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Targeted treatments for hidradenitis suppurativa: a review of the current literature and ongoing clinical trials

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Pages 441-449 | Received 06 Oct 2017, Accepted 18 Oct 2017, Published online: 10 Nov 2017

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Fabrizio Martora, Massimiliano Scalvenzi, Teresa Battista, Luigi Fornaro, Luca Potestio, Angelo Ruggiero & Matteo Megna. (2023) Guselkumab, Risankizumab, and Tildrakizumab in the Management of Hidradenitis Suppurativa: A Review of Existing Trials and Real-Life Data. Clinical, Cosmetic and Investigational Dermatology 16, pages 2525-2536.
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Devea R. De, Terri Shih, Denise Fixsen, Brindley Brooks, Jennifer L. Hsiao & Vivian Y. Shi. (2022) Biologic use in hidradenitis suppurativa: patient perspectives and barriers. Journal of Dermatological Treatment 33:7, pages 3060-3062.
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Francesco Messina & Stefano Piaserico. (2022) The dark side of the moon: the immune-mediated adverse events of IL-17A/IL-17R inhibition. Journal of Dermatological Treatment 33:5, pages 2443-2454.
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Claudio Marasca, Maria Carmela Annunziata, Maddalena Napolitano & Gabriella Fabbrocini. (2018) Unconventional therapies for hidradenitis suppurativa. Expert Review of Clinical Pharmacology 11:9, pages 879-887.
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Yonghao Cao, Bohdan P. Harvey, Liang Jin, Susan Westmoreland, Jing Wang, Munish Puri, Yingli Yang, Holly M. Robb, Sultan Tanriverdi, Chenqi Hu, Xue Wang, Xiaofeng Xin, Yingchun Liu, Michael P. Macoritto, Kathleen M. Smith, Yu Tian, Kevin White, Timothy R.D. J. Radstake & Zehra Kaymakcalan. (2023) Therapeutic TNF Inhibitors Exhibit Differential Levels of Efficacy in Accelerating Cutaneous Wound Healing. JID Innovations, pages 100250.
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Ericles Andrei Bellei, André Vicente Esteves de Carvalho, Beatriz Magalhães Eng, Carla Tozato, Danilo Hamilko de Barros, Erika Yumi Tamashiro, Gleison Vieira Duarte, Rafael Toledo Rodrigues de Fátima, Renata Ferreira Magalhães, Roberto Souto da Silva, Wagner Guimarães Galvão Cesar & Felipe Garutti Thies. (2023) Navigating the Multidimensional Impact of Living with Hidradenitis Suppurativa: An In-Depth Netnographic Study on Social Media Platforms. Dermatology and Therapy 13:11, pages 2797-2815.
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Johannes M. Freudenberg, Zhi Liu, Jennifer Singh, Elizabeth Thomas, Christopher Traini, Deepak K. Rajpal & Christopher J. Sayed. (2023) A Hidradenitis Suppurativa molecular disease signature derived from patient samples by high-throughput RNA sequencing and re-analysis of previously reported transcriptomic data sets. PLOS ONE 18:4, pages e0284047.
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Aiko Kiyozuka, Asami Kajiyama, Rie Ootsuki, Masaru Hosokawa, Masahiro Miyaki & Yutaka Takagi. (2022) Efficacy of the continuous use of a lotion with carbon dioxide on male subjects with mild acne. Journal of Cosmetic Dermatology 22:2, pages 577-585.
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Nouf Almuhanna, Sheldon W. Tobe & Raed Alhusayen. (2023) Risk of Chronic Kidney Disease in Hospitalized Patients with Hidradenitis Suppurativa. Dermatology 239:6, pages 912-918.
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José Miguel Neves, Nélia Cunha, André Lencastre & Joana Cabete. (2022) Treating hidradenitis suppurativa patients with adalimumab: a real-life experience of a tertiary care center in Lisboa, Portugal. Anais Brasileiros de Dermatologia 97:6, pages 816-819.
