Advanced search
Publication Cover
Platelets Volume 19, 2008 - Issue 6
Submit an article Journal homepage
727
Views
60
CrossRef citations to date
0
Altmetric
Review

“Message in the Platelet” – more than just vestigial mRNA!

Paul Harrison Oxford Haemophilia and Thrombosis Centre, Churchill Hospital, Oxford, OX3 7LJ, UKCorrespondence[email protected]
, PhD &
Alison H. Goodall Department of Cardiovascular Sciences, University of Leicester, Clinical Sciences Wing, Glenfield Hospital, Leicester, LE3 9QP, UK
Pages 395-404 | Received 13 Feb 2008, Accepted 14 Feb 2008, Published online: 07 Jul 2009

Citations (60)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (5)

Aida Anetsberger, Isabell Bernlochner, Bettina Jungwirth, Manfred Blobner, Bernhard Meyer, Eberhard F Kochs, Dario Bongiovanni, Sebastian Schmid, Clemens Langgartner, Lea Baumgart & Jens Gempt. (2023) Association of immature platelets with perioperative complications in neurosurgery. Platelets 34:1.
Read now
Isabel Wustrow, Christopher Ebner, Nicolas Langwieser, Bernhard Haller, Peter B. Luppa, Christian Bradaric, Dario Bongiovanni, Anja Stundl, Karl-Ludwig Laugwitz, Tareq Ibrahim & Isabell Bernlochner. (2021) Influence of diagnosis of venous thromboembolism on immature platelets, absolute platelet count and platelet aggregation over time. Platelets 32:3, pages 398-403.
Read now
Usman Ali, Gavin Knight, Roz Gibbs & Dimitris A. Tsitsikas. (2017) Reference intervals for absolute and percentage immature platelet fraction using the Sysmex XN-10 automated haematology analyser in a UK population. Scandinavian Journal of Clinical and Laboratory Investigation 77:8, pages 658-664.
Read now
Valery M. Pogorelov, Victoria Ju. Beskorovainova, Marem I. Chanieva, Olga A. Dyagileva, Iren N. Naumova & Marina A. Skedina. (2012) Periodic acid-Schiff (PAS) staining of immature platelets in donors. Platelets 23:1, pages 51-59.
Read now
Pål Aukrust, Bente Halvorsen, Thor Ueland, Annika E Michelsen, Mona Skjelland, Lars Gullestad, Arne Yndestad & Kari Otterdal. (2010) Activated platelets and atherosclerosis. Expert Review of Cardiovascular Therapy 8:9, pages 1297-1307.
Read now

Articles from other publishers (55)

Irene E. Regan, Dermot Cox, Sean T. Kelleher, Beatrice Nolan, Kathryn Shaw, Owen P. Smith & Colin J. McMahon. (2024) Towards a greater understanding of reduced response to aspirin in children with congenital heart disease post-cardiac surgery using immature platelet fraction. Thrombosis Research 233, pages 101-108.
Crossref
Oriol Jornet‐Rius, Montse Mesalles‐Naranjo & Josep Pastor. (2023) Performance of the Sysmex XN‐V hematology analyzer in determining the immature platelet fraction in dogs: A preliminary study and reference values. Veterinary Clinical Pathology.
Crossref
Dmitrii Polokhov, Daria Fedorova, Anastasiya Ignatova, Evgeniya Ponomarenko, Elena Rashevskaya, Alexey Martyanov, Nadezhda Podoplelova, Maxim Aleksenko, Irina Mersiyanova, Elena Seregina, Aleksandr Poletaev, Ekaterina Truchina, Elena Raykina, Svetlana Plyasunova, Galina Novichkova, Pavel Zharkov & Mikhail Panteleev. (2023) Novel SLFN14 mutation associated with macrothrombocytopenia in a patient with severe haemorrhagic syndrome. Orphanet Journal of Rare Diseases 18:1.
Crossref
Harriet E. Allan, Ami Vadgama, Paul C. Armstrong & Timothy D. Warner. (2022) Platelet ageing: A review. Thrombosis Research.
