854
Views
140
CrossRef citations to date
0
Altmetric
Research Article

FUNCTIONS AND MECHANISMS OF ACTION OF THE ADENOVIRUS E3 PROTEINS

, , , &
Pages 75-111 | Published online: 03 Aug 2009

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (4)

Shao-Chia Lu & Michael A Barry. (2022) Locked and loaded: engineering and arming oncolytic adenoviruses to enhance anti-tumor immune responses. Expert Opinion on Biological Therapy 22:11, pages 1359-1378.
Read now
Eric G Romanowski. (2013) Is there an anti-adenoviral drug on the horizon?. Expert Review of Ophthalmology 8:5, pages 427-435.
Read now
Shruthi Naik & Stephen J Russell. (2009) Engineering oncolytic viruses to exploit tumor specific defects in innate immune signaling pathways. Expert Opinion on Biological Therapy 9:9, pages 1163-1176.
Read now

Articles from other publishers (136)

Aleksi J. Leikas, Seppo Ylä-Herttuala & Juha E. K. Hartikainen. (2023) Adenoviral Gene Therapy Vectors in Clinical Use—Basic Aspects with a Special Reference to Replication-Competent Adenovirus Formation and Its Impact on Clinical Safety. International Journal of Molecular Sciences 24:22, pages 16519.
Crossref
Erwan Sallard, Lukas Schulte, Alexander van den Boom, Alexander Klimovitskii, Julius Knierer, Claudia Hagedorn, Maximilian Knocks, Wenli Zhang, Florian Kreppel, Anja Ehrhardt & Eric Ehrke‐Schulz. (2023) Development of oncolytic and gene therapy vectors based on adenovirus serotype 4 as an alternative to adenovirus serotype 5. The Journal of Gene Medicine.
Crossref
Geetha Jagannathan, Astrid Weins, Emily Daniel, Russel J. Crew, Sidney J. Swanson, Glen S. Markowitz, Vivette D. D’Agati, Nicole K. Andeen, Helmut G. Rennke & Ibrahim Batal. (2023) The pathologic spectrum of adenovirus nephritis in the kidney allograft. Kidney International 103:2, pages 378-390.
Crossref
Paola Blanchette & Jose G. Teodoro. (2023) A Renaissance for Oncolytic Adenoviruses?. Viruses 15:2, pages 358.
Crossref
Gustavo Saint-Pierre Contreras, Daniel Conei Valencia, Luis Lizama, Daniela Vargas Zuñiga, Luis Fidel Avendaño Carvajal & Sandra Ampuero Llanos. (2023) An Old Acquaintance: Could Adenoviruses Be Our Next Pandemic Threat?. Viruses 15:2, pages 330.
Crossref
Jasper Götting, Claas Baier, Victoria Panagiota, Britta Maecker-Kolhoff, Akshay Dhingra & Albert Heim. (2022) High genetic stability of co-circulating human adenovirus type 31 lineages over 59 years. Virus Evolution 8:2.
Crossref
Christine J. Chang, Luzmariel Medina Sanchez, Aditya Vageesh, Alexandra J. Popkov, Adithya Chandrasekaran, Bethany B. Moore & Jason B. Weinberg. (2022) Mouse Adenovirus Type 1 Persistence Exacerbates Inflammation Induced by Allogeneic Bone Marrow Transplantation. Journal of Virology 96:6.
Crossref
Camden R. Bair, Wei Zhang, Gabriel Gonzalez, Arash Kamali, Daniel Stylos, Jorge C. G. Blanco & Adriana E. Kajon. (2022) Human Adenovirus Type 4 Comprises Two Major Phylogroups with Distinct Replicative Fitness and Virulence Phenotypes. Journal of Virology 96:5.
Crossref
Selas T.F. Bots, Vera Kemp, Steve J. Cramer, Diana J.M. van den Wollenberg, Marten Hornsveld, Martine L.M. LamfersGabri van der Pluijm & Rob C. Hoeben. (2022) Nonhuman Primate Adenoviruses of the Human Adenovirus B Species Are Potent and Broadly Acting Oncolytic Vector Candidates. Human Gene Therapy 33:5-6, pages 275-289.
Crossref
Paloma Hidalgo & Ramón A. González. 2022. Encyclopedia of Infection and Immunity. Encyclopedia of Infection and Immunity 59 66 .
Joyce Odeke Akello, Richard Kamgang, Maria Teresa Barbani, Franziska Suter-Riniker, Christoph Aebi, Christian Beuret, Daniel H. Paris, Stephen L. Leib & Alban Ramette. (2021) Genomic analyses of human adenoviruses unravel novel recombinant genotypes associated with severe infections in pediatric patients. Scientific Reports 11:1.
Crossref
Karoly Toth, Ann E. Tollefson, G. Chinnadurai, Clifford J. Bellone, Duane P. Grandgenett, Lynda A. Morrison & John E. Tavis. (2021) Biographical Feature: William S. M. Wold, Ph.D., 1944–2021. Journal of Virology 95:22.
Crossref
E. V. Melnikova, O. A. Rachinskaya & V. A. Merkulov. (2021) Advanced Therapy Medicines Based on Oncolytic Viruses (Part I: Development and Authorisation of Products in China). The Bulletin of the Scientific Centre for Expert Evaluation of Medicinal Products 11:3, pages 148-159.