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Adela Markota Čagalj, Branka Marinović & Zrinka Bukvić Mokos. (2022) New and Emerging Targeted Therapies for Hidradenitis Suppurativa. International Journal of Molecular Sciences 23:7, pages 3753.
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Katarzyna P. Kaleta, Georgios Nikolakis, Amir M. Hossini, Ottfried Balthasar, Daifallah Almansouri, Aristeidis Vaiopoulos, Jürgen Knolle, Anna Boguslawska, Anna Wojas-Pelc & Christos C. Zouboulis. (2022) Metabolic Disorders/Obesity Is a Primary Risk Factor in Hidradenitis Suppurativa: An Immunohistochemical Real-World Approach. Dermatology 238:2, pages 251-259.
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Ryan M. Svoboda & Joslyn S. Kirby. 2022. A Comprehensive Guide to Hidradenitis Suppurativa. A Comprehensive Guide to Hidradenitis Suppurativa 121 129 .
Neeta Malviya & Amit Garg. 2022. A Comprehensive Guide to Hidradenitis Suppurativa. A Comprehensive Guide to Hidradenitis Suppurativa 69 76 .
Yonghao Cao, Bohdan P. Harvey, Feng Hong, Melanie Ruzek, Jing Wang, Erin R. Murphy & Zehra Kaymakcalan. (2021) Adalimumab Induces a Wound Healing Profile in Patients with Hidradenitis Suppurativa by Regulating Macrophage Differentiation and Matrix Metalloproteinase Expression. Journal of Investigative Dermatology 141:11, pages 2730-2740.e9.
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Y. Cao, F. Hong, D.M. Conlon, L. Sidur, K.M. Smith, Y. Fang, C.A. Cuff, Z. Kaymakcalan & M.C. Ruzek. (2021) Potential predictive biomarkers of adalimumab response in patients with hidradenitis suppurativa*. British Journal of Dermatology 185:4, pages 804-814.
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Ichiro Kurokawa, Alison M. Layton & Rei Ogawa. (2021) Updated Treatment for Acne: Targeted Therapy Based on Pathogenesis. Dermatology and Therapy 11:4, pages 1129-1139.
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Tasnim Abdalla, Michelle A. Lowes, Nirmal Kaur, Robert G. Micheletti, A. Hillary Steinhart & Afsaneh Alavi. (2021) Is There a Role for Therapeutic Drug Monitoring in Patients with Hidradenitis Suppurativa on Tumor Necrosis Factor-α Inhibitors?. American Journal of Clinical Dermatology 22:2, pages 139-147.
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Giulia ODORICI, Giovanni PELLACANI & Andrea CONTI. (2021) Ixekizumab in hidradenitis suppurativa in a psoriatic patient. Giornale Italiano di Dermatologia e Venereologia 155:6.
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Adam Krusiński, Anna Grzywa-Celińska, Katarzyna Szewczyk, Luiza Grzycka-Kowalczyk, Justyna Emeryk-Maksymiuk & Janusz Milanowski. (2021) Various Forms of Tuberculosis in Patients with Inflammatory Bowel Diseases Treated with Biological Agents. International Journal of Inflammation 2021, pages 1-8.
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Chia-Bao Chu, Chao-Chun Yang & Shaw-Jenq Tsai. (2021) Hidradenitis suppurativa: Disease pathophysiology and sex hormones. Chinese Journal of Physiology 64:6, pages 257.
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Kyla N. Price, Jennifer L. Hsiao & Vivian Y. Shi. (2021) Race and Ethnicity Gaps in Global Hidradenitis Suppurativa Clinical Trials. Dermatology 237:1, pages 97-102.
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Aleksi J. Hendricks, Jennifer L. Hsiao, Michelle A. Lowes & Vivian Y. Shi. (2021) A Comparison of International Management Guidelines for Hidradenitis Suppurativa. Dermatology 237:1, pages 81-96.
