2,332
Views
128
CrossRef citations to date
0
Altmetric
Original

Kinetics and dose-response of residual 53BP1/γ-H2AX foci: Co-localization, relationship with DSB repair and clonogenic survival

, &
Pages 319-329 | Received 04 Nov 2004, Accepted 13 Dec 2006, Published online: 03 Jul 2009

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (16)

Katarína Vigašová, Matúš Durdík, Lukáš Jakl, Zuzana Dolinská, Margita Pobijaková, Marta Fekete, Ingrid Závacká, Igor Belyaev & Eva Marková. (2023) Chemotherapy and cryopreservation affects DNA repair foci in lymphocytes of breast cancer patients. International Journal of Radiation Biology 99:11, pages 1660-1668.
Read now
Mélanie Ferlazzo, Elise Berthel, Adeline Granzotto, Clément Devic, Laurène Sonzogni, Jean-Thomas Bachelet, Sandrine Pereira, Michel Bourguignon, Alain Sarasin, Mauro Mezzina & Nicolas Foray. (2020) Some mutations in the xeroderma pigmentosum D gene may lead to moderate but significant radiosensitivity associated with a delayed radiation-induced ATM nuclear localization. International Journal of Radiation Biology 96:3, pages 394-410.
Read now
Qibin Fu, Jing Wang & Tuchen Huang. (2019) Characterizing the DNA damage response in fibrosarcoma stem cells by in-situ cell tracking. International Journal of Radiation Biology 95:2, pages 99-106.
Read now
Lukáš Jakl, Pavel Lobachevsky, Lenka Vokálová, Matúš Durdík, Eva Marková & Igor Belyaev. (2016) Validation of JCountPro software for efficient assessment of ionizing radiation-induced foci in human lymphocytes. International Journal of Radiation Biology 92:12, pages 766-773.
Read now
Masanori Tomita, Munetoshi Maeda, Noriko Usami, Akinari Yokoya, Ritsuko Watanabe & Katsumi Kobayashi. (2016) Enhancement of DNA double-strand break induction and cell killing by K-shell absorption of phosphorus in human cell lines. International Journal of Radiation Biology 92:11, pages 724-732.
Read now
Eva Marková, Alexandra Somsedíková, Stanislav Vasilyev, Margita Pobijaková, Alica Lacková, Pavol Lukačko & Igor Belyaev. (2015) DNA repair foci and late apoptosis/necrosis in peripheral blood lymphocytes of breast cancer patients undergoing radiotherapy. International Journal of Radiation Biology 91:12, pages 934-945.
Read now
Charlot Vandevoorde, Maria Gomolka, Ute Roessler, Daniel Samaga, Carita Lindholm, Marie Fernet, Janet Hall, Eileen Pernot, Houssein El-Saghire, Sarah Baatout, Ausrele Kesminiene & Hubert Thierens. (2015) EPI-CT: in vitro assessment of the applicability of the γ-H2AX-foci assay as cellular biomarker for exposure in a multicentre study of children in diagnostic radiology. International Journal of Radiation Biology 91:8, pages 653-663.
Read now
Ivana Dokic, Andrea Mairani, Stephan Brons, Brigitte Schoell, Anna Jauch, Damir Krunic, Jürgen Debus, Anne Régnier-Vigouroux & Klaus-Josef Weber. (2015) High resistance to X-rays and therapeutic carbon ions in glioblastoma cells bearing dysfunctional ATM associates with intrinsic chromosomal instability. International Journal of Radiation Biology 91:2, pages 157-165.
Read now
Shuai Xu, Nan Ding, Hailong Pei, Wentao Hu, Wenjun Wei, Xurui Zhang, Guangming Zhou & Jufang Wang. (2014) MiR-21 is involved in radiation-induced bystander effects. RNA Biology 11:9, pages 1161-1170.
Read now
Jitao Li, Mingyuan He, Bo Shen, Dexiao Yuan & Chunlin Shao. (2013) Alpha particle-induced bystander effect is mediated by ROS via a p53-dependent SCO2 pathway in hepatoma cells. International Journal of Radiation Biology 89:12, pages 1028-1034.
Read now
Michael A. Kuefner, Michael Brand, Christina Engert, Hanna Kappey, Michael Uder & Luitpold V. Distel. (2013) The effect of calyculin A on the dephosphorylation of the histone γ-H2AX after formation of X-ray-induced DNA double-strand breaks in human blood lymphocytes. International Journal of Radiation Biology 89:6, pages 424-432.
Read now
Halina Lisowska, Aneta Wegierek-Ciuk, Anna Banasik-Nowak, Janusz Braziewicz, Maria Wojewodzka, Andrzej Wojcik & Anna Lankoff. (2013) The dose-response relationship for dicentric chromosomes and γ-H2AX foci in human peripheral blood lymphocytes: Influence of temperature during exposure and intra- and inter-individual variability of donors. International Journal of Radiation Biology 89:3, pages 191-199.
Read now
Eva Marková, Jesper Torudd & Igor Belyaev. (2011) Long time persistence of residual 53BP1/γ-H2AX foci in human lymphocytes in relationship to apoptosis, chromatin condensation and biological dosimetry. International Journal of Radiation Biology 87:7, pages 736-745.
Read now
Laurence Beels, Joke Werbrouck & Hubert Thierens. (2010) Dose response and repair kinetics of γ-H2AX foci induced by in vitro irradiation of whole blood and T-lymphocytes with X- and γ-radiation. International Journal of Radiation Biology 86:9, pages 760-768.
