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Platelets Volume 32, 2021 - Issue 6
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Opinion Article

Is the endogenous ligand for PEAR1 a proteoglycan: clues from the sea

Caroline Kardeby1 Institute of Cardiovascular Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham, West Midlands, UKCorrespondence[email protected]
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,
Foteini-Nafsika Damaskinaki1 Institute of Cardiovascular Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham, West Midlands, UK;2 Biodiscovery Institute, University of Nottingham, University Park, Nottingham, East Midlands, UK;3 Centre of Membrane Proteins and Receptors, Universities of Birmingham and Nottingham, The Midlands, UKView further author information
,
Yi Sun1 Institute of Cardiovascular Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham, West Midlands, UK;3 Centre of Membrane Proteins and Receptors, Universities of Birmingham and Nottingham, The Midlands, UKView further author information
&
Stephen P. Watson1 Institute of Cardiovascular Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham, West Midlands, UK;3 Centre of Membrane Proteins and Receptors, Universities of Birmingham and Nottingham, The Midlands, UKCorrespondence[email protected]
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Pages 779-785 | Received 30 Sep 2020, Accepted 30 Nov 2020, Published online: 26 Dec 2020

Citations (6)

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Read on this site (2)

Steve P. Watson. (2021) Editorial: structure–function relationships of tyrosine kinase- and tyrosine phosphatase-linked receptors in platelets and megakaryocytes. Platelets 32:6, pages 722-723.
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Eleyna M Martin, Malou Zuidscherwoude, Luis a Morán, Ying Di, Angel García & Steve P Watson. (2021) The structure of CLEC-2: mechanisms of dimerization and higher-order clustering. Platelets 32:6, pages 733-743.
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Articles from other publishers (4)

Eleyna M. Martin, Joanne C. Clark, Samantha J. Montague, Luis A. Morán, Ying Di, Lily J. Bull, Luke Whittle, Florije Raka, Richard J. Buka, Idrees Zafar, Caroline Kardeby, Alexandre Slater & Steve P. Watson. (2023) Trivalent nanobody-based ligands mediate powerful activation of GPVI, CLEC-2, and PEAR1 in human platelets whereas FcγRIIA requires a tetravalent ligand. Journal of Thrombosis and Haemostasis.
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Jared S. Elenbaas, Upasana Pudupakkam, Katrina J. Ashworth, Chul Joo Kang, Ved Patel, Katherine Santana, In-Hyuk Jung, Paul C. Lee, Kendall H. Burks, Junedh M. Amrute, Robert P. Mecham, Carmen M. Halabi, Arturo Alisio, Jorge Di Paola & Nathan O. Stitziel. (2023) SVEP1 is an endogenous ligand for the orphan receptor PEAR1. Nature Communications 14:1.
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Caroline Kardeby, Alice Evans, Joana Campos, Afraa Moosa Al-Wahaibi, Christopher W. Smith, Alexandre Slater, Eleyna M. Martin, Sonia Severin, Alexander Brill, Gunnar Pejler, Yi Sun & Steve P. Watson. (2023) Heparin and heparin proteoglycan-mimetics activate platelets via PEAR1 and PI3Kβ. Journal of Thrombosis and Haemostasis 21:1, pages 101-116.
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Zahra Maqsood, Joanne C. Clark, Eleyna M. Martin, Yam Fung Hilaire Cheung, Luis A. Morán, Sean E. T. Watson, Jeremy A. Pike, Ying Di, Natalie S. Poulter, Alexandre Slater, Bodo M. H. Lange, Bernhard Nieswandt, Johannes A. Eble, Mike G. Tomlinson, Dylan M. Owen, David Stegner, Lloyd J. Bridge, Christoph Wierling & Steve P. Watson. (2022) Experimental validation of computerised models of clustering of platelet glycoprotein receptors that signal via tandem SH2 domain proteins. PLOS Computational Biology 18:11, pages e1010708.
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