Crossref
Vibhu Prasad & Urs F Greber. (2021) The endoplasmic reticulum unfolded protein response – homeostasis, cell death and evolution in virus infections. FEMS Microbiology Reviews 45:5.
Crossref
Ryan G. Clarkin, Joshua Del Papa, Kathy L. Poulin & Robin J. Parks. (2021) The genome position of a therapeutic transgene strongly influences the level of expression in an armed oncolytic human adenovirus vector. Virology 561, pages 87-97.
Crossref
Vardan Andriasyan, Artur Yakimovich, Anthony Petkidis, Fanny Georgi, Robert Witte, Daniel Puntener & Urs F. Greber. (2021) Microscopy deep learning predicts virus infections and reveals mechanics of lytic-infected cells. iScience 24:6, pages 102543.
Crossref
P. Raja, V. Sachin, M. Parthiban & P. Aishwarya Janaki. (2021) Molecular characterization of canine adenovirus type 2 in dogs from India. VirusDisease 32:2, pages 369-374.
Crossref
Ivana Strazic Geljic, Paola Kucan Brlic, Lucija Musak, Dubravka Karner, Andreja Ambriović-Ristov, Stipan Jonjic, Peter Schu & Tihana Lenac Rovis. (2021) Viral Interactions with Adaptor-Protein Complexes: A Ubiquitous Trait among Viral Species. International Journal of Molecular Sciences 22:10, pages 5274.
Crossref
Jerome Custers, Denny Kim, Maarten Leyssen, Marc Gurwith, Frank Tomaka, James Robertson, Esther Heijnen, Richard Condit, Georgi Shukarev, Dirk Heerwegh, Roy van Heesbeen, Hanneke Schuitemaker, Macaya Douoguih, Eric Evans, Emily R. Smith & Robert T. Chen. (2021) Vaccines based on replication incompetent Ad26 viral vectors: Standardized template with key considerations for a risk/benefit assessment. Vaccine 39:22, pages 3081-3101.
Crossref
Mackenzie J. Dodge, Katelyn M. MacNeil, Tanner M. Tessier, Jason B. Weinberg & Joe S. Mymryk. (2021) Emerging antiviral therapeutics for human adenovirus infection: Recent developments and novel strategies. Antiviral Research 188, pages 105034.
Crossref
Kenta Matsuda, Stephen A. Migueles, Jinghe Huang, Lyuba Bolkhovitinov, Sarah Stuccio, Trevor Griesman, Alyssa A. Pullano, Byong H Kang, Elise Ishida, Matthew Zimmerman, Neena Kashyap, Kelly M. Martins, Daniel Stadlbauer, Jessica Pederson, Andy Patamawenu, Nathaniel Wright, Tulley Shofner, Sean Evans, C. Jason Liang, Julián Candia, Angelique Biancotto, Giovanna Fantoni, April Poole, Jon Smith, Jeff Alexander, Marc Gurwith, Florian Krammer & Mark Connors. (2021) A replication-competent adenovirus-vectored influenza vaccine induces durable systemic and mucosal immunity. Journal of Clinical Investigation 131:5.
Crossref
Iga Dalidowska, Olga Gazi, Dorota Sulejczak, Maciej Przybylski & Pawel Bieganowski. (2021) Heat Shock Protein 90 Chaperones E1A Early Protein of Adenovirus 5 and Is Essential for Replication of the Virus. International Journal of Molecular Sciences 22:4, pages 2020.
Crossref
Jida Liu & Dai-Wu Seol. (2020) Helper virus-free gutless adenovirus (HF-GLAd): a new platform for gene therapy. BMB Reports 53:11, pages 565-575.
Crossref
David S Kim. (2020) Cancer stem cell plasticity in glioblastoma multiforme: a perspective on future directions in oncolytic virotherapy. Future Oncology 16:28, pages 2251-2264.
Crossref
Urs F. Greber. (2020) Adenoviruses – Infection, pathogenesis and therapy. FEBS Letters 594:12, pages 1818-1827.
Crossref
Fanny Georgi & Urs F. Greber. (2020) The Adenovirus Death Protein – a small membrane protein controls cell lysis and disease. FEBS Letters 594:12, pages 1861-1878.
Crossref
Vibhu Prasad, Maarit Suomalainen, Yllza Jasiqi, Silvio Hemmi, Patrick Hearing, Louise Hosie, Hans-Gerhard Burgert & Urs F. Greber. (2020) The UPR sensor IRE1α and the adenovirus E3-19K glycoprotein sustain persistent and lytic infections. Nature Communications 11:1.
Crossref
I’ah Donovan-Banfield, Andrew S. Turnell, Julian A. Hiscox, Keith N. Leppard & David A. Matthews. (2020) Deep splicing plasticity of the human adenovirus type 5 transcriptome drives virus evolution. Communications Biology 3:1.
Crossref
Mingliang Zhao, Xueyan Duan, Yongqiang Wang, Li Gao, Hong Cao, Xiaoqi Li & Shijun J. Zheng. (2020) A Novel Role for PX, a Structural Protein of Fowl Adenovirus Serotype 4 (FAdV4), as an Apoptosis-Inducer in Leghorn Male Hepatocellular Cell. Viruses 12:2, pages 228.
