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International Review of Psychiatry Volume 18, 2006 - Issue 2: Lipids
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Original

Lipids and the pathogenesis of Alzheimer's disease: Is there a link?

Michelle M. Mielke PhD Division of Geriatric Psychiatry and Neuropsychiatry, Department of Psychiatry, and the Alzheimer's Disease Research Center, Johns Hopkins University, School of Medicine, Baltimore, MD, USACorrespondence[email protected]
&
C. G. Lyketsos Division of Geriatric Psychiatry and Neuropsychiatry, Department of Psychiatry, and the Alzheimer's Disease Research Center, Johns Hopkins University, School of Medicine, Baltimore, MD, USA
Pages 173-186 | Published online: 11 Jul 2009

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Michelle M Mielke & Norman J Haughey. (2012) Could plasma sphingolipids be diagnostic or prognostic biomarkers for Alzheimer’s disease?. Clinical Lipidology 7:5, pages 525-536.
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Dieter Lütjohann, Sabrina Meichsner & Hanna Pettersson. (2012) Lipids in Alzheimer’s disease and their potential for therapy. Clinical Lipidology 7:1, pages 65-78.
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P.D. Riha, J.C. Rojas, R.A. Colorado & F. Gonzalez-Lima. (2008) Animal model of posterior cingulate cortex hypometabolism implicated in amnestic MCI and AD. Neurobiology of Learning and Memory 90:1, pages 112-124.
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Bor Luen Tang & Christelle En Lin Chua. (2008) SIRT1 and neuronal diseases. Molecular Aspects of Medicine 29:3, pages 187-200.
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Eline M. van der Beek & Patrick J.G.H. Kamphuis. (2008) The potential role of nutritional components in the management of Alzheimer's Disease. European Journal of Pharmacology 585:1, pages 197-207.
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Scott D. Mendelson. 2008. Metabolic Syndrome and Psychiatric Illness. Metabolic Syndrome and Psychiatric Illness 27 48 .

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