Read now
Elke Beyreuther, Elisabeth Lessmann, Jörg Pawelke & Stefan Pieck. (2009) DNA double-strand break signalling: X-ray energy dependence of residual co-localised foci of γ-H2AX and 53BP1. International Journal of Radiation Biology 85:11, pages 1042-1050.
Read now
Nirmal Bhogal, Farid Jalali & Robert G. Bristow. (2009) Microscopic imaging of DNA repair foci in irradiated normal tissues. International Journal of Radiation Biology 85:9, pages 732-746.
Read now

Articles from other publishers (112)

Angeliki Gkikoudi, Spyridon A. Kalospyros, Sotiria Triantopoulou, Stella Logotheti, Vasiliki Softa, Constantin Kappas, Kiki Theodorou, Evagelia C. Laiakis, Gina Manda, Georgia I. Terzoudi & Alexandros G. Georgakilas. (2023) Molecular Biomarkers for Predicting Cancer Patient Radiosensitivity and Radiotoxicity in Clinical Practice. Applied Sciences 13:23, pages 12564.
Crossref
Pamela Akuwudike, Milagrosa López-Riego, Cloé Dehours, Lovisa Lundholm & Andrzej Wojcik. (2023) Impact of fractionated cisplatin and radiation treatment on cell growth and accumulation of DNA damage in two normal cell types differing in origin. Scientific Reports 13:1.
Crossref
Wenxuan Chai, Yunfan Kong, Maria B. Escalona, Chunshan Hu, Adayabalam S. Balajee & Yong Huang. (2023) Evaluation of Low-dose Radiation-induced DNA Damage and Repair in 3D Printed Human Cellular Constructs. Health Physics 125:3, pages 175-185.
Crossref
Matus Durdik, Eva Markova, Pavol Kosik, Katarina Vigasova, Sachin Gulati, Lukas Jakl, Katarina Vrobelova, Marta Fekete, Ingrid Zavacka, Margita Pobijakova, Zuzana Dolinska & Igor Belyaev. (2023) Assessment of Individual Radiosensitivity in Breast Cancer Patients Using a Combination of Biomolecular Markers. Biomedicines 11:4, pages 1122.
Crossref
Marie Denise Roggan, Jessica Kronenberg, Esther Wollert, Sven Hoffmann, Hasan Nisar, Bikash Konda, Sebastian Diegeler, Christian Liemersdorf & Christine E. Hellweg. (2023) Unraveling astrocyte behavior in the space brain: Radiation response of primary astrocytes. Frontiers in Public Health 11.
Crossref
Bára Křížkovská, Martin Schätz, Jan Lipov, Jitka Viktorová & Eva Jablonská. (2023) In Vitro High-Throughput Genotoxicity Testing Using γH2AX Biomarker, Microscopy and Reproducible Automatic Image Analysis in ImageJ—A Pilot Study with Valinomycin. Toxins 15:4, pages 263.
Crossref
Nora Kostova, Albena Staynova, Ljubomira Popova-Hadjiiska, Dimka Georgieva, Ilonka Ivanova, Nevena Aneva, Margarita Atanasova & Rositsa Hristova. (2023) Effect of curcumin on γ–ray-induced cell response. Journal of Radiation Research 64:2, pages 471-479.
Crossref
Seiya Takano, Yuta Shibamoto, Zhen Wang, Takuhito Kondo, Shingo Hashimoto, Tatsuya Kawai & Akio Hiwatashi. (2023) Optimal timing of a γH2AX analysis to predict cellular lethal damage in cultured tumor cell lines after exposure to diagnostic and therapeutic radiation doses. Journal of Radiation Research 64:2, pages 317-327.
Crossref
Kajal Charan, Amitava Giri & Sandip Kar. (2022) Elucidating the Implications of Diverse Dynamical Responses in p53 Protein. ChemPhysChem 24:4.
Crossref
Pankaj Chaudhary, Giuliana Milluzzo, Aodhan McIlvenny, Hamad Ahmed, Aaron McMurray, Carla Maiorino, Kathryn Polin, Lorenzo Romagnani, Domenico Doria, Stephen J McMahon, Stanley W Botchway, Pattathil P Rajeev, Kevin M Prise & Marco Borghesi. (2023) Cellular irradiations with laser-driven carbon ions at ultra-high dose rates. Physics in Medicine & Biology 68:2, pages 025015.
Crossref
Ana Belchior, João F. Canhoto, Ulrich Giesen, Frank Langner, Hans Rabus & Reinhard Schulte. (2022) Repair Kinetics of DSB-Foci Induced by Proton and α-Particle Microbeams of Different Energies. Life 12:12, pages 2040.
Crossref
Pamela Akuwudike, Adrianna Tartas, Milagrosa López-Riego, Iuliana Toma-Dasu, Andrzej Wojcik & Lovisa Lundholm. (2022) Cell Type-Specific Patterns in the Accumulation of DNA Damage Following Multifractional Radiation Exposure. International Journal of Molecular Sciences 23:21, pages 12861.
Crossref
Amith Z Abdulla, Cédric Vaillant & Daniel Jost. (2022) Painters in chromatin: a unified quantitative framework to systematically characterize epigenome regulation and memory. Nucleic Acids Research 50:16, pages 9083-9104.
Crossref
Magdalena Płódowska, Wiktoria Krakowiak, Aneta Węgierek-Ciuk, Anna Lankoff, Karol Szary, Krzysztof Lis, Andrzej Wojcik & Halina Lisowska. (2022) Hypothermia differentially modulates the formation and decay of NBS1, γH2AX and 53BP1 foci in U2OS cells exposed to gamma radiation. Scientific Reports 12:1.
