inducing Potent Cytotoxic and Sensitizing Effects in Lung Cancer. Cancers 14:14, pages 3387.
Crossref
Pooja Dhupkar & Seema Mukherjee. (2021) Ethical dimensions in randomized trials and off-label use of investigational drugs for COVID-19 treatment. Clinical Ethics 17:1, pages 95-104.
Crossref
Nikunjkumar V. Dadhaniya, Isha Sood, Abhishek Patil, Uma Mallaiah, Sundeep Upadhyaya, Rohini Handa & Sirinder J. Gupta. (2021) Screening for Hydroxychloroquine Retinal Toxicity in Indian Patients. JCR: Journal of Clinical Rheumatology 27:8, pages e395-e398.
Crossref
Farnaz Sedigheh Takhsha, Christel Vangestel, Muhammet Tanc, Sven De Bruycker, Maya Berg, Isabel Pintelon, Sigrid Stroobants, Guido R. Y. De Meyer, Pieter Van Der Veken & Wim Martinet. (2021) ATG4B Inhibitor UAMC-2526 Potentiates the Chemotherapeutic Effect of Gemcitabine in a Panc02 Mouse Model of Pancreatic Ductal Adenocarcinoma. Frontiers in Oncology 11.
Crossref
Romain Muller. (2021) Systemic toxicity of chloroquine and hydroxychloroquine: prevalence, mechanisms, risk factors, prognostic and screening possibilities. Rheumatology International 41:7, pages 1189-1202.
Crossref
Zi-Ning Lei, Zhuo-Xun Wu, Shaowei Dong, Dong-Hua Yang, Litu Zhang, Zunfu Ke, Chang Zou & Zhe-Sheng Chen. (2020) Chloroquine and hydroxychloroquine in the treatment of malaria and repurposing in treating COVID-19. Pharmacology & Therapeutics 216, pages 107672.
Crossref
Biljana Stanković, Nikola Kotur, Vladimir Gašić, Kristel Klaassen, Bojan Ristivojević, Maja Stojiljković, Sonja Pavlović & Branka Zukić. (2020) Pharmacogenomics landscape of COVID-19 therapy response in Serbian population and comparison with worldwide populations. Journal of Medical Biochemistry 39:4, pages 488-499.
Crossref
Cynthia Santos & Lewis S. Nelson. 2020. Information Resources in Toxicology. Information Resources in Toxicology 581 584 .
Jie Zhao & Zhefeng Fan. (2019) Using zinc ion-enhanced fluorescence of sulfur quantum dots to improve the detection of the zinc(II)-binding antifungal drug clioquinol. Microchimica Acta 187:1.
Crossref
George A. Kontadakis, Domniki Fragou, Argyro Plaka, Antonio F. Hernández, George D. Kymionis & Aristidis M. Tsatsakis. 2019. Biomarkers in Toxicology. Biomarkers in Toxicology 375 383 .
Brendan F. Boyce, Jinbo Li, Lianping Xing & Zhenqiang Yao. (2018) Bone Remodeling and the Role of TRAF3 in Osteoclastic Bone Resorption. Frontiers in Immunology 9.
Crossref
Domenico Plantone & Tatiana Koudriavtseva. (2018) Current and Future Use of Chloroquine and Hydroxychloroquine in Infectious, Immune, Neoplastic, and Neurological Diseases: A Mini-Review. Clinical Drug Investigation 38:8, pages 653-671.
Crossref
Marit M A de Lange, Laura E V Gijsen, Cornelia C H Wielders, Wim van der Hoek, Arko Scheepmaker & Peter M Schneeberger. (2018) Should Acute Q-Fever Patients be Screened for Valvulopathy to Prevent Endocarditis?. Clinical Infectious Diseases 67:3, pages 360-366.
Crossref
Rosanna Dammacco. (2017) Systemic lupus erythematosus and ocular involvement: an overview. Clinical and Experimental Medicine 18:2, pages 135-149.
Crossref
Ammar Kurdi, Matthias Cleenewerck, Christel Vangestel, Sophie Lyssens, Wim Declercq, Jean-Pierre Timmermans, Sigrid Stroobants, Koen Augustyns, Guido R.Y. De Meyer, Pieter Van Der Veken & Wim Martinet. (2017) ATG4B inhibitors with a benzotropolone core structure block autophagy and augment efficiency of chemotherapy in mice. Biochemical Pharmacology 138, pages 150-162.
