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Original Article

Mixed depressive states: Nosologic and therapeutic issues

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Pages 21-37 | Published online: 11 Jul 2009

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Islam Shahin, Caterina Del Mar Bonnin, Elsayed Saleh, Khaled Helmy, Usama M Youssef & Eduard Vieta. (2020) Validity of the Shahin Mixed Depression Scale: A Self-Rated Instrument Designed to Measure the Non-DSM Mixed Features in Depression. Neuropsychiatric Disease and Treatment 16, pages 2209-2219.
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Articles from other publishers (60)

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S. Nassir Ghaemi, Jules Angst, Paul A. Vohringer, Eric A. Youngstrom, James Phelps, Philip B. Mitchell, Roger S. McIntyre, Michael Bauer, Eduard Vieta & Samuel Gershon. (2022) Clinical research diagnostic criteria for bipolar illness (CRDC-BP): rationale and validity. International Journal of Bipolar Disorders 10:1.
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Alexia E. Koukopoulos, Lavinia De Chiara, Alessio Simonetti, Georgios D. Kotzalidis, Delfina Janiri, Giovanni Manfredi, Gloria Angeletti & Gabriele Sani. (2021) The Koukopoulos mixed depression rating scale (KMDRS) and the assessment of mixed symptoms during the perinatal period. Journal of Affective Disorders 281, pages 980-988.
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Leonardo Tondo, Gustavo H. Vazquez & Ross J. Baldessarini. (2020) Suicidal Behavior Associated with Mixed Features in Major Mood Disorders. Psychiatric Clinics of North America 43:1, pages 83-93.
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Alexia Emilia Koukopoulos, Gloria Angeletti, Gabriele Sani, Delfina Janiri, Giovanni Manfredi, Georgios D. Kotzalidis & Lavinia De Chiara. (2020) Perinatal Mixed Affective State. Psychiatric Clinics of North America 43:1, pages 113-126.
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Gabriele Sani & Alan C. Swann. (2020) Mixed States. Psychiatric Clinics of North America 43:1, pages 1-13.
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Terence A. Ketter. 2020. New Directions in Psychiatry. New Directions in Psychiatry 83 99 .
Gin S. Malhi, Kristina Fritz, Preeya Elangovan & Lauren Irwin. (2019) Mixed States: Modelling and Management. CNS Drugs 33:4, pages 301-313.
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Dian-Jeng Li, Ching-Hua Lin & Feng-Chua Chen. (2018) Factors affecting time to remission for inpatients with bipolar mania – A naturalistic Taiwanese study. Journal of Affective Disorders 232, pages 73-78.
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Gabriele Sani, Paul A. Vöhringer, Sergio A. Barroilhet, Alexia E. Koukopoulos & S. Nassir Ghaemi. (2018) The Koukopoulos Mixed Depression Rating Scale (KMDRS): An International Mood Network (IMN) validation study of a new mixed mood rating scale. Journal of Affective Disorders 232, pages 9-16.
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Eva Solé, Marina Garriga, Marc Valentí & Eduard Vieta. (2016) Mixed features in bipolar disorder. CNS Spectrums 22:2, pages 134-140.
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H. Kim, W. Kim, L. Citrome, H. S. Akiskal, K. C. Goffin, S. Miller, J. N. Holtzman, F. Hooshmand, P. W. Wang, S. J. Hill & T. A. Ketter. (2016) More inclusive bipolar mixed depression definition by permitting overlapping and non-overlapping mood elevation symptoms. Acta Psychiatrica Scandinavica 134:3, pages 199-206.
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W. Kim, H. Kim, L. Citrome, H. S. Akiskal, K. C. Goffin, S. Miller, J. N. Holtzman, F. Hooshmand, P. W. Wang, S. J. Hill & T. A. Ketter. (2016) More inclusive bipolar mixed depression definitions by requiring fewer non-overlapping mood elevation symptoms. Acta Psychiatrica Scandinavica 134:3, pages 189-198.
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Brittany Mason, E. Brown & Paul Croarkin. (2016) Historical Underpinnings of Bipolar Disorder Diagnostic Criteria. Behavioral Sciences 6:3, pages 14.
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G. Perugi, J. Angst, J.-M. Azorin, C. L. Bowden, A. Caciagli, S. Mosolov, E. Vieta & A. H. Young. (2016) Relationships between mixed features and borderline personality disorder in 2811 patients with major depressive episode. Acta Psychiatrica Scandinavica 133:2, pages 133-143.