Crossref
Zastko Lucian, Bereta Martin, Timko Jaroslav & Belyaev Igor. (2022) Classifier Spot Count Optimization of Automated Fluorescent Slide Scanning System. Acta Medica Martiniana 22:1, pages 24-33.
Crossref
Judith Reindl, P. Kundrat, S. Girst, M. Sammer, B. Schwarz & G. Dollinger. (2022) Dosimetry of heavy ion exposure to human cells using nanoscopic imaging of double strand break repair protein clusters. Scientific Reports 12:1.
Crossref
Vasudeva Bhat, Sierra Pellizzari, Alison L. Allan, Eugene Wong, Michael Lock, Muriel Brackstone, Ana Elisa Lohmann, David W. Cescon & Armen Parsyan. (2022) Radiotherapy and radiosensitization in breast cancer: Molecular targets and clinical applications. Critical Reviews in Oncology/Hematology 169, pages 103566.
Crossref
Paula V. Bennett, Alicia M. Johnson, Sarah E. Ackerman, Pankaj Chaudhary, Deborah J. Keszenman & Paul F. Wilson. (2021) Dose-Rate Effects of Protons and Light Ions for DNA Damage Induction, Survival and Transformation in Apparently Normal Primary Human Fibroblasts. Radiation Research 197:3.
Crossref
Yasuhiro Kuraishi, Takeshi Uehara, Takashi Muraki, Mai Iwaya, Yasuhiro Kinugawa, Tomoyuki Nakajima, Takayuki Watanabe, Yusuke Miyagawa & Takeji Umemura. (2021) Impact of DNA double-strand breaks on pancreaticobiliary maljunction carcinogenesis. Diagnostic Pathology 16:1.
Crossref
Matus Durdik, Pavol Kosik, Lukas Jakl, Maria Kozackova, Eva Markova, Katarina Vigasova, Katarina Beresova, Jana Jakubikova, Eva Horvathova, Lucian Zastko, Marta Fekete, Ingrid Zavacka, Margita Pobijakova & Igor Belyaev. (2021) Imaging flow cytometry and fluorescence microscopy in assessing radiation response in lymphocytes from umbilical cord blood and cancer patients. Cytometry Part A 99:12, pages 1198-1208.
Crossref
Lisa Zirjacks, Nicolai Stransky, Lukas Klumpp, Lukas Prause, Franziska Eckert, Daniel Zips, Sabine Schleicher, Rupert Handgretinger, Stephan M. Huber & Katrin Ganser. (2021) Repurposing Disulfiram for Targeting of Glioblastoma Stem Cells: An In Vitro Study. Biomolecules 11:11, pages 1561.
Crossref
Sébastien Penninckx, Eloise Pariset, Egle Cekanaviciute & Sylvain V Costes. (2021) Quantification of radiation-induced DNA double strand break repair foci to evaluate and predict biological responses to ionizing radiation. NAR Cancer 3:4.
Crossref
Melanie Rall-Scharpf, Thomas W.P. Friedl, Shahar Biechonski, Michael Denkinger, Michael Milyavsky & Lisa Wiesmüller. (2021) Sex-specific differences in DNA double-strand break repair of cycling human lymphocytes during aging. Aging 13:17, pages 21066-21089.
Crossref
Alicia M. Johnson, Paula V. Bennett, Katherine Z. Sanidad, Anthony Hoang, James H. Jardine, Deborah J. Keszenman & Paul F. Wilson. (2021) Evaluation of Histone Deacetylase Inhibitors as Radiosensitizers for Proton and Light Ion Radiotherapy. Frontiers in Oncology 11.
Crossref
Haruki Nagashima, Yuki Hayashi, Yuki Sakamoto, Kenshi Komatsu & Hiroshi Tauchi. (2021) Induction of somatic mutations by low concentrations of tritiated water (HTO): evidence for the possible existence of a dose-rate threshold. Journal of Radiation Research 62:4, pages 582-589.
Crossref
Hanns Leonhard Kaatsch, Benjamin Valentin Becker, Simone Schüle, Patrick Ostheim, Kai Nestler, Julia Jakobi, Barbara Schäfer, Thomas Hantke, Marc A. Brockmann, Michael Abend, Stephan Waldeck, Matthias Port, Harry Scherthan & Reinhard Ullmann. (2021) Gene expression changes and DNA damage after ex vivo exposure of peripheral blood cells to various CT photon spectra. Scientific Reports 11:1.
Crossref
Annika Reddig, Linda Voss, Karina Guttek, Dirk Roggenbuck, Eugen Feist & Dirk Reinhold. (2021) Impact of Different JAK Inhibitors and Methotrexate on Lymphocyte Proliferation and DNA Damage. Journal of Clinical Medicine 10:7, pages 1431.
Crossref
Pooja Gupta, Bhaskar Saha, Subrata Chattopadhyay & Birija Sankar Patro. (2021) Pharmacological targeting of differential DNA repair, radio-sensitizes WRN-deficient cancer cells in vitro and in vivo. Biochemical Pharmacology 186, pages 114450.
Crossref
Niels Belmans, Liese Gilles, Jonas Welkenhuysen, Randy Vermeesen, Bjorn Baselet, Benjamin Salmon, Sarah Baatout, Reinhilde Jacobs, Stéphane Lucas, Ivo Lambrichts & Marjan Moreels. (2021) In vitro Assessment of the DNA Damage Response in Dental Mesenchymal Stromal Cells Following Low Dose X-ray Exposure. Frontiers in Public Health 9.