Crossref
Gabriel Gonzalez, Camden R. Bair, Daryl M. Lamson, Hidemi Watanabe, Laura Panto, Michael J. Carr & Adriana E. Kajon. (2019) Genomic characterization of human adenovirus type 4 strains isolated worldwide since 1953 identifies two separable phylogroups evolving at different rates from their most recent common ancestor. Virology 538, pages 11-23.
Crossref
Edson R. A. Oliveira & Marlene Bouvier. (2019) Immune evasion by adenoviruses: a window into host–virus adaptation. FEBS Letters 593:24, pages 3496-3503.
Crossref
Xuehuo Zeng & Cathleen R. Carlin. (2019) Adenovirus early region 3 RIDα protein limits NFκB signaling through stress-activated EGF receptors. PLOS Pathogens 15:8, pages e1008017.
Crossref
William S M Wold, Ann E Tollefson, Baoling Ying, Jacqueline F Spencer & Karoly Toth. (2019) Drug development against human adenoviruses and its advancement by Syrian hamster models. FEMS Microbiology Reviews 43:4, pages 380-388.
Crossref
Kathya Gutiérrez-Huante, Roberta Salinas-Marín, Héctor M Mora-Montes, Ramón A Gonzalez & Iván Martínez-Duncker. (2019) Human adenovirus type 5 increases host cell fucosylation and modifies Ley antigen expression. Glycobiology 29:6, pages 469-478.
Crossref
Ana Angulo, Marta Cuenca, Pablo Martínez-Vicente & Pablo Engel. (2019) Viral CD229 (Ly9) homologs as new manipulators of host immunity. Journal of Leukocyte Biology 105:5, pages 947-954.
Crossref
Jing Zhang, June Kang, Shoaleh Dehghan, Siddharth Sridhar, Susanna Lau, Junxian Ou, Patrick Woo, Qiwei Zhang & Donald Seto. (2019) A Survey of Recent Adenoviral Respiratory Pathogens in Hong Kong Reveals Emergent and Recombinant Human Adenovirus Type 4 (HAdV-E4) Circulating in Civilian Populations. Viruses 11:2, pages 129.
Crossref
Akshay Dhingra, Elias Hage, Tina Ganzenmueller, Sindy Böttcher, Jörg Hofmann, Klaus Hamprecht, Patrick Obermeier, Barbara Rath, Fabian Hausmann, Thomas Dobner & Albert Heim. (2019) Molecular Evolution of Human Adenovirus (HAdV) Species C. Scientific Reports 9:1.
Crossref
Siwen Li, Yu Wang, Hongjing Zhao, Yizhi Shao, Juanjuan Liu & Mingwei Xing. (2019) Characterization, functional and signaling elucidation of pigeon (Columba livia) interferon-α: Knockdown p53 negatively modulates antiviral response. Developmental & Comparative Immunology 90, pages 29-40.
Crossref
Rajesh Kumar, Aakansha Tiwari, Garima Pandey, Raj Narayan Trivedi, Amir Showkat Khan & Mumtesh Kumar Saxena. 2019. Viral Polymerases. Viral Polymerases 429 455 .
A.E. Kajon, J.B. Weinberg & K.R. Spindler. 2019. Reference Module in Biomedical Sciences. Reference Module in Biomedical Sciences.
Abdelrahman Said, Tekeleselassie A. Woldemariam & Suresh K. Tikoo. (2018) Porcine Adenovirus Type 3 E3 Encodes a Structural Protein Essential for Capsid Stability and Production of Infectious Progeny Virions. Journal of Virology 92:20.
Crossref
Ashrafali M. Ismail, Ji Sun Lee, Jeong Yoon Lee, Gurdeep Singh, David W. Dyer, Donald Seto, James Chodosh & Jaya Rajaiya. (2018) Adenoviromics: Mining the Human Adenovirus Species D Genome. Frontiers in Microbiology 9.
Crossref
Aleksei A. Stepanenko & Vladimir P. Chekhonin. (2018) A compendium of adenovirus genetic modifications for enhanced replication, oncolysis, and tumor immunosurveillance in cancer therapy. Gene.
Crossref
Cason R. King, Ali Zhang, Tanner M. Tessier, Steven F. Gameiro & Joe S. Mymryk. (2018) Hacking the Cell: Network Intrusion and Exploitation by Adenovirus E1A. mBio 9:3.
Crossref
Camden R. Bair, Poornima Kotha Lakshmi Narayan & Adriana E. Kajon. (2017) The tripartite leader sequence is required for ectopic expression of HAdV-B and HAdV-E E3 CR1 genes. Virology 505, pages 139-147.
Crossref
Oladunni Olanubi, Jasmine Rae Frost, Sandi Radko & Peter Pelka. (2017) Suppression of Type I Interferon Signaling by E1A via RuvBL1/Pontin. Journal of Virology 91:8.
Crossref
Douglas D. Richman, Richard J. Whitley & Frederick J. HaydenOlli Ruuskanen, Jordan P. Metcalf, Matti Waris & Göran Akusjärvi. 2016. Clinical Virology. Clinical Virology 575 597 .
