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International Journal of Radiation Biology Volume 82, 2006 - Issue 5
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Original

Irradiated KHYG-1 retains cytotoxicity: Potential for adoptive immunotherapy with a natural killer cell line

G. Suck Department of Medical Oncology and Hematology, Princess Margaret Hospital/Ontario Cancer Institute, Toronto; Division of Cell and Molecular Biology, Toronto General Research Institute, Toronto; Division of Biomedical Sciences, John Hopkins in Singapore, 31 Biopolis way, #02-01, The Nanos, Singapore, 138669, +65 6874 0104, +65 6874 0177 [email protected]Correspondence[email protected]
, PhD,
D. R. Branch Division of Cell and Molecular Biology, Toronto General Research Institute, Toronto; Research & Development, Canadian Blood Services, Toronto Centre, Toronto, Ontario, Canada
&
A. Keating Department of Medical Oncology and Hematology, Princess Margaret Hospital/Ontario Cancer Institute, Toronto; Division of Cell and Molecular Biology, Toronto General Research Institute, Toronto
Pages 355-361 | Received 28 Sep 2005, Accepted 20 Feb 2006, Published online: 03 Jul 2009

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Silun Xie, Zhenyi Wu, Lizhi Niu, Jibing Chen, Yunkun Ma & Mingjie Zhang. (2019) Preparation of highly activated natural killer cells for advanced lung cancer therapy. OncoTargets and Therapy 12, pages 5077-5086.
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Christiane L. Mallett, Catherine Mcfadden, Yuhua Chen & Paula J. Foster. (2012) Migration of iron-labeled KHYG-1 natural killer cells to subcutaneous tumors in nude mice, as detected by magnetic resonance imaging. Cytotherapy 14:6, pages 743-751.
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Articles from other publishers (22)

