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Original

High-dose pilot study with the novel progestogen dienogestin patients with endometriosis

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Pages 9-17 | Received 18 Jul 2005, Accepted 15 Nov 2005, Published online: 07 Jul 2009

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (10)

Laura Buggio, Edgardo Somigliana, Giussy Barbara, Maria Pina Frattaruolo & Paolo Vercellini. (2017) Oral and depot progestin therapy for endometriosis: towards a personalized medicine. Expert Opinion on Pharmacotherapy 18:15, pages 1569-1581.
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Nicolò Bizzarri, Valentino Remorgida, Umberto Leone Roberti Maggiore, Carolina Scala, Emanuela Tafi, Valentina Ghirardi, Stefano Salvatore, Massimo Candiani, Pier Luigi Venturini & Simone Ferrero. (2014) Dienogest in the treatment of endometriosis. Expert Opinion on Pharmacotherapy 15:13, pages 1889-1902.
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Giuseppe Bifulco, Attilio Di Spiezio Sardo, Nicoletta De Rosa, Elena Greco, Marialuigia Spinelli, Costantino Di Carlo, Giovanni A. Tommaselli & Carmine Nappi. (2012) The use of an oral contraceptive containing estradiol valerate and dienogest before office operative hysteroscopy: a feasibility study. Gynecological Endocrinology 28:12, pages 949-955.
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Adolf E Schindler. (2011) Dienogest in long-term treatment of endometriosis. International Journal of Women's Health 3, pages 175-184.
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Alfred O Mueck. (2011) Dienogest: an oral progestogen for the treatment of endometriosis. Expert Review of Obstetrics & Gynecology 6:1, pages 5-15.
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Alfred O. Mueck, Harald Seeger & Kai J. Bühling. (2010) Why use of dienogest for the first contraceptive pill with estradiol?. Gynecological Endocrinology 26:2, pages 109-113.
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Adolf E. Schindler, Alexandria Henkel, Bernd Christensen, Michel Oettel & Claudia Moore. (2009) Dienogest and the breast. Gynecological Endocrinology 25:7, pages 472-474.
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C. Gerlinger, J. Endrikat, G. Kallischnigg & J. Wessel. (2007) Evaluation of menstrual bleeding patterns: a new proposal for a universal guideline based on the analysis of more than 4500 bleeding diaries. The European Journal of Contraception & Reproductive Health Care 12:3, pages 203-211.
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Attila Mihalyi, Peter Simsa, Kyama C Mutinda, Christel Meuleman, Jason M Mwenda & Thomas M D’Hooghe. (2006) Emerging drugs in endometriosis. Expert Opinion on Emerging Drugs 11:3, pages 503-524.
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Articles from other publishers (29)