Crossref
Jacqueline Guettler, Désirée Forstner & Martin Gauster. (2022) Maternal platelets at the first trimester maternal-placental interface – Small players with great impact on placenta development. Placenta 125, pages 61-67.
Crossref
Xiaoxia Wen, Guishu Yang, Yongcheng Dong, Liping Luo, Bangrong Cao, Birga Anteneh Mengesha, Ruiling Zu, Yulin Liao, Chang Liu, Shi Li, Yao Deng, Kaijiong Zhang, Xin Ma, Jian Huang, Dongsheng Wang, Keyan Zhao, Ping Leng & Huaichao Luo. (2022) Selection and Validation of Reference Genes for Pan-Cancer in Platelets Based on RNA-Sequence Data. Frontiers in Genetics 13.
Crossref
Samuel Kemble, Amanda Dalby, Gillian C. Lowe, Phillip L. R. Nicolson, Steve P. Watson, Yotis Senis, Steven G. Thomas & Paul Harrison. (2022) Analysis of preplatelets and their barbell platelet derivatives by imaging flow cytometry. Blood Advances 6:9, pages 2932-2946.
Crossref
Constance C.F.M.J. Baaten, Jonas R. Schröer, Jürgen Floege, Nikolaus Marx, Joachim Jankowski, Martin Berger & Heidi Noels. (2022) Platelet Abnormalities in CKD and Their Implications for Antiplatelet Therapy. Clinical Journal of the American Society of Nephrology 17:1, pages 155-170.
Crossref
Waltraud C. Schrottmaier, Marion Mussbacher, Manuel Salzmann, Julia B. Kral-Pointner & Alice Assinger. 2022. PI3K and AKT Isoforms in Immunity. PI3K and AKT Isoforms in Immunity 255 285 .
Harriet E. Allan, Melissa A. Hayman, Simone Marcone, Melissa V. Chan, Matthew L. Edin, Tania Maffucci, Abhishek Joshi, Laura Menke, Marilena Crescente, Manuel Mayr, Darryl C. Zeldin, Paul C. Armstrong & Timothy D. Warner. (2021) Proteome and functional decline as platelets age in the circulation. Journal of Thrombosis and Haemostasis 19:12, pages 3095-3112.
Crossref
Marion Mussbacher, Anita Pirabe, Laura Brunnthaler, Waltraud C. Schrottmaier & Alice Assinger. (2021) Horizontal MicroRNA Transfer by Platelets – Evidence and Implications. Frontiers in Physiology 12.
Crossref
Mafalda Antunes‐Ferreira, Danijela Koppers‐Lalic & Thomas Würdinger. (2020) Circulating platelets as liquid biopsy sources for cancer detection. Molecular Oncology 15:6, pages 1727-1743.
Crossref
Julie Faber, Anne-Mette Hvas, Steen Dalby Kristensen, Erik Lerkevang Grove & Kasper Adelborg. (2020) Immature Platelets and Risk of Cardiovascular Events among Patients with Ischemic Heart Disease: A Systematic Review. Thrombosis and Haemostasis 121:05, pages 659-675.
Crossref
Noé Corpataux, Kilian Franke, Alexander Kille, Christian Marc Valina, Franz-Josef Neumann, Thomas Nührenberg & Willibald Hochholzer. (2020) Reticulated Platelets in Medicine: Current Evidence and Further Perspectives. Journal of Clinical Medicine 9:11, pages 3737.
Crossref
Carolin T. Neu, Tony Gutschner & Monika Haemmerle. (2020) Post-Transcriptional Expression Control in Platelet Biogenesis and Function. International Journal of Molecular Sciences 21:20, pages 7614.
Crossref
Laura Hille, Maximilian Lenz, Andreas Vlachos, Björn Grüning, Lutz Hein, Franz‐Josef Neumann, Thomas G. Nührenberg & Dietmar Trenk. (2020) Ultrastructural, transcriptional, and functional differences between human reticulated and non‐reticulated platelets. Journal of Thrombosis and Haemostasis 18:8, pages 2034-2046.