Larissa H. Haut, Amanda L. GillRaj K. Kurupati, Ang Bian, Yan Li, Wynetta Giles-Davis, Zhiquan Xiang, Xiang Yang Zhou & Hildegund C. J. Ertl. (2016) A Partial E3 Deletion in Replication-Defective Adenoviral Vectors Allows for Stable Expression of Potentially Toxic Transgene Products . Human Gene Therapy Methods 27:5, pages 187-196.
Crossref
Jessica Miciak & Fred Bunz. (2016) Long story short: p53 mediates innate immunity. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 1865:2, pages 220-227.
Crossref
Tien V Nguyen, Greg J Heller, Mary E Barry, Catherine M Crosby, Mallory A Turner & Michael A Barry. (2016) Evaluation of polymer shielding for adenovirus serotype 6 (Ad6) for systemic virotherapy against human prostate cancers. Molecular Therapy - Oncolytics 3, pages 15021.
Crossref
Diana Guimet & Patrick Hearing. 2016. Adenoviral Vectors for Gene Therapy. Adenoviral Vectors for Gene Therapy 59 84 .
Susanne Matthes-Martin. 2016. Transplant Infections. Transplant Infections 609 621 .
Mallory A. Turner, Sumit Middha, Sean E. Hofherr & Michael A. Barry. (2015) Comparison of the Life Cycles of Genetically Distant Species C and Species D Human Adenoviruses Ad6 and Ad26 in Human Cells. Journal of Virology 89:24, pages 12401-12417.
Crossref
Patrick Arbuthnot. 2015. Gene Therapy for Viral Infections. Gene Therapy for Viral Infections 95 126 .
Thomas Lion. (2014) Adenovirus Infections in Immunocompetent and Immunocompromised Patients. Clinical Microbiology Reviews 27:3, pages 441-462.
Crossref
Ingrid Wernstedt Asterholm, Caroline Tao, Thomas S. Morley, Qiong A. Wang, Fernando Delgado-Lopez, Zhao V. Wang & Philipp E. Scherer. (2014) Adipocyte Inflammation Is Essential for Healthy Adipose Tissue Expansion and Remodeling. Cell Metabolism 20:1, pages 103-118.
Crossref
Rodinde HendrickxNicole StichlingJorien KoelenLukasz KurykAgnieszka LipiecUrs F. Greber. (2014) Innate Immunity to Adenovirus. Human Gene Therapy 25:4, pages 265-284.
Crossref
Emma Spurrell, Rathi Gangeswaran, Pengju Wang, Fengyu Cao, Dongling Gao, Baisui Feng, William Wold, Ann Tollefson, Nicholas R. Lemoine & Yaohe Wang. (2014) STAT1 Interaction with E3-14.7K in Monocytes Affects the Efficacy of Oncolytic Adenovirus. Journal of Virology 88:4, pages 2291-2300.
Crossref
Gurdeep Singh, Christopher M. Robinson, Shoaleh Dehghan, Morris S. Jones, David W. Dyer, Donald Seto & James Chodosh. (2013) Homologous Recombination in E3 Genes of Human Adenovirus Species D. Journal of Virology 87:22, pages 12481-12488.
Crossref
Barbara Cervasi, Diane G. Carnathan, Katherine M. Sheehan, Luca Micci, Mirko Paiardini, Raj Kurupati, Steven Tuyishime, Xiang Yang Zhou, James G. Else, Sarah J. Ratcliffe, Hildegund C. J. Ertl & Guido Silvestri. (2013) Immunological and Virological Analyses of Rhesus Macaques Immunized with Chimpanzee Adenoviruses Expressing the Simian Immunodeficiency Virus Gag/Tat Fusion Protein and Challenged Intrarectally with Repeated Low Doses of SIVmac. Journal of Virology 87:17, pages 9420-9430.
Crossref
B A Young, J F Spencer, B Ying, K Toth & W S M Wold. (2013) The effects of radiation on antitumor efficacy of an oncolytic adenovirus vector in the Syrian hamster model. Cancer Gene Therapy 20:9, pages 531-537.
Crossref
B A Young, J F Spencer, B Ying, A E Tollefson, K Toth & W S M Wold. (2013) The role of cyclophosphamide in enhancing antitumor efficacy of an adenovirus oncolytic vector in subcutaneous Syrian hamster tumors. Cancer Gene Therapy 20:9, pages 521-530.
Crossref
Diana Guimet & Patrick Hearing. (2013) The Adenovirus L4-22K Protein Has Distinct Functions in the Posttranscriptional Regulation of Gene Expression and Encapsidation of the Viral Genome. Journal of Virology 87:13, pages 7688-7699.
Crossref
Julia Davydova & Masato Yamamoto. (2013) Oncolytic Adenoviruses: Design, Generation, and Experimental Procedures. Current Protocols in Human Genetics 78:1.
Crossref
Jingzhou Hu, Yue He, Ming Yan, Chao Zhu, Weimin Ye, Hanguang Zhu, Wantao Chen, Chenping Zhang & Zhiyuan Zhang. (2013) Dose Dependent Activation of Retinoic Acid-Inducible Gene-I Promotes Both Proliferation and Apoptosis Signals in Human Head and Neck Squamous Cell Carcinoma. PLoS ONE 8:3, pages e58273.
Crossref
Jyoti Jaggernath, Dominic Haslam & Kovin S. Naidoo. (2013) Climate change: Impact of increased ultraviolet radiation and water changes on eye health. Health 05:05, pages 921-930.