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Jing-Wun Lu, Yu-Wen Huang & Tai-Li Chen. (2021) Efficacy and safety of adalimumab in hidradenitis suppurativa. Medicine 100:22, pages e26190.
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Hong Fang, Xing-Hua Gao, Song-Mei Geng, Heng Gu, Jun Gu, Li He, Xian Jiang, Hong-Zhong Jin, Qiang Ju, Xiao-Jing Kang, Wei Lai, Cheng-Xin Li, Hang Li, Heng-Jin Li, Shan-Shan Li, Yu-Zhen Li, Qing Sun, Juan Tao, Baoxi Wang, Gang Wang, Xin-Feng Wu, Lei-Hong Xiang, Hong-Fu Xie, Hao-Xiang Xu, Jin-Hua Xu, Yan Yan & Zhi-Zhong Zheng. (2021) Diagnosis and Treatment of Acne Inversa/Hidradenitis Suppurativa in China: An Expert Consensus Statement (2021 Version)#. International Journal of Dermatology and Venereology 4:2, pages 100-108.
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Kara Reardon, Jarad Levin & Carly Levin. (2021) Severe hidradenitis suppurativa with herpes simplex virus 1 superinfection and clinical responsiveness to ixekizumab. JAAD Case Reports.
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Carlos A. Penno, Petra Jäger, Claire Laguerre, Franziska Hasler, Andreas Hofmann, Stephanie K. Gass, Barbara Wettstein-Ling, Dirk J. Schaefer, Alexandre Avrameas, Friedrich Raulf, Grazyna Wieczorek, Joachim C.U. Lehmann, Christian Loesche, Lukas Roth & Till A. Röhn. (2020) Lipidomics Profiling of Hidradenitis Suppurativa Skin Lesions Reveals Lipoxygenase Pathway Dysregulation and Accumulation of Proinflammatory Leukotriene B4. Journal of Investigative Dermatology 140:12, pages 2421-2432.e10.
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John W. Frew, Caroline S. Jiang, Neha Singh, Kristina Navrazhina, Roger Vaughan & James G. Krueger. (2020) Quantifying the natural variation in lesion counts over time in untreated hidradenitis suppurativa: Implications for outcome measures and trial design. JAAD International 1:2, pages 208-221.
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Lya Magdalena Moneva-Leniz, Ramón Garcia-Ruiz, Eva María Sanchez-Martinez, Héctor Gegundez-Hernandez, Francisco Javier Melgosa-Ramos & Almudena Mateu-Puchades. (2020) Efectividad de adalimumab en la hidradenitis supurativa: un estudio de la vida real. Piel 35:8, pages 479-483.
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Yan Teng, Xiaohua Tao, Wei Lu, Youming Huang, Danfeng Xu, Meng Li & Yibin Fan. (2020) Identification of Hidradenitis Suppurativa-Related mRNA Expression Patterns Through Analysis of Gene Expression Omnibus. Dose-Response 18:3, pages 155932582094264.
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Joshua S. Davis, David Ferreira, Emma Paige, Craig Gedye & Michael Boyle. (2020) Infectious Complications of Biological and Small Molecule Targeted Immunomodulatory Therapies. Clinical Microbiology Reviews 33:3.
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A.B. Kimball, J.J. Crowley, K. Papp, B. Calimlim, Y. Duan, A.B. Fleischer & J. Sobell. (2020) Baseline patient‐reported outcomes from UNITE : an observational, international, multicentre registry to evaluate hidradenitis suppurativa in clinical practice . Journal of the European Academy of Dermatology and Venereology 34:6, pages 1302-1308.
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Samantha R. Goldburg, Bruce E. Strober & Michael J. Payette. (2020) Hidradenitis suppurativa. Journal of the American Academy of Dermatology 82:5, pages 1061-1082.