Crossref
Guadalupe M. Vedoya, Marcela M. López Nigro & Gabriela A. Martín. (2021) The secretome of non-tumorigenic mammary cells MCF-10A elicits DNA damage in MCF-7 and MDA-MB-231 breast cancer cells. Toxicology in Vitro 70, pages 105018.
Crossref
Yvonne Lorat, Jochen Fleckenstein, Patric Görlinger, Christian Rübe & Claudia E. Rübe. (2020) Assessment of DNA damage by 53PB1 and pKu70 detection in peripheral blood lymphocytes by immunofluorescence and high-resolution transmission electron microscopy. Strahlentherapie und Onkologie 196:9, pages 821-833.
Crossref
Dante Olofsson, Lei Cheng, Rubén Barrios Fernández, Magdalena Płódowska, Milagrosa López Riego, Pamela Akuwudike, Halina Lisowska, Lovisa Lundholm & Andrzej Wojcik. (2020) Biological effectiveness of very high gamma dose rate and its implication for radiological protection. Radiation and Environmental Biophysics 59:3, pages 451-460.
Crossref
Tim Hohmann, Jacqueline Kessler, Dirk Vordermark & Faramarz Dehghani. (2020) Evaluation of machine learning models for automatic detection of DNA double strand breaks after irradiation using a γH2AX foci assay. PLOS ONE 15:2, pages e0229620.
Crossref
Duo Ma, Lawrence Bronk, Matthew Kerr, Mary Sobieski, Mei Chen, Changran Geng, Joycelyn Yiu, Xiaochun Wang, Narayan Sahoo, Wenhua Cao, Xiaodong Zhang, Clifford Stephan, Radhe Mohan, David R. Grosshans & Fada Guan. (2020) Exploring the advantages of intensity-modulated proton therapy: experimental validation of biological effects using two different beam intensity-modulation patterns. Scientific Reports 10:1.
Crossref
Lukáš Jakl, Eva Marková, Lucia Koláriková & Igor Belyaev. (2020) Biodosimetry of Low Dose Ionizing Radiation Using DNA Repair Foci in Human Lymphocytes. Genes 11:1, pages 58.
Crossref
Elise Berthel, Mélanie L. Ferlazzo, Clément Devic, Michel Bourguignon & Nicolas Foray. (2019) What Does the History of Research on the Repair of DNA Double-Strand Breaks Tell Us?—A Comprehensive Review of Human Radiosensitivity. International Journal of Molecular Sciences 20:21, pages 5339.
Crossref
Pinakin Pandya, Alex Braiman & Noah Isakov. (2019) PICOT (GLRX3) is a positive regulator of stress-induced DNA-damage response. Cellular Signalling 62, pages 109340.
Crossref
Shu Lin, Lifeng Yu, Xinyue Song, Jia Bi, Longyang Jiang, Yan Wang, Miao He, Qinghuan Xiao, Mingli Sun, Olufunmilayo I. Olopade, Lin Zhao & Minjie Wei. (2019) Intrinsic adriamycin resistance in p53-mutated breast cancer is related to the miR-30c/FANCF/REV1-mediated DNA damage response. Cell Death & Disease 10:9.
Crossref
Elise Berthel, Nicolas Foray & Mélanie L. Ferlazzo. (2019) The Nucleoshuttling of the ATM Protein: A Unified Model to Describe the Individual Response to High- and Low-Dose of Radiation?. Cancers 11:7, pages 905.
Crossref
Nico Ruprecht, Martin N. Hungerbühler, Ingrid B. Böhm & Johannes T. Heverhagen. (2019) Improved identification of DNA double strand breaks: γ-H2AX-epitope visualization by confocal microscopy and 3D reconstructed images. Radiation and Environmental Biophysics 58:2, pages 295-302.
Crossref
James R. Duncan, Michael R. Lieber, Noritaka Adachi & Richard L. Wahl. (2018) Reply: Radiation Dose Does Matter: Mechanistic Insights into DNA Damage and Repair Support the Linear No-Threshold Model of Low-Dose Radiation Health Risks. Journal of Nuclear Medicine 59:11, pages 1780-1781.
Crossref
Priti Singh, Lalit Mohan Aggarwal, Stephen A Parry & Mercy J Raman. (2018) Radiation dosimetry and repair kinetics of DNA damage foci in mouse pachytene spermatocyte and round spermatid stages. Mutagenesis 33:3, pages 231-239.
Crossref
Asao Noda. (2018) Radiation-induced unrepairable DSBs: their role in the late effects of radiation and possible applications to biodosimetry. Journal of Radiation Research 59:suppl_2, pages ii114-ii120.
Crossref
Haruki Nagashima, Kumiko Shiraishi, Saori Ohkawa, Yuki Sakamoto, Kenshi Komatsu, Shinya Matsuura, Akira Tachibana & Hiroshi Tauchi. (2018) Induction of somatic mutations by low-dose X-rays: the challenge in recognizing radiation-induced events. Journal of Radiation Research 59:suppl_2, pages ii11-ii17.
Crossref
Alice Sollazzo, Beata Brzozowska, Lei Cheng, Lovisa Lundholm, Harry Scherthan & Andrzej Wojcik. (2018) Live Dynamics of 53BP1 Foci Following Simultaneous Induction of Clustered and Dispersed DNA Damage in U2OS Cells. International Journal of Molecular Sciences 19:2, pages 519.
