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Review Paper

The role of genes in the polycystic ovary syndrome: Predisposition and mechanisms

, & , MD, MSc, PhD
Pages 603-609 | Received 24 Mar 2009, Accepted 16 Apr 2009, Published online: 19 Sep 2009

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Read on this site (3)

Yasmin Ahmed Bassiouny, Walaa Ahmed Rabie, Ayman Ahmed Hassan & Rania Kamal Darwish. (2014) Association of the luteinizing hormone/choriogonadotropin receptor gene polymorphism with polycystic ovary syndrome. Gynecological Endocrinology 30:6, pages 428-430.
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E. Deligeoroglou, N. Vrachnis, N. Athanasopoulos, Z. Iliodromiti, S. Sifakis, S. Iliodromiti, C. Siristatidis & G. Creatsas. (2012) Mediators of chronic inflammation in polycystic ovarian syndrome. Gynecological Endocrinology 28:12, pages 974-978.
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Birgit Knebel, Stefan Lehr, Onno E. Janssen, Susanne Hahn, Ulrike Nitzgen, Sylvia Jacob, Jutta Haas, Dirk Muller-Wieland & Jorg Kotzka. (2012) Genetic variants in central metabolic genes influence some but not all relations of inflammatory markers in a collective with polycystic ovary syndrome. Archives of Physiology and Biochemistry 118:4, pages 219-229.
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Articles from other publishers (35)

