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Research Article

cAMP is an important messenger for ADP-induced platelet aggregation

Pages 238-241 | Published online: 07 Jul 2009

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Artur-Aron Weber, Hans-Karl Heim, Marc Schumacher, Karsten Schrör & Thomas Hohlfeld. (2007) Effects of selective cyclooxygenase isoform inhibition on systemic prostacyclin synthesis and on platelet function at rest and after exercise in healthy volunteers. Platelets 18:5, pages 379-385.
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Takuya MatsukawaYoshiaki Hikasa. (2020) Effects of imidazoline and nonimidazoline α-adrenoceptor agonists and antagonists, including xylazine, medetomidine, dexmedetomidine, yohimbine, and atipamezole, on aggregation of feline platelets. American Journal of Veterinary Research 81:2, pages 159-171.
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Dong-Shuai Shen, Ya-Jun Yang, Xiao-Jun Kong, Ning Ma, Xi-Wang Liu, Shi-Hong Li, Zeng-Hua Jiao, Zhe Qin, Mei-Zhou Huang & Jian-Yong Li. (2019) Aspirin eugenol ester inhibits agonist-induced platelet aggregation in vitro by regulating PI3K/Akt, MAPK and Sirt 1/CD40L pathways. European Journal of Pharmacology 852, pages 1-13.
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Ying Gao, Cheng Yu, Shulan Pi, Ling Mao & Bo Hu. (2018) The role of P2Y12 receptor in ischemic stroke of atherosclerotic origin. Cellular and Molecular Life Sciences 76:2, pages 341-354.
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Liwei He, Fangtian Fan, Xianbang Hou, Cuixiang Gao, Li Meng, Shu Meng, Shiwen Huang & Hongyan Wu. (2017) Resveratrol suppresses pulmonary tumor metastasis by inhibiting platelet-mediated angiogenic responses. Journal of Surgical Research 217, pages 113-122.
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Shin- Ichi Yokot & Yoshiaki Hikasa. (2015) Effects of Imidazoline and Nonimidazoline α2-Adrenergic Agents on Intracellular Cyclic AMP and Thromboxane B2 Concentrations in Canine and Leporine Platelets. International Journal of Pharmacology 11:6, pages 625-631.
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Sung Dae Kim, Young Ji Lee, Ji Sue Baik, Joeng Yoon Han, Chang Geun Lee, Kyu Heo, You Soo Park, Joong Sun Kim, Hyun Dong Ji, Se Il Park, Man Hee Rhee & Kwangmo Yang. (2014) Baicalein inhibits agonist- and tumor cell-induced platelet aggregation while suppressing pulmonary tumor metastasis via cAMP-mediated VASP phosphorylation along with impaired MAPKs and PI3K-Akt activation. Biochemical Pharmacology 92:2, pages 251-265.
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Shin-ichi Yokota, Yoshiaki Hikasa & Hitomi Mizushima. (2013) Effects of Imidazoline and Non-Imidazoline α-Adrenergic Agents on Rabbit Platelet Aggregation. Pharmacology 91:3-4, pages 135-144.
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Ji Young Park, Hyun Dong Ji, Bo Ra Jeon, Eun Ju Im, Young Min Son, Joo Young Lee, Dong-Ha Lee, Young-Chul Lee, Eujin Hyun, Qi Jia, Mei Hong, Hwa-Jin Park & Man Hee Rhee. (2013) Chlorin e6 Prevents ADP-Induced Platelet Aggregation by Decreasing PI3K-Akt Phosphorylation and Promoting cAMP Production. Evidence-Based Complementary and Alternative Medicine 2013, pages 1-11.
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Marcel Mischnik, Desislava Boyanova, Katharina Hubertus, Jörg Geiger, Nicole Philippi, Marcus Dittrich, Gaby Wangorsch, Jens Timmer & Thomas Dandekar. (2013) A Boolean view separates platelet activatory and inhibitory signalling as verified by phosphorylation monitoring including threshold behaviour and integrin modulation. Molecular BioSystems 9:6, pages 1326.
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Fatemeh Moheimani & Denise E. Jackson. (2012) P2Y12 receptor: platelet thrombus formation and medical interventions. International Journal of Hematology 96:5, pages 572-587.
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M Endale, WM Lee, SM Kamruzzaman, SD Kim, JY Park, MH Park, TY Park, HJ Park, JY Cho & MH Rhee. (2012) Ginsenoside‐Rp1 inhibits platelet activation and thrombus formation via impaired glycoprotein VI signalling pathway, tyrosine phosphorylation and MAPK activation. British Journal of Pharmacology 167:1, pages 109-127.
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S. M. Kamruzzaman, Mehari Endale, Won‐Jun Oh, Seung‐Chun Park, Tae‐Hwan Kim, In‐Kyoung Lee, Jae Youl Cho, Hwa‐Jin Park, Sang Keun Kim, Bong‐Sik Yun & Man Hee Rhee. (2011) Antiplatelet Activity of Phellinus baummii Methanol Extract is Mediated by Cyclic AMP Elevation and Inhibition of Collagen‐activated Integrin‐α IIb β 3 and MAP Kinase . Phytotherapy Research 25:11, pages 1596-1603.
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Hyun-Sub Lee, Sung Dae Kim, Whi Min Lee, Mehari Endale, S.M. Kamruzzaman, Won Jun Oh, Jae Youl Cho, Sang Keun Kim, Hyun-Jeong Cho, Hwa-Jin Park & Man Hee Rhee. (2010) A noble function of BAY 11-7082: Inhibition of platelet aggregation mediated by an elevated cAMP-induced VASP, and decreased ERK2/JNK1 phosphorylations. European Journal of Pharmacology 627:1-3, pages 85-91.
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Nicholas Hoenich, Stephan Thijssen, Thomas Kitzler, Robert Levin & Claudio Ronco. (2008) Impact of Water Quality and Dialysis Fluid Composition on Dialysis Practice. Blood Purification 26:1, pages 6-11.
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Jean-Etienne Fabre, MyTrang Nguyen, Krairek Athirakul, Kenneth Coggins, John D. McNeish, Sandra Austin, Leslie K. Parise, Garret A. FitzGerald, Thomas M. Coffman & Beverly H. Koller. (2001) Activation of the murine EP3 receptor for PGE2 inhibits cAMP production and promotes platelet aggregation. Journal of Clinical Investigation 107:5, pages 603-610.
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Michael T Osinski & Karsten Schrör. (2000) Inhibition of platelet-derived growth factor-induced mitogenesis by phosphodiesterase 3 inhibitors. Biochemical Pharmacology 60:3, pages 381-387.
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