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Original article

Platelet and monocyte activation by hyperglycemia and hyperinsulinemia in healthy subjects

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Pages 577-585 | Received 03 Apr 2006, Accepted 19 Apr 2006, Published online: 07 Jul 2009

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David J. Schneider. (2009) Factors Contributing to Increased Platelet Reactivity in People With Diabetes. Diabetes Care 32:4, pages 525-527.
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Crossref
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Anetta Undas, Ilona Wiek, Ewa Stêpień, Krzysztof Zmudka & Wiesława Tracz. (2008) Hyperglycemia Is Associated With Enhanced Thrombin Formation, Platelet Activation, and Fibrin Clot Resistance to Lysis in Patients With Acute Coronary Syndrome. Diabetes Care 31:8, pages 1590-1595.
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Camila Manrique, Guido Lastra, John Palmer, Michael Gardner & James R. Sowers. (2008) Review: Aspirin and Diabetes Mellitus: revisiting an old player. Therapeutic Advances in Cardiovascular Disease 2:1, pages 37-42.
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Guenther Boden, Vijender R. Vaidyula, Carol Homko, Peter Cheung & A. Koneti Rao. (2007) Circulating Tissue Factor Procoagulant Activity and Thrombin Generation in Patients with Type 2 Diabetes: Effects of Insulin and Glucose. The Journal of Clinical Endocrinology & Metabolism 92:11, pages 4352-4358.
Crossref
M. BorchertT. SchöndorfG. LübbenT. ForstA. Pfützner. (2007) Review of the Pleiotropic Effects of Peroxisome Proliferator-Activated Receptor γ Agonists on Platelet Function . Diabetes Technology & Therapeutics 9:5, pages 410-420.
Crossref
Guenther Boden & A. Koneti Rao. (2007) Effects of hyperglycemia and hyperinsulinemia on the tissue factor pathway of blood coagulation. Current Diabetes Reports 7:3, pages 223-227.
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