2,576
Views
65
CrossRef citations to date
0
Altmetric
Articles

Quercetin inhibits advanced glycation end product formation via chelating metal ions, trapping methylglyoxal, and trapping reactive oxygen species

, , &
Pages 882-890 | Received 27 Sep 2016, Accepted 29 Dec 2016, Published online: 08 Feb 2017

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (2)

Yaqian Geng, Yao Mou, Yingfeng Xie, Junfu Ji, Fang Chen, Xiaojun Liao, Xiaosong Hu & Lingjun Ma. (2023) Dietary Advanced Glycation End Products: An Emerging Concern for Processed Foods. Food Reviews International 0:0, pages 1-17.
Read now
Makoto Ubukata. (2018) The logic of biologically active small molecules: amazing ability of microorganisms . Bioscience, Biotechnology, and Biochemistry 82:7, pages 1063-1072.
Read now

Articles from other publishers (63)

Izabela Berdowska, Małgorzata Matusiewicz & Izabela Fecka. (2023) Methylglyoxal in Cardiometabolic Disorders: Routes Leading to Pathology Counterbalanced by Treatment Strategies. Molecules 28:23, pages 7742.
Crossref
Miao Zhou, Jie Ma, Meng Kang, Wenjie Tang, Siting Xia, Jie Yin & Yulong Yin. (2023) Flavonoids, gut microbiota, and host lipid metabolism. Engineering in Life Sciences.
Crossref
Deepika Kathuria, Hamid, Sunakshi Gautam & Abhimanyu Thakur. (2023) Maillard reaction in different food products: Effect on product quality, human health and mitigation strategies. Food Control 153, pages 109911.
Crossref
Nilima S. Bangar, Selvan Ravindran, Shamim A. Shaikh, Nilesh Shah & Rashmi S. Tupe. (2023) Homeopathic Formulations of Syzygium jambolanum Alleviate Glycation-Mediated Structural and Functional Modifications of Albumin: Evaluation through Multi-Spectroscopic and Microscopic Approaches. Homeopathy.
Crossref
Xi Peng, Xing Hu, Kai Liu, Deming Gong & Guowen Zhang. (2023) Exploring inhibitory effect and mechanism of hesperetin-Cu (II) complex against protein glycation. Food Chemistry 416, pages 135801.
Crossref
Yaxu Liang, Huan Wang, Bencheng Wu, Ning Peng, Dongming Yu, Xin Wu & Xiang Zhong. (2023) The emerging role of N6-methyladenine RNA methylation in metal ion metabolism and metal-induced carcinogenesis. Environmental Pollution 331, pages 121897.
Crossref
Carolina Añazco, Janin Riedelsberger, Lorenzo Vega-Montoto & Armando Rojas. (2023) Exploring the Interplay between Polyphenols and Lysyl Oxidase Enzymes for Maintaining Extracellular Matrix Homeostasis. International Journal of Molecular Sciences 24:13, pages 10985.
Crossref
Juan Liu, Zhiqiang Xiao, Siqi Zhang, Zhen Wang, Yun Chen & Yang Shan. (2023) Restricting Promiscuity of Plant Flavonoid 3′-Hydroxylase and 4′- O -Methyltransferase Improves the Biosynthesis of (2 S )-Hesperetin in E. coli . Journal of Agricultural and Food Chemistry 71:25, pages 9826-9835.
Crossref
Laura Accipe, Alisson Abadie, Remi Neviere & Sylvie Bercion. (2023) Antioxidant Activities of Natural Compounds from Caribbean Plants to Enhance Diabetic Wound Healing. Antioxidants 12:5, pages 1079.
Crossref
Izabela Fecka, Katarzyna Bednarska & Adam Kowalczyk. (2023) In Vitro Antiglycation and Methylglyoxal Trapping Effect of Peppermint Leaf (Mentha × piperita L.) and Its Polyphenols. Molecules 28:6, pages 2865.
Crossref
Amisha Punmiya & Arati Prabhu. (2023) Structural fingerprinting of pleiotropic flavonoids for multifaceted Alzheimer's disease. Neurochemistry International 163, pages 105486.
Crossref
Yizhen SimaJunwei LiLeimei XuChengzhen XiaoLisha LiLing WangYisong Chen. (2023) Quercetin antagonized advanced glycated end products induced apoptosis and functional inhibition of fibroblasts from the prolapsed uterosacral ligament. Drug Discoveries & Therapeutics.
