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Original Article

Cilostazol inhibits platelet–leukocyte interaction by suppression of platelet activation

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Pages 293-301 | Published online: 07 Jul 2009

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Masaaki Higashiyama, Ryota Hokari, Chie Kurihara, Toshihide Ueda, Chikako Watanabe, Kengo Tomita, Shunsuke Komoto, Yoshikiyo Okada, Atsushi Kawaguchi, Shigeaki Nagao & Soichiro Miura. (2012) Indomethacin-induced small intestinal injury is ameliorated by cilostazol, a specific PDE-3 inhibitor. Scandinavian Journal of Gastroenterology 47:8-9, pages 993-1002.
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Masaaki Higashiyama, Ryota Hokari, Hisayuki Matsunaga, Koichi Takebayashi, Chikako Watanabe, Shunsuke Komoto, Yoshikiyo Okada, Chie Kurihara, Atsushi Kawaguchi, Shigeaki Nagao, Kazuro Itoh & Soichiro Miura. (2008) P-Selectin-Dependent Monocyte Recruitment Through Platelet Interaction in Intestinal Microvessels of LPS-Treated Mice. Microcirculation 15:5, pages 441-450.
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Articles from other publishers (24)

Rosane de Oliveira Lopes, Gabriel Ferreira Lima, Ana Beatriz Araújo Mendes, Lis Jappour Autran, Nikolas Cunha de Assis Pereira, Stephani Correia Brazão, Beatriz Alexandre-Santos, Eliete Dalla Corte Frantz, Christianne Brêtas Vieira Scaramello, Fernanda Carla Ferreira Brito & Nadia Alice Vieira Motta. (2022) Cilostazol attenuates cardiac oxidative stress and inflammation in hypercholesterolemic rats. Naunyn-Schmiedeberg's Archives of Pharmacology 395:7, pages 789-801.
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Lin Zheng, Zhimin Duan, Dingjie Tang, Yanzhi He, Xu Chen, Qing Chen & Min Li. (2021) GP IIb/IIIa-Mediated Platelet Activation and Its Modulation of the Immune Response of Monocytes Against Candida albicans. Frontiers in Cellular and Infection Microbiology 11.
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Daniëlle M. Coenen, Alexandra C. A. Heinzmann, Silvia Oggero, Hugo J. Albers, Magdolna Nagy, Perrine Hagué, Marijke J. E. Kuijpers, Jean-Marie Vanderwinden, Andries D. van der Meer, Mauro Perretti, Rory R. Koenen & Judith M. E. M. Cosemans. (2021) Inhibition of Phosphodiesterase 3A by Cilostazol Dampens Proinflammatory Platelet Functions. Cells 10:8, pages 1998.
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Nadia Alice Vieira Motta, Lis Jappour Autran, Stephani Correia Brazão, Rosane de Oliveira Lopes, Christianne Brêtas Vieira Scaramello, Gabriel Ferreira Lima & Fernanda Carla Ferreira de Brito. (2021) Could cilostazol be beneficial in COVID-19 treatment? Thinking about phosphodiesterase-3 as a therapeutic target. International Immunopharmacology 92, pages 107336.
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Daniela Hernandez, Wee Ming Yeo, Marjory B. Brooks, Sally L. Ness, Thomas J. Divers & Tracy Stokol. (2016) Effects of various antiplatelet drugs on ex vivo platelet activation induced by equine herpesvirus type 1. American Journal of Veterinary Research 77:12, pages 1366-1373.
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Tracy Stokol, Priscila B. D. Serpa, Muhammad N. Zahid & Marjory B. Brooks. (2016) Unfractionated and Low-Molecular-Weight Heparin and the Phosphodiesterase Inhibitors, IBMX and Cilostazol, Block Ex Vivo Equid Herpesvirus Type-1-Induced Platelet Activation. Frontiers in Veterinary Science 3.
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Maria Lukasik & Michal K. Owecki. (2013) Efficacy of Antiplatelet Treatment in Stroke Prevention: Past, Present, and Future. Drug Development Research 74:7, pages 428-439.
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Yasuo Ikeda, Toshiki Sudo & Yukio Kimura. 2013. Platelets. Platelets 1171 1183 .
Michael Sobel. 2013. Platelets. Platelets 699 710 .
Hideki Ito, Kenji Uehara, Yutaka Matsumoto, Ayako Hashimoto, Chifumi Nagano, Manabu Niimi, Goro Miyakoda & Keisuke Nagano. (2012) Cilostazol Inhibits Accumulation of Triglyceride in Aorta and Platelet Aggregation in Cholesterol-Fed Rabbits. PLoS ONE 7:6, pages e39374.