Eiji Kobayashi, Tatsuhiko Ozawa, Hiroshi Hamana, Atsushi Muraguchi & Hiroyuki Kishi. (2023) Gene modified NK cell line as a powerful tool for evaluation of cloned TCRs for TCR-T cell therapy. Cellular Immunology 383, pages 104656.
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Jen-Tsun Lin, Yi-Ching Chuang, Mu-Kuan Chen, Yu-Sheng Lo, Chia-Chieh Lin, Hsin-Yu Ho, Yen-Tze Liu & Ming-Ju Hsieh. (2022) Shuterin Enhances the Cytotoxicity of the Natural Killer Leukemia Cell Line KHYG-1 by Increasing the Expression Levels of Granzyme B and IFN-γ through the MAPK and Ras/Raf Signaling Pathways. International Journal of Molecular Sciences 23:21, pages 12816.
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Cheng Nong, Pengbo Guan, Li Li, Huiyuan Zhang & Hongbo Hu. (2022) Tumor immunotherapy: Mechanisms and clinical applications. MedComm – Oncology 1:1.
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Yasin Bagheri, Alireza Barati, Ali Aghebati‐Maleki, Leili Aghebati‐Maleki & Mehdi Yousefi. (2020) Current progress in cancer immunotherapy based on natural killer cells. Cell Biology International 45:1, pages 2-17.
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Chia-Hsuan Donna Hu, Yoko Kosaka, Paula Marcus, Iran Rashedi & Armand Keating. (2019) Differential Immunomodulatory Effects of Human Bone Marrow-Derived Mesenchymal Stromal Cells on Natural Killer Cells. Stem Cells and Development 28:14, pages 933-943.
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Upasana Sunil Arvindam, Ethan George Aguilar, Martin Felices, William Murphy & Jeffrey Miller. 2019. Immune Biology of Allogeneic Hematopoietic Stem Cell Transplantation. Immune Biology of Allogeneic Hematopoietic Stem Cell Transplantation 275 292 .
Rohtesh S. Mehta, Brion Randolph, May Daher & Katayoun Rezvani. (2018) NK cell therapy for hematologic malignancies. International Journal of Hematology 107:3, pages 262-270.
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Simon Kavanagh, Tracy Murphy, Arjun Law, Dana Yehudai, Jenny M. Ho, Steve Chan & Aaron D. Schimmer. (2017) Emerging therapies for acute myeloid leukemia: translating biology into the clinic. JCI Insight 2:18.
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Diana Resetca, Anton Neschadim & Jeffrey A. Medin. (2016) Engineering Hematopoietic Cells for Cancer Immunotherapy: Strategies to Address Safety and Toxicity Concerns. Journal of Immunotherapy 39:7, pages 249-259.
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Petra S. A. Becker, Garnet Suck, Paulina Nowakowska, Evelyn Ullrich, Erhard Seifried, Peter Bader, Torsten Tonn & Christian Seidl. (2016) Selection and expansion of natural killer cells for NK cell-based immunotherapy. Cancer Immunology, Immunotherapy 65:4, pages 477-484.
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Garnet Suck, Marcus Odendahl, Paulina Nowakowska, Christian Seidl, Winfried S. Wels, Hans G. Klingemann & Torsten Tonn. (2015) NK-92: an ‘off-the-shelf therapeutic’ for adoptive natural killer cell-based cancer immunotherapy. Cancer Immunology, Immunotherapy 65:4, pages 485-492.
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Garnet Suck, Yeh Ching Linn & Torsten Tonn. (2016) Natural Killer Cells for Therapy of Leukemia. Transfusion Medicine and Hemotherapy 43:2, pages 89-95.
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Zachary B. Davis, Martin Felices, Michael R. Verneris & Jeffrey S. Miller. (2015) Natural Killer Cell Adoptive Transfer Therapy. The Cancer Journal 21:6, pages 486-491.
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Eiji Kobayashi, Sotaro Motoi, Masahito Sugiura, Masunori Kajikawa, Shuji Kojima, Junya Kohroki & Yasuhiko Masuho. (2014) Antibody-dependent cellular cytotoxicity and cytokine/chemokine secretion by KHYG-1 cells stably expressing FcγRIIIA. Immunology Letters 161:1, pages 59-64.
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Min Cheng, Yongyan Chen, Weihua Xiao, Rui Sun & Zhigang Tian. (2013) NK cell-based immunotherapy for malignant diseases. Cellular & Molecular Immunology 10:3, pages 230-252.
Crossref
Bree Foley, Maite Alvarez, William Murphy & Jeffrey S. Miller. 2013. Immune Biology of Allogeneic Hematopoietic Stem Cell Transplantation. Immune Biology of Allogeneic Hematopoietic Stem Cell Transplantation 327 356 .
Min Cheng, Jian Zhang, Wen Jiang, Yongyan Chen & Zhigang Tian. (2012) Natural killer cell lines in tumor immunotherapy. Frontiers of Medicine 6:1, pages 56-66.
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Min Cheng, Juan Ma, Yongyan Chen, Jianhua Zhang, Weidong Zhao, Jian Zhang, Haiming Wei, Bin Ling, Rui Sun & Zhigang Tian. (2011) Establishment, Characterization, and Successful Adaptive Therapy against Human Tumors of NKG Cell, a New Human NK Cell Line. Cell Transplantation 20:11-12, pages 1731-1746.
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Yoko Kosaka & Armand Keating. 2011. Experimental and Applied Immunotherapy. Experimental and Applied Immunotherapy 85 105 .
Sarah Cooley & Daniel S Weisdorf. (2010) Natural killer cells and tumor control. Current Opinion in Hematology 17:6, pages 514-521.
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Nadine Shehata, Yulia Lin, Jacob Pendergrast & Donald R. Branch. (2007) Cellular Therapies: A Canadian Blood Services Research and Development Symposium. Transfusion Medicine Reviews 21:4, pages 317-336.
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Garnet Suck. (2006) Novel approaches using natural killer cells in cancer therapy. Seminars in Cancer Biology 16:5, pages 412-418.
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