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Ocular Immunology and Inflammation Volume 15, 2007 - Issue 1
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ORIGINAL ARTICLE

Targeting Tissue Factor for Immunotherapy of Choroidal Neovascularization by Intravitreal Delivery of Factor VII-Fc Chimeric Antibody

Tongalp H. Tezel Department of Ophthalmology & Visual Sciences, Kentucky Lions Eye Center, University of Louisville School of Medicine, Louisville, KY, USA
,
Ewa Bodek Department of Ophthalmology & Visual Sciences, Kentucky Lions Eye Center, University of Louisville School of Medicine, Louisville, KY, USA
,
Kenan Sönmez Department of Ophthalmology & Visual Sciences, Kentucky Lions Eye Center, University of Louisville School of Medicine, Louisville, KY, USA
,
Sankar Kaliappan Department of Ophthalmology & Visual Sciences, Kentucky Lions Eye Center, University of Louisville School of Medicine, Louisville, KY, USA
,
Henry J. Kaplan Department of Ophthalmology & Visual Sciences, Kentucky Lions Eye Center, University of Louisville School of Medicine, Louisville, KY, USA
,
Zhiwei Hu Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT, USA
&
Alan Garen Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT, USA
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Pages 3-10 | Accepted 30 Nov 2006, Published online: 08 Jul 2009

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Mohamed Al-Shabrawey, Mohamed Elsherbiny, Julian Nussbaum, Amira Othman, Sylvia Megyerdi & Amany Tawfik. (2013) Targeting neovascularization in ischemic retinopathy: recent advances. Expert Review of Ophthalmology 8:3, pages 267-286.
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Youngeun Cho, Frederick R Rickles, Leonard M Parver, Jingsheng Tuo & Chi-Chao Chan. (2010) The potential pathophysiological role of tissue factor in age-related macular degeneration. Expert Review of Ophthalmology 5:1, pages 27-34.
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Tongalp H Tezel. (2007) Intraocular pharmacotherapy: specificity and safety issues. Expert Review of Ophthalmology 2:5, pages 671-675.
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Articles from other publishers (26)