Crossref
Zhong Wang, Feng Zhou, Yang Dou, Xiaodi Tian, Chenglin Liu, Haiying Li, Haitao Shen & Gang Chen. (2017) Melatonin Alleviates Intracerebral Hemorrhage-Induced Secondary Brain Injury in Rats via Suppressing Apoptosis, Inflammation, Oxidative Stress, DNA Damage, and Mitochondria Injury. Translational Stroke Research 9:1, pages 74-91.
Crossref
Alice Sollazzo, Beata Brzozowska, Lei Cheng, Lovisa Lundholm, Siamak Haghdoost, Harry Scherthan & Andrzej Wojcik. (2017) Alpha Particles and X Rays Interact in Inducing DNA Damage in U2OS Cells. Radiation Research 188:4, pages 400.
Crossref
Anastasia Tsvetkova, Ivan V. Ozerov, Margarita Pustovalova, Anna Grekhova, Petr Eremin, Natalia Vorobyeva, Ilya Eremin, Andrey Pulin, Vadim Zorin, Pavel Kopnin, Sergey Leonov, Alex Zhavoronkov, Dmitry Klokov & Andreyan N. Osipov. (2017) γH2AX, 53BP1 and Rad51 protein foci changes in mesenchymal stem cells during prolonged X-ray irradiation. Oncotarget 8:38, pages 64317-64329.
Crossref
Alaa El-Din Hamid Sayed & Hiroshi Mitani. (2017) Immunostaining of UVA-induced DNA damage in erythrocytes of medaka ( Oryzias latipes ). Journal of Photochemistry and Photobiology B: Biology 171, pages 90-95.
Crossref
Pavol Kosik, Milan Skorvaga, Matus Durdik, Lukas Jakl, Ekaterina Nikitina, Eva Markova, Katarina Kozics, Eva Horvathova & Igor Belyaev. (2017) Low numbers of pre-leukemic fusion genes are frequently present in umbilical cord blood without affecting DNA damage response. Oncotarget 8:22, pages 35824-35834.
Crossref
Alaa El-Din Hamid Sayed, Kento Igarashi, Tomomi Watanabe-Asaka & Hiroshi Mitani. (2017) Double strand break repair and γ-H2AX formation in erythrocytes of medaka (Oryzias latipes) after γ-irradiation. Environmental Pollution 224, pages 35-43.
Crossref
Emad A. Ahmed, Eukene Vélaz, Michael Rosemann, Klaus-P. Gilbertz & Harry Scherthan. (2016) DNA repair kinetics in SCID mice Sertoli cells and DNA-PKcs-deficient mouse embryonic fibroblasts. Chromosoma 126:2, pages 287-298.
Crossref
Roswitha Runge, Jana Arlt, Liane Oehme, Robert Freudenberg & Jörg Kotzerke. (2018) Comparison of clonogenic cell survival and DNA damage induced by 188Re and X-rays in rat thyroid cells. Nuklearmedizin 56:01, pages 47-54.
Crossref
Fredrik Qvarnström, Martin Simonsson, Jan Nyman, Ingegerd Hermansson, Majlis Book, Karl-Axel Johansson & Ingela Turesson. (2017) Double strand break induction and kinetics indicate preserved hypersensitivity in keratinocytes to subtherapeutic doses for 7weeks of radiotherapy. Radiotherapy and Oncology 122:1, pages 163-169.
Crossref
Yi Chieh Lim. 2017. ATM Kinase. ATM Kinase 71 84 .
Nicolas Malaquin, Aurélie Martinez & Francis Rodier. (2016) Keeping the senescence secretome under control: Molecular reins on the senescence-associated secretory phenotype. Experimental Gerontology 82, pages 39-49.
Crossref
Ioana Baldea, Diana Elena Olteanu, Pompei Bolfa, Flaviu Tabaran, Rodica-Mariana Ion & Gabriela Adriana Filip. (2016) Melanogenesis and DNA damage following photodynamic therapy in melanoma with two meso-substituted porphyrins. Journal of Photochemistry and Photobiology B: Biology 161, pages 402-410.
Crossref
Deepa M. Sridharan, Aroumougame Asaithamby, Steve R. Blattnig, Sylvain V. Costes, Paul W. Doetsch, William S. Dynan, Philip Hahnfeldt, Lynn Hlatky, Yared Kidane, Amy Kronenberg, Mamta D. Naidu, Leif E. Peterson, Ianik Plante, Artem L. Ponomarev, Janapriya Saha, Antoine M. Snijders, Kalayarasan Srinivasan, Jonathan Tang, Erica Werner & Janice M. Pluth. (2016) Evaluating biomarkers to model cancer risk post cosmic ray exposure. Life Sciences in Space Research 9, pages 19-47.
Crossref
Sebastian Oeck, Nathalie M. Malewicz, Sebastian Hurst, Justine Rudner & Verena Jendrossek. (2015) The Focinator - a new open-source tool for high-throughput foci evaluation of DNA damage. Radiation Oncology 10:1.
Crossref
R.K.K. Lam, Wei Han & K.N. Yu. (2015) Unirradiated cells rescue cells exposed to ionizing radiation: Activation of NF-κB pathway in irradiated cells. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 782, pages 23-33.
Crossref
Henning Willers, Liliana Gheorghiu, Qi Liu, Jason A. Efstathiou, Lori J. Wirth, Mechthild Krause & Cläre von Neubeck. (2015) DNA Damage Response Assessments in Human Tumor Samples Provide Functional Biomarkers of Radiosensitivity. Seminars in Radiation Oncology 25:4, pages 237-250.
