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International Journal of Radiation Biology Volume 81, 2005 - Issue 3
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Original Article

Factors effecting the Th2-like immune response after gamma-irradiation: low production of IL-12 heterodimer in antigen-presenting cells and small expression of the IL-12 receptor in T cells

Hae-Ran Park Radiation Food and Biotechnology Team, Korea Atomic Energy Research Institute (KAERI), Yusong, Daejeon, KoreaCorrespondence[email protected]
,
Sung-Kee Jo Radiation Food and Biotechnology Team, Korea Atomic Energy Research Institute (KAERI), Yusong, Daejeon, Korea
&
Sang-Gi Paik Department of Biology, Chungnam National University, Yusong, Daejeon, Korea
Pages 221-231 | Received 20 Aug 2004, Accepted 10 Feb 2005, Published online: 03 Jul 2009

Citations (28)

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Hae-Ran Park, Sung-Kee Jo & Hyeon-Soo Eom. (2011) Chronic effects of single and fractionated 𝛄-irradiation on an impairment of Th1-related immune response. International Journal of Radiation Biology 87:5, pages 534-543.
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Sung Kee Jo, Min-A Seol, Hae-Ran Park, Uhee Jung & Changhyun Roh. (2011) Ionising radiation triggers fat accumulation in white adipose tissue. International Journal of Radiation Biology 87:3, pages 302-310.
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Hae-Ran Park, Sung-Kee Jo & Sang-Gi Paik. (2006) The NK1.1+T cells alive in irradiated mice play an important role in a Th1/Th2 balance. International Journal of Radiation Biology 82:3, pages 161-170.
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Ruchi Pandey, Bhavani S. Shankar, Deepak Sharma & Krishna B. Sainis. (2005) Low dose radiation induced immunomodulation: Effect on macrophages and CD8+ T cells. International Journal of Radiation Biology 81:11, pages 801-812.
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Articles from other publishers (24)