Crossref
Mauro Buttarello, Giacomo Mezzapelle, Francesca Freguglia & Mario Plebani. (2020) Reticulated platelets and immature platelet fraction: Clinical applications and method limitations. International Journal of Laboratory Hematology 42:4, pages 363-370.
Crossref
Bernadett Szilágyi, Zsolt Fejes, Szilárd Póliska, Marianna Pócsi, Zsolt Czimmerer, Andreas Patsalos, Ferenc Fenyvesi, Ágnes Rusznyák, György Nagy, György Kerekes, Mariann Berhés, Ildikó Szűcs, Satya P. Kunapuli, János Kappelmayer & Béla NagyJr.Jr.. (2020) Reduced miR-26b Expression in Megakaryocytes and Platelets Contributes to Elevated Level of Platelet Activation Status in Sepsis. International Journal of Molecular Sciences 21:3, pages 866.
Crossref
Ruth Maria Schorling, Christian Pfrepper, Thomas Golombek, Chiara Alessandra Cella, Nerea Muñoz-Unceta, Roland Siegemund, Christoph Engel, Sirak Petros, Florian Lordick & Maren Knödler. (2020) Evaluation of Biomarkers for the Prediction of Venous Thromboembolism in Ambulatory Cancer Patients. Oncology Research and Treatment 43:9, pages 414-427.
Crossref
Sidra Asghar, Fahed Parvaiz & Sobia Manzoor. (2019) Multifaceted role of cancer educated platelets in survival of cancer cells. Thrombosis Research 177, pages 42-50.
Crossref
Samuel Kemble, Carol Briggs & Paul Harrison. 2019. Platelets. Platelets 581 591 .
Constance C.F.M.J. Baaten, Hugo ten Cate, Paola E.J. van der Meijden & Johan W.M. Heemskerk. (2017) Platelet populations and priming in hematological diseases. Blood Reviews 31:6, pages 389-399.
Crossref
Adi Lador, Dorit Leshem-Lev, Galia Spectre, Aryeh Abelow, Ran Kornowski & Eli I. Lev. (2017) Characterization of surface antigens of reticulated immature platelets. Journal of Thrombosis and Thrombolysis 44:3, pages 291-297.
Crossref
Gang Deng, Shifang Yu, Yunlei He, Tao Sun, Wei Liang, Lu Yu, Deyi Xu, Qiang Li & Ri Zhang. (2017) MicroRNA profiling of platelets from immune thrombocytopenia and target gene prediction. Molecular Medicine Reports 16:3, pages 2835-2843.
Crossref
Aida Anetsberger, Manfred Blobner, Bernhard Haller, Sebastian Schmid, Katrin Umgelter, Theresa Hager, Clemens Langgartner, Eberhard Kochs, Karl-Ludwig Laugwitz, Bettina Jungwirth & Isabell Bernlochner. (2017) Immature platelets as a novel biomarker for adverse cardiovascular events in patients after non-cardiac surgery. Thrombosis and Haemostasis 117:10, pages 1887-1895.
Crossref
Anne Zufferey, Mark Ibberson, Jean-Luc Reny, Séverine Nolli, Domitille Schvartz, Mylène Docquier, Ioannis Xenarios, Jean-Charles Sanchez & Pierre Fontana. (2016) New molecular insights into modulation of platelet reactivity in aspirin-treated patients using a network-based approach. Human Genetics 135:4, pages 403-414.
Crossref
Alon Eisen, Hila Lerman-Shivek, Leor Perl, Eldad Rechavia, Dorit Leshem-Lev, Noa Zemer-Wassercug, Oshrat Dadush, Shirit Kazum, Pablo Codner, Ran Kornowski & Eli I. Lev. (2014) Circulating reticulated platelets over time in patients with myocardial infarction treated with prasugrel or ticagrelor. Journal of Thrombosis and Thrombolysis 40:1, pages 70-75.
