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Research Article

Prophylactic Dose of Neem (Azadirachta indica) Leaf Preparation Restricting Murine Tumor Growth is Nontoxic, Hematostimulatory and Immunostimulatory

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Pages 33-50 | Published online: 08 Oct 2008

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Jahanzeb Ansari, Sohail Hassan Khan, Ahsan ul Haq & Muhammad Yousaf. (2012) Effect of the levels of Azadirachta indica dried leaf meal as phytogenic feed additive on the growth performance and haemato-biochemical parameters in broiler chicks. Journal of Applied Animal Research 40:4, pages 336-345.
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Articles from other publishers (40)

Pranob Jyoti BHARALİ, Sushanta Kumar BORDOLOİ, Swarnamoni DAS & Kingshuk LAHON. (2022) Effect of chronic administration of aqueous extract of Neem (Azadirachta indica) leaves on Paracetamol-induced hepatotoxicity in Wistar albino rats. Current Perspectives on Medicinal and Aromatic Plants (CUPMAP).
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Abdul Kader, Sankar Narayan Sinha & Parthadeb Ghosh. (2022) A strategy for development of genetically stable synseeds of Azadirachta indica A. Juss. (Neem) suitable for in vitro storage. Plant Cell, Tissue and Organ Culture (PCTOC) 151:1, pages 47-58.
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Vidya Devanathadesikan Seshadri, Atif Abdulwahab A. Oyouni, Waleed M. Bawazir, Suliman A. Alsagaby, Khalaf F. Alsharif, Ashraf Albrakati & Osama M. Al‐Amer. (2022) Zingiberene exerts chemopreventive activity against 7,12‐dimethylbenz(a)anthracene‐induced breast cancer in Sprague‐Dawley rats. Journal of Biochemical and Molecular Toxicology 36:10.
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Bhanu Prakash, Bidhan C. Mondal, Jyoti Palod, Anil Kumar, Manjulata & Ripusudan Kumar. (2022) Effect of Dietary Inclusion of Neem Leaf Powder on Growth Performance, Nutrient Utilization, and Haemato-Biochemical Parameters of Japanese Quail. Indian Journal of Veterinary Sciences & Biotechnology 18:4, pages 109-113.
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V.M. Berlin Grace, D. David Wilson, R. Anushya & Siddikuzzaman. (2021) Regulation of inflammation and COX-2 gene expression in benzo (a) pyrene induced lung carcinogenesis in mice by all trans retinoic acid (ATRA). Life Sciences 285, pages 119967.
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Stéphane Zingue, Julia Cisilotto, Robinson Charly Mbe Fogang, Edwige Nana Tchoupang, Derek Tantoh Ndinteh, Nestor‐Fernand Tchuenguem Fohouo, Dieudonné Njamen & Tânia Beatriz Creczynski‐Pasa. (2021) The antimammary tumor effects of ethanolic extract of propolis from Adamawa region (Cameroon) are by apoptosis via reactive oxygen species‐mediated mitochondrial pathway. Environmental Toxicology 36:5, pages 861-873.
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Irma Seriana, Muslim Akmal, Darusman Darusman, Sri Wahyuni, Khairan Khairan & Sugito Sugito. (2021) Neem Leaf (Azadirachta indica A. Juss) Ethanolic Extract on the Liver and Kidney Function of Rats. The Scientific World Journal 2021, pages 1-7.
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Teresa M. Braga, Lídia Rocha, Tsz Yan Chung, Rita F. Oliveira, Cláudia Pinho, Ana I. Oliveira, Joaquim Morgado & Agostinho Cruz. (2021) Azadirachta indica A. Juss. In Vivo Toxicity—An Updated Review. Molecules 26:2, pages 252.
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Merline Ymele Nguedia, Alain Brice Tueche, Abel Joël Gbaweng Yaya, Vincent Yadji, Derek Tantoh Ndinteh, Dieudonné Njamen & Stéphane Zingue. (2020) Daucosterol from Crateva adansonii DC (Capparaceae) reduces 7,12‐dimethylbenz(a)anthracene ‐induced mammary tumors in Wistar rats . Environmental Toxicology 35:10, pages 1125-1136.
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Bharat Singh & Ram Avtar Sharma. 2020. Secondary Metabolites of Medicinal Plants. Secondary Metabolites of Medicinal Plants 184 196 .
Shahid AkbarShahid Akbar. 2020. Handbook of 200 Medicinal Plants. Handbook of 200 Medicinal Plants 381 400 .
Vanessa Mafouo Sonhafouo, Jean Raphaël Kana & Kissel Nguepi Dongmo. (2019) Effects of graded levels of Azadirachta indica seed oil on growth performance and biochemical profiles of broiler chickens . Veterinary Medicine and Science 5:3, pages 442-450.
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Stephane Zingue, Kevine Kamga Silihe, Innocent Fouba Bourfane, Ali Boukar, Alain Brice Tueche, Amstrong Nang Njuh & Dieudonné Njamen. (2019) Potential of Regular Consumption of Cameroonian Neem ( Azadirachta indica L.) Oil for Prevention of the 7,12-Dimethylbenz(a)anthracene-Induced Breast Cancer in High-Fat/Sucrose-Fed Wistar Rats . Evidence-Based Complementary and Alternative Medicine 2019, pages 1-13.
