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Oral Delivery of WR-1065/PLGA Nanoparticles

Radioprotection in mice following oral administration of WR-1065/PLGA nanoparticles

, , PhD, , &
Pages 900-908 | Received 12 Dec 2007, Accepted 01 Sep 2008, Published online: 03 Jul 2009

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Jiani Xie, Maoru Zhao, Chengyan Wang, Yuan Yong, Zhanjun Gu & Yuliang Zhao. (2021) Rational Design of Nanomaterials for Various Radiation‐Induced Diseases Prevention and Treatment. Advanced Healthcare Materials 10:6, pages 2001615.
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Xiaona Lin, Xinxin Wang & Hongqi Tian. (2020) Oral delivery of WR-1065 by ROS-responsive PEG-PCL nanoparticles for radioprotection. Colloids and Surfaces A: Physicochemical and Engineering Aspects 599, pages 124886.
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Xiang Yu, Minshu Li, Lin Zhu, Jingfei Li, Guoli Zhang, Rongzhen Fang, Zhihong Wu & Yiguang Jin. (2020) Amifostine-loaded armored dissolving microneedles for long-term prevention of ionizing radiation-induced injury. Acta Biomaterialia 112, pages 87-100.
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Jessica M. Molkentine, Tara N. Fujimoto, Thomas D. Horvath, Aaron J. Grossberg, Carolina J. Garcia Garcia, Amit Deorukhkar, Marimar de la Cruz Bonilla, Daniel Lin, Errol L. G. Samuel, Wai Kin Chan, Philip L. Lorenzi, Helen Piwnica-Worms, Robert Dantzer, James M. Tour, Kathryn A. Mason & Cullen M. Taniguchi. (2019) Enteral Activation of WR-2721 Mediates Radioprotection and Improved Survival from Lethal Fractionated Radiation. Scientific Reports 9:1.
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Jiani Xie, Chengyan Wang, Feng Zhao, Zhanjun Gu & Yuliang Zhao. (2018) Application of Multifunctional Nanomaterials in Radioprotection of Healthy Tissues. Advanced Healthcare Materials 7:20, pages 1800421.
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Yuan Yang, Zhen Qin, Wei Zeng, Ting Yang, Yubin Cao, Chaorong Mei & Yu Kuang. (2017) Toxicity assessment of nanoparticles in various systems and organs. Nanotechnology Reviews 6:3, pages 279-289.
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Chitho P. Feliciano, Koji Tsuboi, Kenshi Suzuki, Hiroyuki Kimura & Yukio Nagasaki. (2017) Long-term bioavailability of redox nanoparticles effectively reduces organ dysfunctions and death in whole-body irradiated mice. Biomaterials 129, pages 68-82.
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Afshin Kheradmand, Alireza M. Nayebi, Masoumeh Jorjani, Solmaz Khalifeh & Rasool Haddadi. (2016) Effects of WR1065 on 6-hydroxydopamine-induced motor imbalance: Possible involvement of oxidative stress and inflammatory cytokines. Neuroscience Letters 627, pages 7-12.
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Xiao Yang, Yanping Ding, Tianjiao Ji, Xiao Zhao, Hai Wang, Xiaozheng Zhao, Ruifang Zhao, Jingyan Wei, Sheng Qi & Guangjun Nie. (2016) Improvement of the in vitro safety profile and cytoprotective efficacy of amifostine against chemotherapy by PEGylation strategy. Biochemical Pharmacology 108, pages 11-21.
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Jodi E. Belz, Wilfred Ngwa, Houari Korideck, Robert A. Cormack, Ross Berbeco, Mike Makrigiorgos, Srinivas Sridhar & Rajiv Kumar. 2014. The Science and Function of Nanomaterials: From Synthesis to Application. The Science and Function of Nanomaterials: From Synthesis to Application 75 106 .
Gula A, Lei Ren, Zhe Zhou, Dandan Lu & Shengqi Wang. (2013) Design and evaluation of biodegradable enteric microcapsules of amifostine for oral delivery. International Journal of Pharmaceutics 453:2, pages 441-447.
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M I Koukourakis. (2012) Radiation damage and radioprotectants: new concepts in the era of molecular medicine. The British Journal of Radiology 85:1012, pages 313-330.
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Lurong Zhang, Weimin Sun, Jianjun Wang, Mei Zhang, Shanmin Yang, Yeping Tian, Sadasivan Vidyasagar, Louis A. Peña, Kunzhong Zhang, Yongbing Cao, Liangjie Yin, Wei Wang, Lei Zhang, Katherine L. Schaefer, Lawrence J. Saubermann, Steven G. Swarts, Bruce M. Fenton, Peter C. Keng & Paul Okunieff. (2010) Mitigation Effect of an FGF-2 Peptide on Acute Gastrointestinal Syndrome After High-Dose Ionizing Radiation. International Journal of Radiation Oncology*Biology*Physics 77:1, pages 261-268.
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