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International Journal of Radiation Biology Volume 56, 1989 - Issue 5
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Original Article

Radiobiology and Clinical Application of Halogenated Pyrimidine Radiosensitizers

James B. Mitchell Radiation Oncology Branch, National Cancer Institute, National Institutes of Health, Bldg. 10, Room B3-B69, Bethesda, Maryland, 20892, U.S.A.
,
Angelo Russo Radiation Oncology Branch, National Cancer Institute, National Institutes of Health, Bldg. 10, Room B3-B69, Bethesda, Maryland, 20892, U.S.A.
,
John A. Cook Radiation Oncology Branch, National Cancer Institute, National Institutes of Health, Bldg. 10, Room B3-B69, Bethesda, Maryland, 20892, U.S.A.
,
Karen L. Straus Radiation Oncology Branch, National Cancer Institute, National Institutes of Health, Bldg. 10, Room B3-B69, Bethesda, Maryland, 20892, U.S.A.
&
Eli Glatstein Radiation Oncology Branch, National Cancer Institute, National Institutes of Health, Bldg. 10, Room B3-B69, Bethesda, Maryland, 20892, U.S.A.
Pages 827-836 | Published online: 03 Jul 2009

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Prabha Tiwari & Kaushala Prasad Mishra. (2020) Flavonoids sensitize tumor cells to radiation: molecular mechanisms and relevance to cancer radiotherapy. International Journal of Radiation Biology 96:3, pages 360-369.
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John E. Moulder. (2019) Chemical radiosensitizers: the Journal history. International Journal of Radiation Biology 95:7, pages 940-944.
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Irina V. Panyutin, Rhoda Eniafe, Igor G. Panyutin & Ronald D. Neumann. (2012) Effect of 5-[125I]iodo-2′-deoxyuridine uptake on the proliferation and pluripotency of human embryonic stem cells. International Journal of Radiation Biology 88:12, pages 954-960.
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Y. Wang, G.E. Pantelias & G. Iliakis. (1994) Mechanism of Radiosensitization by Halogenated Pyrimidines: The Contribution of Excess DNA and Chromosome Damage in BrdU Radiosensitization may be Minimal in Plateau-phase Cells. International Journal of Radiation Biology 66:2, pages 133-142.
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Articles from other publishers (25)

