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Original Article

A Relationship between Microdosimetric Spectra and Cell Survival for High-LET Irradiation

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Pages 447-457 | Received 19 Feb 1990, Accepted 06 Jul 1990, Published online: 03 Jul 2009

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (3)

Sonia M. de Toledo, Manuela Buonanno, Andrew L. Harris & Edouard I. Azzam. (2017) Genomic instability induced in distant progeny of bystander cells depends on the connexins expressed in the irradiated cells. International Journal of Radiation Biology 93:10, pages 1182-1194.
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M. PUGLIESE, M. DURANTE, G. F. GROSSI, F. MONFORTI, D. ORLANDO, A. OTTOLENGHI, P. SCAMPOLI and G. GIALANELLA. (1997) Inactivation of individual mammalian cells by single alpha-particles. International Journal of Radiation Biology 72:4, pages 397-407.
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D. E. CHARLTON & MARIA S. TURNER. (1996) Use of chord lengths through the nucleus to simulate the survival of mammalian cells exposed to high LET alpha-radiation. International Journal of Radiation Biology 69:2, pages 213-217.
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Articles from other publishers (35)

Géraldine Gonon, Sonia M. de Toledo, Venkatachalam Perumal, Jean-Paul Jay-Gerin & Edouard I. Azzam. (2022) Impact of the redox environment on propagation of radiation bystander effects: The modulating effect of oxidative metabolism and oxygen partial pressure. Mutation Research/Genetic Toxicology and Environmental Mutagenesis 883-884, pages 503559.
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Pablo Mínguez Gabiña, John C Roeske, Ricardo Mínguez, Emilia Rodeño & Alfonso Gómez de Iturriaga. (2020) Microdosimetry-based determination of tumour control probability curves for treatments with 225 Ac-PSMA of metastatic castration resistant prostate cancer . Physics in Medicine & Biology 65:23, pages 235012.
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Wenzong Ma, Xudong Wang, Weihao Liu, Huan Ma, Yue Su, Yuanyou Yang, Ning Liu, Yugang Wang & Gen Yang. (2019) A Theoretical Model for Predicting and Optimizing In Vitro Screening of Potential Targeted Alpha-Particle Therapy Drugs. Radiation Research 191:5, pages 475.
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Tomer Nawrocki, Thomas C Tritt, Prasad V S V Neti, Alex S Rosen, Akhil R Dondapati & Roger W Howell. (2018) Design and testing of a microcontroller that enables alpha particle irradiators to deliver complex dose rate patterns. Physics in Medicine & Biology 63:24, pages 245022.
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J. J. M. Kouwenberg, H. T. Wolterbeek, A. G. Denkova & A. J. J. Bos. (2018) Fluorescent nuclear track detectors for alpha radiation microdosimetry. Radiation Oncology 13:1.
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Pablo Mínguez, John C Roeske, Ricardo Mínguez, Alfonso Gómez de Iturriaga & Emilia Rodeño. (2018) Comparison of microdosimetry-based absorbed doses to control tumours and clinically obtained tumour absorbed doses in treatments with 223 Ra . Physics in Medicine & Biology 63:14, pages 145005.
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A.A. Almahwasi, J.C. Jeynes, M.J. Merchant, D.A. Bradley & P.H. Regan. (2017) Delayed persistence of giant-nucleated cells induced by X-ray and proton irradiation in the progeny of replicating normal human f ibroblast cells. Radiation Physics and Chemistry 137, pages 163-168.
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Fei Ye, Jing Ning, Xinguo Liu, Xiaodong Jin, Tieshan Wang & Qiang Li. (2016) The influence of non-DNA-targeted effects on carbon ion–induced low-dose hyper-radiosensitivity in MRC-5 cells. Journal of Radiation Research 57:2, pages 103-109.