Crossref
Yan−Xiang Wang, Zhan−Dong Liu, Chong−Wen Bi, Lu Liu, Hong−Bin Deng & Dan−Qing Song. (2017) How can tricyclic sophoridinic derivatives be used as autophagy inhibitors for cancer treatments?. Future Medicinal Chemistry 9:9, pages 835-837.
Crossref
Cheryl Haskes, Michael Shea & David Imondi. (2017) Minocycline-Induced Scleral and Dermal Hyperpigmentation. Optometry and Vision Science 94:3, pages 436-442.
Crossref
Doo-ri Eo, Min Gyu Lee, Don-Il Ham, Se Woong Kang, Jaejoon Lee, Hoon Suk Cha, Eunmi Koh & Sang Jin Kim. (2017) Frequency and Clinical Characteristics of Hydroxychloroquine Retinopathy in Korean Patients with Rheumatologic Diseases. Journal of Korean Medical Science 32:3, pages 522.
Crossref
Michael J. Tidman & Catherine H. Smith. 2016. Rook's Textbook of Dermatology, Ninth Edition. Rook's Textbook of Dermatology, Ninth Edition 1 51 .
Hui Jen Ding, Alastair K. Denniston, Vijay K. Rao & Caroline Gordon. (2016) Hydroxychloroquine-related retinal toxicity. Rheumatology 55:6, pages 957-967.
Crossref
Sara Capolla, Nelly Mezzaroba, Sonia Zorzet, Claudio Tripodo, Ramiro Mendoza-Maldonado, Marilena Granzotto, Francesca Vita, Ruben Spretz, Gustavo Larsen, Sandra Noriega, Eduardo Mansilla, Michele Dal Bo, Valter Gattei, Gabriele Pozzato, Luis Núñez & Paolo Macor. (2015) A new approach for the treatment of CLL using chlorambucil/hydroxychloroquine-loaded anti-CD20 nanoparticles. Nano Research 9:2, pages 537-548.
Crossref
Paradee Kunavisarut, Pimploy Chavengsaksongkram, Aniki Rothova & Kessara Pathanapitoon. (2016) Screening for chloroquine maculopathy in populations with uncertain reliability in outcomes of automatic visual field testing. Indian Journal of Ophthalmology 64:10, pages 710.
Crossref
Eduardo V. Navajas, Hatem Krema, Dena S. Hammoudi, Jeffrey H. Lipton, E. Rand Simpson, Shelley Boyd & Michael Easterbrook. (2015) Retinal toxicity of high-dose hydroxychloroquine in patients with chronic graft-versus-host disease. Canadian Journal of Ophthalmology 50:6, pages 442-450.
Crossref
Nathalie Costedoat-Chalumeau, Bertrand Dunogué, Gaëlle Leroux, Nathalie Morel, Moez Jallouli, Véronique Le Guern, Jean-Charles Piette, Antoine P. Brézin, Ronald B. Melles & Michael F. Marmor. (2015) A Critical Review of the Effects of Hydroxychloroquine and Chloroquine on the Eye. Clinical Reviews in Allergy & Immunology 49:3, pages 317-326.
Crossref
K. D. Rainsford, Ann L. Parke, Matthew Clifford-Rashotte & W. F. Kean. (2015) Therapy and pharmacological properties of hydroxychloroquine and chloroquine in treatment of systemic lupus erythematosus, rheumatoid arthritis and related diseases. Inflammopharmacology 23:5, pages 231-269.
Crossref
Phillippa M. Cumberland, Isabelle Russell-Eggitt & Jugnoo S. Rahi. (2015) Active surveillance of visual impairment due to adverse drug reactions: findings from a national study in the United Kingdom. Pharmacology Research & Perspectives 3:1, pages e00107.
Crossref
Junyeop LeeJoo Yong Lee. (2015) Hydroxychloroquine Retinopathy. Journal of Rheumatic Diseases 22:3, pages 140.