Michael Oettel, Hans Joachim Zentel & Klaus Nickisch. (2021) A progestin isn’t a progestin: dienogest for endometriosis as a blueprint for future research – Review as a contribution for discussion -. Hormone Molecular Biology and Clinical Investigation 42:2, pages 133-142.
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Kalinkina O.B., Tezikov Yu.V., Lipatov I.S. & Aravina O.R.. (2020) CLINICAL CASE OF SUCCESSFUL TREATMENT OF INFERTILITY IN A PATIENT WITH FAILURE IVF RESULTS IN ANAMNESIS. "Medical & pharmaceutical journal "Pulse", pages 61-67.
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Sa Ra Lee, Kyong Wook Yi, Jae Yen Song, Seok Kyo Seo, Dong-Yun Lee, SiHyun Cho & Sung Hoon Kim. (2018) Efficacy and Safety of Long-Term Use of Dienogest in Women With Ovarian Endometrioma. Reproductive Sciences 25:3, pages 341-346.
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Sutrisno Sutrisno, Chandra Sulistyorini, Eviyani Margaretha Manungkalit, Lilik Winarsih, Noorhamdani Noorhamdani & Sri Winarsih. (2017) The effect of genistein on TGF-β signal, dysregulation of apoptosis, cyclooxygenase-2 pathway, and NF-kB pathway in mice peritoneum of endometriosis model. Middle East Fertility Society Journal 22:4, pages 295-299.
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Shifana Lalani, Amanda Black, Meryl C. Hodge, Togas Tulandi & Innie Chen. (2017) Dienogest Therapy as a Treatment for Catamenial Pneumothorax: Case Report and Review of Hormonal Options. Journal of Obstetrics and Gynaecology Canada 39:9, pages 764-768.
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V. E. Balan, S. A. Orlova, A. S. Zhuravel, V. V. Ovchinnikova, Yu. P. Titchenko, E. V. Tikhomirova, Yu. P. Zlotnikova, Z. V. Torshina, E. A. Levkovich, V. A. Ananyev, I. D. Rizhinashvili, I. N. Lazareva & Yu. M. Belaya. (2016) From the history of studies of endometriosis to current treatments. Rossiiskii vestnik akushera-ginekologa 16:4, pages 102.
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A. A. Popov, A. A. Fedorov, T. N. Manannikova, K. N. Abramyan, S. A. Orlova & Sh. Zingan. (2016) The combined approach (laparoscopy + dienogest) for endometrios-associated infertility treatment. Problemy reproduktsii 22:4, pages 76.
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I. Yu. Kogan, D. A. Gerkulov, L. Kh. Dzhemlikhanova, I. O. Krikheli & A. M. Gzgzyan. (2015) The effeciency of IVF protocols in patients with moderate to severe endometriosis after adjuvant therapy. Problemy reproduktsii 21:2, pages 39.
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Erkan Efe, Murat Bakacak, Salih Serin, Eyüp Kolus, Önder Ercan & Sefa Resim. (2014) Hormonal Treatment for Severe Hydronephrosis Caused by Bladder Endometriosis. Case Reports in Urology 2014, pages 1-5.
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Fanuel Lampiao. (2013) New developments of the effect of melatonin on reproduction. World Journal of Obstetrics and Gynecology 2:2, pages 8.
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Carmen Maccagnano, Federico Pellucchi, Lorenzo Rocchini, Massimo Ghezzi, Vincenzo Scattoni, Francesco Montorsi, Patrizio Rigatti & Renzo Colombo. (2013) Ureteral Endometriosis: Proposal for a Diagnostic and Therapeutic Algorithm with a Review of the Literature. Urologia Internationalis 91:1, pages 1-9.
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Christoph Gerlinger, Thomas Faustmann, Jeffrey J Hassall & Christian Seitz. (2012) Treatment of endometriosis in different ethnic populations: a meta-analysis of two clinical trials. BMC Women's Health 12:1.
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Hartmut Blode, Susan Zeun, Susanne Parke, Torsten Zimmermann, Beate Rohde, Uwe Mellinger & Michael Kunz. (2012) Evaluation of the effects of rifampicin, ketoconazole and erythromycin on the steady-state pharmacokinetics of the components of a novel oral contraceptive containing estradiol valerate and dienogest in healthy postmenopausal women. Contraception 86:4, pages 337-344.
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Kaoruko Yamanaka, Bing Xu, Izumi Suganuma, Izumi Kusuki, Shizuka Mita, Yutaka Shimizu, Kiyoshi Mizuguchi & Jo Kitawaki. (2012) Dienogest inhibits aromatase and cyclooxygenase-2 expression and prostaglandin E2 production in human endometriotic stromal cells in spheroid culture. Fertility and Sterility 97:2, pages 477-482.