Thomas Stax Jakobsen, Bjørn K. Fabian-Jessing, Silja Hansen, Toke Bek, Anne Louise Askou & Thomas J. Corydon. (2023) Porcine models of choroidal neovascularization: A systematic review. Experimental Eye Research 234, pages 109590.
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Xi Huang, Li Zhang, Yanyan Fu, Meixia Zhang, Qian Yang & Jinrong Peng. (2023) Rethinking the potential and necessity of drug delivery systems in neovascular age-related macular degeneration therapy. Frontiers in Bioengineering and Biotechnology 11.
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Haiyuan Li, Yang Yu, Lei Gao, Peng Zheng, Xiaolong Liu & Hao Chen. (2022) Tissue factor: a neglected role in cancer biology. Journal of Thrombosis and Thrombolysis 54:1, pages 97-108.
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Zhiwei Hu. 2021. Successes and Challenges of NK Immunotherapy. Successes and Challenges of NK Immunotherapy 193 212 .
Salvador Gomez, Allan Tsung & Zhiwei Hu. (2020) Current Targets and Bioconjugation Strategies in Photodynamic Diagnosis and Therapy of Cancer. Molecules 25:21, pages 4964.
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Zhiwei Hu. (2020) Tissue factor as a new target for CAR-NK cell immunotherapy of triple-negative breast cancer. Scientific Reports 10:1.
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G. Ece Akinci, Ahmet M. Hondur & Tongalp H. Tezel. (2019) MANAGEMENT OF METASTATIC BREAST CARCINOMA OF IRIS WITH INTRAOCULAR BEVACIZUMAB INJECTIONS. RETINAL Cases & Brief Reports 13:3, pages 220-223.
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Zhiwei Hu, Rulong Shen, Amanda Campbell, Elizabeth McMichael, Lianbo Yu, Bhuvaneswari Ramaswamy, Cheryl A. London, Tian Xu & William E. CarsonIIIIII. (2018) Targeting Tissue Factor for Immunotherapy of Triple-Negative Breast Cancer Using a Second-Generation ICON. Cancer Immunology Research 6:6, pages 671-684.
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John A. Wells, Christine R. Gonzales, Brian B. Berger, Victor H. Gonzalez, Brian D. Sippy & Gabriela Burian. (2018) A Phase 1, Open-Label, Dose-Escalation Trial to Investigate Safety and Tolerability of Single Intravitreous Injections of ICON-1 Targeting Tissue Factor in Wet AMD. Ophthalmic Surgery, Lasers and Imaging Retina 49:5, pages 336-345.
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Zhiwei Hu. (2018) Therapeutic Antibody-Like Immunoconjugates against Tissue Factor with the Potential to Treat Angiogenesis-Dependent as Well as Macrophage-Associated Human Diseases. Antibodies 7:1, pages 8.
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Zhiwei Hu, Jijun Cheng, Jie Xu, Wolfram Ruf & Charles J. Lockwood. (2016) Tissue factor is an angiogenic-specific receptor for factor VII-targeted immunotherapy and photodynamic therapy. Angiogenesis 20:1, pages 85-96.
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William R. Strohl. (2015) Fusion Proteins for Half-Life Extension of Biologics as a Strategy to Make Biobetters. BioDrugs 29:4, pages 215-239.
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Li Wang, Zhongkai Yang, Ying Yu, Chen Cui, Huaijin Guan & Hui Chen. (2014) Blockage of tissue factor ameliorates the lesion of laser-induced choroidal neovascularization in mice. Experimental Eye Research 127, pages 117-123.
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Zhiwei Hu. (2013) Overcome the Impairment of NK Cells for Icon and Antibody Immunotherapy of Cancer. Journal of Immune Based Therapies, Vaccines and Antimicrobials 02:01, pages 1-8.
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Graciela Krikun. (2012) Endometriosis, Angiogenesis and Tissue Factor. Scientifica 2012, pages 1-10.
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Emiliano Cocco, Joyce Varughese, Natalia Buza, Stefania Bellone, Ken-Yu Lin, Marta Bellone, Paola Todeschini, Dan-Arin Silasi, Masoud Azodi, Peter E. Schwartz, Thomas J. Rutherford, Luisa Carrara, Renata Tassi, Sergio Pecorelli, Charles J. Lockwood & Alessandro D. Santin. (2011) Tissue factor expression in ovarian cancer: implications for immunotherapy with hI-con1, a factor VII-IgGFc chimeric protein targeting tissue factor. Clinical & Experimental Metastasis 28:7, pages 689-700.
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Youngeun Cho, Xiaoguang Cao, DeFen Shen, Jingsheng Tuo, Leonard M Parver, Frederick R Rickles & Chi-Chao Chan. (2010) Evidence for enhanced tissue factor expression in age-related macular degeneration. Laboratory Investigation 91:4, pages 519-526.
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J Duanmu, J Cheng, J Xu, C J Booth & Z Hu. (2011) Effective treatment of chemoresistant breast cancer in vitro and in vivo by a factor VII-targeted photodynamic therapy. British Journal of Cancer 104:9, pages 1401-1409.
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Zhiwei Hu, Benqiang Rao, Shimin Chen & Jinzhong Duanmu. (2010) Selective and effective killing of angiogenic vascular endothelial cells and cancer cells by targeting tissue factor using a factor VII-targeted photodynamic therapy for breast cancer. Breast Cancer Research and Treatment 126:3, pages 589-600.
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Kaylon L. Bruner‐Tran, Melinda E. McConaha & Kevin G. Osteen. 2011. Endometriosis. Endometriosis 270 284 .
Zhiwei Hu, Benqiang Rao, Shimin Chen & Jinzhong Duanmu. (2010) Targeting tissue factor on tumour cells and angiogenic vascular endothelial cells by factor VII-targeted verteporfin photodynamic therapy for breast cancer in vitro and in vivoin mice. BMC Cancer 10:1.
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Zhiwei Hu & Jing Li. (2010) Natural killer cells are crucial for the efficacy of Icon (factor VII/human IgG1 Fc) immunotherapy in human tongue cancer. BMC Immunology 11:1.
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E Cocco, Z Hu, C E Richter, S Bellone, F Casagrande, M Bellone, P Todeschini, G Krikun, D-A Silasi, M Azodi, P E Schwartz, T J Rutherford, N Buza, S Pecorelli, C J Lockwood & A D Santin. (2010) hI-con1, a factor VII-IgGFc chimeric protein targeting tissue factor for immunotherapy of uterine serous papillary carcinoma. British Journal of Cancer 103:6, pages 812-819.
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Graciela Krikun, Zhiwei Hu, Kevin Osteen, Kaylon L. Bruner-Tran, Frederick Schatz, Hugh S. Taylor, Paolo Toti, Felice Arcuri, William Konigsberg, Alan Garen, Carmen J. Booth & Charles J. Lockwood. (2010) The Immunoconjugate “Icon” Targets Aberrantly Expressed Endothelial Tissue Factor Causing Regression of Endometriosis. The American Journal of Pathology 176:2, pages 1050-1056.
Crossref
Aize Kijlstra, Ellen C. La Heij, Fleur Goezinne & Fred Hendrikse. 2009. Uveitis and Immunological Disorders. Uveitis and Immunological Disorders 73 85 .
Roberto Solaro. (2008) Targeted delivery of proteins by nanosized carriers. Journal of Polymer Science Part A: Polymer Chemistry 46:1, pages 1-11.
Crossref

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