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Dhara Thakore & Ashok K. Srivastava. (2017) Production of biopesticide azadirachtin using plant cell and hairy root cultures. Engineering in Life Sciences 17:9, pages 997-1005.
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Madhurima Sarkar, Sarbari Ghosh, Avishek Bhuniya, Tithi Ghosh, Ipsita Guha, Subhasis Barik, Jaydip Biswas, Anamika Bose & Rathindranath Baral. (2017) Neem leaf glycoprotein prevents post-surgical sarcoma recurrence in Swiss mice by differentially regulating cytotoxic T and myeloid-derived suppressor cells. PLOS ONE 12:4, pages e0175540.
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Shradha M. Patel, Kalyan C. Nagulapalli Venkata, Piyali Bhattacharyya, Gautam Sethi & Anupam Bishayee. (2016) Potential of neem ( Azadirachta indica L.) for prevention and treatment of oncologic diseases. Seminars in Cancer Biology 40-41, pages 100-115.
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Sarbari Ghosh, Madhurima Sarkar, Tithi Ghosh, Ipsita Guha, Avishek Bhuniya, Akata Saha, Shayani Dasgupta, Subhasis Barik, Anamika Bose & Rathindranath Baral. (2016) Neem leaf glycoprotein promotes dual generation of central and effector memory CD8 + T cells against sarcoma antigen vaccine to induce protective anti-tumor immunity. Molecular Immunology 71, pages 42-53.
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Shanying Wang, Hao Zhang, Xinglin Li & Jian Zhang. (2016) Gene expression profiling analysis reveals a crucial gene regulating metabolism in adventitious roots of neem (Azadirachta indica). RSC Advances 6:115, pages 114889-114898.
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Saptak Banerjee, Tithi Ghosh, Subhasis Barik, Arnab Das, Sarbari Ghosh, Avishek Bhuniya, Anamika Bose & Rathindranath Baral. (2014) Neem Leaf Glycoprotein Prophylaxis Transduces Immune Dependent Stop Signal for Tumor Angiogenic Switch within Tumor Microenvironment. PLoS ONE 9:11, pages e110040.
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K.K. Goswami, S. Barik, M. Sarkar, A. Bhowmick, J. Biswas, A. Bose & R. Baral. (2014) Targeting STAT3 phosphorylation by neem leaf glycoprotein prevents immune evasion exerted by supraglottic laryngeal tumor induced M2 macrophages. Molecular Immunology 59:2, pages 119-127.
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Rasika M Samarasinghe, Rupinder K Kanwar, Kuldeep Kumar & Jagat R Kanwar. (2014) Antiarthritic and chondroprotective activity of Lakshadi Guggul in novel alginate-enclosed chitosan calcium phosphate nanocarriers. Nanomedicine 9:6, pages 819-837.
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Mio Takagi, Yosuke Tachi, Jie Zhang, Takuro Shinozaki, Kenta Ishii, Takashi Kikuchi, Motohiko Ukiya, Norihiro Banno, Harukuni Tokuda & Toshihiro Akihisa. (2014) Cytotoxic and Melanogenesis-Inhibitory Activities of Limonoids from the Leaves of Azadirachta indica (Neem) . Chemistry & Biodiversity 11:3, pages 451-468.
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Chhavi Sharma, Andrea J. Vas, Payal Goala, Taher M. Gheewala, Tahir A. Rizvi & Arif Hussain. (2014) Ethanolic Neem ( Azadirachta indica ) Leaf Extract Prevents Growth of MCF-7 and HeLa Cells and Potentiates the Therapeutic Index of Cisplatin . Journal of Oncology 2014, pages 1-10.
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M. Singh & R. Chaturvedi. (2013) Sustainable production of azadirachtin from differentiated in vitro cell lines of neem (Azadirachta indica). AoB PLANTS 5:0, pages plt034-plt034.
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Atanu Mallick, Subhasis Barik, Kuntal Kanti Goswami, Saptak Banerjee, Sarbari Ghosh, Koustav Sarkar, Anamika Bose & Rathindranath Baral. (2013) Neem Leaf Glycoprotein Activates CD8+ T Cells to Promote Therapeutic Anti-Tumor Immunity Inhibiting the Growth of Mouse Sarcoma. PLoS ONE 8:1, pages e47434.
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Atanu Mallick, Sarbari Ghosh, Saptak Banerjee, Sayantani Majumder, Arnab Das, Bipasha Mondal, Subhasis Barik, Kuntal K. Goswami, Smarajit Pal, Subrata Laskar, Koustav Sarkar, Anamika Bose & Rathindranath Baral. (2013) Neem leaf glycoprotein is nontoxic to physiological functions of Swiss mice and Sprague Dawley rats: Histological, biochemical and immunological perspectives. International Immunopharmacology 15:1, pages 73-83.