Miles Piper, Adam C. Mueller & Sana D. Karam. (2020) The interplay between cancer associated fibroblasts and immune cells in the context of radiation therapy. Molecular Carcinogenesis 59:7, pages 754-765.
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Xiaochang Liu, Zheng Liu, Duo Wang, Yang Han, Sai Hu, Ying Xie, Yike Liu, Maoxiang Zhu, Hua Guan, Yongqing Gu & Ping-Kun Zhou. (2020) Effects of low dose radiation on immune cells subsets and cytokines in mice. Toxicology Research 9:3, pages 249-262.
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Takashi Ito & Toshiyuki Yamamoto. (2020) Wells syndrome after radiation therapy. The Journal of Dermatology 47:3.
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Hui Gao, Zhuo Dong, Xinkou Gong, Juancong Dong, Yuyu Zhang, Wei Wei, Rui Wang & Shunzi Jin. (2018) Effects of various radiation doses on induced T-helper cell differentiation and related cytokine secretion. Journal of Radiation Research 59:4, pages 395-403.
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Hae-Ran Park, Sung-Kee Jo & Uhee Jung. (2017) Thoracic Irradiation Recruit M2 Macrophage into the Lung, Leading to Pneumonitis and Pulmonary Fibrosis. Journal of Radiation Protection and Research 42:4, pages 177-188.
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Kun Cao, Xiao Lei, Hu Liu, Hainan Zhao, Jiaming Guo, Yuanyuan Chen, Yang Xu, Ying Cheng, Cong Liu, Jianguo Cui, Bailong Li, Jianming Cai, Fu Gao & Yanyong Yang. (2017) Polydatin alleviated radiation-induced lung injury through activation of Sirt3 and inhibition of epithelial-mesenchymal transition. Journal of Cellular and Molecular Medicine 21:12, pages 3264-3276.
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Hu Liu, Bailong Li, Xiaojing Jia, Yan Ma, Yifeng Gu, Pei Zhang, Qun Wei, Jianming Cai, Jianguo Cui, Fu Gao & Yanyong Yang. (2017) Radiation-induced decrease of CD8 + dendritic cells contributes to Th1/Th2 shift. International Immunopharmacology 46, pages 178-185.
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Zoya Gluzman-Poltorak, Sarita R Mendonca, Vladimir Vainstein, Hue Kha & Lena A Basile. (2014) Randomized comparison of single dose of recombinant human IL-12 versus placebo for restoration of hematopoiesis and improved survival in rhesus monkeys exposed to lethal radiation. Journal of Hematology & Oncology 7:1.
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Neda Babaee, Dariush Moslemi, Mohammad Khalilpour, Fatemeh Vejdani, Yasaman Moghadamnia, Ali Bijani, Mahmoud Baradaran, Mohammad Taghi Kazemi, Asieh Khalilpour, Mahdi Pouramir & Ali Akbar Moghadamnia. (2013) Antioxidant capacity of calendula officinalis flowers extract and prevention of radiation induced oropharyngeal mucositis in patients with head and neck cancers: a randomized controlled clinical study. DARU Journal of Pharmaceutical Sciences 21:1.
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Casey M. Manning, Carl J. Johnston, Eric Hernady, Jen-nie H. Miller, Christina K. Reed, B. Paige Lawrence, Jacqueline P. Williams & Jacob N. Finkelstein. (2013) Exacerbation of Lung Radiation Injury by Viral Infection: The Role of Clara Cells and Clara Cell Secretory Protein. Radiation Research 179:6, pages 617-629.
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Hae-Ran Park, Sung-Kee Jo, Dong-Kyung Yu & Uhee Jung. (2012) Fractionated irradiations lead to chronic allergic airway inflammation through increasing the influx of macrophages. Inflammation Research 62:1, pages 27-36.
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Hae-Ran Park, Sung-Kee Jo, Nam-Hee Choi & Uhee Jung. (2012) HemoHIM Ameliorates the Persistent Down-Regulation of Th1-like Immune Responses in Fractionated γ-Irradiated Mice by Modulating the IL-12p70-STAT4 Signaling Pathway. Radiation Research 177:5, pages 676-684.
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A. Kunwar, P. P. Bag, S. Chattopadhyay, V. K. Jain & K. I. Priyadarsini. (2011) Anti-apoptotic, anti-inflammatory, and immunomodulatory activities of 3,3′-diselenodipropionic acid in mice exposed to whole body γ-radiation. Archives of Toxicology 85:11, pages 1395-1405.
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Hae-Ran Park & Sung-Kee Jo. (2011) Lasting effects of an impairment of Th1-like immune response in γ-irradiated mice: A resemblance between irradiated mice and aged mice. Cellular Immunology 267:1, pages 1-8.
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Changhyun Roh, Nam‐Hee Choi, Hae‐Ran Park, Uhee Jung & Sung Kee Jo. (2010) Effects of Orlistat on white adipose tissue (WAT) in the γ‐irradiated mouse model. European Journal of Lipid Science and Technology 112:12, pages 1384-1388.
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Yanyan Qu, Baojun Zhang, Shuchun Liu, Aijun Zhang, Tingting Wu & Yong Zhao. (2010) 2-Gy whole-body irradiation significantly alters the balance of CD4+CD25−T effector cells and CD4+CD25+Foxp3+T regulatory cells in mice. Cellular & Molecular Immunology 7:6, pages 419-427.
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B Watkins, K Pouliot, E Fey, C Tuthill & S Sonis. (2010) Attenuation of radiation- and chemoradiation-induced mucositis using gamma-d-glutamyl-l-tryptophan (SCV-07). Oral Diseases 16:7, pages 655-660.
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Yanyan Qu, Shuguang Jin, Aijun Zhang, Baojun Zhang, Xiaoyun Shi, Junjie Wang & Yong Zhao. (2010) Gamma-Ray Resistance of Regulatory CD4 + CD25 + Foxp3 + T Cells in Mice . Radiation Research 173:2, pages 148-157.
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Hae-Ran Park, Eun-Jin Ju, Sung-Kee Jo, Uhee Jung & Sung-Ho Kim. (2010) HemoHIM Enhances the Therapeutic Efficacy of Ionizing Radiation Treatment in Tumor-Bearing Mice. Journal of Medicinal Food 13:1, pages 47-53.
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Christine Linard & Maâmar Souidi. (2010) PPARs in Irradiation-Induced Gastrointestinal Toxicity. PPAR Research 2010, pages 1-12.
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Hae-Ran Park, Eun-Jin Ju, Sung-Kee Jo, Uhee Jung, Sung-Ho Kim & Sung-Tae Yee. (2009) Enhanced antitumor efficacy of cisplatin in combination with HemoHIM in tumor-bearing mice. BMC Cancer 9:1.
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Sarita Garg, Marjan Boerma, Junru Wang, Qiang Fu, David S. Loose, K. Sree Kumar & Martin Hauer-Jensen. (2009) Influence of Sublethal Total-Body Irradiation on Immune Cell Populations in the Intestinal Mucosa. Radiation Research 173:4, pages 469.
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Olivier Grémy, Marc Benderitter & Christine Linard. (2008) Acute and persisting Th2-like immune response after fractionated colorectal γ-irradiation. World Journal of Gastroenterology 14:46, pages 7075.
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Hae-Ran Park, Uhee Jung & Sung-Kee Jo. (2007) Impairment of Natural Killer (NK) Cells is an Important Factor in a Weak Th1-like Response in Irradiated Mice. Radiation Research 168:4, pages 446-452.
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