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Narongchai Autsavapromporn, Masao Suzuki, Ianik Plante, Cuihua Liu, Yukio Uchihori, Tom K. Hei, Edouard I. Azzam & Takeshi Murakami. (2013) Participation of gap junction communication in potentially lethal damage repair and DNA damage in human fibroblasts exposed to low- or high-LET radiation. Mutation Research/Genetic Toxicology and Environmental Mutagenesis 756:1-2, pages 78-85.
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Géraldine Gonon, Jean-Emmanuel Groetz, Sonia M. de Toledo, Roger W. Howell, Michel Fromm & Edouard I. Azzam. (2013) Nontargeted Stressful Effects in Normal Human Fibroblast Cultures Exposed to Low Fluences of High Charge, High Energy (HZE) Particles: Kinetics of Biologic Responses and Significance of Secondary Radiations. Radiation Research 179:4, pages 444.
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N. Autsavapromporn, S. M. De Toledo, J.-P. Jay-Gerin, A. L. Harris & E. I. Azzam. (2012) Human cell responses to ionizing radiation are differentially affected by the expressed connexins. Journal of Radiation Research 54:2, pages 251-259.
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Edouard I. Azzam, Sonia M. de Toledo, Andrew L. Harris, Vladimir Ivanov, Hongning Zhou, Sally A. Amundson, Howard B. Lieberman & Tom K. Hei. 2013. Pathobiology of Cancer Regimen-Related Toxicities. Pathobiology of Cancer Regimen-Related Toxicities 35 61 .
Kurtis J. Haro, Aneesh Sheth & David A. Scheinberg. (2012) Dysregulation of IRP1-Mediated Iron Metabolism Causes Gamma Ray-specific Radioresistance in Leukemia Cells. PLoS ONE 7:11, pages e48841.
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Kurtis J. Haro, Andrew C. Scott & David A. Scheinberg. (2012) Mechanisms of resistance to high and low linear energy transfer radiation in myeloid leukemia cells. Blood 120:10, pages 2087-2097.
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E. Lazarov, L. Arazi, M. Efrati, T. Cooks, M. Schmidt, Y. Keisari & I. Kelson. (2012) Comparative In Vitro Microdosimetric Study of Murine- and Human-Derived Cancer Cells Exposed to Alpha Particles . Radiation Research 177:3, pages 280-287.
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Chen-Yu Huang, Bradley M. Oborn, Susanna Guatelli & Barry J. Allen. (2012) Monte Carlo calculation of the maximum therapeutic gain of tumor antivascular alpha therapy. Medical Physics 39:3, pages 1282-1288.
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Manuela Buonanno, Sonia M. de Toledo & Edouard I. Azzam. (2011) Increased Frequency of Spontaneous Neoplastic Transformation in Progeny of Bystander Cells from Cultures Exposed to Densely Ionizing Radiation. PLoS ONE 6:6, pages e21540.
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Manuela Buonanno, Sonia M de Toledo, Debkumar Pain & Edouard I Azzam. (2011) Long-Term Consequences of Radiation-Induced Bystander Effects Depend on Radiation Quality and Dose and Correlate with Oxidative Stress. Radiation Research 175:4, pages 405-415.
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Narongchai Autsavapromporn, Sonia M. de Toledo, John B. Little, Jean-Paul Jay-Gerin, Andrew L. Harris & Edouard I. Azzam. (2011) The Role of Gap Junction Communication and Oxidative Stress in the Propagation of Toxic Effects among High-Dose α-Particle-Irradiated Human Cells. Radiation Research 175:3, pages 347-357.
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N. Chouin, K. Bernardeau, F. Davodeau, M. Chérel, A. Faivre-Chauvet, M. Bourgeois, C. Apostolidis, A. Morgenstern, A. Lisbona & M. Bardiès. (2009) Evidence of Extranuclear Cell Sensitivity to Alpha-Particle Radiation Using a Microdosimetric Model. I. Presentation and Validation of a Microdosimetric Model. Radiation Research 171:6, pages 657-663.
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Sylvain Gaillard, David Pusset, Sonia M. de Toledo, Michel Fromm & Edouard I. Azzam. (2009) Propagation Distance of the α-Particle-Induced Bystander Effect: The Role of Nuclear Traversal and Gap Junction Communication. Radiation Research 171:5, pages 513-520.