Crossref
Sanaz Sadig Baheran, Raid G. Alany, Sianne Schwikkard, Wisam Muen, Lena Namaan Salman, Nicholas Freestone & Ali A. Al-Kinani. (2023) Pharmacological treatment strategies of pterygium: Drugs, biologics, and novel natural products. Drug Discovery Today 28:1, pages 103416.
Crossref
Sadia Afrin & Mohammad Nazrul Islam Bhuiyan. (2023) Antagonistic activity of Bacillus amyloliquefaciens subsp. amyloliquefaciens against multidrug resistant Serratia rubidaea. Current Research in Microbial Sciences 5, pages 100206.
Crossref
Aghileh Mohammadzadeh & Ali Gol. (2022) Synergistic properties of garlic and Citrullus colocynthis on reproductive injury caused by diabetes in male rats: Structural and molecular evidence . Journal of Food Biochemistry 46:12.
Crossref
Firdaus Jahan, Sahir Sultan Alvi & Mohammad Hayatul Islam. (2022) Berberis aristata and its secondary metabolites: Insights into nutraceutical and therapeutical applications. Pharmacological Research - Modern Chinese Medicine 5, pages 100184.
Crossref
Katarzyna Bednarska & Izabela Fecka. (2022) Aspalathin and Other Rooibos Flavonoids Trapped α-Dicarbonyls and Inhibited Formation of Advanced Glycation End Products In Vitro. International Journal of Molecular Sciences 23:23, pages 14738.
Crossref
Heaji Lee, Younmi Kim, Sun Yeou Kim & Yunsook Lim. (2022) Quamoclit angulata extract supplementation attenuates hepatic damage via regulation of AMPK/SIRT associated hepatic lipid metabolism in streptozotocin and high fat diet–induced T2DM mice. Nutrition Research 104, pages 10-19.
Crossref
Lory Sthephany Rochín-Hernández, Lory Jhenifer Rochín-Hernández & Luis Bernardo Flores-Cotera. (2022) Endophytes, a Potential Source of Bioactive Compounds to Curtail the Formation–Accumulation of Advanced Glycation End Products: A Review. Molecules 27:14, pages 4469.
Crossref
Chi-Heung Cho, Chang-Jun Lee, Min-Gyeong Kim, Bomi Ryu, Jun-Geon Je, Yoonsook Kim & Sang-Hoon Lee. (2022) Therapeutic Potential of Phlorotannin-Rich Ecklonia cava Extract on Methylglyoxal-Induced Diabetic Nephropathy in In Vitro Model. Marine Drugs 20:6, pages 355.
Crossref
Chun-yu Chen, Jia-Qi Zhang, Li Li, Miao-miao Guo, Yi-fan He, Yin-mao Dong, Hong Meng & Fan Yi. (2022) Advanced Glycation End Products in the Skin: Molecular Mechanisms, Methods of Measurement, and Inhibitory Pathways. Frontiers in Medicine 9.
Crossref
Annamária Bardelčíková, Andrej Miroššay, Jindřich Šoltýs & Ján Mojžiš. (2022) Therapeutic and prophylactic effect of flavonoids in post ‐COVID‐19 therapy . Phytotherapy Research 36:5, pages 2042-2060.
Crossref
Karolina Bernacka, Katarzyna Bednarska, Aneta Starzec, Sylwester Mazurek & Izabela Fecka. (2022) Antioxidant and Antiglycation Effects of Cistus × incanus Water Infusion, Its Phenolic Components, and Respective Metabolites. Molecules 27:8, pages 2432.
Crossref
Warintorn Ruksiriwanich, Chiranan Khantham, Pichchapa Linsaenkart, Tanakarn Chaitep, Pensak Jantrawut, Chuda Chittasupho, Pornchai Rachtanapun, Kittisak Jantanasakulwong, Yuthana Phimolsiripol, Sarana Rose Sommano, Chaiwat Arjin, Houda Berrada, Francisco J. Barba & Korawan Sringarm. (2022) In Vitro and In Vivo Regulation of SRD5A mRNA Expression of Supercritical Carbon Dioxide Extract from Asparagus racemosus Willd. Root as Anti-Sebum and Pore-Minimizing Active Ingredients. Molecules 27:5, pages 1535.
Crossref
Maryam Farokhcheh, Leilabeigom Hejazian, Zeinab Akbarnejad, Fereshteh Pourabdolhossein, Seyed Mohammad Hosseini, Tahereh Mohammad Mehraei & Nabiollah Soltanpour. (2021) Geraniol improved memory impairment and neurotoxicity induced by zinc oxide nanoparticles in male wistar rats through its antioxidant effect. Life Sciences 282, pages 119823.