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Ashwin A. Patkar, Chi-Un Pae, Paul A. Vöhringer, Sivan Mauer, Meera Narasimhan, Shannon Dalley, Antony Loebel, Prakash S. Masand & S. Nassir Ghaemi. (2015) A 13-Week, Randomized Double-Blind, Placebo-Controlled, Cross-Over Trial of Ziprasidone in Bipolar Spectrum Disorder. Journal of Clinical Psychopharmacology 35:3, pages 319-323.
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Giulio Perugi, Giuseppe Quaranta & Liliana Dell’Osso. (2014) The Significance of Mixed States in Depression and Mania. Current Psychiatry Reports 16:10.
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Chen-Chung Liu. (2014) Adjuvant valproate therapy for patients with suspected mixed-depressive features. Therapeutic Advances in Psychopharmacology 4:4, pages 143-148.
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A. Erfurth, G. Sachs, G. Perugi & L. Tondo. (2014) Athanasios Koukopoulos (1931–2013)Athanasios Koukopoulos (1931–2013). psychopraxis. neuropraxis 17:3, pages 5-8.
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S Nassir Ghaemi & Shannon Dalley. (2014) The bipolar spectrum: Conceptions and misconceptions. Australian & New Zealand Journal of Psychiatry 48:4, pages 314-324.
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Ineke Keizer, Camille Piguet, Sophie Favre, Jean-Michel Aubry, Alexandre Dayer, Nicola Gervasoni, Marianne Gex-Fabry & Gilles Bertschy. (2014) Subjective Experience of Thought Overactivation in Mood Disorders: Beyond Racing and Crowded Thoughts. Psychopathology 47:3, pages 174-184.
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A. Koukopoulos & G. Sani. (2014) DSM-5 criteria for depression with mixed features: a farewell to mixed depression. Acta Psychiatrica Scandinavica 129:1, pages 4-16.
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Kursat Altinbas, Aysegul Ozerdem, Miguel L. Prieto, Manuel E. Fuentes, Nefize Yalin, Zeliha Ersoy, Omer Aydemir, Danilo Quiroz, Signem Oztekin, Jennifer R. Geske, Scott E. Feeder, Jules Angst & Mark A. Frye. (2014) A multinational study to pilot the modified Hypomania Checklist (mHCL) in the assessment of mixed depression. Journal of Affective Disorders 152-154, pages 478-482.
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A. Koukopoulos, D. Reginaldi, L. Tondo, C. Visioli & R.J. Baldessarini. (2013) Course sequences in bipolar disorder: Depressions preceding or following manias or hypomanias. Journal of Affective Disorders 151:1, pages 105-110.
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Isabella Pacchiarotti, Alessandra M.A. Nivoli, Lorenzo Mazzarini, Georgios D. Kotzalidis, Gabriele Sani, Athanasios Koukopoulos, Jan Scott, Sergio Strejilevich, José Sánchez-Moreno, Andrea Murru, Marc Valentí, Paolo Girardi, Eduard Vieta & Francesc Colom. (2013) The symptom structure of bipolar acute episodes: In search for the mixing link. Journal of Affective Disorders 149:1-3, pages 56-66.
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Gin S Malhi. (2013) Have the CANMAT bipolar guidelines transmogrified from do matter to can matter? . Bipolar Disorders 15:1, pages 54-57.
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Per Bech, Marianne Lunde & Stine Bjerrum Møller. (2012) Eysenck’s Two Big Personality Factors and Their Relationship to Depression in Patients with Chronic Idiopathic Pain Disorder: A Clinimetric Validation Analysis. ISRN Psychiatry 2012, pages 1-9.
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S. Nassir Ghaemi, Paul A. Vöhringer & Derick E. Vergne. (2012) The Varieties of Depressive Experience: Diagnosing Mood Disorders. Psychiatric Clinics of North America 35:1, pages 73-86.
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Ricardo Sánchez, Álvaro Navarro, Germán Eduardo Rueda-Jaimes & Carlos Gómez-Restrepo. (2011) Desarrollo y validación de la versión II de la escala EMUN. Revista Colombiana de Psiquiatría 40:4, pages 647-659.
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Bruno Biancosino, Angelo Picardi, Luciana Marmai, Massimo Biondi & Luigi Grassi. (2010) Factor structure of the Brief Psychiatric Rating Scale in unipolar depression. Journal of Affective Disorders 124:3, pages 329-334.
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Jonathan Cavanagh, Matthias Schwannauer, Mick Power & Guy M. Goodwin. (2009) A novel scale for measuring mixed states in bipolar disorder. Clinical Psychology & Psychotherapy 16:6, pages 497-509.
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G.B. Cassano, A. Benvenuti, M. Miniati, S. Calugi, M. Mula, L. Maggi, P. Rucci, A. Fagiolini, F. Perris & E. Frank. (2009) The factor structure of lifetime depressive spectrum in patients with unipolar depression. Journal of Affective Disorders 115:1-2, pages 87-99.
