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International Journal of Radiation Biology Volume 84, 2008 - Issue 11
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Radiation Induced Double Strand Breaks

Stochastic properties of radiation-induced DSB: DSB distributions in large scale chromatin loops, the HPRT gene and within the visible volumes of DNA repair foci

Artem L. Ponomarev The Universities Space Research Association, Division of Space Life Sciences, Houston, Texas, USA; National Aeronautics and Space Administration (NASA), Lyndon B. Johnson Space Center, Human Adaptations and Countermeasures Division, Houston, Texas, USACorrespondence[email protected]
,
Sylvain V. Costes Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California, USA
&
Francis A. Cucinotta National Aeronautics and Space Administration (NASA), Lyndon B. Johnson Space Center, Human Adaptations and Countermeasures Division, Houston, Texas, USA
Pages 916-929 | Received 10 Jan 2008, Accepted 15 Sep 2008, Published online: 03 Jul 2009

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Artem L. Ponomarev, Janice Huff & Francis A. Cucinotta. (2010) The analysis of the densely populated patterns of radiation-induced foci by a stochastic, Monte Carlo model of DNA double-strand breaks induction by heavy ions. International Journal of Radiation Biology 86:6, pages 507-515.
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Elke Beyreuther, Elisabeth Lessmann, Jörg Pawelke & Stefan Pieck. (2009) DNA double-strand break signalling: X-ray energy dependence of residual co-localised foci of γ-H2AX and 53BP1. International Journal of Radiation Biology 85:11, pages 1042-1050.
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Sonwabile Arthur Ngcezu & Hans Rabus. (2021) Investigation into the foundations of the track-event theory of cell survival and the radiation action model based on nanodosimetry. Radiation and Environmental Biophysics 60:4, pages 559-578.
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Tony C. Slaba, Ianik Plante, Artem Ponomarev, Zarana S. Patel & Megumi Hada. (2020) Determination of Chromosome Aberrations in Human Fibroblasts Irradiated by Mixed Fields Generated with Shielding. Radiation Research 194:3, pages 246.
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Sébastien Penninckx, Egle Cekanaviciute, Charlotte Degorre, Elodie Guiet, Louise Viger, Stéphane Lucasb & Sylvain V. Costes. (2019) Dose, LET and Strain Dependence of Radiation-Induced 53BP1 Foci in 15 Mouse Strains Ex Vivo Introducing Novel DNA Damage Metrics. Radiation Research 192:1, pages 1.
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Hans Rabus, Sofia Barbieri, Giorgio Baiocco, Andrea Ottolenghi & Ulrich Giesen. (2019) INVESTIGATION INTO THE PROBABILITY FOR MISCOUNTING IN FOCI-BASED ASSAYS. Radiation Protection Dosimetry 183:1-2, pages 126-130.
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Géraldine Gonon, Carmen Villagrasa, Pascale Voisin, Sylvain Meylan, Marta Bueno, Mohamed Amine Benadjaoud, Nicolas Tang, Frank Langner, Hans Rabus, Joan-Francesc Barquinero, Ulrich Giesen & Gaëtan Gruel. (2019) From Energy Deposition of Ionizing Radiation to Cell Damage Signaling: Benchmarking Simulations by Measured Yields of Initial DNA Damage after Ion Microbeam Irradiation. Radiation Research 191:6, pages 566.
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J. Schuemann, A. L. McNamara, J. W. Warmenhoven, N. T. Henthorn, K. J. Kirkby, M. J. Merchant, S. Ingram, H. Paganetti, K. D. Held, J. Ramos-Mendez, B. Faddegon, J. Perl, D. T. Goodhead, I. Plante, H. Rabus, H. Nettelbeck, W. Friedland, P. Kundrát, A. Ottolenghi, G. Baiocco, S. Barbieri, M. Dingfelder, S. Incerti, C. Villagrasa, M. Bueno, M. A. Bernal, S. Guatelli, D. Sakata, J. M. C. Brown, Z. Francis, I. Kyriakou, N. Lampe, F. Ballarini, M. P. Carante, M. Davídková, V. Štěpán, X. Jia, F. A. Cucinotta, R. Schulte, R. D. Stewart, D. J. Carlson, S. Galer, Z. Kuncic, S. Lacombe, J. Milligan, S. H. Cho, G. Sawakuchi, T. Inaniwa, T. Sato, W. Li, A. V. Solov'yov, E. Surdutovich, M. Durante, K. M. Prise & S. J. McMahon. (2018) A New Standard DNA Damage (SDD) Data Format. Radiation Research 191:1, pages 76.
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Shayoni Ray, Egle Cekanaviciute, Ivan Paulino Lima, Brita Singers Sørensen & Sylvain V. Costes. (2018) Comparing Photon and Charged Particle Therapy Using DNA Damage Biomarkers. International Journal of Particle Therapy 5:1, pages 15-24.
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John James Tello Cajiao, Mario Pietro Carante, Mario Antonio Bernal Rodriguez & Francesca Ballarini. (2017) Proximity effects in chromosome aberration induction by low-LET ionizing radiation. DNA Repair 58, pages 38-46.