Crossref
Kathryn M Frietze, Samuel K Campos & Adriana E Kajon. (2012) No evidence of a death-like function for species B1 human adenovirus type 3 E3-9K during A549 cell line infection. BMC Research Notes 5:1.
Crossref
Artur Yakimovich, Heidi Gumpert, Christoph J. Burckhardt, Verena A. Lütschg, Andreas Jurgeit, Ivo F. Sbalzarini & Urs F. Greber. (2012) Cell-Free Transmission of Human Adenovirus by Passive Mass Transfer in Cell Culture Simulated in a Computer Model. Journal of Virology 86:18, pages 10123-10137.
Crossref
Changyu ZhengAna P. CotrimNikolay NikolovFumi MineshibaWilliam SwaimBruce J. Baum. (2012) A Novel Hybrid Adenoretroviral Vector with More Extensive E3 Deletion Extends Transgene Expression in Submandibular Glands. Human Gene Therapy Methods 23:3, pages 169-181.
Crossref
Seetharaman Usha, Vairamani Abinaya, Shunmugham Loghambal & Lakshmanan Rajendran. (2012) Non-Linear Mathematical Model of the Interaction between Tumor and Oncolytic Viruses. Applied Mathematics 03:09, pages 1089-1096.
Crossref
Vincenzo Cerullo, Anniina Koski, Markus Vähä-Koskela & Akseli Hemminki. 2012. Applications of viruses for cancer therapy. Applications of viruses for cancer therapy 265 318 .
Vu Thuy Khanh Le, Mirko Trilling & Hartmut Hengel. (2011) The Cytomegaloviral Protein pUL138 Acts as Potentiator of Tumor Necrosis Factor (TNF) Receptor 1 Surface Density To Enhance UL b ′-Encoded Modulation of TNF-α Signaling . Journal of Virology 85:24, pages 13260-13270.
Crossref
Matthias W. Kron, Tatjana Engler, Erika Schmidt, Reinhold Schirmbeck, Stefan Kochanek & Florian Kreppel. (2011) High‐capacity adenoviral vectors circumvent the limitations of ΔE1 and ΔE1/ΔE3 adenovirus vectors to induce multispecific transgene product‐directed CD8 T‐cell responses. The Journal of Gene Medicine 13:12, pages 648-657.
Crossref
Vladimir Tchikov, Uwe Bertsch, Jürgen Fritsch, Bärbel Edelmann & Stefan Schütze. (2011) Subcellular compartmentalization of TNF receptor-1 and CD95 signaling pathways. European Journal of Cell Biology 90:6-7, pages 467-475.
Crossref
Amita Joshi, Biwei Zhao, Cara Romanowski, David Rosen & Phyllis Flomenberg. (2011) Comparison of Human Memory CD8 T Cell Responses to Adenoviral Early and Late Proteins in Peripheral Blood and Lymphoid Tissue. PLoS ONE 6:5, pages e20068.
Crossref
R M Eager & J Nemunaitis. (2011) Clinical development directions in oncolytic viral therapy. Cancer Gene Therapy 18:5, pages 305-317.
Crossref
Jerome Schaack, Michael L. Bennett, Gary S. Shapiro, James DeGregori, James L. McManaman & John W. Moorhead. (2011) Strong foreign promoters contribute to innate inflammatory responses induced by adenovirus transducing vectors. Virology 412:1, pages 28-35.
Crossref
Jerome Schaack, Liping Qiao, Marcin P. Walkiewicz, Martin Stonehouse, Daniel A. Engel, Andres Vazquez-Torres, Steven K. Nordeen, Jianhua Shao & John W. Moorhead. (2011) Insertion of CTCF-binding sites into a first-generation adenovirus vector reduces the innate inflammatory response and prolongs transgene expression. Virology 412:1, pages 136-145.
Crossref
Anon SrikiatkhachornJyothi ChintapalliJun LiuMohammad JamaluddinKevin S. HarrodJeffrey A. WhitsettRichard I. EnelowChilakamarti V. Ramana. (2010) Interference with Intraepithelial TNF-α Signaling Inhibits CD8 + T-Cell-Mediated Lung Injury in Influenza Infection . Viral Immunology 23:6, pages 639-645.
Crossref
T Cherry, S L Longo, Z Tovar-Spinoza & D E Post. (2010) Second-generation HIF-activated oncolytic adenoviruses with improved replication, oncolytic, and antitumor efficacy. Gene Therapy 17:12, pages 1430-1441.
Crossref
Baoling Ying, Ann E. Tollefson & William S. M. Wold. (2010) Identification of a Previously Unrecognized Promoter That Drives Expression of the UXP Transcription Unit in the Human Adenovirus Type 5 Genome. Journal of Virology 84:21, pages 11470-11478.
Crossref
Kathryn M. Frietze, Samuel K. Campos & Adriana E. Kajon. (2010) Open Reading Frame E3-10.9K of Subspecies B1 Human Adenoviruses Encodes a Family of Late Orthologous Proteins That Vary in Their Predicted Structural Features and Subcellular Localization. Journal of Virology 84:21, pages 11310-11322.
Crossref
K Toth, M Kuppuswamy, E V Shashkova, J F Spencer & W S M Wold. (2010) A fully replication-competent adenovirus vector with enhanced oncolytic properties. Cancer Gene Therapy 17:11, pages 761-770.