Crossref
Pernille J. Vinholt, Anne-Mette Hvas & Mads Nybo. (2014) An overview of platelet indices and methods for evaluating platelet function in thrombocytopenic patients. European Journal of Haematology 92:5, pages 367-376.
Crossref
Michel Prudent, Angelo D’Alessandro, Jean-Pierre Cazenave, Dana V. Devine, Christian Gachet, Andreas Greinacher, Niels Lion, Peter Schubert, Leif Steil, Thomas Thiele, Jean-Daniel Tissot, Uwe Völker & Lello Zolla. (2014) Proteome Changes in Platelets After Pathogen Inactivation—An Interlaboratory Consensus. Transfusion Medicine Reviews 28:2, pages 72-83.
Crossref
Julia M. BurkhartStepan GambaryanStephen P. WatsonKerstin JurkUlrich WalterAlbert SickmannJohan W.M. HeemskerkRené P. Zahedi. (2014) What Can Proteomics Tell Us About Platelets?. Circulation Research 114:7, pages 1204-1219.
Crossref
Maria Diquattro. (2014) Piastrine reticolate: dalla ricerca alla pratica clinicaReticulated platelets: from research to clinical practice. La Rivista Italiana della Medicina di Laboratorio - Italian Journal of Laboratory Medicine 10:1, pages 15-19.
Crossref
Robert D. McBaneIIII, Catherine Gonzalez, David O. Hodge & Waldemar E. Wysokinski. (2013) Propensity for young reticulated platelet recruitment into arterial thrombi. Journal of Thrombosis and Thrombolysis 37:2, pages 148-154.
Crossref
Johannes J.M.L. Hoffmann. (2014) Reticulated platelets: analytical aspects and clinical utility. Clinical Chemistry and Laboratory Medicine (CCLM) 52:8.
Crossref
Thomas R. Everett, Stephen F. Garner, Christoph C. Lees & Alison H. Goodall. (2017) Immature platelet fraction analysis demonstrates a difference in thrombopoiesis between normotensive and preeclamptic pregnancies. Thrombosis and Haemostasis 111:06, pages 1177-1179.
Crossref
Johannes J. M. L. HoffmannNicole M. A. van den BroekJoyce Curvers. (2013) Reference Intervals of Reticulated Platelets and Other Platelet Parameters and Their Associations. Archives of Pathology & Laboratory Medicine 137:11, pages 1635-1640.
Crossref
Jörg Geiger, Julia M. Burkhart, Stepan Gambaryan, Ulrich Walter, Albert Sickmann & René P. Zahedi. (2013) Response: platelet transcriptome and proteome—relation rather than correlation. Blood 121:26, pages 5257-5258.
Crossref
Francesca Cesari, Rossella Marcucci, Anna Gori, Roberto Caporale, Alessandra Fanelli, Giulia Casola, Daniela Balzi, Alessandro Barchielli, Serafina Valente, Cristina Giglioli, Gian Gensini & Rosanna Abbate. (2017) Reticulated platelets predict cardiovascular death in acute coronary syndrome patients. Thrombosis and Haemostasis 109:05, pages 846-853.
Crossref
Anne Zufferey, Mark Ibberson, Jean-Luc Reny, Ioannis Xenarios, Jean-Charles Sanchez & Pierre Fontana. (2013) Unraveling modulators of platelet reactivity in cardiovascular patients using omics strategies: Towards a network biology paradigm. Translational Proteomics 1:1, pages 25-37.
Crossref
Paul Harrison & Carol Briggs. 2013. Platelets. Platelets 547 557 .
Paul F. Bray, Chris I. Jones, Nicole Soranzo & Willem H. Ouwehand. 2013. Platelets. Platelets 67 89 .
Jesse W. Rowley, Hansjörg Schwertz & Andrew S. Weyrich. (2012) Platelet mRNA. Current Opinion in Hematology 19:5, pages 385-391.
