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Review Article

Pathogen reduction technologies: The pros and cons for platelet transfusion

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Pages 2-8 | Received 20 Feb 2017, Accepted 07 Mar 2017, Published online: 19 May 2017

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Read on this site (3)

Zhi Cai, Junyan Feng, Nian Dong, Pan Zhou, Yuanshuai Huang & Hongwei Zhang. (2023) Platelet-derived extracellular vesicles play an important role in platelet transfusion therapy. Platelets 34:1.
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Norman F. Luc, Nathan Rohner, Aditya Girish, Ujjal Didar Singh Sekhon, Matthew D. Neal & Anirban Sen Gupta. (2022) Bioinspired artificial platelets: past, present and future. Platelets 33:1, pages 35-47.
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Marie Lordkipanidzé. (2018) Platelets at the heart of therapy. Platelets 29:2, pages 103-104.
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Articles from other publishers (27)

Cheng Liu, Yang Su, Wanwan Guo, Xiaolong Ma & Rui Qiao. (2023) The platelet storage lesion, what are we working for?. Journal of Clinical Laboratory Analysis.
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Justin Lu, Keyvan Karkouti, Miki Peer, Marina Englesakis, Philip C. Spinella, Torunn O. Apelseth, Thomas G. Scorer, Walter H. A. Kahr, Mark McVey, Vivek Rao, Lusine Abrahamyan, Lani Lieberman, Holly Mewhort, Dana V. Devine, Jeannie Callum & Justyna Bartoszko. (2023) Cold-stored platelets for acute bleeding in cardiac surgical patients: a narrative reviewPlaquettes conservées au froid pour les saignements aigus chez les patient·es de chirurgie cardiaque : un compte rendu narratif. Canadian Journal of Anesthesia/Journal canadien d'anesthésie 70:10, pages 1682-1700.
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Stefan F. van Wonderen, Floor L.F. van Baarle, Sanne de Bruin, Anna L. Peters, Dirk de Korte, Robin van Bruggen & Alexander P.J. Vlaar. (2023) Biotinylated Platelets: A Promising Labeling Technique?. Transfusion Medicine Reviews, pages 150719.
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Saeede Bagheri, Shahram Samiee, Mahin Nikougoftar Zarif & Mohammad Reza Deyhim. (2022) l-carnitine modulates free mitochondrial DNA DAMPs and platelet storage lesions during storage of platelet concentrates. Journal of Thrombosis and Thrombolysis 55:1, pages 60-66.
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Shruti Raghunathan, Julie Rayes & Anirban Sen Gupta. (2022) Platelet‐inspired nanomedicine in hemostasis thrombosis and thromboinflammation. Journal of Thrombosis and Haemostasis 20:7, pages 1535-1549.
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Ujjal Didar Singh Sekhon, Kelsey Swingle, Aditya GirishNorman Luc, Maria de la Fuente, Jurgis Alvikas, Shannon Haldeman, Adnan Hassoune, Kaisal ShahYoujoung Kim, Steven Eppell, Jeffrey Capadona, Andrew Shoffstall, Matthew D. Neal, Wei Li, Marvin Nieman & Anirban Sen Gupta. (2022) Platelet-mimicking procoagulant nanoparticles augment hemostasis in animal models of bleeding. Science Translational Medicine 14:629.
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Sahra Fonseca, Marie-Pierre Cayer, K. M. Tanvir Ahmmed, Nima Khadem-Mohtaram, Steve J. Charette & Danny Brouard. (2022) Characterization of the Antibacterial Activity of an SiO2 Nanoparticular Coating to Prevent Bacterial Contamination in Blood Products. Antibiotics 11:1, pages 107.
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Saeede Bagheri, Shahram Samiee, Mahin Nikougoftar Zarif & Mohammad Reza Deyhim. (2022) The evaluation of reactive oxygen species generation and free mitochondrial DNA in platelet concentrates during 5 days of storage. Blood Coagulation & Fibrinolysis Publish Ahead of Print.
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Andrea Vernerova, Luiz Felipe Garcia-Souza, Ondrej Soucek, Milan Kostal, Vit Rehacek, Lenka Kujovska Krcmova, Erich Gnaiger & Ondrej Sobotka. (2021) Mitochondrial Respiration of Platelets: Comparison of Isolation Methods. Biomedicines 9:12, pages 1859.
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Hong Liu & Xun Wang. (2021) Pathogen reduction technology for blood component: A promising solution for prevention of emerging infectious disease and bacterial contamination in blood transfusion services. Journal of Photochemistry and Photobiology 8, pages 100079.
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Nicolas Malvaux, Anne Schuhmacher, Fanette Defraigne, Remy Jacob, Aicha Bah & Marcia Cardoso. (2021) Remodelling whole blood processing through automation and pathogen reduction technology at the Luxembourg Red Cross. Transfusion and Apheresis Science 60:5, pages 103195.
