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Growth Factors Volume 22, 2004 - Issue 1
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Original Article

Effects of Local Application of Growth and Differentiation Factor-5 (GDF-5) in a Full-thickness Cartilage Defect Model

Hans-Georg Simank , Orthopädische Universitätsklinik Heidelberg, Heidelberg, GermanyCorrespondence[email protected]
,
Consolato Sergi Department of Paediatric Pathology, St. Michael's University Hospital, UK
,
Martin Jung , Orthopädische Universitätsklinik Heidelberg, Heidelberg, Germany
,
Stefanie Adolf , Orthopädische Universitätsklinik Heidelberg, Heidelberg, Germany
,
Christina Eckhardt , AO Research Institute, Switzerland
,
Volker Ehemann , Pathologisches Institut der Universität Heidelberg, Heidelberg, Germany
,
Rainer Ries , Biopharm Inc., Germany
,
Christoph Lill , Orthopädische Universitätsklinik Heidelberg, Heidelberg, Germany
&
Wiltrud Richter , Orthopädische Universitätsklinik Heidelberg, Heidelberg, Germany
 show all
Pages 35-43 | Published online: 07 Aug 2009

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C. P. Bramlage, C. Kaps, U. Ungethüm, P. Bramlage, M. Koziolek, J. Wessels, V. Krenn, A. Pruß, G. A. Müller, F. Strutz, G‐R. Burmester & T. Häupl. (2008) Modulatory effects of inflammation and therapy on GDF‐5 expression in rheumatoid arthritis synovium. Scandinavian Journal of Rheumatology 37:6, pages 401-409.
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Martin Jung, Jens Sascha Tuischer, Consolato Sergi, Tobias Gotterbarm, Jens Pohl, Wiltrud Richter & Hans-Georg Simank. (2006) Local application of a collagen type I/hyaluronate matrix and growth and differentiation factor 5 influences the closure of osteochondral defects in a minipig model by enchondral ossification. Growth Factors 24:4, pages 225-232.
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Articles from other publishers (13)

Consolato M. SergiConsolato M. Sergi. 2020. Pathology of Childhood and Adolescence. Pathology of Childhood and Adolescence 1095 1166 .
Consolato Sergi, Fan Shen & Song-Mei Liu. (2019) Insulin/IGF-1R, SIRT1, and FOXOs Pathways—An Intriguing Interaction Platform for Bone and Osteosarcoma. Frontiers in Endocrinology 10.
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Fernando Y.K. Kawamoto, Leonardo A.L. Muzzi, Bruno O.A.G. Liria, José A.A. Camassa, Stella H. Moreira, Pedro P. Rossignoli & Ruthnéa A.L. Muzzi. (2017) Ressonância magnética na avaliação de enxerto osteocondral autógeno na cartilagem articular de coelhos. Pesquisa Veterinária Brasileira 37:5, pages 502-510.
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Philip Kasten, Ingo Beyen, Dirk Bormann, Reto Luginbühl, Frank Plöger & Wiltrud Richter. (2010) The effect of two point mutations in GDF-5 on ectopic bone formation in a β-tricalciumphosphate scaffold. Biomaterials 31:14, pages 3878-3884.
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B. Appel, J. Baumer, D. Eyrich, H. Sarhan, S. Toso, C. Englert, D. Skodacek, S. Ratzinger, S. Grässel, A. Goepferich & T. Blunk. (2009) Synergistic effects of growth and differentiation factor-5 (GDF-5) and insulin on expanded chondrocytes in a 3-D environment. Osteoarthritis and Cartilage 17:11, pages 1503-1512.
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Martin Jung, Steffen Breusch, Wolfgang Daecke & Tobias Gotterbarm. (2009) The effect of defect localization on spontaneous repair of osteochondral defects in a Göttingen minipig model: a retrospective analysis of the medial patellar groove versus the medial femoral condyle. Laboratory Animals 43:2, pages 191-197.
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Laurent Dupoirieux, Jens Pohl, Michael Hanke & Didier Pourquier. (2009) A preliminary report on the effect of dimeric rhGDF-5 and its monomeric form rhGDF-5C465A on bone healing of rat cranial defects. Journal of Cranio-Maxillofacial Surgery 37:1, pages 30-35.
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Cynthia M. Coleman. (2008) Chicken embryo as a model for regenerative medicine. Birth Defects Research Part C: Embryo Today: Reviews 84:3, pages 245-256.
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H. Kadomatsu, T. Matsuyama, T. Yoshimoto, Y. Negishi, H. Sekiya, M. Yamamoto & Y. Izumi. (2008) Injectable growthdifferentiation factor-5recombinant human collagen composite induces endochondral ossification via Sry-related HMG box 9 (Sox9)expression and angiogenesis in murine calvariae. Journal of Periodontal Research, pages ???-???.
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Rudolf M. Gruber, Arwed Ludwig, Hans-Albert Merten, Mirjam Achilles, Sylke Poehling & Henning Schliephake. (2008) Sinus floor augmentation with recombinant human growth and differentiation factor-5 (rhGDF-5): a histological and histomorphometric study in the Goettingen miniature pig. Clinical Oral Implants Research 19:5, pages 522-529.
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Susan Chubinskaya, Mark Hurtig & David C. Rueger. 2008. Bone Morphogenetic Proteins: From Local to Systemic Therapeutics. Bone Morphogenetic Proteins: From Local to Systemic Therapeutics 277 315 .
Takehiko Yoshimoto, Matsuo Yamamoto, Hideshi Kadomatsu, Kenji Sakoda, Yutaka Yonamine & Yuichi Izumi. (2006) Recombinant human growth/differentiation factor-5 (rhGDF-5) induced bone formation in murine calvariae. Journal of Periodontal Research 41:2, pages 140-147.
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Peter J. Wild, Rene C. Krieg, Juergen Seidl, Robert Stoehr, Kerstin Reher, Claudia Hofmann, Jari Louhelainen, André Rosenthal, Arndt Hartmann, Christian Pilarsky, Anja K. Bosserhoff & Ruth Knuechel. (2005) RNA expression profiling of normal and tumor cells following photodynamic therapy with 5-aminolevulinic acid–induced protoporphyrin IX in vitro . Molecular Cancer Therapeutics 4:4, pages 516-528.
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