Crossref
A. Molina-Martín, D. P. Piñero & R. J. Pérez-Cambrodí. (2015) Decreased Perifoveal Sensitivity Detected by Microperimetry in Patients Using Hydroxychloroquine and without Visual Field and Fundoscopic Anomalies. Journal of Ophthalmology 2015, pages 1-4.
Crossref
Stephane Emonet, Timothee Wuillemin, Stephan Harbarth, Nasstasja Wassilew, Mustafa Cikirikcioglu, Jacques Schrenzel, Jean-Christophe Lagier, Didier Raoult & Christian van Delden. (2015) Relapse of Tropheryma whipplei endocarditis treated by trimethoprim/sulfamethoxazole, cured by hydroxychloroquine plus doxycycline. International Journal of Infectious Diseases 30, pages 17-19.
Crossref
Shin C. Beh, Teresa C. Frohman & Elliot M. Frohman. (2014) Neuro-ophthalmic Manifestations of Cerebellar Disease. Neurologic Clinics 32:4, pages 1009-1080.
Crossref
Cornelia Schneider, Miriam Adamcova, Susan S. Jick, Patricia Schlagenhauf, Mary K. Miller, Hans-Georg Rhein & Christoph R. Meier. (2014) Use of anti-malarial drugs and the risk of developing eye disorders. Travel Medicine and Infectious Disease 12:1, pages 40-47.
Crossref
George A. Kontadakis, Argyro Plaka, Domniki Fragou, George D. Kymionis & Aristides M. Tsatsakis. 2014. Biomarkers in Toxicology. Biomarkers in Toxicology 317 324 .
David J. BrowningDavid J. Browning. 2014. Hydroxychloroquine and Chloroquine Retinopathy. Hydroxychloroquine and Chloroquine Retinopathy 155 226 .
David J. BrowningDavid J. Browning. 2014. Hydroxychloroquine and Chloroquine Retinopathy. Hydroxychloroquine and Chloroquine Retinopathy 133 154 .
David J. BrowningDavid J. Browning. 2014. Hydroxychloroquine and Chloroquine Retinopathy. Hydroxychloroquine and Chloroquine Retinopathy 107 131 .
David J. BrowningDavid J. Browning. 2014. Hydroxychloroquine and Chloroquine Retinopathy. Hydroxychloroquine and Chloroquine Retinopathy 35 63 .
Chun Lei Li, Jing He, Zhan Guo Li, Li Wu Zheng & Hong Hua. (2013) Effects of total glucosides of paeony for delaying onset of Sjogren's syndrome: An animal study. Journal of Cranio-Maxillofacial Surgery 41:7, pages 610-615.
Crossref
Lucía Martínez-Costa, María Victoria Ibañez, Cinta Murcia-Bello, Irene Epifanio, Cristina Verdejo-Gimeno, Emma Beltrán-Catalán & Pilar Marco-Ventura. (2013) Use of microperimetry to evaluate hydroxychloroquine and chloroquine retinal toxicity. Canadian Journal of Ophthalmology 48:5, pages 400-405.
Crossref
Nelly Mezzaroba, Sonia Zorzet, Erika Secco, Stefania Biffi, Claudio Tripodo, Marco Calvaruso, Ramiro Mendoza-Maldonado, Sara Capolla, Marilena Granzotto, Ruben Spretz, Gustavo Larsen, Sandra Noriega, Marianna Lucafò, Eduardo Mansilla, Chiara Garrovo, Gustavo H. Marín, Gabriele Baj, Valter Gattei, Gabriele Pozzato, Luis Núñez & Paolo Macor. (2013) New Potential Therapeutic Approach for the Treatment of B-Cell Malignancies Using Chlorambucil/Hydroxychloroquine-Loaded Anti-CD20 Nanoparticles. PLoS ONE 8:9, pages e74216.
Crossref
Ingrid Rabach, Furio Poli, Floriana Zennaro, Claudio Germani, Alessandro Ventura & Egidio Barbi. (2013) ¿Es eficaz el tratamiento con hidroxicloroquina en el déficit de proteína C surfactante?. Archivos de Bronconeumología 49:5, pages 213-215.