Crossref
Felipe Andrade. (2010) Non-cytotoxic antiviral activities of granzymes in the context of the immune antiviral state. Immunological Reviews 235:1, pages 128-146.
Crossref
Rachmat Hidajat, Seraphin Kuate, David Venzon, Vaniambadi Kalyanaraman, Irene Kalisz, James Treece, Ying Lian, Susan W. Barnett & Marjorie Robert-Guroff. (2010) Construction and immunogenicity of replication-competent adenovirus 5 host range mutant recombinants expressing HIV-1 gp160 of SF162 and TV1 strains. Vaccine 28:23, pages 3963-3971.
Crossref
Yan Li, Xingyi Ge, Huajun Zhang, Peng Zhou, Yan Zhu, Yunzhi Zhang, Junfa Yuan, Lin-Fa Wang & Zhengli Shi. (2010) Host Range, Prevalence, and Genetic Diversity of Adenoviruses in Bats. Journal of Virology 84:8, pages 3889-3897.
Crossref
John Nemunaitis, Alex W Tong, Michael Nemunaitis, Neil Senzer, Anagha P Phadke, Cynthia Bedell, Ned Adams, Yu-An Zhang, Phillip B Maples, Salina Chen, Beena Pappen, James Burke, Daiju Ichimaru, Yasuo Urata & Toshiyoshi Fujiwara. (2010) A Phase I Study of Telomerase-specific Replication Competent Oncolytic Adenovirus (Telomelysin) for Various Solid Tumors. Molecular Therapy 18:2, pages 429-434.
Crossref
Martina Sester, Katja Koebernick, Douglas Owen, Minghui Ao, Yana Bromberg, Ed May, Emily Stock, Lawrence Andrews, Veronika Groh, Thomas Spies, Alexander Steinle, Beatrice Menz & Hans-Gerhard Burgert. (2010) Conserved Amino Acids within the Adenovirus 2 E3/19K Protein Differentially Affect Downregulation of MHC Class I and MICA/B Proteins. The Journal of Immunology 184:1, pages 255-267.
Crossref
Shin-ichi Yokota, Tamaki Okabayashi & Nobuhiro Fujii. (2010) The Battle between Virus and Host: Modulation of Toll-Like Receptor Signaling Pathways by Virus Infection. Mediators of Inflammation 2010, pages 1-12.
Crossref
Vera L. Tarakanova & William S.M. Wold. (2010) Adenovirus E1A and E1B-19K proteins protect human hepatoma cells from transforming growth factor β1-induced apoptosis. Virus Research 147:1, pages 67-76.
Crossref
Debanjan Dhar, Jacqueline F Spencer, Karoly Toth & William SM Wold. (2009) Pre-existing Immunity and Passive Immunity to Adenovirus 5 Prevents Toxicity Caused by an Oncolytic Adenovirus Vector in the Syrian Hamster Model. Molecular Therapy 17:10, pages 1724-1732.
Crossref
AM Young & Iain A McNeish. (2009) Oncolytic adenoviral gene therapy in ovarian cancer: why we are not wasting our time. Future Oncology 5:3, pages 339-357.
Crossref
C. T. Garnett, G. Talekar, J. A. Mahr, W. Huang, Y. Zhang, D. A. Ornelles & L. R. Gooding. (2009) Latent Species C Adenoviruses in Human Tonsil Tissues. Journal of Virology 83:6, pages 2417-2428.
Crossref
Debanjan Dhar, Jacqueline F. Spencer, Karoly Toth & William S. M. Wold. (2009) Effect of Preexisting Immunity on Oncolytic Adenovirus Vector INGN 007 Antitumor Efficacy in Immunocompetent and Immunosuppressed Syrian Hamsters. Journal of Virology 83:5, pages 2130-2139.
Crossref
A. Joshi, J. Tang, M. Kuzma, J. Wagner, B. Mookerjee, J. Filicko, M. Carabasi, N. Flomenberg & P. Flomenberg. (2009) Adenovirus DNA polymerase is recognized by human CD8+ T cells. Journal of General Virology 90:1, pages 84-94.
Crossref
Dawn E. Post & Erwin G. Van Meir. 2009. CNS Cancer. CNS Cancer 1137 1164 .
Stefan Schütze & Wulf Schneider-Brachert. 2009. Death Receptors and Cognate Ligands in Cancer. Death Receptors and Cognate Ligands in Cancer 63 85 .
John R. Šedý, Patricia G. Spear & Carl F. Ware. (2008) Cross-regulation between herpesviruses and the TNF superfamily members. Nature Reviews Immunology 8:11, pages 861-873.
Crossref
Beatrice Menz, Martina Sester, Katja Koebernick, Ralf Schmid & Hans-Gerhard Burgert. (2008) Structural analysis of the adenovirus type 2 E3/19K protein using mutagenesis and a panel of conformation-sensitive monoclonal antibodies. Molecular Immunology 46:1, pages 16-26.
Crossref
Marcela Echavarría. (2008) Adenoviruses in Immunocompromised Hosts. Clinical Microbiology Reviews 21:4, pages 704-715.
