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ORIGINAL ARTICLE

Microneedle penetration and injection past the stratum corneum in humans

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Pages 156-159 | Received 22 Sep 2008, Accepted 26 Sep 2008, Published online: 28 Oct 2009

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N. Sanoj Rejinold, Ju-Hyung Shin, Hae Yong Seok & Yeu-Chun Kim. (2016) Biomedical applications of microneedles in therapeutics: recent advancements and implications in drug delivery. Expert Opinion on Drug Delivery 13:1, pages 109-131.
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Shaun D. Gittard, Bo Chen, Huadong Xu, Aleksandr Ovsianikov, Boris N. Chichkov, Nancy A. Monteiro-Riviere & Roger J. Narayan. (2013) The effects of geometry on skin penetration and failure of polymer microneedles. Journal of Adhesion Science and Technology 27:3, pages 227-243.
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Martin J Garland, Katarzyna Migalska, Tuan Mazlelaa Tuan Mahmood, Thakur Raghu Raj Singh, A David Woolfson & Ryan F Donnelly. (2011) Microneedle arrays as medical devices for enhanced transdermal drug delivery. Expert Review of Medical Devices 8:4, pages 459-482.
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Articles from other publishers (25)

Vahid Ebrahiminejad, Philip D. Prewett, Graham J. Davies & Zahra Faraji Rad. (2022) Microneedle Arrays for Drug Delivery and Diagnostics: Toward an Optimized Design, Reliable Insertion, and Penetration. Advanced Materials Interfaces 9:6, pages 2101856.
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Fateme Nazary Abrbekoh, Leila Salimi, Sepideh Saghati, Hassan Amini, Sonia Fathi Karkan, Keyvan Moharamzadeh, Emel Sokullu & Reza Rahbarghazi. (2022) Application of microneedle patches for drug delivery; doorstep to novel therapies. Journal of Tissue Engineering 13, pages 204173142210853.
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Ishrat Zahoor, Sukhbir Singh, Tapan Behl, Neelam Sharma, Tanveer Naved, Vetriselvan Subramaniyan, Shivkanya Fuloria, Neeraj Kumar Fuloria, Saurabh Bhatia, Ahmed Al-Harrasi, Lotfi Aleya, Shahid Nazir Wani, Celia Vargas-De-La-Cruz & Simona Bungau. (2021) Emergence of microneedles as a potential therapeutics in diabetes mellitus. Environmental Science and Pollution Research 29:3, pages 3302-3322.
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Noriyuki Uchida, Masayoshi Yanagi & Hiroki Hamada. (2021) Physical Enhancement? Nanocarrier? Current Progress in Transdermal Drug Delivery. Nanomaterials 11:2, pages 335.
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Defu Zhi, Ting Yang, Justin O'Hagan, Shubiao Zhang & Ryan F. Donnelly. (2020) Photothermal therapy. Journal of Controlled Release 325, pages 52-71.
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Rehan Al-Kasasbeh, Aaron J. Brady, Aaron J. Courtenay, Eneko Larrañeta, Maelíosa T.C. McCrudden, Donal O’Kane, Stephen Liggett & Ryan F. Donnelly. (2020) Evaluation of the clinical impact of repeat application of hydrogel-forming microneedle array patches. Drug Delivery and Translational Research 10:3, pages 690-705.
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Kyung Ju Lee, Seong Sik Jeong, Dong Hyun Roh, Dong Yeong Kim, Hoo-Kyun Choi & Eun Hee Lee. (2020) A practical guide to the development of microneedle systems – In clinical trials or on the market. International Journal of Pharmaceutics 573, pages 118778.
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Mayank Singhal, César E. S. Jimenez, Maria Lapteva & Yogeshvar N. Kalia. 2019. Innovative Dosage Forms. Innovative Dosage Forms 245 279 .
Helen L. Quinn & Ryan F. Donnelly. 2018. Microneedles for Drug and Vaccine Delivery and Patient Monitoring. Microneedles for Drug and Vaccine Delivery and Patient Monitoring 71 91 .
Akihiko Ono, Hiroaki Azukizawa, Sayami Ito, Yuki Nakamura, Hideo Asada, Ying-Shu Quan, Fumio Kamiyama, Ichiro Katayama, Sachiko Hirobe & Naoki Okada. (2017) Development of novel double-decker microneedle patches for transcutaneous vaccine delivery. International Journal of Pharmaceutics 532:1, pages 374-383.