Crossref
María Lucía Rodríguez, Iván Millán & Ángel Luis Ortega. (2021) Cellular targets in diabetic retinopathy therapy. World Journal of Diabetes 12:9, pages 1442-1462.
Crossref
R. A. Litvinov, A. V. Gontareva, L. E. Usmiyanova & D. R. Klimenko. (2021) INFLUENCE OF CERTAIN D-METALS ON FORMATION OF ADVANCED GLYCATION END PRODUCTS, AGGREGATION AND AMYLOID TRANSFORMATION OF ALBUMIN IN GLYCATION REACTION. Pharmacy & Pharmacology 9:4, pages 306-317.
Crossref
Yantao Zhao, Yao Tang & Shengmin Sang. (2021) Dietary Quercetin Reduces Plasma and Tissue Methylglyoxal and Advanced Glycation End Products in Healthy Mice Treated with Methylglyoxal. The Journal of Nutrition 151:9, pages 2601-2609.
Crossref
Xie Xing, Chen Chun, Huang Qiang, Fu Xiong & Liu Rui-Hai. (2021) Investigation into the mechanisms of quercetin-3- O -glucuronide inhibiting α-glucosidase activity and non-enzymatic glycation by spectroscopy and molecular docking . Food & Function 12:17, pages 7825-7835.
Crossref
Jasmina Primožič, Borut Poljšak, Polona Jamnik, Vito Kovač, Gordana Čanadi Jurešić & Stjepan Spalj. (2021) Risk Assessment of Oxidative Stress Induced by Metal Ions Released from Fixed Orthodontic Appliances during Treatment and Indications for Supportive Antioxidant Therapy: A Narrative Review. Antioxidants 10:9, pages 1359.
Crossref
Stefaniya Velichkova, Kenn Foubert & Luc Pieters. (2021) Natural Products as a Source of Inspiration for Novel Inhibitors of Advanced Glycation Endproducts (AGEs) Formation. Planta Medica 87:10/11, pages 780-801.
Crossref
Mouchira A. Choucry, Akram A. Shalabi, Ali M. El Halawany, Fatma S. El-Sakhawy, Ali Zaiter, Hiroyuki Morita, Patrick Chaimbault & Essam Abdel-Sattar. (2021) New Pregnane Glycosides Isolated from Caralluma hexagona Lavranos as Inhibitors of α-Glucosidase, Pancreatic Lipase, and Advanced Glycation End Products Formation . ACS Omega 6:29, pages 18881-18889.
Crossref
Éva Szabó, Tamás Marosvölgyi, Gábor Szilágyi, László Kőrösi, János Schmidt, Kristóf Csepregi, László Márk & Ágnes Bóna. (2021) Correlations between Total Antioxidant Capacity, Polyphenol and Fatty Acid Content of Native Grape Seed and Pomace of Four Different Grape Varieties in Hungary. Antioxidants 10:7, pages 1101.
Crossref
Shobha Regmi, Yoojin Seo, Ji-Su Ahn, Shiva Pathak, Suman Acharya, Tiep Tien Nguyen, Simmyung Yook, Jong-Hyuk Sung, Jun-Beom Park, Jong Oh Kim, Chul Soon Young, Hyung-Sik Kim & Jee-Heon Jeong. (2021) Heterospheroid formation improves therapeutic efficacy of mesenchymal stem cells in murine colitis through immunomodulation and epithelial regeneration. Biomaterials 271, pages 120752.
Crossref
Zdeněk Kejík, Robert Kaplánek, Michal Masařík, Petr Babula, Adam Matkowski, Petr Filipenský, Kateřina Veselá, Jakub Gburek, David Sýkora, Pavel Martásek & Milan Jakubek. (2021) Iron Complexes of Flavonoids-Antioxidant Capacity and Beyond. International Journal of Molecular Sciences 22:2, pages 646.
Crossref
Shuqing Zhang, Chingyuan Hu, Yurong Guo, Xiaoyu Wang & Yonghong Meng. (2021) Polyphenols in fermented apple juice: Beneficial effects on human health. Journal of Functional Foods 76, pages 104294.
Crossref
Katarzyna Bednarska, Piotr Kuś & Izabela Fecka. (2020) Investigation of the Phytochemical Composition, Antioxidant Activity, and Methylglyoxal Trapping Effect of Galega officinalis L. Herb In Vitro. Molecules 25:24, pages 5810.
Crossref
Mahesha M. Poojary, Wei Zhang, Sarah Bisgaard Olesen, Valentin Rauh & Marianne N. Lund. (2020) Green Tea Extract Decreases Arg-Derived Advanced Glycation Endproducts but Not Lys-Derived AGEs in UHT Milk during 1-Year Storage. Journal of Agricultural and Food Chemistry 68:48, pages 14261-14273.