Andreas Hans, Philipp Schmidt, Catmarna Küstner-Wetekam, Florian Trinter, Sascha Deinert, Dana Bloß, Johannes H. Viehmann, Rebecca Schaf, Miriam Gerstel, Clara M. Saak, Jens Buck, Stephan Klumpp, Gregor Hartmann, Lorenz S. Cederbaum, Nikolai V. Kryzhevoi & André Knie. (2021) Suppression of X-ray-Induced Radiation Damage to Biomolecules in Aqueous Environments by Immediate Intermolecular Decay of Inner-Shell Vacancies. The Journal of Physical Chemistry Letters 12:30, pages 7146-7150.
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Rezvan Golbaz, Samideh Khoei, Sepideh Khoee, Sakine Shirvalilou, Majid Safa, Seied R Mahdavi & Mohammad R Karimi. (2020) Apoptosis pathway in the combined treatment of x-ray and 5-FU-loaded triblock copolymer-coated magnetic nanoparticles. Nanomedicine 15:23, pages 2255-2270.
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Sara Kavyani & Robabeh Baharfar. (2020) Design and characterization of Fe 3 O 4 /GO/Au‐Ag nanocomposite as an efficient catalyst for the green synthesis of spirooxindole‐dihydropyridines . Applied Organometallic Chemistry 34:4.
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Andrew Cassidy, Nataliya Tsud, Sofiia Bercha, Vitaliy Feyer, Kevin C. Prince & Oksana Plekan. (2019) Adsorption of 5-Fluorouracil on Au(111) and Cu(111) surfaces. AIP Advances 9:8.
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Santanu Mondal & Govindasamy Mugesh. (2019) Dehalogenation of Halogenated Nucleobases and Nucleosides by Organoselenium Compounds. Chemistry - A European Journal 25:7, pages 1773-1780.
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Mohammad Rezaee, Richard P. Hill & David A. Jaffray. (2017) The Exploitation of Low-Energy Electrons in Cancer Treatment. Radiation Research 188:2, pages 123-143.
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Emilie Bayart, Frédéric Pouzoulet, Lucie Calmels, Jonathan Dadoun, Fabien Allot, Johann Plagnard, Jean-Luc Ravanat, André Bridier, Marc Denozière, Jean Bourhis & Eric Deutsch. (2017) Enhancement of IUdR Radiosensitization by Low-Energy Photons Results from Increased and Persistent DNA Damage. PLOS ONE 12:1, pages e0168395.
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Yu-Qing Li, Zoey Cheng & Shun Wong. (2016) Differential Apoptosis Radiosensitivity of Neural Progenitors in Adult Mouse Hippocampus. International Journal of Molecular Sciences 17:6, pages 970.
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Elaine M. Zeman. 2016. Clinical Radiation Oncology. Clinical Radiation Oncology 2 40.e5 .
YOSHIHIRO FUJII, MATTHEW D. GENET, ERICA J. ROYBAL, NOBUO KUBOTA, RYUICHI OKAYASU, KIYOSHI MIYAGAWA, AKIRA FUJIMORI & TAKAMITSU A. KATO. (2013) Comparison of the bromodeoxyuridine-mediated sensitization effects between low-LET and high-LET ionizing radiation on DNA double-strand breaks. Oncology Reports 29:6, pages 2133-2139.
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Elaine M. Zeman. 2012. Clinical Radiation Oncology. Clinical Radiation Oncology 3 42 .
Conchita Vens & Adrian C. Begg. (2010) Targeting Base Excision Repair as a Sensitization Strategy in Radiotherapy. Seminars in Radiation Oncology 20:4, pages 241-249.
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Massimo Pinto, Edouard I. Azzam & Roger W. Howell. (2010) Investigation of Adaptive Responses in Bystander Cells in 3D Cultures Containing Tritium-Labeled and Unlabeled Normal Human Fibroblasts. Radiation Research 174:2, pages 216-227.
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Yu Zeng & Yinsheng Wang. (2007) UVB-Induced Formation of Intrastrand Cross-Link Products of DNA in MCF-7 Cells Treated with 5-Bromo-2‘-deoxyuridine. Biochemistry 46:27, pages 8189-8195.
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Jean-Philippe Pignol, Eileen Rakovitch, David Beachey & Claude Le Sech. (2003) Clinical significance of atomic inner shell ionization (ISI) and Auger cascade for radiosensitization using IUdR, BUdR, platinum salts, or gadolinium porphyrin compounds. International Journal of Radiation Oncology*Biology*Physics 55:4, pages 1082-1091.
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JodiAnne T Hale, James C Bigelow, Linda A Mathews & John J McCormack. (2002) Analytical and pharmacokinetic studies with 5-chloro-2′-deoxycytidine. Biochemical Pharmacology 64:10, pages 1493-1502.
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Xuan Yuan, Larry E. Dillehay, Jerry R. Williams & Jeffery A. Williams. (2001) IUdR polymers for combined continuous low-dose rate and high-dose rate sensitization of experimental human malignant gliomas. International Journal of Cancer 96:2, pages 118-125.
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Jacob J Steinberg, Gary W OliverJr.Jr., Nazih Farah, Payman Simoni, Raz Winiarsky & Antonio Cajigas. (1997) In vivo determination of 5-bromo-2′-deoxyuridine incorporation into DNA tumor tissue by a new 32P-postlabelling thin-layer chromatographic method. Journal of Chromatography B: Biomedical Sciences and Applications 694:2, pages 333-341.
Crossref
E.E. Vokes, M.E. Dolan, S. Krishnasamy, R. Mick, M.J. Ratain, F. Berezin, D. Brachman, G. Whitman, R.L. Schilsky, J. Charette, R.R. Weichselbaum, G.J. Dohrmann & J. Hekmatpanah. (1993) 5-Fluorouracil, hydroxyurea and escalating doses of iododeoxyuridine with concomitant radiotherapy for malignant gliomas: A clinical and pharmacologic analysis. Annals of Oncology 4:7, pages 591-595.
Crossref
James B. Mitchell, John A. Cook, Murali C. Krishna, Stephen Hahn, Thomas Goffman & Eli Glatstein. 1992. Congress Proceedings. Congress Proceedings 745 750 .
Roy B. Tishler & Charles R. Geard. (1992) Correlation of sensitizer enhancement ratio with bromodeoxyuridine concentration and exposure time in human cervical carcinoma cells treated with low dose rate irradiation. International Journal of Radiation Oncology*Biology*Physics 22:3, pages 495-498.
Crossref
Michael R.L. Stratford & Madeleine F. Dennis. (1992) Measurement of incorporation of bromodeoxyuridine into DNA by high performance liquid chromatography using a novel fluorescent labelling technique. International Journal of Radiation Oncology*Biology*Physics 22:3, pages 485-487.
Crossref
Ya Wang & George Iliakis. (1992) Effects of 5′-iododeoxyuridine on the repair of radiation induced potentially lethal damage interphase chromatin breaks and DNA double strand breaks in chinese hamster ovary cells. International Journal of Radiation Oncology*Biology*Physics 23:2, pages 353-360.
Crossref
Roy B. Tishler & Charles R. Geard. (1991) Low dose rate irradiation and halogenated pyrimidine effects on human cervical carcinoma cells. International Journal of Radiation Oncology*Biology*Physics 21:4, pages 975-982.
Crossref
Mark J. Suto. 1991. 151 160 .

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