Crossref
Ingrid Rabach, Furio Poli, Floriana Zennaro, Claudio Germani, Alessandro Ventura & Egidio Barbi. (2013) Is Treatment With Hydroxychloroquine Effective in Surfactant Protein C Deficiency?. Archivos de Bronconeumología (English Edition) 49:5, pages 213-215.
Crossref
Z. Wang, J. Zhang, Y. Wang, R. Xing, C. Yi, H. Zhu, X. Chen, J. Guo, W. Guo, W. Li, L. Wu, Y. Lu & S. Liu. (2012) Matrine, a novel autophagy inhibitor, blocks trafficking and the proteolytic activation of lysosomal proteases. Carcinogenesis 34:1, pages 128-138.
Crossref
Didier Bessis. 2013. Lupus érythémateux. Lupus érythémateux 241 245 .
Leandro Teixeira & Richard R. Dubielzig. 2013. Haschek and Rousseaux's Handbook of Toxicologic Pathology. Haschek and Rousseaux's Handbook of Toxicologic Pathology 2095 2185 .
Zhiwei Huang, Sankaranarayanan Srinivasan, Jianhuai Zhang, Kaifu Chen, Yongxiang Li, Wei Li, Florante A. Quiocho & Xuewen Pan. (2012) Discovering Thiamine Transporters as Targets of Chloroquine Using a Novel Functional Genomics Strategy. PLoS Genetics 8:11, pages e1003083.
Crossref
C. Tang, T. Godfrey, R. Stawell & M. Nikpour. (2012) Hydroxychloroquine in lupus: emerging evidence supporting multiple beneficial effects. Internal Medicine Journal 42:9, pages 968-978.
Crossref
Ilan Ben-Zvi, Shaye Kivity, Pnina Langevitz & Yehuda Shoenfeld. (2011) Hydroxychloroquine: From Malaria to Autoimmunity. Clinical Reviews in Allergy & Immunology 42:2, pages 145-153.
Crossref
Jonathan B. Kahn, Ilyse D. Haberman & Shantan Reddy. (2011) Spectral-Domain Optical Coherence Tomography as a Screening Technique for Chloroquine and Hydroxychloroquine Retinal Toxicity. Ophthalmic Surgery, Lasers and Imaging Retina 42:6, pages 493-497.
Crossref
Gabriela Schmajuk & Jinoos Yazdany. (2011) Drug Monitoring in Systemic Lupus Erythematosus: A Systematic Review. Seminars in Arthritis and Rheumatism 40:6, pages 559-575.
Crossref
Steven J Katz & Anthony S Russell. (2011) Re-evaluation of antimalarials in treating rheumatic diseases: re-appreciation and insights into new mechanisms of action. Current Opinion in Rheumatology 23:3, pages 278-281.
Crossref
Jennifer S. Carew, Claudia M. Espitia, Juan A. EsquivelIIII, Devalingam Mahalingam, Kevin R. Kelly, Guru Reddy, Francis J. Giles & Steffan T. Nawrocki. (2011) Lucanthone Is a Novel Inhibitor of Autophagy That Induces Cathepsin D-mediated Apoptosis. Journal of Biological Chemistry 286:8, pages 6602-6613.
Crossref
Naoto Yokogawa. (2011) 10. Hydroxychloroquine10．ヒドロキシクロロキン. Nihon Naika Gakkai Zasshi 100:10, pages 2960-2965.
Crossref
Edward Pringle & Miles Stanford. 2011. Autoimmune Diseases. Autoimmune Diseases 291 313 .
A. KuhnF. Ochsendorf & G. Bonsmann. (2010) Treatment of cutaneous lupus erythematosus. Lupus 19:9, pages 1125-1136.
Crossref
Robert A. EttlinJunji KurodaStephanie PlassmannMakoto HayashiDavid E. Prentice. (2010) Successful Drug Development Despite Adverse Preclinical Findings Part 2: Examples. Journal of Toxicologic Pathology 23:4, pages 213-234.
Crossref
Anne Chiffoleau, Aurélie Guillet, Xavier Zanlonghi & Pascale Jolliet. (2009) La rétinopathie liée aux antipaludéens de synthèse reste une menace d’actualité. La Presse Médicale 38:4, pages 662-663.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.