Crossref
Alexander Fedintsev & Alexey Moskalev. (2020) Stochastic non-enzymatic modification of long-lived macromolecules - A missing hallmark of aging. Ageing Research Reviews 62, pages 101097.
Crossref
Lu Zhang, Wen-na Zhou, Zong-cai Tu, Si-hang Yang, Liang Xu & Tao Yuan. (2020) Influence of Hydroxyl Substitution on the Suppression of Flavonol in Harmful Glycation Product Formation and the Inhibition Mechanism Revealed by Spectroscopy and Mass Spectrometry. Journal of Agricultural and Food Chemistry 68:31, pages 8263-8273.
Crossref
Xiaqing Wu, Guowen Zhang, Mingming Hu, Junhui Pan, Ang Li & Ying Zhang. (2020) Molecular characteristics of gallocatechin gallate affecting protein glycation. Food Hydrocolloids 105, pages 105782.
Crossref
Shengyi Yang, Huanhuan Zhou, Guiping Wang, Xiao‐Hong Zhong, Qi‐Liang Shen, Xue‐Jing Zhang, Ru‐Yi Li, Li‐Hua Chen, Ya‐Han Zhang & Zhongxiao Wan. (2020) Quercetin is protective against short‐term dietary advanced glycation end products intake induced cognitive dysfunction in aged ICR mice. Journal of Food Biochemistry 44:4.
Crossref
Ileana González, Miguel A. Morales & Armando Rojas. (2020) Polyphenols and AGEs/RAGE axis. Trends and challenges. Food Research International 129, pages 108843.
Crossref
Lu Zhang, Liang Xu, Zong-cai Tu, Hong-hong Wang, Juan Luo & Tian-xin Ma. (2020) Mechanisms of isoquercitrin attenuates ovalbumin glycation: Investigation by spectroscopy, spectrometry and molecular docking. Food Chemistry 309, pages 125667.
Crossref
Rosario Pastor & Josep A. Tur. (2020) Response to exercise in older adults who take supplements of antioxidants and/or omega-3 polyunsaturated fatty acids: A systematic review. Biochemical Pharmacology 173, pages 113649.
Crossref
Shengyi Yang, Guiping Wang, Zheng feei Ma, Li‐qiang Qin, Yu‐jia Zhai, Zeng‐Li Yu, Man Xue, Ya‐han Zhang & Zhongxiao Wan. (2020) DietaryAdvancedGlycationEnd Products–InducedCognitive Impairment in Aged ICR Mice: Protective Role of Quercetin. Molecular Nutrition & Food Research 64:3, pages 1901019.
Crossref
Austin Hellings, Levi Buchan, Monica Castro, Chaheyla R St. Aubin, Amy L Fisher, Layla Al-Nakkash, Tom L Broderick & Jeffrey H Plochocki. (2019) Bone Strength Is Improved with Genistein Treatment in Mice with Diet-Induced Obesity. Current Developments in Nutrition 3:11, pages nzz121.
Crossref
Moon Ho Do, Jiwon Choi, Yoonsook Kim, Ho-Young Park, Yongkon Park, Sang Keun Ha & Jinyoung Hur. (2019) Schizonepeta tenuifolia reduces methylglyoxal-induced cytotoxicity and oxidative stress in mesangial cells. Journal of Functional Foods 62, pages 103531.
Crossref
Hongkai Zhu, Mahesha M. Poojary, Mogens L. Andersen & Marianne N. Lund. (2019) Effect of pH on the reaction between naringenin and methylglyoxal: A kinetic study. Food Chemistry 298, pages 125086.
Crossref
Agnieszka Piwowar, Anna Rorbach-Dolata & Izabela Fecka. (2019) The Antiglycoxidative Ability of Selected Phenolic Compounds—An In Vitro Study. Molecules 24:15, pages 2689.
Crossref
Tess De Bruyne, Bieke Steenput, Lynn Roth, Guido De Meyer, Claudia Santos, Kateřina Valentová, Maija Dambrova & Nina Hermans. (2019) Dietary Polyphenols Targeting Arterial Stiffness: Interplay of Contributing Mechanisms and Gut Microbiome-Related Metabolism. Nutrients 11:3, pages 578.
Crossref
Lu Zhang, Yu Lu, Yun-hua Ye, Si-hang Yang, Zong-cai Tu, Juan Chen, Hui Wang, Hong-hong Wang & Tao Yuan. (2018) Insights into the Mechanism of Quercetin against BSA-Fructose Glycation by Spectroscopy and High-Resolution Mass Spectrometry: Effect on Physicochemical Properties. Journal of Agricultural and Food Chemistry 67:1, pages 236-246.