Crossref
M. LORDKIPANIDZÉ & P. HARRISON. (2012) Aspirin twice a day keeps new COX‐1 at bay. Journal of Thrombosis and Haemostasis 10:7, pages 1217-1219.
Crossref
Mikio Marumo, Tomoyuki Nakano, Yuji Takeda, Kaoru Goto & Ichiro Wakabayashi. (2012) Inhibition of thrombin-induced Ca2+ influx in platelets by R59949, an inhibitor of diacylglycerol kinase. Journal of Pharmacy and Pharmacology 64:6, pages 855-861.
Crossref
Véronique Lauzière, Mandy Lessard, Alexandre J. Meunier, Marie McCoy, Lucien Junior Bergeron & Francois Corbin. (2012) Unusual subcellular confinement of the fragile X mental retardation protein (FMRP) in circulating human platelets: Complete polyribosome dissociation. Biochimie 94:4, pages 1069-1073.
Crossref
Vrinda Kulkarni, Seongcheol Kim, Lala Zafreen & Pudur Jagadeeswaran. (2012) Separation of young and mature thrombocytes by a novel immuno-selection method. Blood Cells, Molecules, and Diseases 48:3, pages 183-187.
Crossref
Patrizia Ferroni, Silvia Riondino, Natale Vazzana, Nicole Santoro, Fiorella Guadagni & Giovanni Davì. (2017) Biomarkers of platelet activation in acute coronary syndromes. Thrombosis and Haemostasis 108:12, pages 1109-1123.
Crossref
Christian Stratz, Thomas G. Nührenberg, Harald Binder, Christian M. Valina, Dietmar Trenk, Willibald Hochholzer, Franz Neumann & Bernd L. Fiebich. (2017) Micro-array profiling exhibits remarkable intra-individual stability of human platelet micro-RNA. Thrombosis and Haemostasis 107:04, pages 634-641.
Crossref
Katarína Larsen, Caroline Cheng, Dennie Tempel, Sherry Parker, Saami Yazdani, Wijnand K. den Dekker, Jaco H. Houtgraaf, Renate de Jong, Stijn Swager-ten Hoor, Erik Ligtenberg, Stephen R. Hanson, Steve Rowland, Frank Kolodgie, Patrick W. Serruys, Renu Virmani & Henricus J. Duckers. (2012) Capture of circulatory endothelial progenitor cells and accelerated re-endothelialization of a bio-engineered stent in human ex vivo shunt and rabbit denudation model. European Heart Journal 33:1, pages 120-128.
Crossref
Ronald G. Stanley, Katherine L. Tucker, Natasha E. Barrett & Jonathan M. Gibbins. 2011. Platelet Proteomics. Platelet Proteomics 1 26 .
Armen Yuri Gasparyan, Antonios Stavropoulos-Kalinoglou, Dimitri P. Mikhailidis, Karen M. J. Douglas & George D. Kitas. (2010) Platelet function in rheumatoid arthritis: arthritic and cardiovascular implications. Rheumatology International 31:2, pages 153-164.
Crossref
David W. Greening, Rosemary L. Sparrow & Richard J. Simpson. 2011. Serum/Plasma Proteomics. Serum/Plasma Proteomics 267 278 .
Stephen P Watson & Paul Harrison. 2010. Postgraduate Haematology. Postgraduate Haematology 772 792 .
P. Schubert & D. V. Devine. (2010) Retracted: De novo protein synthesis in mature platelets: a consideration for transfusion medicine . Vox Sanguinis 99:2, pages 112-122.
Crossref
Eduardo Arellano-Rodrigo. (2009) Papel de las plaquetas reticuladas en la evaluación clínica de la trombocitopoyesis. Medicina Clínica 133:3, pages 95-97.
Crossref
Manuel Monteagudo, Gianni Lucchetti, Ma. José Amengual, Luz Muñoz, J. Alfonso Soler, Inmaculada Roig & Carlos Tolosa. (2009) Relación entre plaquetas reticuladas y número de megacariocitos en pacientes con trombocitopenia. Medicina Clínica 133:3, pages 81-85.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.