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Davide Mancusi, Lembit Sihver, Koji Niita, Qiang Li, Tatsuhiko Sato, Hiroshi Iwase, Yosuke Iwamoto, Norihiro Matsuda, Yukio Sakamoto & Hiroshi Nakashima. (2008) Calculation of energy-deposition distributions and microdosimetric estimation of the biological effect of a 9C beam. Radiation and Environmental Biophysics 48:2, pages 135-143.
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John C. Roeske, Bulent Aydogan, Manuel Bardies & John L. Humm. (2008) Small-Scale Dosimetry: Challenges and Future Directions. Seminars in Nuclear Medicine 38:5, pages 367-383.
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John C Roeske & Mark Hoggarth. (2007) Alpha-particle Monte Carlo simulation for microdosimetric calculations using a commercial spreadsheet. Physics in Medicine and Biology 52:7, pages 1909-1922.
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Roger W. Howell & Prasad V. S V. Neti. (2005) Modeling Multicellular Response to Nonuniform Distributions of Radioactivity: Differences in Cellular Response to Self-Dose and Cross-Dose. Radiation Research 163:2, pages 216-221.
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Thomas G. Stinchcomb, Steven J. Wang & John C. Roeske. (2004) Simulation of Binary Methods for the Microdosimetric Analysis of Cell Survival after Alpha-Particle Irradiation: Ability to Distinguish between Different Models. Radiation Research 162:5, pages 585-591.
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Prasad V. S V. Neti, Sonia M. de Toledo, Venkatachalam Perumal, Edouard I. Azzam & Roger W. Howell. (2004) A Multi-port Low-Fluence Alpha-Particle Irradiator: Fabrication, Testing and Benchmark Radiobiological Studies. Radiation Research 161:6, pages 732-738.
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Qiang Li, Tatsuaki Kanai & Atsushi Kitagawa. (2004) The potential application of β-delayed particle decay beam 9 C in cancer therapy . Physics in Medicine and Biology 49:9, pages 1817-1831.
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H. Paganetti. (2016) Significance and Implementation of RBE Variations in Proton Beam Therapy. Technology in Cancer Research & Treatment 2:5, pages 413-426.
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Qiang Li, Tatsuaki Kanai & Atsushi Kitagawa. (2003) A model to evaluate the biological effect induced by the emitted particles from a  -delayed particle decay beam. Physics in Medicine and Biology 48:18, pages 2971-2986.
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Thomas G. Stinchcomb, Christina Soyland, Sindre P. Hassfjell, John Westman, Steven J. Wang, Jenny L. Whitlock, Richard C. Reba, Jacob Rotmensch & John C. Roeske. (2003) Binary Methods for the Microdosimetric Analysis of Cell Survival Data from Alpha-Particle Irradiation. Cancer Biotherapy and Radiopharmaceuticals 18:3, pages 481-487.
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Sindre Hassfjell & Martin W. Brechbiel. (2001) The Development of the α-Particle Emitting Radionuclides 212 Bi and 213 Bi, and Their Decay Chain Related Radionuclides, for Therapeutic Applications . Chemical Reviews 101:7, pages 2019-2036.
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Corine van Vliet-Vroegindeweij, Floyd Wheeler, Finn Stecher-Rasmussen, Ray Moss & René Huiskamp. (2001) Microdosimetry Model for Boron Neutron Capture Therapy: I. Determination of Microscopic Quantities of Heavy Particles on a Cellular Scale. Radiation Research 155:3, pages 490-497.
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John C. Roeske & Thomas G. Stinchcomb. (2000) Tumor Control Probability Model for Alpha-Particle-Emitting Radionuclides. Radiation Research 153:1, pages 16-22.
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J A Simmons. (1992) Absorbed dose-an irrelevant concept for irradiation with heavy charged particles?. Journal of Radiological Protection 12:3, pages 173-179.
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