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Original

Overexpression of Reg3α increases cell growth and the levels of cyclin D1 and CDK4 in insulinoma cells

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Pages 195-202 | Received 15 Sep 2008, Accepted 27 Feb 2009, Published online: 11 Jul 2009

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Read on this site (2)

Ying Wang, Cecile Jacovetti, Bing Li, Tehmina Siddique, Xiaoquan Xiong, Hongping Yin, Min Wang, Hong Zhao & Jun-Li Liu. (2011) Coordinated age-dependent and pancreatic-specific expression of mouse Reg2Reg3α, and Reg3β genes. Growth Factors 29:2-3, pages 72-81.
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Lu Liu, Jun-Li Liu & Coimbatore B. Srikant. (2010) Reg2 protects mouse insulinoma cells from streptozotocin-induced mitochondrial disruption and apoptosis. Growth Factors 28:5, pages 370-378.
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Articles from other publishers (26)

Rajni Sharma, Manju Kumari, Suman Mishra, Dharmendra K. Chaudhary, Alok Kumar, Batia Avni & Swasti Tiwari. (2021) Exosomes Secreted by Umbilical Cord Blood-Derived Mesenchymal Stem Cell Attenuate Diabetes in Mice. Journal of Diabetes Research 2021, pages 1-15.
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Annefleur Koopen, Julia Witjes, Koen Wortelboer, Soumia Majait, Andrei Prodan, Evgeni Levin, Hilde Herrema, Maaike Winkelmeijer, Steven Aalvink, Jacques J G H M Bergman, Stephan Havik, Bolette Hartmann, Han Levels, Per-Olof Bergh, Jamie van Son, Manon Balvers, Diogo Mendes Bastos, Erik Stroes, Albert K Groen, Marcus Henricsson, Ellis Marleen Kemper, Jens Holst, Christopher M Strauch, Stanley L Hazen, Fredrik Bäckhed, Willem M De Vos, Max Nieuwdorp & Elena Rampanelli. (2021) Duodenal Anaerobutyricum soehngenii infusion stimulates GLP-1 production, ameliorates glycaemic control and beneficially shapes the duodenal transcriptome in metabolic syndrome subjects: a randomised double-blind placebo-controlled cross-over study . Gut, pages gutjnl-2020-323297.
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Zijing Chen, Shawna Downing & Emmanuel S. Tzanakakis. (2019) Four Decades After the Discovery of Regenerating Islet-Derived (Reg) Proteins: Current Understanding and Challenges. Frontiers in Cell and Developmental Biology 7.
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Yuwei WangXiao LiuJingshu LiuTao Zhang. (2019) Knockdown of REG Iα Enhances the Sensitivity to 5-Fluorouracil of Colorectal Cancer Cells via Cyclin D1/CDK4 Pathway and BAX/BCL-2 Pathways. Cancer Biotherapy and Radiopharmaceuticals 34:6, pages 362-370.
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Md. Moniruzzaman, Ran Wang, Varinder Jeet, Michael A. McGuckin & Sumaira Z. Hasnain. (2019) Interleukin (IL)-22 from IL-20 Subfamily of Cytokines Induces Colonic Epithelial Cell Proliferation Predominantly through ERK1/2 Pathway. International Journal of Molecular Sciences 20:14, pages 3468.
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Chikatsugu Tsuchida, Sumiyo Sakuramoto-Tsuchida, Maiko Taked, Asako Itaya-Hironaka, Akiyo Yamauchi, Masayasu Misu, Ryogo Shobatake, Tomoko Uchiyama, Mai Makino, Irma Pujol-Autonell, Marta Vives-Pi, Chiho Ohbayashi & Shin Takasawa. (2017) Expression of REG family genes in human inflammatory bowel diseases and its regulation. Biochemistry and Biophysics Reports 12, pages 198-205.
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Xiaoquan Xiong, Qing Li, Wei Cui, Zu-Hua Gao & Jun-Li Liu. (2016) Deteriorated high-fat diet-induced diabetes caused by pancreatic β-cell-specific overexpression of Reg3β gene in mice. Endocrine 54:2, pages 360-370.
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Chen Luo, Lu-Ting Yu, Meng-Qi Yang, Xiang Li, Zhi-Yuan Zhang, Martin O Alfred, Jun-Li Liu & Min Wang. (2016) Recombinant Reg3β protein protects against streptozotocin-induced β-cell damage and diabetes. Scientific Reports 6:1.
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Fei Xia, Hui Cao, Jiao Du, Xiulan Liu, Yang Liu & Ming Xiang. (2016) Reg3g overexpression promotes β cell regeneration and induces immune tolerance in nonobese-diabetic mouse model. Journal of Leukocyte Biology 99:6, pages 1131-1140.
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Qianqian Xu, Rong Fu, Guoxiao Yin, Xiulan Liu, Yang Liu & Ming Xiang. (2016) Microarray-based gene expression profiling reveals genes and pathways involved in the oncogenic function of REG3A on pancreatic cancer cells. Gene 578:2, pages 263-273.