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S.D. Schäfer & L. Kiesel. (2011) Medikamentöse Therapie der chronischen EndometrioseConservative therapy of chronic endometriosis. Gynäkologische Endokrinologie 9:4, pages 247-256.
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Satoshi Ichigo, Hiroshi Takagi, Kazutoshi Matsunami, Noriko Suzuki & Atsushi Imai. (2010) Beneficial effects of dienogest on uterine myoma volume: a retrospective controlled study comparing with gonadotropin-releasing hormone agonist. Archives of Gynecology and Obstetrics 284:3, pages 667-670.
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Jo Kitawaki, Izumi Kusuki, Kaoruko Yamanaka & Izumi Suganuma. (2011) Maintenance therapy with dienogest following gonadotropin-releasing hormone agonist treatment for endometriosis-associated pelvic pain. European Journal of Obstetrics & Gynecology and Reproductive Biology 157:2, pages 212-216.
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Andrew Horne & Hilary O. D. Critchley. 2011. Endometriosis. Endometriosis 351 356 .
Yutaka Shimizu, Shizuka Mita, Takashi Takeuchi, Tatsuto Notsu, Kiyoshi Mizuguchi & Satoru Kyo. (2011) Dienogest, a synthetic progestin, inhibits prostaglandin E2 production and aromatase expression by human endometrial epithelial cells in a spheroid culture system. Steroids 76:1-2, pages 60-67.
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Paul L. McCormack. (2010) Dienogest. Drugs 70:16, pages 2073-2088.
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Adolf E. Schindler, Alexandra Henkel, Claudia Moore & Michael Oettel. (2009) Effect and safety of high-dose dienogest (20 mg/day) in the treatment of women with endometriosis. Archives of Gynecology and Obstetrics 282:5, pages 507-514.
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Thomas Strowitzki, Thomas Faustmann, Christoph Gerlinger & Christian Seitz. (2010) Dienogest in the treatment of endometriosis-associated pelvic pain: a 12-week, randomized, double-blind, placebo-controlled study. European Journal of Obstetrics & Gynecology and Reproductive Biology 151:2, pages 193-198.
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T. Strowitzki, J. Marr, C. Gerlinger, T. Faustmann & C. Seitz. (2010) Dienogest is as effective as leuprolide acetate in treating the painful symptoms of endometriosis: a 24-week, randomized, multicentre, open-label trial. Human Reproduction 25:3, pages 633-641.
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Tasuku HaradaFuminori Taniguchi. (2010) Dienogest: A New Therapeutic Agent for the Treatment of Endometriosis. Women's Health 6:1, pages 27-35.
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Günter Köhler, Thomas A. Faustmann, Christoph Gerlinger, Christian Seitz & Alfred O. Mueck. (2010) A dose-ranging study to determine the efficacy and safety of 1, 2, and 4 mg of dienogest daily for endometriosis. International Journal of Gynecology & Obstetrics 108:1, pages 21-25.
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Y. Shimizu, T. Takeuchi, S. Mita, K. Mizuguchi, T. Kiyono, M. Inoue & S. Kyo. (2009) Dienogest, a synthetic progestin, inhibits the proliferation of immortalized human endometrial epithelial cells with suppression of cyclin D1 gene expression. Molecular Human Reproduction 15:10, pages 693-701.
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Li Fu, Yutaka Osuga, Chieko Morimoto, Tetsuya Hirata, Yasushi Hirota, Tetsu Yano & Yuji Taketani. (2008) Dienogest inhibits BrdU uptake with G0/G1 arrest in cultured endometriotic stromal cells. Fertility and Sterility 89:5, pages 1344-1347.
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Shinichi Sasagawa, Yutaka Shimizu, Hideaki Kami, Takashi Takeuchi, Shizuka Mita, Kazunori Imada, Shigeaki Kato & Kiyoshi Mizuguchi. (2008) Dienogest is a selective progesterone receptor agonist in transactivation analysis with potent oral endometrial activity due to its efficient pharmacokinetic profile. Steroids 73:2, pages 222-231.
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Elizabeth Ball, Hugh Byrne & Colin Davis. (2007) The value of two-step operative laparoscopy with interval pituitary suppression in the treatment of infertility caused by severe endometriosis. Current Opinion in Obstetrics & Gynecology 19:4, pages 303-307.
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