Crossref
Mohammad Sabbir Siddiqui, Maxime François, Michael F. Fenech & Wayne R. Leifert. (2015) Persistent γH2AX: A promising molecular marker of DNA damage and aging. Mutation Research/Reviews in Mutation Research 766, pages 1-19.
Crossref
Ying Liang, Qibin Fu, Weikang Wang, Yu Liu, Feng Liu, Gen Yang & Yugang Wang. (2015) An integrated on-line irradiation and in situ live cell imaging system. Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms 358, pages 26-31.
Crossref
Weiwei Li, Xueyan Gu, Xiaoning Zhang, Jinxin Kong, Nan Ding, Yongmei Qi, Yingmei Zhang, Jufang Wang & Dejun Huang. (2015) Cadmium delays non-homologous end joining (NHEJ) repair via inhibition of DNA-PKcs phosphorylation and downregulation of XRCC4 and Ligase IV. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 779, pages 112-123.
Crossref
Ana Bizarro, Isabel Ferreira, Marina Soković, Leo van Griensven, Diana Sousa, M. Vasconcelos & Raquel Lima. (2015) Cordyceps militaris (L.) Link Fruiting Body Reduces the Growth of a Non-Small Cell Lung Cancer Cell Line by Increasing Cellular Levels of p53 and p21. Molecules 20:8, pages 13927-13940.
Crossref
Dmitry Klokov & Roopa Suppiah. (2015) AN ImageJ-BASED ALGORITHM FOR A SEMI-AUTOMATED METHOD FOR MICROSCOPIC IMAGE ENHANCEMENT AND DNA REPAIR FOCI COUNTING. AECL Nuclear Review 4:1, pages 75-82.
Crossref
Torsten Groesser, Gerald V Fontenay, Ju Han, Hang Chang, Janice Pluth & Bahram Parvin. 2015. Video Bioinformatics. Video Bioinformatics 253 263 .
Jonathan Tang, Walter Georgescu, Thomas Deschamps, Steven M. Yannone & Sylvain V. Costes. 2015. Genomic Instability and Cancer Metastasis. Genomic Instability and Cancer Metastasis 75 93 .
Adam B. Robertson, Julia Robertson, Markus Fusser & Arne Klungland. (2014) Endonuclease G preferentially cleaves 5-hydroxymethylcytosine-modified DNA creating a substrate for recombination. Nucleic Acids Research 42:21, pages 13280-13293.
Crossref
A. Alan Moghissi, Vikrham Kumar Gerraa, Dennis K. McBride & Michael Swetnam. (2014) Scientific Foundation of Regulating Ionizing Radiation. Health Physics 107:5, pages 388-394.
Crossref
S. Gil, Y. Prezado & M. Sabés. (2013) Double-strand breaks on F98 glioma rat cells induced by minibeam and broad-beam synchrotron radiation therapy. Clinical and Translational Oncology 16:8, pages 696-701.
Crossref
Yuko Kinashi, Kakuji Okumura, Yoshihisa Kubota, Erika Kitajima, Ryuichi Okayasu, Koji Ono & Sentaro Takahashi. (2014) Dose-rate effect was observed in T98G glioma cells following BNCT. Applied Radiation and Isotopes 88, pages 81-85.
Crossref
Erika ElgströmOtto LjungbergSophie E. ErikssonAnders ÖrbomSven-Erik StrandTomas G. OhlssonRune NilssonJan Tennvall. (2014) Change in Cell Death Markers During 177 Lu-mAb Radioimmunotherapy-Induced Rejection of Syngeneic Rat Colon Carcinoma . Cancer Biotherapy and Radiopharmaceuticals 29:4, pages 143-152.
Crossref
Helen C. Turner, P. Sharma, J. R. Perrier, A. Bertucci, L. Smilenov, G. Johnson, M. Taveras, D. J. Brenner & G. Garty. (2014) The RABiT: high-throughput technology for assessing global DSB repair. Radiation and Environmental Biophysics 53:2, pages 265-272.
Crossref
Nitya N. Srivastava, Sandeep K. Shukla, M.H. Yashavarddhan, Memita Devi, Rajendra P. Tripathi & Manju L. Gupta. (2014) Modification of radiation-induced DNA double strand break repair pathways by chemicals extracted from Podophyllum hexandrum : An in vitro study in human blood leukocytes . Environmental and Molecular Mutagenesis 55:5, pages 436-448.
Crossref
Anna Acheva, Mihaela Ghita, Gaurang Patel, Kevin M. Prise & Giuseppe Schettino. (2014) Mechanisms of DNA Damage Response to Targeted Irradiation in Organotypic 3D Skin Cultures. PLoS ONE 9:2, pages e86092.
Crossref
Andreas Lamkowski, Fabien Forcheron, Diane Agay, Emad A. Ahmed, Michel Drouet, Viktor Meineke & Harry Scherthan. (2014) DNA Damage Focus Analysis in Blood Samples of Minipigs Reveals Acute Partial Body Irradiation. PLoS ONE 9:2, pages e87458.
Crossref
Bregje Oorschot, Arlene Oei, Anna Nuijens, Hans Rodermond, Ron Hoeben, Jan Stap, Lukas Stalpers & Nicolaas Franken. (2014) Decay of γ-H2AX foci correlates with potentially lethal damage repair and P53 status in human colorectal carcinoma cells. Cellular and Molecular Biology Letters 19:1.