Crossref
Maria A Thomas, Jacqueline F Spencer, Karoly Toth, John E Sagartz, Nancy J Phillips & William SM Wold. (2008) Immunosuppression Enhances Oncolytic Adenovirus Replication and Antitumor Efficacy in the Syrian Hamster Model. Molecular Therapy 16:10, pages 1665-1673.
Crossref
Ching-Huang WuChing-Hai KaoAhmad R. Safa. (2008) TRAIL Recombinant Adenovirus Triggers Robust Apoptosis in Multidrug-Resistant HL-60/Vinc Cells Preferentially Through Death Receptor DR5. Human Gene Therapy 19:7, pages 731-743.
Crossref
Brian P. McSharry, Hans-Gerhard Burgert, Douglas P. Owen, Richard J. Stanton, Virginie Prod'homme, Martina Sester, Katja Koebernick, Veronika Groh, Thomas Spies, Steven Cox, Ann-Margaret Little, Eddie C. Y. Wang, Peter Tomasec & Gavin W. G. Wilkinson. (2008) Adenovirus E3/19K Promotes Evasion of NK Cell Recognition by Intracellular Sequestration of the NKG2D Ligands Major Histocompatibility Complex Class I Chain-Related Proteins A and B. Journal of Virology 82:9, pages 4585-4594.
Crossref
A Danielsson, H Dzojic, B Nilsson & M Essand. (2008) Increased therapeutic efficacy of the prostate-specific oncolytic adenovirus Ad[I/PPT-E1A] by reduction of the insulator size and introduction of the full-length E3 region. Cancer Gene Therapy 15:4, pages 203-213.
Crossref
E V Shashkova, M N Kuppuswamy, W S M Wold & K Doronin. (2007) Anticancer activity of oncolytic adenovirus vector armed with IFN-α and ADP is enhanced by pharmacologically controlled expression of TRAIL. Cancer Gene Therapy 15:2, pages 61-72.
Crossref
JAMES H. STRAUSS & ELLEN G. STRAUSS. 2008. Viruses and Human Disease. Viruses and Human Disease 369 421 .
Ankur H. Shah, Nicholas L. Cianciola, Jeffrey L. Mills, Frank D. Sönnichsen & Cathleen Carlin. (2007) Adenovirus RIDα regulates endosome maturation by mimicking GTP-Rab7. The Journal of Cell Biology 179:5, pages 965-980.
Crossref
Marie L. Nguyen, Rachel M. Kraft & John A. Blaho. (2007) Susceptibility of cancer cells to herpes simplex virus-dependent apoptosis. Journal of General Virology 88:7, pages 1866-1875.
Crossref
Felipe Andrade, Edward Fellows, Dieter E Jenne, Antony Rosen & C S H Young. (2007) Granzyme H destroys the function of critical adenoviral proteins required for viral DNA replication and granzyme B inhibition. The EMBO Journal 26:8, pages 2148-2157.
Crossref
Hong Liu, Jie Fu & Marlene Bouvier. (2007) Allele- and Locus-Specific Recognition of Class I MHC Molecules by the Immunomodulatory E3-19K Protein from Adenovirus. The Journal of Immunology 178:7, pages 4567-4575.
Crossref
Elena V Shashkova, Jacqueline F Spencer, William S M Wold & Konstantin Doronin. (2007) Targeting Interferon-? Increases Antitumor Efficacy and Reduces Hepatotoxicity of E1A-mutated Spread-enhanced Oncolytic Adenovirus. Molecular Therapy 15:3, pages 598-607.
Crossref
K Benihoud, S Esselin, D Descamps, B Jullienne, B Salone, P Bobé, D Bonardelle, E Connault, P Opolon, I Saggio & M Perricaudet. (2006) Respective roles of TNF-α and IL-6 in the immune response-elicited by adenovirus-mediated gene transfer in mice. Gene Therapy 14:6, pages 533-544.
Crossref
T Au, S Thorne, W M Korn, D Sze, D Kirn & T R Reid. (2006) Minimal hepatic toxicity of Onyx-015: spatial restriction of coxsackie-adenoviral receptor in normal liver. Cancer Gene Therapy 14:2, pages 139-150.
Crossref
Wulf Schneider-Brachert, Vladimir Tchikov, Oliver Merkel, Marten Jakob, Cora Hallas, Marie-Luise Kruse, Peter Groitl, Alexander Lehn, Eberhard Hildt, Janka Held-Feindt, Thomas Dobner, Dieter Kabelitz, Martin Krönke & Stefan Schütze. (2006) Inhibition of TNF receptor 1 internalization by adenovirus 14.7K as a novel immune escape mechanism. Journal of Clinical Investigation 116:11, pages 2901-2913.
Crossref
R G van der Most, B W S Robinson & D J Nelson. (2006) Gene therapy for malignant mesothelioma: beyond the infant years. Cancer Gene Therapy 13:10, pages 897-904.
Crossref
Zsolt Ruzsics, Markus Wagner, Andrea Osterlehner, Jonathan Cook, Ulrich Koszinowski & Hans-Gerhard Burgert. (2006) Transposon-Assisted Cloning and Traceless Mutagenesis of Adenoviruses: Development of a Novel Vector Based on SpeciesD. Journal of Virology 80:16, pages 8100-8113.
Crossref
Y-B Chen, S Y Seo, D G Kirsch, T-T Sheu, W-C Cheng & J M Hardwick. (2006) Alternate functions of viral regulators of cell death. Cell Death & Differentiation 13:8, pages 1318-1324.