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Francesco Tommasino, Thomas Friedrich, Burkhard Jakob, Barbara Meyer, Marco Durante & Michael Scholz. (2015) Induction and Processing of the Radiation-Induced Gamma-H2AX Signal and Its Link to the Underlying Pattern of DSB: A Combined Experimental and Modelling Study. PLOS ONE 10:6, pages e0129416.
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F. Antonelli, A. Campa, G. Esposito, P. Giardullo, M. Belli, V. Dini, S. Meschini, G. Simone, E. Sorrentino, S. Gerardi, G. A. P. Cirrone & M. A. Tabocchini. (2015) Induction and Repair of DNA DSB as Revealed by H2AX Phosphorylation Foci in Human Fibroblasts Exposed to Low- and High-LET Radiation: Relationship with Early and Delayed Reproductive Cell Death. Radiation Research 183:4, pages 417-431.
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D. M. Sridharan, A. Asaithamby, S. M. Bailey, S. V. Costes, P. W. Doetsch, W. S. Dynan, A. Kronenberg, K. N. Rithidech, J. Saha, A. M. Snijders, E. Werner, C. Wiese, F. A. Cucinotta & J. M. Pluth. (2015) Understanding Cancer Development Processes after HZE-Particle Exposure: Roles of ROS, DNA Damage Repair and Inflammation. Radiation Research 183:1, pages 1-26.
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Janapriya Saha, Paul Wilson, Peter Thieberger, Derek Lowenstein, Minli Wang & Francis A Cucinotta. (2014) Biological Characterization of Low-Energy Ions with High-Energy Deposition on Human Cells. Radiation Research 182:3, pages 282.
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Artem L. Ponomarev, Kerry George & Francis A. Cucinotta. (2014) Generalized Time-Dependent Model of Radiation-Induced Chromosomal Aberrations in Normal and Repair-Deficient Human Cells. Radiation Research 181:3, pages 284-292.
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Irene Chiolo, Jonathan Tang, Walter Georgescu & Sylvain V. Costes. (2013) Nuclear dynamics of radiation-induced foci in euchromatin and heterochromatin. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 750:1-2, pages 56-66.
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Artem L. Ponomarev & Francis A. Cucinotta. 2013. Computational Intelligence Methods for Bioinformatics and Biostatistics. Computational Intelligence Methods for Bioinformatics and Biostatistics 1 11 .
Maria Antonella Tabocchini, Alessandro Campa & Valentina Dini. (2012) DNA and Cellular Effects of Charged Particles. Health Physics 103:5, pages 547-555.
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Artem L Ponomarev, Kerry George & Francis A Cucinotta. (2012) Computational Model of Chromosome Aberration Yield Induced by High- and Low-LET Radiation Exposures. Radiation Research 177:6, pages 727-737.
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Teresa NeumaierJoel Swenson, Christopher PhamAris PolyzosAlvin T. LoPoAn YangJane DyballAroumougame AsaithambyDavid J. ChenMina J. BissellStefan ThalhammerSylvain V. Costes. (2011) Evidence for formation of DNA repair centers and dose-response nonlinearity in human cells. Proceedings of the National Academy of Sciences 109:2, pages 443-448.
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Somnath Ghosh, Himanshi Narang, Asitikantha Sarma & Malini Krishna. (2011) DNA damage response signaling in lung adenocarcinoma A549 cells following gamma and carbon beam irradiation. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 716:1-2, pages 10-19.
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I. Plante, A. Ponomarev & F. A. Cucinotta. (2011) 3D visualisation of the stochastic patterns of the radial dose in nano-volumes by a Monte Carlo simulation of HZE ion track structure. Radiation Protection Dosimetry 143:2-4, pages 156-161.
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Lori J. Chappell, Mary K. Whalen, Sheena Gurai, Artem Ponomarev, Francis A. Cucinotta & Janice M. Pluth. (2010) Analysis of Flow Cytometry DNA Damage Response Protein Activation Kinetics after Exposure to X Rays and High-Energy Iron Nuclei. Radiation Research 174:6a, pages 691-702.
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Maximilian Stephan Kreipl, Werner Friedland & Herwig G. Paretzke. (2009) Interaction of ion tracks in spatial and temporal proximity. Radiation and Environmental Biophysics 48:4, pages 349-359.
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Kerry A. George, Megumi Hada, Lori J. Jackson, Todd Elliott, Tetsuya Kawata, Janice M. Pluth & Francis A. Cucinotta. (2009) Dose Response of γ Rays and Iron Nuclei for Induction of Chromosomal Aberrations in Normal and Repair-Deficient Cell Lines. Radiation Research 171:6, pages 752-763.
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