Crossref
Tiago dos Santos, Marta Oliveira, Diana Sousa, Raquel T. Lima, Anabela Martins, Isabel C.F.R. Ferreira & M. Helena Vasconcelos. (2014) Suillus luteus methanolic extract inhibits proliferation and increases expression of p-H2A.X in a non-small cell lung cancer cell line. Journal of Functional Foods 6, pages 100-106.
Crossref
Luca G. Mariotti, Giacomo Pirovano, Kienan I. Savage, Mihaela Ghita, Andrea Ottolenghi, Kevin M. Prise & Giuseppe Schettino. (2013) Use of the γ-H2AX Assay to Investigate DNA Repair Dynamics Following Multiple Radiation Exposures. PLoS ONE 8:11, pages e79541.
Crossref
Annika Willitzki, Sebastian Lorenz, Rico Hiemann, Karina Guttek, Alexander Goihl, Roland Hartig, Karsten Conrad, Eugen Feist, Ulrich Sack, Peter Schierack, Lisa Heiserich, Caroline Eberle, Vanessa Peters, Dirk Roggenbuck & Dirk Reinhold. (2013) Fully automated analysis of chemically induced γH2AX foci in human peripheral blood mononuclear cells by indirect immunofluorescence. Cytometry Part A 83:11, pages 1017-1026.
Crossref
Irene Chiolo, Jonathan Tang, Walter Georgescu & Sylvain V. Costes. (2013) Nuclear dynamics of radiation-induced foci in euchromatin and heterochromatin. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 750:1-2, pages 56-66.
Crossref
Paola Villani, Anna Fresegna, Roberto Ranaldi, Patrizia Eleuteri, Lorena Paris, Francesca Pacchierotti & Eugenia Cordelli. (2013) X-Ray Induced DNA Damage and Repair in Germ Cells of PARP1−/− Male Mice. International Journal of Molecular Sciences 14:9, pages 18078-18092.
Crossref
Maria Moroni, Daisuke Maeda, Mark Whitnall, William Bonner & Christophe Redon. (2013) Evaluation of the Gamma-H2AX Assay for Radiation Biodosimetry in a Swine Model. International Journal of Molecular Sciences 14:7, pages 14119-14135.
Crossref
Bram Herpers & Bob van de Water. 2013. High-Throughput Screening Methods in Toxicity Testing. High-Throughput Screening Methods in Toxicity Testing 143 157 .
Derek M. van Pel, Irene J. Barrett, Yoko Shimizu, Babu V. Sajesh, Brent J. Guppy, Tom Pfeifer, Kirk J. McManus & Philip Hieter. (2013) An Evolutionarily Conserved Synthetic Lethal Interaction Network Identifies FEN1 as a Broad-Spectrum Target for Anticancer Therapeutic Development. PLoS Genetics 9:1, pages e1003254.
Crossref
Alesia Ivashkevich, Christophe E. Redon, Asako J. Nakamura, Roger F. Martin & Olga A. Martin. (2012) Use of the γ-H2AX assay to monitor DNA damage and repair in translational cancer research. Cancer Letters 327:1-2, pages 123-133.
Crossref
Kurtis J. Haro, Andrew C. Scott & David A. Scheinberg. (2012) Mechanisms of resistance to high and low linear energy transfer radiation in myeloid leukemia cells. Blood 120:10, pages 2087-2097.
Crossref
Lin Wang, Haiyan Xing, Zheng Tian, Leiwen Peng, Yan Li, Kejing Tang, Qing Rao, Min Wang & Jianxiang Wang. (2012) iASPPsv antagonizes apoptosis induced by chemotherapeutic agents in MCF-7 cells and mouse thymocytes. Biochemical and Biophysical Research Communications 424:3, pages 414-420.
Crossref
S. L. Ondovcik, L. Tamblyn, J. P. McPherson,P. G. Wells. (2012) Oxoguanine Glycosylase 1 (OGG1) Protects Cells from DNA Double-Strand Break Damage Following Methylmercury (MeHg) Exposure. Toxicological Sciences 128:1, pages 272-283.
Crossref
K. Suzuki & S. Yamashita. (2012) Low-dose Radiation Exposure and Carcinogenesis. Japanese Journal of Clinical Oncology 42:7, pages 563-568.
Crossref
O. Zlobinskaya, G. Dollinger, D. Michalski, V. Hable, C. Greubel, G. Du, G. Multhoff, B. Röper, M. Molls & T. E. Schmid. (2012) Induction and repair of DNA double-strand breaks assessed by gamma-H2AX foci after irradiation with pulsed or continuous proton beams. Radiation and Environmental Biophysics 51:1, pages 23-32.
Crossref
Nghi Phan, Michael De Lisio, Gianni Parise & Douglas R Boreham. (2012) Biological Effects and Adaptive Response from Single and Repeated Computed Tomography Scans in Reticulocytes and Bone Marrow of C57BL/6 Mice. Radiation Research 177:2, pages 164-175.
Crossref
Elina Staaf, Karl Brehwens, Siamak Haghdoost, Joanna Czub & Andrzej Wojcik. (2012) Gamma-H2AX foci in cells exposed to a mixed beam of X-rays and alpha particles. Genome Integrity 3:1, pages 8.
Crossref
Andrew McVean, Simon Kent, Alexei Bakanov, Tom Hobbs & Rhona Anderson. (2012) Development and validation of 'AutoRIF': software for the automated analysis of radiation-induced foci. Genome Integrity 3:1, pages 1.