Mojgan Asadi, Zeynab Nickhah Klashami, Nekoo Panahi, Yodit Oheb, Sara Khorasani & Mahsa M. Amoli. (2023) ACE I/D gene polymorphisms and polycystic ovary syndrome manifestations. Journal of Diabetes & Metabolic Disorders.
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Roy Homburg & Claudia Raperport. 2022. Polycystic Ovary Syndrome. Polycystic Ovary Syndrome 58 66 .
Florentina Duică, Cezara Alina Dănilă, Andreea Elena Boboc, Panagiotis Antoniadis, Carmen Elena Condrat, Sebastian Onciul, Nicolae Suciu, Sanda Maria Creţoiu, Valentin Nicolae Varlas & Dragoş Creţoiu. (2021) Impact of Increased Oxidative Stress on Cardiovascular Diseases in Women With Polycystic Ovary Syndrome. Frontiers in Endocrinology 12.
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Lei Bao, Rabbani Syed & Mustafa Sawsan Aloahd. (2019) Analysis of VEGF gene polymorphisms and serum VEGF protein levels contribution in polycystic ovary syndrome of patients. Molecular Biology Reports 46:6, pages 5821-5829.
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Claudia Raperport & Roy Homburg. (2019) The Source of Polycystic Ovarian Syndrome. Clinical Medicine Insights: Reproductive Health 13, pages 117955811987146.
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Mariangela Torreglosa Ruiz Cintra, Marly Aparecida Spadotto Balarin, Sarah Cristina Sato Vaz Tanaka, Vanessa Iorrana Mota da Silva, Alessandra Bernadete Trovó de Marqui, Elisabete Aparecida Mantovani Rodrigues de Resende, Marco Fábio Prata Lima & Mariana Kefálas Oliveira Gomes. (2018) Polycystic ovarian syndrome: rs1799752 polymorphism of ACE gene. Revista da Associação Médica Brasileira 64:11, pages 1017-1022.
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Swati Sharma & Anindya J. Mishra. (2018) Tabooed disease in alienated bodies: A study of women suffering from Polycystic Ovary Syndrome (PCOS). Clinical Epidemiology and Global Health 6:3, pages 130-136.
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Nila Ghanei, Nima Rezaei, Ghorban Ali Amiri, Farid Zayeri, Golbou Makki & Esmat Nasseri. (2018) The probiotic supplementation reduced inflammation in polycystic ovary syndrome: A randomized, double-blind, placebo-controlled trial. Journal of Functional Foods 42, pages 306-311.
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Mahdie Hajimonfarednejad, Majid Nimrouzi, Mojtaba Heydari, Mohammad Mehdi Zarshenas, Mohammad Javad Raee & Bahia Namavar Jahromi. (2018) Insulin resistance improvement by cinnamon powder in polycystic ovary syndrome: A randomized double-blind placebo controlled clinical trial. Phytotherapy Research 32:2, pages 276-283.
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F. Ramezani Tehrani, M. Zarkesh, M. Tohidi, F. Azizi & A. Zadeh-Vakili. (2017) Is the association between insulin resistance and diabetogenic haematopoietically expressed homeobox (HHEX) polymorphism (rs1111875) affected by polycystic ovary syndrome status?. Reproduction, Fertility and Development 29:4, pages 670.
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Anthony M. DeAngelis, Meaghan Roy-O'Reilly & Annabelle Rodriguez-Oquendo. 2016. Translational Cardiometabolic Genomic Medicine. Translational Cardiometabolic Genomic Medicine 251 282 .
Renyong Guo, Ying Zheng, Jiezuan Yang & Nengneng Zheng. (2015) Association of TNF-alpha, IL-6 and IL-1beta gene polymorphisms with polycystic ovary syndrome: a meta-analysis. BMC Genetics 16:1.
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Alessandro D. Genazzani, Susanna Santagni, Erika Rattighieri, Elisa Chierchia, Giulia Despini, Alessia Prati & Federica Ricchieri. 2015. Frontiers in Gynecological Endocrinology. Frontiers in Gynecological Endocrinology 11 23 .
Jianhong Zhao, Zhiying Hu, Long Cai, Ling Liu, Xijing Jiang, Linzhen Wu & Junling Gong. (2014) Association Between Single Nucleotide Polymorphisms of Sterol Regulatory Element Binding Protein-2 and Liver X Receptor α Gene and Risk of Polycystic Ovary Syndrome in a Chinese Han Population. Cell Biochemistry and Biophysics 70:2, pages 1421-1426.
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Christos C. Zouboulis. (2014) Acne as a chronic systemic disease. Clinics in Dermatology 32:3, pages 389-396.
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Tsuyoshi Baba, Toshiaki Endo, Sayaka Adachi, Keiko Ikeda, Ayumi Shimizu, Miyuki Morishita, Yoshika Kuno, Hiroyuki Honnma, Tamotsu Kiya & Tsuyoshi Saito. (2014) Excessive Androgen Exposure as an Etiological Factor of Polycystic Ovary Syndrome. Journal of Mammalian Ova Research 31:1, pages 23-30.
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C.P. Crum & E.E.K Meserve. 2014. Pathobiology of Human Disease. Pathobiology of Human Disease 1384 1397 .
Alessandro D. Genazzani, Alessia Prati, Giulia Despini, Giulia Marini & Federica Ricchieri. 2014. Frontiers in Gynecological Endocrinology. Frontiers in Gynecological Endocrinology 59 67 .
