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Inhalation Toxicology
International Forum for Respiratory Research
Volume 18, 2006 - Issue 10
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Research Article

Challenges in Validating CFD-Derived Inhaled Aerosol Deposition Predictions

Michael J. Oldham Air Pollution Health Effects Laboratory, School of Medicine, College of Health Sciences, University of California, Irvine, California, USA
Pages 781-786 | Received 15 Dec 2005, Accepted 13 Feb 2006, Published online: 06 Oct 2008

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Michael J. Oldham, Nicolas Castro, Jingjie Zhang, Ali Rostami, Francesco Lucci, Yezdi Pithawalla, Arkadiusz K. Kuczaj, I. Gene Gilman, Pasha Kosachevsky, Julia Hoeng & K. Monica Lee. (2020) Deposition efficiency and uniformity of monodisperse solid particle deposition in the Vitrocell® 24/48 Air–Liquid-Interface in vitro exposure system. Aerosol Science and Technology 54:1, pages 52-65.
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Mahdi Asgari, Francesco Lucci, Jakub Bialek, Barthélemy Dunan, Gaëlle Andreatta, Rita Smajda, Sébastien Lani, Nicolas Blondiaux, Shoaib Majeed, Sandro Steiner, Jean-Pierre Schaller, Stefan Frentzel, Julia Hoeng & Arkadiusz K. Kuczaj. (2019) Development of a realistic human respiratory tract cast representing physiological thermal conditions. Aerosol Science and Technology 53:8, pages 860-870.
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Robert F. Phalen, Loyda B. Mendez & Michael J. Oldham. (2010) New developments in aerosol dosimetry. Inhalation Toxicology 22:sup2, pages 6-14.
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Jinxiang Xi & P. Worth Longest. (2009) Characterization of Submicrometer Aerosol Deposition in Extrathoracic Airways during Nasal Exhalation. Aerosol Science and Technology 43:8, pages 808-827.
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Risa J. Robinson, Pamela Snyder & Michael J. Oldham. (2008) Comparison of Analytical and Numerical Particle Deposition Using Commercial CFD Packages: Impaction and Sedimentation. Inhalation Toxicology 20:5, pages 485-497.
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P. Worth Longest, Michael Hindle, Suparna Das Choudhuri & PeterR. Byron. (2007) Numerical Simulations of Capillary Aerosol Generation: CFD Model Development and Comparisons with Experimental Data. Aerosol Science and Technology 41:10, pages 952-973.
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Risa J. Robinson, Pam Snyder & Michael J. Oldham. (2007) Comparison of Particle Tracking Algorithms in Commercial CFD Packages: Sedimentation and Diffusion. Inhalation Toxicology 19:6-7, pages 517-531.
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Articles from other publishers (18)