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C.C. Zouboulis, A. Nogueira da Costa, E. Makrantonaki, X.X. Hou, D. Almansouri, J.T. Dudley, H. Edwards, B. Readhead, O. Balthasar, G.B.E. Jemec, N.G. Bonitsis, G. Nikolakis, D. Trebing, K.C. Zouboulis & A.M. Hossini. (2020) Alterations in innate immunity and epithelial cell differentiation are the molecular pillars of hidradenitis suppurativa. Journal of the European Academy of Dermatology and Venereology 34:4, pages 846-861.
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Robert Sabat, Gregor B. E. Jemec, Łukasz Matusiak, Alexa B. Kimball, Errol Prens & Kerstin Wolk. (2020) Hidradenitis suppurativa. Nature Reviews Disease Primers 6:1.
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Mondana H. Ghias, Michael J. Hyde, Lewis E. Tomalin, B. Paul Morgan, Afsaneh Alavi, Michelle A. Lowes & Vincent Piguet. (2020) Role of the Complement Pathway in Inflammatory Skin Diseases: A Focus on Hidradenitis Suppurativa. Journal of Investigative Dermatology 140:3, pages 531-536.e1.
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Langan, Recke, Bokor-Billmann, Billmann, Kahle & Zillikens. (2020) The Role of the Cutaneous Microbiome in Hidradenitis Suppurativa—Light at the End of the Microbiological Tunnel. International Journal of Molecular Sciences 21:4, pages 1205.
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John W. Frew, Kristina Navrazhina & James G. Krueger. 2020. Stiehm's Immune Deficiencies. Stiehm's Immune Deficiencies 773 786 .
Jacob W. Lucas, Andrew M. Higgins & Jay Simhan. 2020. Textbook of Male Genitourethral Reconstruction. Textbook of Male Genitourethral Reconstruction 751 763 .
Raphaël André, Hélène Marescassier, Cem Gabay, Brigitte Pittet & Emmanuel Laffitte. (2019) Long‐term therapy with anakinra in hidradenitis suppurativa in three patients. International Journal of Dermatology 58:11.
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Kelsey S. Flood, Martina L. Porter & Alexa B. Kimball. (2019) Biologic Treatment for Hidradenitis Suppurativa. American Journal of Clinical Dermatology 20:5, pages 625-638.
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Damiani, Mahroum, Pigatto, Pacifico, Malagoli, Tiodorovic, Conic, Amital, Bragazzi, Watad & Adawi. (2019) The Safety and Impact of a Model of Intermittent, Time-Restricted Circadian Fasting (“Ramadan Fasting”) on Hidradenitis Suppurativa: Insights from a Multicenter, Observational, Cross-Over, Pilot, Exploratory Study. Nutrients 11:8, pages 1781.
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C.C. Zouboulis. (2019) Ex vivo human models of hidradenitis suppurativa/acne inversa for laboratory research and drug screening . British Journal of Dermatology 181:2, pages 244-246.
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Ji Yeoun Shin, Jung Yeon Hong, Ho Jung Lee, Chang Yoon Sim, Young Lip Park, Jong Suk Lee, Sung Yul Lee & Jung Eun Kim. (2019) Treatment of Hidradenitis Suppurativa Patient with Klinefelter Syndrome by Adalimumab. Annals of Dermatology 31:4, pages 446.
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John W. Frew, Jason E. Hawkes & James G. Krueger. (2019) Topical, systemic and biologic therapies in hidradenitis suppurativa: pathogenic insights by examining therapeutic mechanisms. Therapeutic Advances in Chronic Disease 10, pages 204062231983064.
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M.-A. Gkini & A.P. Bewley. (2018) Development of hidradenitis suppurativa in a patient treated with ustekinumab for her psoriasis: A potential paradoxical reaction?. Dermatologic Therapy 31:6, pages e12742.
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B.C. Melnik, S.M. John, W. Chen & G. Plewig. (2018) T helper 17 cell/regulatory T-cell imbalance in hidradenitis suppurativa/acne inversa: the link to hair follicle dissection, obesity, smoking and autoimmune comorbidities. British Journal of Dermatology.
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