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Lu-Ting Yu, Meng-Qi Yang, Jun-Li Liu, Martin O. Alfred, Xiang Li, Xue-Qing Zhang, Juan Zhang, Ming-Yuan Wu, Min Wang & Chen Luo. (2016) Recombinant Reg3α protein protects against experimental acute pancreatitis in mice. Molecular and Cellular Endocrinology 422, pages 150-159.
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Qing Li, Xiaoquan Xiong & Jun-Li Liu. 2015. Islets of Langerhans. Islets of Langerhans 955 987 .
Jun Wang, Hong Zhou, Yong Han, Xiulan Liu, Min Wang, Xin Wang, Guoxiao Yin, Xu Li & Ming Xiang. (2014) SOCS3 methylation in synergy with Reg3A overexpression promotes cell growth in pancreatic cancer. Journal of Molecular Medicine 92:12, pages 1257-1269.
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Jie Cheng, Min Fei, Min Fei, Xuezi Sang, Xuezi Sang, Zhe Cheng, Suxin Gui, Xiaoyang Zhao, Lei Sheng, Qingqing Sun, Renping Hu, Ling Wang & Fashui Hong. (2014) Gene expression profile in chronic mouse liver injury caused by long-term exposure to CeCl 3 . Environmental Toxicology 29:7, pages 837-846.
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Ying Ding, Yuemei Xu, Xuanyu Shuai, Xuhui Shi, Xiang Chen, Wenbin Huang, Yun Liu, Xiubin Liang, Zhihong Zhang & Dongming Su. (2014) Reg3α Overexpression Protects Pancreatic β Cells from Cytokine-Induced Damage and Improves Islet Transplant Outcome. Molecular Medicine 20:1, pages 548-558.
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Qing Li, Xiaoquan Xiong & Jun-Li Liu. 2013. Islets of Langerhans, 2. ed.. Islets of Langerhans, 2. ed. 1 30 .
Baktiar O Karim, Ki-Jong Rhee, Guosheng Liu, Dongfeng Zheng & David L Huso. (2013) Chemoprevention utility of silibinin and Cdk4 pathway inhibition in Apc −/+ ice. BMC Cancer 13:1.
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Hiroyo Ota, Asako Itaya-Hironaka, Akiyo Yamauchi, Sumiyo Sakuramoto-Tsuchida, Tomoko Miyaoka, Takanori Fujimura, Hiroki Tsujinaka, Kiyomi Yoshimoto, Kan-ichi Nakagawara, Shinji Tamaki, Shin Takasawa & Hiroshi Kimura. (2013) Pancreatic β cell proliferation by intermittent hypoxia via up-regulation of Reg family genes and HGF gene. Life Sciences 93:18-19, pages 664-672.
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Bing Li, Chen Luo, Subrata Chowdhury, Zu-Hua Gao & Jun-Li Liu. (2013) Parp1 deficient mice are protected from streptozotocin-induced diabetes but not caerulein-induced pancreatitis, independent of the induction of Reg family genes. Regulatory Peptides 186, pages 83-91.
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Bing LiYarong LuCoimbatore B. SrikantZu-Hua GaoJun-Li Liu. (2013) Intestinal adaptation and Reg gene expression induced by antidiabetic duodenal-jejunal bypass surgery in Zucker fatty rats. American Journal of Physiology-Gastrointestinal and Liver Physiology 304:7, pages G635-G645.
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Chen Luo, Bing Li, Lu Liu, Hong-Ping Yin, Min Wang & Jun-Li Liu. (2013) Transcriptional activation of Reg2 and Reg3β genes by glucocorticoids and interleukin-6 in pancreatic acinar and islet cells. Molecular and Cellular Endocrinology 365:2, pages 187-196.
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G. S. GuptaG. S. Gupta. 2012. Animal Lectins: Form, Function and Clinical Applications. Animal Lectins: Form, Function and Clinical Applications 847 880 .
Xiaoquan XiongXiao Wang, Bing LiSubrata ChowdhuryYarong LuCoimbatore B. SrikantGuang Ning & Jun-Li Liu. (2011) Pancreatic islet-specific overexpression of Reg3β protein induced the expression of pro-islet genes and protected the mice against streptozotocin-induced diabetes mellitus. American Journal of Physiology-Endocrinology and Metabolism 300:4, pages E669-E680.
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Hiroyuki Konishi, Tokiko Ogawa, Shinichi Kawahara, Sakiko Matsumoto & Hiroshi Kiyama. (2011) Continuous stress-induced dopamine dysregulation augments PAP-I and PAP-II expression in melanotrophs of the pituitary gland. Biochemical and Biophysical Research Communications 407:1, pages 7-12.
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Bing LiXiao Wang & Jun-Li Liu. (2010) Pancreatic acinar-specific overexpression of Reg2 gene offered no protection against either experimental diabetes or pancreatitis in mice. American Journal of Physiology-Gastrointestinal and Liver Physiology 299:2, pages G413-G421.
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Jong-Ho Choi, Min-Young Lee, Yoolee Kim, Jeong-Yun Shim, Sang-Moon Han, Kyung-Ah Lee, Young-Kil Choi, Hae-Myung Jeon & Kwang-Hyun Baek. (2010) Isolation of genes involved in pancreas regeneration by subtractive hybridization. Biological Chemistry 391:9.
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