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Akihiko Ono, Sayami Ito, Shun Sakagami, Hideo Asada, Mio Saito, Ying-Shu Quan, Fumio Kamiyama, Sachiko Hirobe & Naoki Okada. (2017) Development of Novel Faster-Dissolving Microneedle Patches for Transcutaneous Vaccine Delivery. Pharmaceutics 9:4, pages 27.
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Eva M. Vicente-Perez, Eneko Larra?eta, Mael?osa T.C. McCrudden, Adrien Kissenpfennig, Shauna Hegarty, Helen O. McCarthy & Ryan F. Donnelly. (2017) Repeat application of microneedles does not alter skin appearance or barrier function and causes no measurable disturbance of serum biomarkers of infection, inflammation or immunity in mice in vivo. European Journal of Pharmaceutics and Biopharmaceutics 117, pages 400-407.
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Didac Vega Bru & ?ngel Rodr?guez Mart?nez. 2017. New Research on Silicon - Structure, Properties, Technology. New Research on Silicon - Structure, Properties, Technology.
Emma McAlister, Martin J. Garland, Thakur Raghu Raj Singh & Ryan F. Donnelly. 2017. Percutaneous Penetration Enhancers Physical Methods in Penetration Enhancement. Percutaneous Penetration Enhancers Physical Methods in Penetration Enhancement 273 303 .
Jelena Predic Atkinson, Howard I. Maibach & Nina Dragicevic. 2015. Percutaneous Penetration Enhancers Chemical Methods in Penetration Enhancement. Percutaneous Penetration Enhancers Chemical Methods in Penetration Enhancement 93 108 .
Michael S. Leo, Hadar A. Lev-Tov, Faranak Kamangar, Howard I. Maibach & Raja K. Sivamani. 2014. Topical Drug Bioavailability, Bioequivalence, and Penetration. Topical Drug Bioavailability, Bioequivalence, and Penetration 237 246 .
Yeu-Chun Kim, Jung-Hwan Park & Mark R. Prausnitz. (2012) Microneedles for drug and vaccine delivery. Advanced Drug Delivery Reviews 64:14, pages 1547-1568.
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Kent D. Butz, Adam J. Griebel, Tyler Novak, Kevin Harris, Amy Kornokovich, Michael F. Chiappetta & Corey P. Neu. (2012) Prestress as an optimal biomechanical parameter for needle penetration. Journal of Biomechanics 45:7, pages 1176-1179.
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Ryan F. Donnelly, Thakur Raghu Raj Singh, Desmond I. J. Morrow & A. David Woolfson. 2012. Microneedle‐Mediated Transdermal and Intradermal Drug Delivery. Microneedle‐Mediated Transdermal and Intradermal Drug Delivery 79 112 .
Elsa E. Kis, Gerhard Winter & Julia Myschik. (2012) Devices for intradermal vaccination. Vaccine 30:3, pages 523-538.
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José Juan Escobar‐Chávez, Dalia Bonilla‐Martínez, Martha Angélica, Villegas‐González, Eva Molina‐Trinidad, Norma Casas‐Alancaster & Alma Luisa Revilla‐Vázquez. (2013) Microneedles: A Valuable Physical Enhancer to Increase Transdermal Drug Delivery. The Journal of Clinical Pharmacology 51:7, pages 964-977.
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Helmut Beltraminelli, Nathalie Dietrich & Thomas Hunziker. (2011) Fractional Transepidermal Delivery: A Histological Analysis. Dermatology 223:4, pages 321-324.
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Siôn A. Coulman, James C. Birchall, Aneesh Alex, Marc Pearton, Bernd Hofer, Conor O’Mahony, Wolfgang Drexler & Boris Považay. (2010) In Vivo, In Situ Imaging of Microneedle Insertion into the Skin of Human Volunteers Using Optical Coherence Tomography. Pharmaceutical Research 28:1, pages 66-81.
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Yasmine A. Gomaa, Desmond I.J. Morrow, Martin J. Garland, Ryan F. Donnelly, Labiba K. El-Khordagui & Victor M. Meidan. (2010) Effects of microneedle length, density, insertion time and multiple applications on human skin barrier function: Assessments by transepidermal water loss. Toxicology in Vitro 24:7, pages 1971-1978.
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Liévin Daugimont, Nolwenn Baron, Gaëlle Vandermeulen, Natasa Pavselj, Damijan Miklavcic, Marie-Caroline Jullien, Gonzalo Cabodevila, Lluis M. Mir & Véronique Préat. (2010) Hollow Microneedle Arrays for Intradermal Drug Delivery and DNA Electroporation. The Journal of Membrane Biology 236:1, pages 117-125.
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