Crossref
Mathias D G Van den Eynde, Johanna M Geleijnse, Jean L J M Scheijen, Nordin M J Hanssen, James I Dower, Lydia A Afman, Coen D A Stehouwer, Peter C H Hollman & Casper G Schalkwijk. (2018) Quercetin, but Not Epicatechin, Decreases Plasma Concentrations of Methylglyoxal in Adults in a Randomized, Double-Blind, Placebo-Controlled, Crossover Trial with Pure Flavonoids. The Journal of Nutrition 148:12, pages 1911-1916.
Crossref
Julius Grosche, Juliane Meißner & Johannes A. Eble. (2018) More than a syllable in fib-ROS-is: The role of ROS on the fibrotic extracellular matrix and on cellular contacts. Molecular Aspects of Medicine 63, pages 30-46.
Crossref
Shiva Pathak, Shobha Regmi, Tiep Tien Nguyen, Biki Gupta, Milan Gautam, Chul Soon Yong, Jong Oh Kim, Youlim Son, Jae-Ryong Kim, Min Hui Park, Young Kyung Bae, So Young Park, Daewon Jeong, Simmyung Yook & Jee-Heon Jeong. (2018) Polymeric microsphere-facilitated site-specific delivery of quercetin prevents senescence of pancreatic islets in vivo and improves transplantation outcomes in mouse model of diabetes. Acta Biomaterialia 75, pages 287-299.
Crossref
Jonathan Fusi, Sara Bianchi, Simona Daniele, Silvia Pellegrini, Claudia Martini, Fabio Galetta, Luca Giovannini & Ferdinando Franzoni. (2018) An in vitro comparative study of the antioxidant activity and SIRT1 modulation of natural compounds. Biomedicine & Pharmacotherapy 101, pages 805-819.
Crossref
Kengo Shigetomi, Naoki Okada, Takashi Kumaki, Shinya Mitsuhashi & Makoto Ubukata. (2018) Inhibitory activities of tree bark extracts against AGEs formation and their correlation with phenolic components. Wood Science and Technology 52:3, pages 873-886.
Crossref
Yi Yang, Xiaokang Liu, Ting Wu, Wenping Zhang, Jianhong Shu, Yulong He & Shao-Jun Tang. (2018) Quercetin attenuates AZT-induced neuroinflammation in the CNS. Scientific Reports 8:1.
Crossref
Lu Zhang, Chong-ju Zhang, Zong-cai Tu, Wen-hua Yang, Yi Zhao, Zheng-qi Xin, Hui Wang, Xiao-mei Sha & Juan Chen. (2018) Nelumbo nucifera leaf extracts inhibit the formation of advanced glycation end-products and mechanism revealed by Nano LC-Orbitrap-MS/MS. Journal of Functional Foods 42, pages 254-261.
Crossref
Toshinori NAKAGAWA, Hiromi SAIJO, Hiroya ISHIKAWA, Shinji HIJIYA, Suguru KOUGETSU, Akira IWAMOTO, Yumi TSURUTA, Keisuke TSUGE, Takashi YOSHIMURA, Koichiro OHNUKI & Kuniyoshi SHIMIZU. (2018) The Evaluation of Shikimi (<i>Illicium anisatum</i>) Cultivated in Saga Prefecture as Functional Food and Cosmetic Material佐賀県で生産されたシキミ(<i>Illicium anisatum</i>)の機能性食品および化粧品素材としての機能性評価. Food Preservation Science 44:6, pages 303-308.
Crossref
Irina Milisav, Samo Ribarič & Borut Poljsak. 2018. Biochemistry and Cell Biology of Ageing: Part I Biomedical Science. Biochemistry and Cell Biology of Ageing: Part I Biomedical Science 1 23 .
Ladislav Mirossay, Lenka Varinská & Ján Mojžiš. (2017) Antiangiogenic Effect of Flavonoids and Chalcones: An Update. International Journal of Molecular Sciences 19:1, pages 27.
Crossref
Lucian Hritcu, Radu Ionita, Paula Alexandra Postu, Girish Kumar Gupta, Hasan Turkez, Tamires Cardoso Lima, Caroline Uchôa Souza Carvalho & Damião Pergentino de Sousa. (2017) Antidepressant Flavonoids and Their Relationship with Oxidative Stress. Oxidative Medicine and Cellular Longevity 2017, pages 1-18.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.