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Growth Factors Volume 27, 2009 - Issue 3
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A truncated soluble epidermal growth factor receptor-Fc fusion ligand trap displays anti-tumour activity in vivo

Timothy E. Adams CSIRO Division of Molecular and Health Technologies, 343 Royal Parade, Parkville, VIC, 3052, AustraliaCorrespondence[email protected]
,
Eva J. Koziolek CSIRO Division of Molecular and Health Technologies, 343 Royal Parade, Parkville, VIC, 3052, Australia
,
Peter H. Hoyne CSIRO Division of Molecular and Health Technologies, 343 Royal Parade, Parkville, VIC, 3052, Australia
,
John D. Bentley CSIRO Division of Molecular and Health Technologies, 343 Royal Parade, Parkville, VIC, 3052, Australia
,
Louis Lu CSIRO Division of Molecular and Health Technologies, 343 Royal Parade, Parkville, VIC, 3052, Australia
,
George Lovrecz CSIRO Division of Molecular and Health Technologies, 343 Royal Parade, Parkville, VIC, 3052, Australia
,
Colin W. Ward CSIRO Division of Molecular and Health Technologies, 343 Royal Parade, Parkville, VIC, 3052, Australia
,
F. T. Lee Ludwig Institute for Cancer Research, Melbourne Centre for Clinical Sciences, Austin Health, Studley Road, Heidelberg, VIC, 3084, Australia
,
Andrew M. Scott Ludwig Institute for Cancer Research, Melbourne Centre for Clinical Sciences, Austin Health, Studley Road, Heidelberg, VIC, 3084, Australia
,
Andrew D. Nash CSL Limited, 45 Poplar Road, Parkville, VIC, 3052, Australia
,
Julie Rothacker Melbourne Tumour Biology Branch, Ludwig Institute for Cancer Research, P.O. Box 2008, Royal Melbourne Hospital, Parkville, VIC, 3050, Australia
,
Edouard C. Nice Melbourne Tumour Biology Branch, Ludwig Institute for Cancer Research, P.O. Box 2008, Royal Melbourne Hospital, Parkville, VIC, 3050, Australia
,
Antony W. Burgess Melbourne Tumour Biology Branch, Ludwig Institute for Cancer Research, P.O. Box 2008, Royal Melbourne Hospital, Parkville, VIC, 3050, Australia
,
Terrance G. Johns Ludwig Institute for Cancer Research, Melbourne Centre for Clinical Sciences, Austin Health, Studley Road, Heidelberg, VIC, 3084, Australia
,
Timothy E. Adams CSIRO Division of Molecular and Health Technologies, 343 Royal Parade, Parkville, VIC, 3052, AustraliaCorrespondence[email protected]
,
Eva J. Koziolek CSIRO Division of Molecular and Health Technologies, 343 Royal Parade, Parkville, VIC, 3052, Australia
,
Peter H. Hoyne CSIRO Division of Molecular and Health Technologies, 343 Royal Parade, Parkville, VIC, 3052, Australia
,
John D. Bentley CSIRO Division of Molecular and Health Technologies, 343 Royal Parade, Parkville, VIC, 3052, Australia
,
Louis Lu CSIRO Division of Molecular and Health Technologies, 343 Royal Parade, Parkville, VIC, 3052, Australia
,
George Lovrecz CSIRO Division of Molecular and Health Technologies, 343 Royal Parade, Parkville, VIC, 3052, Australia
,
Colin W. Ward CSIRO Division of Molecular and Health Technologies, 343 Royal Parade, Parkville, VIC, 3052, Australia
,
F. T. Lee Ludwig Institute for Cancer Research, Melbourne Centre for Clinical Sciences, Austin Health, Studley Road, Heidelberg, VIC, 3084, Australia
,
Andrew M. Scott Ludwig Institute for Cancer Research, Melbourne Centre for Clinical Sciences, Austin Health, Studley Road, Heidelberg, VIC, 3084, Australia
,
Andrew D. Nash CSL Limited, 45 Poplar Road, Parkville, VIC, 3052, Australia
,
Julie Rothacker Melbourne Tumour Biology Branch, Ludwig Institute for Cancer Research, P.O. Box 2008, Royal Melbourne Hospital, Parkville, VIC, 3050, Australia
,
Edouard C. Nice Melbourne Tumour Biology Branch, Ludwig Institute for Cancer Research, P.O. Box 2008, Royal Melbourne Hospital, Parkville, VIC, 3050, Australia
,
Antony W. Burgess Melbourne Tumour Biology Branch, Ludwig Institute for Cancer Research, P.O. Box 2008, Royal Melbourne Hospital, Parkville, VIC, 3050, Australia
&
Terrance G. Johns Ludwig Institute for Cancer Research, Melbourne Centre for Clinical Sciences, Austin Health, Studley Road, Heidelberg, VIC, 3084, Australia
 show all
Pages 141-154 | Received 02 Dec 2008, Accepted 23 Feb 2009, Published online: 11 Jul 2009

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Karin Taylor, Christopher B Howard, Martina L Jones, Ilya Sedliarou, Jennifer MacDiarmid, Himanshu Brahmbhatt, Trent P Munro & Stephen M Mahler. (2015) Nanocell targeting using engineered bispecific antibodies. mAbs 7:1, pages 53-65.
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Francesca Walker, Julie Rothacker, Christine Henderson, Edouard C. Nice, Bruno Catimel, Hui-Hua Zhang, Andrew M. Scott, Michael F. Bailey, Suzanne G. Orchard, Timothy E. Adams, Zhanqi Liu, Thomas P.J. Garrett, Andrew H.A. Clayton & Antony W. Burgess. (2012) Ligand binding induces a conformational change in epidermal growth factor receptor dimers. Growth Factors 30:6, pages 394-409.