Frantisek Lizal, Jan Jedelsky, Kaye Morgan, Katrin Bauer, Jordi Llop, Unai Cossio, Stavros Kassinos, Sylvia Verbanck, Jesús Ruiz-Cabello, Arnoldo Santos, Edmund Koch & Christian Schnabel. (2018) Experimental methods for flow and aerosol measurements in human airways and their replicas. European Journal of Pharmaceutical Sciences 113, pages 95-131.
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John FlemingJoy ConwayCaroline MajoralIra KatzGeorges CaillibotteMarine PichelinSpyridon MontesantosMichael Bennett. (2015) Controlled, Parametric, Individualized, 2-D and 3-D Imaging Measurements of Aerosol Deposition in the Respiratory Tract of Asthmatic Human Subjects for Model Validation. Journal of Aerosol Medicine and Pulmonary Drug Delivery 28:6, pages 432-451.
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Landon T. Holbrook & P. Worth Longest. (2013) Validating CFD predictions of highly localized aerosol deposition in airway models: In vitro data and effects of surface properties. Journal of Aerosol Science 59, pages 6-21.
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Kevin R. Minard, Andrew P. Kuprat, Senthil Kabilan, Richard E. Jacob, Daniel R. Einstein, James P. Carson & Richard A. Corley. (2012) Phase-contrast MRI and CFD modeling of apparent 3He gas flow in rat pulmonary airways. Journal of Magnetic Resonance 221, pages 129-138.
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Zheng Li. (2012) Particle Deposition in Oral-tracheal Airway Models with Very Low Inhalation Profiles. Journal of Bionic Engineering 9:2, pages 252-261.
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Paul A. Solomon, Peter Gehr, Deborah H. Bennett, Robert F. Phalen, Loyda B. Méndez, Barbara Rothen-Rutishauser, Martin Clift, Christina Brandenberger & Christian Mühlfeld. (2012) Macroscopic to microscopic scales of particle dosimetry: from source to fate in the body. Air Quality, Atmosphere & Health 5:2, pages 169-187.
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P. Worth Longest & Landon T. Holbrook. (2012) In silico models of aerosol delivery to the respiratory tract — Development and applications. Advanced Drug Delivery Reviews 64:4, pages 296-311.
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Jeffry D. Schroeter, Guilherme J.M. Garcia & Julia S. Kimbell. (2011) Effects of surface smoothness on inertial particle deposition in human nasal models. Journal of Aerosol Science 42:1, pages 52-63.
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Peter R. ByronMichael HindleCarlos F. LangeP. Worth LongestDonald McRobbieMichael J. OldhamBo OlssonCharles G. ThielHerbert WachtelWarren H. Finlay. (2010) In Vivo–In Vitro Correlations: Predicting Pulmonary Drug Deposition from Pharmaceutical Aerosols . Journal of Aerosol Medicine and Pulmonary Drug Delivery 23:S2, pages S-59-S-69.
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Jae Ho Cho, Atul Kulkarni, Hojoong Kim, Jin Uk Yoon, Jae Hyuck Sung, Il Je Yu & Taesung Kim. (2010) Numerical study on spatial distribution of silver nanoparticles inside whole-body type inhalation toxicity chamber. Journal of Mechanical Science and Technology 24:11, pages 2215-2220.
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Baoshun Ma, Vincent Ruwet, Patricia Corieri, Raf Theunissen, Michel Riethmuller & Chantal Darquenne. (2009) CFD simulation and experimental validation of fluid flow and particle transport in a model of alveolated airways. Journal of Aerosol Science 40:5, pages 403-414.
Crossref
Robert Phalen. 2008. Inhalation Studies. Inhalation Studies 229 257 .
Warren H. FinlayAndrew R. Martin. (2008) Recent Advances in Predictive Understanding of Respiratory Tract Deposition. Journal of Aerosol Medicine and Pulmonary Drug Delivery 21:2, pages 189-206.
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Árpád Farkas & Imre Balásházy. (2008) Quantification of particle deposition in asymmetrical tracheobronchial model geometry. Computers in Biology and Medicine 38:4, pages 508-518.
Crossref
Robert F. PhalenMichael J. OldhamRonald K. Wolff. (2008) The Relevance of Animal Models for Aerosol Studies. Journal of Aerosol Medicine and Pulmonary Drug Delivery 21:1, pages 113-124.
Crossref
Warren H. Finlay & Andrew R. Martin. (2008) Recent Advances in Predictive Understanding of Respiratory Tract Deposition. Journal of Aerosol Medicine 0:0, pages 080225123426385-18.
Crossref
Robert F. Phalen, Michael J. Oldham & Ronald K. Wolff. (2008) The Relevance of Animal Models for Aerosol Studies. Journal of Aerosol Medicine 0:0, pages 080207080519480-12.
Crossref
P. Worth Longest & Michael J. Oldham. (2008) Numerical and experimental deposition of fine respiratory aerosols: Development of a two-phase drift flux model with near-wall velocity corrections. Journal of Aerosol Science 39:1, pages 48-70.
Crossref

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