Michelle R. Jones, Ning Xu & Mark O. Goodarzi. 2014. Polycystic Ovary Syndrome. Polycystic Ovary Syndrome 29 52 .
Zahra Daneshian, Fahimeh Ramezani Tehrani, Maryam Zarkesh, Mahsa Norooz Zadeh, Reza Mahdian & Azita ZadehVakili. (2013) Antimullerian Hormone and Its Receptor Gene Expression in Prenatally Androgenized Female Rats. International Journal of Endocrinology and Metabolism 13:1.
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Han Zhao & Zi-Jiang Chen. (2013) Genetic association studies in female reproduction: from candidate-gene approaches to genome-wide mapping. MHR: Basic science of reproductive medicine 19:10, pages 644-654.
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George Paltoglou, George Tavernarakis, Panagiotis Christopoulos, Margarita Vlassi, Maria Gazouli, Efthimios Deligeoroglou, George Creatsas & George Mastorakos. (2013) PON1-108 TT and PON1-192 RR genotypes are more frequently encountered in Greek PCOS than non-PCOS women, and are associated with hyperandrogenaemia. Clinical Endocrinology 79:2, pages 259-266.
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Nana Liu, Yanmin Ma, Shuyu Wang, Xiaowei Zhang, Qiufang Zhang, Xue Zhang, Li Fu & Jie Qiao. (2012) Association of the genetic variants of luteinizing hormone, luteinizing hormone receptor and polycystic ovary syndrome. Reproductive Biology and Endocrinology 10:1.
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N. Schweighofer, E. Lerchbaum, O. Trummer, V. Schwetz, S. Pilz, T.R. Pieber & B. Obermayer-Pietsch. (2012) Androgen levels and metabolic parameters are associated with a genetic variant of F13A1 in women with polycystic ovary syndrome. Gene 504:1, pages 133-139.
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Hong Zhang, Yan Bi, Changjun Hu, Weiping Lu & Dalong Zhu. (2012) Association between the Pro12Ala polymorphism of PPAR-γ gene and the polycystic ovary syndrome: A meta-analysis of case–control studies. Gene 503:1, pages 12-17.
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Birgit Knebel, Onno E. Janssen, Susanne Hahn, Sylvia Jacob, Ulrike Nitzgen, Jutta Haas, Dirk Muller-Wieland & Jorg Kotzka. (2012) Genetic variations in SREBP-1 and LXRα are not directly associated to PCOS but contribute to the physiological specifics of the syndrome. Molecular Biology Reports 39:6, pages 6835-6842.
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Liye Sun, Weihong Hu, Qiao Liu, Qinfang Hao, Bo Sun, Qi Zhang, Sha Mao, Jie Qiao & Xianzhong Yan. (2012) Metabonomics Reveals Plasma Metabolic Changes and Inflammatory Marker in Polycystic Ovary Syndrome Patients. Journal of Proteome Research 11:5, pages 2937-2946.
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Maureen Shannon & Yusharn Wang. (2012) Polycystic Ovary Syndrome: A Common But Often Unrecognized Condition. Journal of Midwifery & Women's Health 57:3, pages 221-230.
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Hind A. Beydoun, May A. Beydoun, Natasha Wiggins & Laurel Stadtmauer. (2012) Relationship of obesity-related disturbances with LH/FSH ratio among post-menopausal women in the United States. Maturitas 71:1, pages 55-61.
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W Chen, B Obermayer-Pietsch, J-B Hong, BC Melnik, O Yamasaki, C Dessinioti, Q Ju, AI Liakou, S Al-Khuzaei, A Katsambas, J Ring & CC Zouboulis. (2011) Acne-associated syndromes: models for better understanding of acne pathogenesis. Journal of the European Academy of Dermatology and Venereology 25:6, pages 637-646.
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Shakila Abdul-Majeed & Surya M. Nauli. (2011) Polycystic Diseases in Visceral Organs. Obstetrics and Gynecology International 2011, pages 1-7.
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Mette Eriksen, Ann Dorte Pørneki, Vibe Skov, Jorge S. Burns, Henning Beck-Nielsen, Dorte Glintborg & Michael Gaster. (2010) Insulin Resistance Is Not Conserved in Myotubes Established from Women with PCOS. PLoS ONE 5:12, pages e14469.
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Johannes Ott, Stefanie Aust, Christine Kurz, Kazem Nouri, Stefan Wirth, Johannes C. Huber & Klaus Mayerhofer. (2010) Elevated antithyroid peroxidase antibodies indicating Hashimoto's thyroiditis are associated with the treatment response in infertile women with polycystic ovary syndrome. Fertility and Sterility 94:7, pages 2895-2897.
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Catherine G. Baptiste, Marie-Claude Battista, Andréanne Trottier & Jean-Patrice Baillargeon. (2010) Insulin and hyperandrogenism in women with polycystic ovary syndrome. The Journal of Steroid Biochemistry and Molecular Biology 122:1-3, pages 42-52.
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Alessandro D Genazzani, Federica Ricchieri & Chiara Lanzoni. (2010) Use of Metformin in the Treatment of Polycystic Ovary Syndrome. Women's Health 6:4, pages 577-593.
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