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Theodore Parker, Vipul Davé, Robert Falotico, Jonathon Zhao, Thai Nguyen, Sylvia He, Yi‐Ping Sun & Campbell Rogers. (2012) Control of cilostazol release kinetics and direction from a stent using a reservoir‐based design. Journal of Biomedical Materials Research Part B: Applied Biomaterials 100B:3, pages 603-610.
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Richard Amison, Clive Page & Simon Pitchford. 2012. Antiplatelet Agents. Antiplatelet Agents 447 468 .
Gabriella Passacquale & Albert Ferro. (2011) Current concepts of platelet activation: possibilities for therapeutic modulation of heterotypic vs. homotypic aggregation. British Journal of Clinical Pharmacology 72:4, pages 604-618.
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Hiroki Iida, Mami Iida, Motoyasu Takenaka, Naokazu Fukuoka & Shuji Dohi. (2009) Comparative effects of cilostazol and aspirin on the impairment of endothelium-dependent cerebral vasodilation caused by acute cigarette smoking in rats. Journal of Thrombosis and Thrombolysis 29:4, pages 483-488.
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Hideki Ito, Ayako Hashimoto, Yutaka Matsumoto, Hiroshi Yao & Goro Miyakoda. (2009) Cilostazol, a Phosphodiesterase Inhibitor, Attenuates Photothrombotic Focal Ischemic Brain Injury in Hypertensive Rats. Journal of Cerebral Blood Flow & Metabolism 30:2, pages 343-351.
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Hisayuki Matsunaga, Ryota Hokari, Masaaki Higashiyama, Chie Kurihara, Yoshikiyo Okada, Chikako Watanabe, Shunsuke Komoto, Mitsuyasu Nakamura, Atsushi Kawaguchi, Shigeaki Nagao & Soichiro Miura. (2009) Cilostazol, a specific PDE-3 inhibitor, ameliorates chronic ileitis via suppression of interaction of platelets with monocytes. American Journal of Physiology-Gastrointestinal and Liver Physiology 297:6, pages G1077-G1084.
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M. Cleanthis, V. Bhattacharya, J. Smout, H. Ashour & G. Stansby. (2009) Combined Aspirin and Cilostazol Treatment is Associated with Reduced Platelet Aggregation and Prevention of Exercise-Induced Platelet Activation. European Journal of Vascular and Endovascular Surgery 37:5, pages 604-610.
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Hideki Ito, Mari Fukunaga, Hidenori Suzuki, Goro Miyakoda, Makoto Ishikawa, Youichi Yabuuchi & Waro Taki. (2008) Effect of cilostazol on delayed cerebral vasospasm after subarachnoid hemorrhage in rats: Evaluation using black blood magnetic resonance imaging. Neurobiology of Disease 32:1, pages 157-161.
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D. IWAMA, K. MIYAMOTO, S. MIYAHARA, H. TAMURA, A. TSUJIKAWA, K. YAMASHIRO, J. KIRYU & N. YOSHIMURA. (2007) Neuroprotective effect of cilostazol against retinal ischemic damage via inhibition of leukocyte–endothelial cell interactions. Journal of Thrombosis and Haemostasis 5:4, pages 818-825.
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Victor Serebruany, Alex Malinin, Alex Pokov, Umesh Arora, Dan Atar & Dominick Angiolillo. (2007) Effects of escalating doses of tirofiban on platelet aggregation and major receptor expression in diabetic patients: Hitting the TARGET in the TENACITY trial?. Thrombosis Research 119:2, pages 175-181.
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Yasuo Ikeda, Toshiki Sudo & Yukio Kimura. 2007. Platelets. Platelets 1181 1191 .
Toshiaki Iba, Akio Kidokoro, Masaki Fukunaga, Kitoji Takuhiro, Masakazu Ouchi & Yoshitomo Ito. (2006) COMPARISON OF THE PROTECTIVE EFFECTS OF TYPE III PHOSPHODIESTERASE (PDE3) INHIBITOR (CILOSTAZOL) AND ACETYLSALICYLIC ACID ON INTESTINAL MICROCIRCULATION AFTER ISCHEMIA REPERFUSION INJURY IN MICE. Shock 26:5, pages 522-526.
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Sebastián F. Ameriso, Roberto Lagos, Luis Mariano Ferreira, Lucía Fernández Cisneros & Antonio Ricardo La Mura. (2006) Cerebrovascular Effects of Cilostazol in Patients With Atherosclerotic Disease. Journal of Stroke and Cerebrovascular Diseases 15:6, pages 273-276.
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Jae B. Park & Norberta Schoene. (2006) Clovamide-Type Phenylpropenoic Acid Amides, N -Coumaroyldopamine and N -Caffeoyldopamine, Inhibit Platelet-Leukocyte Interactions via Suppressing P-Selectin Expression . Journal of Pharmacology and Experimental Therapeutics 317:2, pages 813-819.
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