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Oz Malkesman, Daniel S. Pine, Tyson Tragon, Daniel R. Austin, Ioline D. Henter, Guang Chen & Husseini K. Manji. (2009) Animal models of suicide-trait-related behaviors. Trends in Pharmacological Sciences 30:4, pages 165-173.
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Athanasios Koukopoulos & S. Nassir Ghaemi. (2020) The primacy of mania: A reconsideration of mood disorders. European Psychiatry 24:2, pages 125-134.
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Michele Raja, Antonella Azzoni & Alexia E. Koukopoulos. (2009) Psychopharmacological treatment before suicide attempt among patients admitted to a Psychiatric Intensive Care Unit. Journal of Affective Disorders 113:1-2, pages 37-44.
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Jules Angst, Alex Gamma, Franco Benazzi, Vladeta Ajdacic & Wulf Rössler. (2008) Does psychomotor agitation in major depressive episodes indicate bipolarity?. European Archives of Psychiatry and Clinical Neuroscience 259:1, pages 55-63.
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G.B. Cassano, M. Mula, P. Rucci, M. Miniati, E. Frank, D.J. Kupfer, A. Oppo, S. Calugi, L. Maggi, R. Gibbons & A. Fagiolini. (2009) The structure of lifetime manic–hypomanic spectrum. Journal of Affective Disorders 112:1-3, pages 59-70.
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S Nassir Ghaemi. (2008) Why antidepressants are not antidepressants: STEP-BD, STAR*D, and the return of neurotic depression. Bipolar Disorders 10:8, pages 957-968.
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Franco Benazzi. (2008) Defining mixed depression. Progress in Neuro-Psychopharmacology and Biological Psychiatry 32:4, pages 932-939.
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Claire O'Donovan, Julie S. Garnham, Tomas Hajek & Martin Alda. (2008) Antidepressant monotherapy in pre-bipolar depression; predictive value and inherent risk. Journal of Affective Disorders 107:1-3, pages 293-298.
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S Nassir Ghaemi. (2008) All mixed up: On the absence of diagnostic guidelines for mixed states in the ISBD Diagnostic Guidelines Task Force Report . Bipolar Disorders 10:1p2, pages 129-130.
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Franco Benazzi. (2020) Impulsividad en el trastorno bipolar-II: ¿rasgo, estado o ambos?. European psychiatry (Ed. Española) 15:1, pages 43-50.
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Franco Benazzi. (2008) A tetrachoric factor analysis validation of mixed depression. Progress in Neuro-Psychopharmacology and Biological Psychiatry 32:1, pages 186-192.
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Franco Benazzi. (2020) Reviewing the diagnostic validity and utility of mixed depression (depressive mixed states). European Psychiatry 23:1, pages 40-48.
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Franco Benazzi. (2007) Testing predictors of bipolar-II disorder with a 2-day minimum duration of hypomania. Psychiatry Research 153:2, pages 153-162.
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Franco Benazzi. (2007) Impulsivity in bipolar-II disorder: Trait, state, or both?. European Psychiatry 22:7, pages 472-478.
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C. Henry, K. M’baïlara, R. Poinsot & B. Falissard. (2007) Construction et validation d’une échelle dimensionnelle de l’humeur : multidimensional assessment of thymic states (MAThyS). L'Encéphale 33:5, pages 768-774.
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Franco Benazzi. (2007) Delineation of the clinical picture of Dysphoric/Mixed Hypomania. Progress in Neuro-Psychopharmacology and Biological Psychiatry 31:4, pages 944-951.
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Chantal Henry, Katia M’Baïlara, Rollon Poinsot, Anne-Aurelie Casteret, Frédéric Sorbara, Marion Leboyer & Eduard Vieta. (2007) Evidence for Two Types of Bipolar Depression Using a Dimensional Approach. Psychotherapy and Psychosomatics 76:6, pages 325-331.
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Franco Benazzi. (2007) Mixed Depression and the Dimensional View of Mood Disorders. Psychopathology 40:6, pages 431-439.
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Franco Benazzi. (2007) Challenging the unipolar–bipolar division: Does mixed depression bridge the gap?. Progress in Neuro-Psychopharmacology and Biological Psychiatry 31:1, pages 97-103.
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I. Thauvin & F. Limosin. (2007) Clinique des états mixtes. EMC - Psychiatrie 4:2, pages 1-5.
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Franco Benazzi. (2006) The continuum/spectrum concept of mood disorders: is mixed depression the basic link?. European Archives of Psychiatry and Clinical Neuroscience 256:8, pages 512-515.
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