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Eva J. Koziolek, Jacqueline F. Donoghue, John D. Bentley, George Lovrecz, Olan Dolezal, Colin W. Ward, Julie Rothacker, Edouard C. Nice, Antony W. Burgess, M. Hafner, Terrance G. Johns & Timothy E. Adams. (2012) A high-affinity ErbB4Fc fusion protein is a potent antagonist of heregulin-mediated receptor activation. Growth Factors 30:5, pages 310-319.
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Nicholas C Nicolaides, Philip M Sass & Luigi Grasso. (2010) Advances in targeted therapeutic agents. Expert Opinion on Drug Discovery 5:11, pages 1123-1140.
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Kelly Karl, Taylor P. Light & Kalina Hristova. 2022. Comprehensive Pharmacology. Comprehensive Pharmacology 10 36 .
Ruth A. Mitchell, Rodney B. Luwor & Antony W. Burgess. (2018) Epidermal growth factor receptor: Structure-function informing the design of anticancer therapeutics. Experimental Cell Research 371:1, pages 1-19.
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Miles A. Miller, Marcia L. Moss, Gary Powell, Robert Petrovich, Lori Edwards, Aaron S. Meyer, Linda G. Griffith & Douglas A. Lauffenburger. (2015) Targeting autocrine HB-EGF signaling with specific ADAM12 inhibition using recombinant ADAM12 prodomain. Scientific Reports 5:1.
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Stephen Goodall, Christopher B. Howard, Martina L. Jones, Trent Munro, Zhongfan Jia, Michael J. Monteiro & Stephen Mahler. (2015) An EGFR targeting nanoparticle self assembled from a thermoresponsive polymer. Journal of Chemical Technology & Biotechnology 90:7, pages 1222-1229.
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Yibin Xu, Priscilla Soo, Francesca Walker, Hui Hua Zhang, Nicholas Redpath, Chin Wee Tan, Nicos A. Nicola, Timothy E. Adams, Thomas P. Garrett, Jian-Guo Zhang & Antony W. Burgess. (2015) LRIG1 Extracellular Domain: Structure and Function Analysis. Journal of Molecular Biology 427:10, pages 1934-1948.
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S A Greenall, J F Donoghue, N G Gottardo, T G Johns & T E Adams. (2014) Glioma-specific Domain IV EGFR cysteine mutations promote ligand-induced covalent receptor dimerization and display enhanced sensitivity to dacomitinib in vivo.. Oncogene 34:13, pages 1658-1666.
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Jiali Zhai, Judith A. Scoble, Nan Li, George Lovrecz, Lynne J. Waddington, Nhiem Tran, Benjamin W. Muir, Gregory Coia, Nigel Kirby, Calum J. Drummond & Xavier Mulet. (2015) Epidermal growth factor receptor-targeted lipid nanoparticles retain self-assembled nanostructures and provide high specificity. Nanoscale 7:7, pages 2905-2913.
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Nicholas J. Bessman, Atrish Bagchi, Kathryn M. Ferguson & Mark A. Lemmon. (2014) Complex Relationship between Ligand Binding and Dimerization in the Epidermal Growth Factor Receptor. Cell Reports 9:4, pages 1306-1317.
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V. Chandana Epa, Olan Dolezal, Larissa Doughty, Xiaowen Xiao, Christian Jost, Andreas Plückthun & Timothy E. Adams. (2013) Structural Model for the Interaction of a Designed Ankyrin Repeat Protein with the Human Epidermal Growth Factor Receptor 2. PLoS ONE 8:3, pages e59163.
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M Lindzen, S Carvalho, A Starr, N Ben-Chetrit, C-R Pradeep, W J Köstler, A Rabinkov, S Lavi, S S Bacus & Y Yarden. (2011) A recombinant decoy comprising EGFR and ErbB-4 inhibits tumor growth and metastasis. Oncogene 31:30, pages 3505-3515.
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Sameer A. Greenall, Ermanno Gherardi, Zhanqi Liu, Jacqueline F. Donoghue, Angela A. Vitali, Qian Li, Roger Murphy, Luisa Iamele, Andrew M. Scott & Terrance G. Johns. (2012) Non-Agonistic Bivalent Antibodies That Promote c-MET Degradation and Inhibit Tumor Growth and Others Specific for Tumor Related c-MET. PLoS ONE 7:4, pages e34658.
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Tsun-Wen Yao, Woo-Shin Kim, Denise MT. Yu, George Sharbeen, Geoffrey W. McCaughan, Kang-Yell Choi, Pu Xia & Mark D. Gorrell. (2011) A Novel Role of Dipeptidyl Peptidase 9 in Epidermal Growth Factor Signaling. Molecular Cancer Research 9:7, pages 948-959.
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Maria-del-Mar Inda, Rudy Bonavia, Akitake Mukasa, Yoshitaka Narita, Dinah W.Y. Sah, Scott Vandenberg, Cameron Brennan, Terrance G. Johns, Robert Bachoo, Philipp Hadwiger, Pamela Tan, Ronald A. DePinho, Webster Cavenee & Frank Furnari. (2010) Tumor heterogeneity is an active process maintained by a mutant EGFR-induced cytokine circuit in glioblastoma. Genes & Development 24:16, pages 1731-1745.
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Diego Alvarado, Daryl E. Klein & Mark A. Lemmon. (2010) Structural Basis for Negative Cooperativity in Growth Factor Binding to an EGF Receptor. Cell 142:4, pages 568-579.
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