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Saswati Mahapatra, R. Jeffrey Karnes, Michael W. Holmes, Charles Y. F. Young, John C. Cheville, Manish Kohli, Eric W. Klee, Donald J. Tindall & Krishna Vanaja Donkena. (2011) Novel Molecular Targets of Azadirachta indica Associated with Inhibition of Tumor Growth in Prostate Cancer. The AAPS Journal 13:3, pages 365-377.
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Tathagata Chakraborty, Anamika Bose, Subhasis Barik, Kuntal Kanti Goswami, Saptak Banerjee, Shyamal Goswami, Diptendu Ghosh, Soumyabrata Roy, Krishnendu Chakraborty, Koustav Sarkar & Rathindranath Baral. (2011) Neem leaf glycoprotein inhibits CD4 + CD25 + Foxp3 + Tregs to restrict murine tumor growth . Immunotherapy 3:8, pages 949-969.
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Soumyabrata Roy, Shyamal Goswami, Anamika Bose, Krishnendu Chakraborty, Smarajit Pal, Atanu Haldar, Parthasarathi Basu, Jaydip Biswas & Rathindranath Baral. (2011) Neem Leaf Glycoprotein Partially Rectifies Suppressed Dendritic Cell Functions and Associated T Cell Efficacy in Patients with Stage IIIB Cervical Cancer. Clinical and Vaccine Immunology 18:4, pages 571-579.
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Shyamal Goswami, Anamika Bose, Koustav Sarkar, Soumyabrata Roy, Tathagata Chakraborty, Utpal Sanyal & Rathindranath Baral. (2010) Neem leaf glycoprotein matures myeloid derived dendritic cells and optimizes anti-tumor T cell functions. Vaccine 28:5, pages 1241-1252.
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Anamika Bose, Krishnendu Chakraborty, Koustav Sarkar, Shyamal Goswami, Tathagata Chakraborty, Smarajit Pal & Rathindranath Baral. (2009) Neem Leaf Glycoprotein Induces Perforin-mediated Tumor Cell Killing by T and NK Cells Through Differential Regulation of IFNγ Signaling. Journal of Immunotherapy 32:1, pages 42-53.
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Anamika Bose, Krishnendu Chakraborty, Koustav Sarkar, Shyamal Goswami, Enamul Haque, Tathagata Chakraborty, Diptendu Ghosh, Soumyabrata Roy, Subrata Laskar & Rathindranath Baral. (2009) Neem leaf glycoprotein directs T-bet–associated type 1 immune commitment. Human Immunology 70:1, pages 6-15.
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Koustav Sarkar, Anamika Bose, Krishnendu Chakraborty, Enamul Haque, Diptendu Ghosh, Shyamal Goswami, Tathagata Chakraborty, Subrata Laskar & Rathindranath Baral. (2008) Neem leaf glycoprotein helps to generate carcinoembryonic antigen specific anti-tumor immune responses utilizing macrophage-mediated antigen presentation. Vaccine 26:34, pages 4352-4362.
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Krishnendu Chakraborty, Anamika Bose, Smarajit Pal, Koustav Sarkar, Shyamal Goswami, Diptendu Ghosh, Subrata Laskar, Utpala Chattopadhyay & Rathindranath Baral. (2008) Neem leaf glycoprotein restores the impaired chemotactic activity of peripheral blood mononuclear cells from head and neck squamous cell carcinoma patients by maintaining CXCR3/CXCL10 balance. International Immunopharmacology 8:2, pages 330-340.
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M. Abdel-Kader .A.H. Mahmoud .H.M. Motawa .H.E. Wahba .A.Y. Ebrahim .. (2007) Antitumor Activity of Urtica pilulifera on Ehrlich Ascites Carcinoma in Mice. Asian Journal of Biochemistry 2:6, pages 375-385.
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Anamika Bose & Rathindranath Baral. (2007) Natural killer cell mediated cytotoxicity of tumor cells initiated by neem leaf preparation is associated with CD40–CD40L–mediated endogenous production of interleukin-12. Human Immunology 68:10, pages 823-831.
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Anamika Bose, Enamul Haque & Rathindranath Baral. (2007) Neem leaf preparation induces apoptosis of tumor cells by releasing cytotoxic cytokines from human peripheral blood mononuclear cells. Phytotherapy Research 21:10, pages 914-920.
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Koustav Sarkar, Anamika Bose, Subrata Laskar, Soumitra K. Choudhuri, Subhabrata Dey, Purnendu K. Roychowdhury & Rathindranath Baral. (2007) Antibody response against neem leaf preparation recognizes carcinoembryonic antigen. International Immunopharmacology 7:3, pages 306-312.
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Diptendu Ghosh, Anamika Bose, Enamul Haque & Rathindranath Baral. (2006) Pretreatment with neem (Azadirachta indica) leaf preparation in swiss mice diminishes leukopenia and enhances the antitumor activity of cyclophosphamide. Phytotherapy Research 20:9, pages 814-818.
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Rathindranath Baral, Ishita Mandal & Utpala Chattopadhyay. (2005) Immunostimulatory neem leaf preparation acts as an adjuvant to enhance the efficacy of poorly immunogenic B16 melanoma surface antigen vaccine. International Immunopharmacology 5:7-8, pages 1343-1352.
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