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Platelets Volume 32, 2021 - Issue 6
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Special review series

Structure-function relationship of the platelet glycoprotein VI (GPVI) receptor: does it matter if it is a dimer or monomer?

Joanne C. Clark1 Institute of Cardiovascular Sciences, Level 1 IBR, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK;2 Centre of Membrane Proteins and Receptors (COMPARE), The Universities of Birmingham and Nottingham, The Midlands, UKORCID Iconhttps://orcid.org/0000-0002-1912-7816View further author information
ORCID Icon,
Foteini-Nafsika Damaskinaki1 Institute of Cardiovascular Sciences, Level 1 IBR, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK;2 Centre of Membrane Proteins and Receptors (COMPARE), The Universities of Birmingham and Nottingham, The Midlands, UK;3 School of Pharmacy, Biodiscovery Institute, University Park, University of Nottingham, Nottingham, UKView further author information
,
Yam Fung Hilaire Cheung1 Institute of Cardiovascular Sciences, Level 1 IBR, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK;4 Department of Biochemistry, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, The Netherlands;5 Department of Bioanalytics, Leibniz-Institut Für Analytische Wissenschaften - ISAS -e.v, Dortmund, GermanyView further author information
,
Alexandre Slater1 Institute of Cardiovascular Sciences, Level 1 IBR, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UKORCID Iconhttps://orcid.org/0000-0001-7166-438XView further author information
ORCID Icon &
Steve P. Watson1 Institute of Cardiovascular Sciences, Level 1 IBR, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK;2 Centre of Membrane Proteins and Receptors (COMPARE), The Universities of Birmingham and Nottingham, The Midlands, UKCorrespondence[email protected]
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Pages 724-732 | Received 28 Sep 2020, Accepted 26 Oct 2020, Published online: 26 Feb 2021

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Steve P. Watson. (2021) Editorial: structure–function relationships of tyrosine kinase- and tyrosine phosphatase-linked receptors in platelets and megakaryocytes. Platelets 32:6, pages 722-723.
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Foteini-Nafsika Damaskinaki, Luis A. Moran, Angel Garcia, Barrie Kellam & Steve P. Watson. (2021) Overcoming challenges in developing small molecule inhibitors for GPVI and CLEC-2. Platelets 32:6, pages 744-752.
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Articles from other publishers (8)

Foteini-Nafsika Damaskinaki, Natalie J. Jooss, Eleyna M. Martin, Joanne C. Clark, Mark R. Thomas, Natalie S. Poulter, Jonas Emsley, Barrie Kellam, Steve P. Watson & Alexandre Slater. (2023) Characterizing the binding of glycoprotein VI with nanobody 35 reveals a novel monomeric structure of glycoprotein VI where the conformation of D1+D2 is independent of dimerization. Journal of Thrombosis and Haemostasis 21:2, pages 317-328.
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Silvia Hoirisch-Clapauch. (2022) The Fibrinolytic System in Peripartum Depression. Seminars in Thrombosis and Hemostasis.
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Wan-Jung Lu, Chung-Hsin Tsai, Ray-Jade Chen, Li-Ting Huang, Ting-Yu Chen, Lih-Chyang Chen, Hsueh-Hsiao Wang, Hsien-Yu Peng, Yu-Yo Sun & Kuan-Hung Lin. (2022) Artesunate as a glycoprotein VI antagonist for preventing platelet activation and thrombus formation. Biomedicine & Pharmacotherapy 153, pages 113531.
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Eduardo Fuentes. (2022) Modulation of Glycoprotein VI and Its Downstream Signaling Pathways as an Antiplatelet Target. International Journal of Molecular Sciences 23:17, pages 9882.
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Valentina Shpakova, Natalia Rukoyatkina, Nada Al Arawe, Anna Prilepskaya, Alexandra Kharazova, Iraida Sharina, Stepan Gambaryan & Emil Martin. (2022) ML355 Modulates Platelet Activation and Prevents ABT-737 Induced Apoptosis in Platelets. Journal of Pharmacology and Experimental Therapeutics 381:2, pages 164-175.
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Raluca A. I. Neagoe, Elizabeth E. Gardiner, David Stegner, Bernhard Nieswandt, Steve P. Watson & Natalie S. Poulter. (2022) Rac Inhibition Causes Impaired GPVI Signalling in Human Platelets through GPVI Shedding and Reduction in PLCγ2 Phosphorylation. International Journal of Molecular Sciences 23:7, pages 3746.
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Chek Ziu Koo, Alexandra L. Matthews, Neale Harrison, Justyna Szyroka, Bernhard Nieswandt, Elizabeth E. Gardiner, Natalie S. Poulter & Michael G. Tomlinson. (2022) The Platelet Collagen Receptor GPVI Is Cleaved by Tspan15/ADAM10 and Tspan33/ADAM10 Molecular Scissors. International Journal of Molecular Sciences 23:5, pages 2440.
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Gina Perrella, Samantha J. Montague, Helena C. Brown, Lourdes Garcia Quintanilla, Alexandre Slater, David Stegner, Mark Thomas, Johan W. M. Heemskerk & Steve P. Watson. (2022) Role of Tyrosine Kinase Syk in Thrombus Stabilisation at High Shear. International Journal of Molecular Sciences 23:1, pages 493.
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