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Autoimmunity Volume 42, 2009 - Issue 5
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Original

The p85β regulatory subunit of phosphoinositide 3-kinase has unique and redundant functions in B cells

Jean S. Oak Department of Molecular Biology and Biochemistry, and Center Institute for Immunology, University of California, Irvine, Irvine, CAUSA
,
Jing Chen Department of Molecular Biology and Biochemistry, and Center Institute for Immunology, University of California, Irvine, Irvine, CAUSA
,
Raechel Q. Peralta Department of Molecular Biology and Biochemistry, and Center Institute for Immunology, University of California, Irvine, Irvine, CAUSA
,
Jonathan A. Deane Department of Molecular Biology and Biochemistry, and Center Institute for Immunology, University of California, Irvine, Irvine, CAUSA; Genomics Institute of the Novartis Research Foundation, San Diego, CAUSA
&
David A. Fruman Department of Molecular Biology and Biochemistry, and Center Institute for Immunology, University of California, Irvine, Irvine, CAUSACorrespondence[email protected]
Pages 447-458 | Received 29 Jan 2009, Accepted 20 Mar 2009, Published online: 13 Aug 2009

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Yoshihiro Ito, Jonathan R. Hart & Peter K. Vogt. (2018) Isoform-specific activities of the regulatory subunits of phosphatidylinositol 3-kinases – potentially novel therapeutic targets. Expert Opinion on Therapeutic Targets 22:10, pages 869-877.
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Maciej Szydłowski, Ewa Jabłońska & Przemysław Juszczyński. (2014) FOXO1 Transcription Factor: A Critical Effector of the PI3K-AKT Axis in B-Cell Development. International Reviews of Immunology 33:2, pages 146-157.
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Ralitsa R. Madsen. 2023. Precision Cancer Therapies, Volume 1 ‐ Targeting Oncogenic Drivers and Signaling Pathways in Lymphoid Malignancies. Precision Cancer Therapies, Volume 1 ‐ Targeting Oncogenic Drivers and Signaling Pathways in Lymphoid Malignancies 53 70 .
Keyur Thummar & Chozha Vendan Rathinam. (2022) Class I PI3K regulatory subunits control differentiation of dendritic cell subsets and regulate Flt3L mediated signal transduction. Scientific Reports 12:1.
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Junsik M Lee, Renyan Liu & Sang Won Park. (2021) The regulatory subunits of PI3K, p85α and p85β, differentially affect BRD7-mediated regulation of insulin signaling. Journal of Molecular Cell Biology 13:12, pages 889-901.
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Jesús Vallejo-Díaz, Monica Chagoyen, Manuel Olazabal-Morán, Ana González-García & Ana Clara Carrera. (2019) The Opposing Roles of PIK3R1/p85α and PIK3R2/p85β in Cancer. Trends in Cancer 5:4, pages 233-244.
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N. TsolakosT. N. DurrantT. ChessaS. M. SuireD. OxleyS. KulkarniJ. DownwardO. Perisic, R. L. Williams, L. StephensP. T. Hawkins. (2018) Quantitation of class IA PI3Ks in mice reveals p110-free-p85s and isoform-selective subunit associations and recruitment to receptors. Proceedings of the National Academy of Sciences 115:48, pages 12176-12181.
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Xinchen Li, Ying Ding, Mengting Zi, Li Sun, Wenjie Zhang, Shun Chen & Yuekang Xu. (2017) CD19, from bench to bedside. Immunology Letters 183, pages 86-95.
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Tamas Balla. (2013) Phosphoinositides: Tiny Lipids With Giant Impact on Cell Regulation. Physiological Reviews 93:3, pages 1019-1137.
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Mandy Pierau, Shin-Young Na, Narasimhulu Simma, Theresa Lowinus, Alexander Marx, Burkhart Schraven & Ursula H. Bommhardt. (2012) Constitutive Akt1 signals attenuate B-cell receptor signaling and proliferation, but enhance B-cell migration and effector function. European Journal of Immunology 42:12, pages 3381-3393.
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GV Baracho, AV Miletic, SA Omori, MH Cato & RC Rickert. (2011) Emergence of the PI3-kinase pathway as a central modulator of normal and aberrant B cell differentiation. Current Opinion in Immunology 23:2, pages 178-183.
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Faruk RamadaniDaniel J. BollandFabien GarconJuliet L. EmeryBart VanhaesebroeckAnne E. CorcoranKlaus Okkenhaug. (2010) The PI3K Isoforms p110α and p110δ Are Essential for Pre–B Cell Receptor Signaling and B Cell Development. Science Signaling 3:134.
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Jing Chen, Jose J. Limon, Caroline Blanc, Stanford L. Peng & David A. Fruman. (2010) Foxo1 regulates marginal zone B‐cell development. European Journal of Immunology 40:7, pages 1890-1896.
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Klaus Okkenhaug & David A. Fruman. 2011. Phosphoinositide 3-kinase in Health and Disease. Phosphoinositide 3-kinase in Health and Disease 57 85 .
David A. Fruman. 2011. Phosphoinositide 3-kinase in Health and Disease. Phosphoinositide 3-kinase in Health and Disease 225 244 .

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