Crossref
Fernando Delgado-Lopez & Marshall S. Horwitz. (2006) Adenovirus RIDαβ Complex Inhibits Lipopolysaccharide Signaling without Altering TLR4 Cell Surface Expression. Journal of Virology 80:13, pages 6378-6386.
Crossref
Janet Strath & G. E. Blair. (2006) Adenovirus Subversion of Immune Surveillance, Apoptotic and Growth Regulatory Pathways: A Model for Tumorigenesis. Acta Microbiologica et Immunologica Hungarica 53:2, pages 145-169.
Crossref
Maria A. Thomas, Jacqueline F. Spencer, Marie C. La Regina, Debanjan Dhar, Ann E. Tollefson, Karoly Toth & William S.M. Wold. (2006) Syrian Hamster as a Permissive Immunocompetent Animal Model for the Study of Oncolytic Adenovirus Vectors. Cancer Research 66:3, pages 1270-1276.
Crossref
M Filippova, T A Brown-Bryan, C A Casiano & P J Duerksen-Hughes. (2005) The human papillomavirus 16 E6 protein can either protect or further sensitize cells to TNF: effect of dose. Cell Death & Differentiation 12:12, pages 1622-1635.
Crossref
Matthew D Weitzman & David A Ornelles. (2005) Inactivating intracellular antiviral responses during adenovirus infection. Oncogene 24:52, pages 7686-7696.
Crossref
Clodagh C O'Shea. (2005) Viruses – seeking and destroying the tumor program. Oncogene 24:52, pages 7640-7655.
Crossref
M Kuppuswamy, J F Spencer, K Doronin, A E Tollefson, W S M Wold & K Toth. (2005) Oncolytic adenovirus that overproduces ADP and replicates selectively in tumors due to hTERT promoter-regulated E4 gene expression. Gene Therapy 12:22, pages 1608-1617.
Crossref
J. J. Davis & B. Fang. (2005) Oncolytic virotherapy for cancer treatment: challenges and solutions. The Journal of Gene Medicine 7:11, pages 1380-1389.
Crossref
Hideki Kasuya, Shin Takeda, Shuji Nomoto & Akimasa Nakao. (2005) The potential of oncolytic virus therapy for pancreatic cancer. Cancer Gene Therapy 12:9, pages 725-736.
Crossref
Elena V Shashkova, Lubov V Cherenova, Dmitry B Kazansky & Konstantin Doronin. (2005) Avian adenovirus vector CELO-TK displays anticancer activity in human cancer cells and suppresses established murine melanoma tumors. Cancer Gene Therapy 12:7, pages 617-626.
Crossref
Dawn E Post, Hyunsuk Shim, Esra Toussaint-Smith & Erwin G Van Meir. (2005) Cancer Scene Investigation: how a cold virus became a tumor killer. Future Oncology 1:2, pages 247-258.
Crossref
Jerome Schaack. (2005) Induction and Inhibition of Innate Inflammatory Responses by Adenovirus Early Region Proteins. Viral Immunology 18:1, pages 79-88.
Crossref
Karoly Toth, Konstantin Doronin, Mohan Kuppuswamy, Peter Ward, Ann E. Tollefson & William S.M. Wold. (2005) Adenovirus immunoregulatory E3 proteins prolong transplants of human cells in immunocompetent mice. Virus Research 108:1-2, pages 149-159.
Crossref
Karoly TothJacqueline F. SpencerAnn E. TollefsonMohan KuppuswamyKonstantin DoroninDrew L. LichtensteinMarie C. La ReginaGregory A. PrinceWilliam S.M. Wold. (2005) Cotton Rat Tumor Model for the Evaluation of Oncolytic Adenoviruses. Human Gene Therapy 16:1, pages 139-146.
Crossref
Drew L Lichtenstein & William S M Wold. (2004) Experimental infections of humans with wild-type adenoviruses and with replication-competent adenovirus vectors: replication, safety, and transmission. Cancer Gene Therapy 11:12, pages 819-829.
Crossref
Drew L. LichtensteinKonstantin Doronin, Karoly Toth, Mohan Kuppuswamy, William S. M. Wold & Ann E. Tollefson. (2004) Adenovirus E3-6.7K Protein Is Required in Conjunction with the E3-RID Protein Complex for the Internalization and Degradation of TRAIL Receptor 2. Journal of Virology 78:22, pages 12297-12307.
Crossref
Mohamed A. I. Abou El Hassan, Ida van der Meulen-Muileman, Saman Abbas & Frank A. E. Kruyt. (2004) Conditionally Replicating Adenoviruses Kill Tumor Cells via a Basic Apoptotic Machinery-Independent Mechanism That Resembles Necrosis-Like Programmed Cell Death. Journal of Virology 78:22, pages 12243-12251.
Crossref
W BURSCH. (2004) Multiple cell death programs: Charon’s lifts to Hades. FEMS Yeast Research 5:2, pages 101-110.
Crossref
Roland L. Chu, Dawn E. Post, Fadlo R. Khuri & Erwin G. Van Meir. (2004) Use of Replicating Oncolytic Adenoviruses in Combination Therapy for Cancer. Clinical Cancer Research 10:16, pages 5299-5312.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.