Crossref
Martin Falk, Emilie Lukasova & Stanislav Kozubek. 2012. Radiation Damage in Biomolecular Systems. Radiation Damage in Biomolecular Systems 329 357 .
Lorena Paris, Eugenia Cordelli, Patrizia Eleuteri, Maria Giuseppa Grollino, Emanuela Pasquali, Roberto Ranaldi, Roberta Meschini & Francesca Pacchierotti. (2011) Kinetics of γ-H2AX induction and removal in bone marrow and testicular cells of mice after X-ray irradiation. Mutagenesis 26:4, pages 563-572.
Crossref
Alesia N. Ivashkevich, Olga A. Martin, Andrea J. Smith, Christophe E. Redon, William M. Bonner, Roger F. Martin & Pavel N. Lobachevsky. (2011) γH2AX foci as a measure of DNA damage: A computational approach to automatic analysis. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 711:1-2, pages 49-60.
Crossref
Jessica M. Hair, Georgia I. Terzoudi, Vasiliki I. Hatzi, Katie A. Lehockey, Devika Srivastava, Weixin Wang, Gabriel E. Pantelias & Alexandros G. Georgakilas. (2010) BRCA1 role in the mitigation of radiotoxicity and chromosomal instability through repair of clustered DNA lesions. Chemico-Biological Interactions 188:2, pages 350-358.
Crossref
L-J Mah, A El-Osta & T C Karagiannis. (2010) γH2AX: a sensitive molecular marker of DNA damage and repair. Leukemia 24:4, pages 679-686.
Crossref
I.Y. Belyaev. (2010) Radiation-induced DNA repair foci: Spatio-temporal aspects of formation, application for assessment of radiosensitivity and biological dosimetry. Mutation Research/Reviews in Mutation Research 704:1-3, pages 132-141.
Crossref
Eva Markovà, Lars O.G. Malmgren & Igor Y. Belyaev. (2010) Microwaves from Mobile Phones Inhibit 53BP1 Focus Formation in Human Stem Cells More Strongly Than in Differentiated Cells: Possible Mechanistic Link to Cancer Risk. Environmental Health Perspectives 118:3, pages 394-399.
Crossref
Genro KASHINO, Yong LIU, Minoru SUZUKI, Shin-ichiro MASUNAGA, Yuko KINASHI, Koji ONO, Keizo TANO & Masami WATANABE. (2010) An Alternative Mechanism for Radioprotection by Dimethyl Sulfoxide; Possible Facilitation of DNA Double-strand Break Repair. Journal of Radiation Research 51:6, pages 733-740.
Crossref
Osama Al-Assar, Ruth J. Muschel, Tine S. Mantoni, W. Gillies McKenna & Thomas B. Brunner. (2009) Radiation Response of Cancer Stem-Like Cells From Established Human Cell Lines After Sorting for Surface Markers. International Journal of Radiation Oncology*Biology*Physics 75:4, pages 1216-1225.
Crossref
Leon Mullenders, Mike Atkinson, Herwig Paretzke, Laure Sabatier & Simon Bouffler. (2009) Assessing cancer risks of low-dose radiation. Nature Reviews Cancer 9:8, pages 596-604.
Crossref
Aroumougame Asaithamby & David J. Chen. (2009) Cellular responses to DNA double-strand breaks after low-dose γ-irradiation. Nucleic Acids Research 37:12, pages 3912-3923.
Crossref
Maddalena Mognato, Cristina Girardi, Sonia Fabris & Lucia Celotti. (2009) DNA repair in modeled microgravity: Double strand break rejoining activity in human lymphocytes irradiated with γ-rays. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 663:1-2, pages 32-39.
Crossref
Igor Y. Belyaev, Eva Markovà, Lena Hillert, Lars O.G. Malmgren & Bertil R.R. Persson. (2009) Microwaves from UMTS/GSM mobile phones induce long-lasting inhibition of 53BP1/γ-H2AX DNA repair foci in human lymphocytes. Bioelectromagnetics 30:2, pages 129-141.
Crossref
William M. Bonner, Christophe E. Redon, Jennifer S. Dickey, Asako J. Nakamura, Olga A. Sedelnikova, Stéphanie Solier & Yves Pommier. (2008) γH2AX and cancer. Nature Reviews Cancer 8:12, pages 957-967.
Crossref
Christoph Greubel, Volker Hable, Guido A. Drexler, Andreas Hauptner, Steffen Dietzel, Hilmar Strickfaden, Iris Baur, Reiner Krücken, Thomas Cremer, Anna A. Friedl & Günther Dollinger. (2008) Quantitative analysis of DNA-damage response factors after sequential ion microirradiation. Radiation and Environmental Biophysics 47:4, pages 415-422.
Crossref
Ulrike MurzikPeter Hemmerich, Stefanie Weidtkamp-Peters, Tobias Ulbricht, Wendy Bussen, Julia HentschelFerdinand von EggelingChristian Melle. (2008) Rad54B Targeting to DNA Double-Strand Break Repair Sites Requires Complex Formation with S100A11. Molecular Biology of the Cell 19:7, pages 2926-2935.
Crossref
Dave C. Francisco, Prakash Peddi, Jessica M. Hair, Brittany A. Flood, Angela M. Cecil, Peter T. Kalogerinis, George Sigounas & Alexandros G. Georgakilas. (2008) Induction and processing of complex DNA damage in human breast cancer cells MCF-7 and nonmalignant MCF-10A cells. Free Radical Biology and Medicine 44:4, pages 558-569.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.