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Catherine Ravanat, Anaïs Pongérard, Monique Freund, Véronique Heim, Floriane Rudwill, Catherine Ziessel, Anita Eckly, Fabienne Proamer, Hervé Isola & Christian Gachet. (2021) Human platelets labeled at two discrete biotin densities are functional in vitro and are detected in vivo in the murine circulation: A promising approach to monitor platelet survival in vivo in clinical research. Transfusion 61:5, pages 1642-1653.
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Sanjida J. Mowla, Ian T. Kracalik, Mathew R.P. Sapiano, Lynne O'Hearn, Chester AndrzejewskiJr.Jr. & Sridhar V. Basavaraju. (2021) A Comparison of Transfusion-Related Adverse Reactions Among Apheresis Platelets, Whole Blood-Derived Platelets, and Platelets Subjected to Pathogen Reduction Technology as Reported to the National Healthcare Safety Network Hemovigilance Module. Transfusion Medicine Reviews 35:2, pages 78-84.
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Veronika Brixner, Gesine Bug, Petra Pohler, Doris Krämer, Bernd Metzner, Andreas Voß, Jochen Casper, Ulrich Ritter, Stefan Klein, Nael Alakel, Rudolf Peceny, Hans G. Derigs, Frank Stegelmann, Martin Wolf, Hubert Schrezenmeier, Thomas Thiele, Erhard Seifried, Hans-Hermann Kapels, Andrea Döscher, Eduard K. Petershofen, Thomas H. Müller & Axel Seltsam. (2021) Efficacy of UVC-treated, pathogen-reduced platelets versus untreated platelets: a randomized controlled non-inferiority trial. Haematologica.
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Louise Helander & Caroline Raasch Alquist. 2021. Essentials of Blood Product Management in Anesthesia Practice. Essentials of Blood Product Management in Anesthesia Practice 11 19 .
Anirban Sen Gupta. 2021. Trauma Induced Coagulopathy. Trauma Induced Coagulopathy 719 743 .
Patricia Martínez-Botía, Andrea Acebes-Huerta, Jerard Seghatchian & Laura Gutiérrez. (2020) On the Quest for In Vitro Platelet Production by Re-Tailoring the Concepts of Megakaryocyte Differentiation. Medicina 56:12, pages 671.
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Thomas Thiele. (2020) Thrombozytentransfusion bei hämatologisch-onkologischen Patienten. InFo Hämatologie + Onkologie 23:6, pages 31-35.
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Idrissa Diallo, Abderrahim Benmoussa, Jonathan Laugier, Abdimajid Osman, Walter E. Hitzler & Patrick Provost. (2020) Platelet Pathogen Reduction Technologies Alter the MicroRNA Profile of Platelet-Derived Microparticles. Frontiers in Cardiovascular Medicine 7.
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Genevieve Marcoux, Audrey Magron, Caroline Sut, Audree Laroche, Sandrine Laradi, Hind Hamzeh‐Cognasse, Isabelle Allaeys, Ophelie Cabon, Anne‐Sophie Julien, Olivier Garraud, Fabrice Cognasse & Eric Boilard. (2019) Platelet‐derived extracellular vesicles convey mitochondrial DAMPs in platelet concentrates and their levels are associated with adverse reactions. Transfusion 59:7, pages 2403-2414.
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Stephen J. Wagner & Todd M. Getz. (2019) Is a platelet suntan the answer?. Transfusion 59:4, pages 1163-1165.
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Melanie Störmer, Erica M. Wood & Birgit Gathof. (2019) Microbial safety of cellular therapeutics-lessons from over ten years’ experience in microbial safety of platelet concentrates. ISBT Science Series 14:1, pages 37-44.
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Olivier Garraud. (2018) Pathogen reduction or inactivation technologies for platelet components: Does decision making have to await further clinical trials?. Transfusion and Apheresis Science 57:6, pages 797-798.
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Aicha Bah, Marcia Cardoso, Jerard Seghatchian & Raymond P. Goodrich. (2018) Reflections on the dynamics of bacterial and viral contamination of blood components and the levels of efficacy for pathogen inactivation processes. Transfusion and Apheresis Science 57:5, pages 683-688.
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O. Garraud & M. Lozano. (2018) Pathogen inactivation/reduction technologies for platelet transfusion: Where do we stand?. Transfusion Clinique et Biologique 25:3, pages 165-171.
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Peter Schubert, Lacey Johnson, Denese C. Marks & Dana V. Devine. (2018) Ultraviolet-Based Pathogen Inactivation Systems: Untangling the Molecular Targets Activated in Platelets. Frontiers in Medicine 5.
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G. Marcoux & E. Boilard. (2017) Mitochondrial damage‐associated molecular patterns in blood transfusion products. ISBT Science Series 12:4, pages 501-505.
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